ParkinsonFranceV1, PubMed, Checkpoint, bibRecord, 000823

Do Parkinson's disease patients disclose their adverse events spontaneously?

Identifieur interne : 000823 ( PubMed/Checkpoint ); précédent : 000822; suivant : 000824

Do Parkinson's disease patients disclose their adverse events spontaneously?

Auteurs : Santiago Perez-Lloret [France] ; María Ver Nica Rey ; Nelly Fabre ; Fabienne Ory ; Umberto Spampinato ; Jean-Louis Montastruc ; Olivier Rascol

Source :

European journal of clinical pharmacology [ 1432-1041 ] ; 2012.

RBID : pubmed:22205275

Descripteurs français

Wicri :
- geographic : France.

English descriptors

KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Cross-Sectional Studies, Disclosure, Drug Monitoring, Female, France, Hospitals, University, Humans, Interviews as Topic, Male, Outpatient Clinics, Hospital, Parkinson Disease (drug therapy), Surveys and Questionnaires.
MESH :
- chemical , adverse effects : Antiparkinson Agents.
- chemical , therapeutic use : Antiparkinson Agents.
- geographic : France.
- drug therapy : Parkinson Disease.
- Aged, Cross-Sectional Studies, Disclosure, Drug Monitoring, Female, Hospitals, University, Humans, Interviews as Topic, Male, Outpatient Clinics, Hospital, Surveys and Questionnaires.

Abstract

Underreporting of adverse drug reactions is common but has been rarely studied in Parkinson's disease (PD).

DOI: 10.1007/s00228-011-1198-x
PubMed: 22205275

Affiliations:

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to stream PubMed, to step Corpus: 000871
to stream PubMed, to step Curation: 000835

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pubmed:22205275

Le document en format XML

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<author><name sortKey="Perez Lloret, Santiago" sort="Perez Lloret, Santiago" uniqKey="Perez Lloret S" first="Santiago" last="Perez-Lloret">Santiago Perez-Lloret</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Pharmacologie Médicale et Clinique, INSERM U 1027 Equipe de PharmacoEpidémiologie, Faculté de Médecine, Université de Toulouse, Toulouse, France. splloret@fleni.org.ar</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Pharmacologie Médicale et Clinique, INSERM U 1027 Equipe de PharmacoEpidémiologie, Faculté de Médecine, Université de Toulouse, Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
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<author><name sortKey="Rey, Maria Ver Nica" sort="Rey, Maria Ver Nica" uniqKey="Rey M" first="María Ver Nica" last="Rey">María Ver Nica Rey</name>
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<author><name sortKey="Fabre, Nelly" sort="Fabre, Nelly" uniqKey="Fabre N" first="Nelly" last="Fabre">Nelly Fabre</name>
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<author><name sortKey="Ory, Fabienne" sort="Ory, Fabienne" uniqKey="Ory F" first="Fabienne" last="Ory">Fabienne Ory</name>
</author>
<author><name sortKey="Spampinato, Umberto" sort="Spampinato, Umberto" uniqKey="Spampinato U" first="Umberto" last="Spampinato">Umberto Spampinato</name>
</author>
<author><name sortKey="Montastruc, Jean Louis" sort="Montastruc, Jean Louis" uniqKey="Montastruc J" first="Jean-Louis" last="Montastruc">Jean-Louis Montastruc</name>
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<author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Do Parkinson's disease patients disclose their adverse events spontaneously?</title>
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<affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Pharmacologie Médicale et Clinique, INSERM U 1027 Equipe de PharmacoEpidémiologie, Faculté de Médecine, Université de Toulouse, Toulouse, France. splloret@fleni.org.ar</nlm:affiliation>
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<author><name sortKey="Rey, Maria Ver Nica" sort="Rey, Maria Ver Nica" uniqKey="Rey M" first="María Ver Nica" last="Rey">María Ver Nica Rey</name>
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<author><name sortKey="Fabre, Nelly" sort="Fabre, Nelly" uniqKey="Fabre N" first="Nelly" last="Fabre">Nelly Fabre</name>
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<author><name sortKey="Ory, Fabienne" sort="Ory, Fabienne" uniqKey="Ory F" first="Fabienne" last="Ory">Fabienne Ory</name>
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<author><name sortKey="Spampinato, Umberto" sort="Spampinato, Umberto" uniqKey="Spampinato U" first="Umberto" last="Spampinato">Umberto Spampinato</name>
</author>
<author><name sortKey="Montastruc, Jean Louis" sort="Montastruc, Jean Louis" uniqKey="Montastruc J" first="Jean-Louis" last="Montastruc">Jean-Louis Montastruc</name>
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<author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
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<series><title level="j">European journal of clinical pharmacology</title>
<idno type="eISSN">1432-1041</idno>
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<term>Cross-Sectional Studies</term>
<term>Disclosure</term>
<term>Drug Monitoring</term>
<term>Female</term>
<term>France</term>
<term>Hospitals, University</term>
<term>Humans</term>
<term>Interviews as Topic</term>
<term>Male</term>
<term>Outpatient Clinics, Hospital</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Surveys and Questionnaires</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Cross-Sectional Studies</term>
<term>Disclosure</term>
<term>Drug Monitoring</term>
<term>Female</term>
<term>Hospitals, University</term>
<term>Humans</term>
<term>Interviews as Topic</term>
<term>Male</term>
<term>Outpatient Clinics, Hospital</term>
<term>Surveys and Questionnaires</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term>
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<front><div type="abstract" xml:lang="en">Underreporting of adverse drug reactions is common but has been rarely studied in Parkinson's disease (PD).</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22205275</PMID>
<DateCreated><Year>2012</Year>
<Month>04</Month>
<Day>24</Day>
</DateCreated>
<DateCompleted><Year>2012</Year>
<Month>08</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>11</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1041</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>68</Volume>
<Issue>5</Issue>
<PubDate><Year>2012</Year>
<Month>May</Month>
</PubDate>
</JournalIssue>
<Title>European journal of clinical pharmacology</Title>
<ISOAbbreviation>Eur. J. Clin. Pharmacol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Do Parkinson's disease patients disclose their adverse events spontaneously?</ArticleTitle>
<Pagination><MedlinePgn>857-65</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00228-011-1198-x</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Underreporting of adverse drug reactions is common but has been rarely studied in Parkinson's disease (PD).</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To compare the prevalence of adverse events (AEs) in relation to antiparkinsonian drugs in PD patients using two different data collection methods: patient's spontaneous reporting versus a predefined investigator-driven structured interview. Secondary objectives were to assess factors related to spontaneous reporting and to compare the rate of AE reporting in PD patients with that of a group of non-parkinsonian post-stroke patients.</AbstractText>
<AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">Cross-sectional study.</AbstractText>
<AbstractText Label="PATIENTS" NlmCategory="METHODS">Ambulatory, cognitively intact PD or post-stroke outpatients.</AbstractText>
<AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">None.</AbstractText>
<AbstractText Label="OUTCOME MEASURES" NlmCategory="METHODS">Patients were first asked by means of an an open question to disclose any unpleasant effects in connection with their current medications that had occurred during the previous week. Afterwards, a predefined questionnaire listing the most common AEs known to be related to antiparkinsonian drugs was used to question the same patients in a systematic manner about the presence of any AE during the same week. Chronological and semiological criteria were used to classify the reported AEs as "unrelated" or "possibly/plausibly related" to the antiparkinsonian treatment.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 203 PD and 52 post-stroke patients of comparable age and sex were recruited. Eighty-five PD and five post-stroke patients reported spontaneously at least one AE (42 vs. 10%, p < 0.01), while 203 PD and 47 post-stroke patients reported at least one AE following the structured questionnaire (100 vs. 90%, p < 0.001). In PD patients, there were a total of 112 spontaneously reported AEs as compared with 1,574 according to the structured questionnaire (7%). Spontaneous disclosure of AEs was associated with experiencing >2 AEs [OR = 1.2 (1.1-3.2)], logistic regression). Seventy-four percent of PD patients had ≥1 AE possibly/plausibly related to antiparkinsonian drugs.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Results showed that only 7% of AEs were reported spontaneously by patients, thus underscoring the importance of systematically asking about AEs in PD patients.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Perez-Lloret</LastName>
<ForeName>Santiago</ForeName>
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<AffiliationInfo><Affiliation>Laboratoire de Pharmacologie Médicale et Clinique, INSERM U 1027 Equipe de PharmacoEpidémiologie, Faculté de Médecine, Université de Toulouse, Toulouse, France. splloret@fleni.org.ar</Affiliation>
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<Author ValidYN="Y"><LastName>Rey</LastName>
<ForeName>María Verónica</ForeName>
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<Author ValidYN="Y"><LastName>Fabre</LastName>
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<Author ValidYN="Y"><LastName>Ory</LastName>
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<Author ValidYN="Y"><LastName>Spampinato</LastName>
<ForeName>Umberto</ForeName>
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<Author ValidYN="Y"><LastName>Montastruc</LastName>
<ForeName>Jean-Louis</ForeName>
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<Author ValidYN="Y"><LastName>Rascol</LastName>
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<MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName>
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<tree><noCountry><name sortKey="Fabre, Nelly" sort="Fabre, Nelly" uniqKey="Fabre N" first="Nelly" last="Fabre">Nelly Fabre</name>
<name sortKey="Montastruc, Jean Louis" sort="Montastruc, Jean Louis" uniqKey="Montastruc J" first="Jean-Louis" last="Montastruc">Jean-Louis Montastruc</name>
<name sortKey="Ory, Fabienne" sort="Ory, Fabienne" uniqKey="Ory F" first="Fabienne" last="Ory">Fabienne Ory</name>
<name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
<name sortKey="Rey, Maria Ver Nica" sort="Rey, Maria Ver Nica" uniqKey="Rey M" first="María Ver Nica" last="Rey">María Ver Nica Rey</name>
<name sortKey="Spampinato, Umberto" sort="Spampinato, Umberto" uniqKey="Spampinato U" first="Umberto" last="Spampinato">Umberto Spampinato</name>
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<country name="France"><region name="Occitanie (région administrative)"><name sortKey="Perez Lloret, Santiago" sort="Perez Lloret, Santiago" uniqKey="Perez Lloret S" first="Santiago" last="Perez-Lloret">Santiago Perez-Lloret</name>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Do Parkinson's disease patients disclose their adverse events spontaneously?

Do Parkinson's disease patients disclose their adverse events spontaneously?

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki