Dissociable effects of dopaminergic therapy on spatial versus non-spatial working memory in Parkinson's disease.
Identifieur interne : 001008 ( PubMed/Checkpoint ); précédent : 001007; suivant : 001009Dissociable effects of dopaminergic therapy on spatial versus non-spatial working memory in Parkinson's disease.
Auteurs : H. Mollion [France] ; J. Ventre-Dominey ; P F Dominey ; E. BroussolleSource :
- Neuropsychologia [ 0028-3932 ] ; 2003.
English descriptors
- KwdEn :
- Adult, Aged, Analysis of Variance, Association Learning (drug effects), Cognition (drug effects), Discrimination Learning (drug effects), Dopamine Agents (administration & dosage), Drug Administration Schedule, Humans, Levodopa (administration & dosage), Matched-Pair Analysis, Memory (drug effects), Middle Aged, Motor Skills (drug effects), Neuropsychological Tests, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Pattern Recognition, Visual (drug effects), Space Perception (drug effects).
- MESH :
- chemical , administration & dosage : Dopamine Agents, Levodopa.
- drug effects : Association Learning, Cognition, Discrimination Learning, Memory, Motor Skills, Pattern Recognition, Visual, Space Perception.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Adult, Aged, Analysis of Variance, Drug Administration Schedule, Humans, Matched-Pair Analysis, Middle Aged, Neuropsychological Tests.
Abstract
There is now evidence for definite and early cognitive deficits in Parkinson's disease (PD), involving, in particular, executive functions and working memory. However, the distinction between visuo-spatial and non-spatial working memory deficits and the impact of dopamine on these deficits are still open to debate. The aim of this study was therefore to investigate cognitive and motor performance in PD patients in two conditional associative learning tasks requiring either spatial or non-spatial visual working memory. The subject had to point to visual targets according to the visual characteristics of memorised visual cues (colour, position and form). To assess the effect of L-dopa therapy, PD patients were studied over two consecutive days: one ON/OFF group of nine PD patients with treatment (ON condition) on the first day and without treatment (OFF condition) on the second day; and another OFF/ON group of nine PD patients tested on reverse. The PD groups were compared to a control group of nine age-matched healthy subjects. Our main data demonstrate that: (1) in PD patients with OFF treatment, the response time of manual pointing is increased mainly in the non-spatial working memory task; and (2) in PD patients with ON treatment, either the response time is normal (on the first day) or is increased in both visuo-spatial and non-spatial tasks. We suggest that this dissociation between spatial versus non-spatial working memory deficits in non-medicated PD might be related to compensatory mechanisms that occur following fronto-striatal dysfunction.
PubMed: 12849762
Affiliations:
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However, the distinction between visuo-spatial and non-spatial working memory deficits and the impact of dopamine on these deficits are still open to debate. The aim of this study was therefore to investigate cognitive and motor performance in PD patients in two conditional associative learning tasks requiring either spatial or non-spatial visual working memory. The subject had to point to visual targets according to the visual characteristics of memorised visual cues (colour, position and form). To assess the effect of L-dopa therapy, PD patients were studied over two consecutive days: one ON/OFF group of nine PD patients with treatment (ON condition) on the first day and without treatment (OFF condition) on the second day; and another OFF/ON group of nine PD patients tested on reverse. The PD groups were compared to a control group of nine age-matched healthy subjects. Our main data demonstrate that: (1) in PD patients with OFF treatment, the response time of manual pointing is increased mainly in the non-spatial working memory task; and (2) in PD patients with ON treatment, either the response time is normal (on the first day) or is increased in both visuo-spatial and non-spatial tasks. We suggest that this dissociation between spatial versus non-spatial working memory deficits in non-medicated PD might be related to compensatory mechanisms that occur following fronto-striatal dysfunction.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12849762</PMID><DateCreated><Year>2003</Year><Month>07</Month><Day>09</Day></DateCreated><DateCompleted><Year>2003</Year><Month>09</Month><Day>24</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0028-3932</ISSN><JournalIssue CitedMedium="Print"><Volume>41</Volume><Issue>11</Issue><PubDate><Year>2003</Year></PubDate></JournalIssue><Title>Neuropsychologia</Title><ISOAbbreviation>Neuropsychologia</ISOAbbreviation></Journal><ArticleTitle>Dissociable effects of dopaminergic therapy on spatial versus non-spatial working memory in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1442-51</MedlinePgn></Pagination><Abstract><AbstractText>There is now evidence for definite and early cognitive deficits in Parkinson's disease (PD), involving, in particular, executive functions and working memory. However, the distinction between visuo-spatial and non-spatial working memory deficits and the impact of dopamine on these deficits are still open to debate. The aim of this study was therefore to investigate cognitive and motor performance in PD patients in two conditional associative learning tasks requiring either spatial or non-spatial visual working memory. The subject had to point to visual targets according to the visual characteristics of memorised visual cues (colour, position and form). To assess the effect of L-dopa therapy, PD patients were studied over two consecutive days: one ON/OFF group of nine PD patients with treatment (ON condition) on the first day and without treatment (OFF condition) on the second day; and another OFF/ON group of nine PD patients tested on reverse. The PD groups were compared to a control group of nine age-matched healthy subjects. Our main data demonstrate that: (1) in PD patients with OFF treatment, the response time of manual pointing is increased mainly in the non-spatial working memory task; and (2) in PD patients with ON treatment, either the response time is normal (on the first day) or is increased in both visuo-spatial and non-spatial tasks. 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MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016555" MajorTopicYN="N">Matched-Pair Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008568" MajorTopicYN="N">Memory</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009048" MajorTopicYN="N">Motor Skills</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009483" MajorTopicYN="N">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson 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Broussolle</name><name sortKey="Dominey, P F" sort="Dominey, P F" uniqKey="Dominey P" first="P F" last="Dominey">P F Dominey</name><name sortKey="Ventre Dominey, J" sort="Ventre Dominey, J" uniqKey="Ventre Dominey J" first="J" last="Ventre-Dominey">J. Ventre-Dominey</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Mollion, H" sort="Mollion, H" uniqKey="Mollion H" first="H" last="Mollion">H. Mollion</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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