Do Parkinson's disease patients disclose their adverse events spontaneously?
Identifieur interne : 000835 ( PubMed/Curation ); précédent : 000834; suivant : 000836Do Parkinson's disease patients disclose their adverse events spontaneously?
Auteurs : Santiago Perez-Lloret [France] ; María Ver Nica Rey ; Nelly Fabre ; Fabienne Ory ; Umberto Spampinato ; Jean-Louis Montastruc ; Olivier RascolSource :
- European journal of clinical pharmacology [ 1432-1041 ] ; 2012.
Descripteurs français
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Cross-Sectional Studies, Disclosure, Drug Monitoring, Female, France, Hospitals, University, Humans, Interviews as Topic, Male, Outpatient Clinics, Hospital, Parkinson Disease (drug therapy), Surveys and Questionnaires.
- MESH :
- chemical , adverse effects : Antiparkinson Agents.
- chemical , therapeutic use : Antiparkinson Agents.
- geographic : France.
- drug therapy : Parkinson Disease.
- Aged, Cross-Sectional Studies, Disclosure, Drug Monitoring, Female, Hospitals, University, Humans, Interviews as Topic, Male, Outpatient Clinics, Hospital, Surveys and Questionnaires.
Abstract
Underreporting of adverse drug reactions is common but has been rarely studied in Parkinson's disease (PD).
DOI: 10.1007/s00228-011-1198-x
PubMed: 22205275
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pubmed:22205275Le document en format XML
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<author><name sortKey="Perez Lloret, Santiago" sort="Perez Lloret, Santiago" uniqKey="Perez Lloret S" first="Santiago" last="Perez-Lloret">Santiago Perez-Lloret</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Pharmacologie Médicale et Clinique, INSERM U 1027 Equipe de PharmacoEpidémiologie, Faculté de Médecine, Université de Toulouse, Toulouse, France. splloret@fleni.org.ar</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Pharmacologie Médicale et Clinique, INSERM U 1027 Equipe de PharmacoEpidémiologie, Faculté de Médecine, Université de Toulouse, Toulouse</wicri:regionArea>
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<author><name sortKey="Rey, Maria Ver Nica" sort="Rey, Maria Ver Nica" uniqKey="Rey M" first="María Ver Nica" last="Rey">María Ver Nica Rey</name>
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<author><name sortKey="Fabre, Nelly" sort="Fabre, Nelly" uniqKey="Fabre N" first="Nelly" last="Fabre">Nelly Fabre</name>
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<author><name sortKey="Ory, Fabienne" sort="Ory, Fabienne" uniqKey="Ory F" first="Fabienne" last="Ory">Fabienne Ory</name>
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<author><name sortKey="Spampinato, Umberto" sort="Spampinato, Umberto" uniqKey="Spampinato U" first="Umberto" last="Spampinato">Umberto Spampinato</name>
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<term>Disclosure</term>
<term>Drug Monitoring</term>
<term>Female</term>
<term>France</term>
<term>Hospitals, University</term>
<term>Humans</term>
<term>Interviews as Topic</term>
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<term>Outpatient Clinics, Hospital</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
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<term>Female</term>
<term>Hospitals, University</term>
<term>Humans</term>
<term>Interviews as Topic</term>
<term>Male</term>
<term>Outpatient Clinics, Hospital</term>
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<front><div type="abstract" xml:lang="en">Underreporting of adverse drug reactions is common but has been rarely studied in Parkinson's disease (PD).</div>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22205275</PMID>
<DateCreated><Year>2012</Year>
<Month>04</Month>
<Day>24</Day>
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<DateCompleted><Year>2012</Year>
<Month>08</Month>
<Day>21</Day>
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<Month>11</Month>
<Day>19</Day>
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<JournalIssue CitedMedium="Internet"><Volume>68</Volume>
<Issue>5</Issue>
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<Month>May</Month>
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<Title>European journal of clinical pharmacology</Title>
<ISOAbbreviation>Eur. J. Clin. Pharmacol.</ISOAbbreviation>
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<ArticleTitle>Do Parkinson's disease patients disclose their adverse events spontaneously?</ArticleTitle>
<Pagination><MedlinePgn>857-65</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00228-011-1198-x</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Underreporting of adverse drug reactions is common but has been rarely studied in Parkinson's disease (PD).</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To compare the prevalence of adverse events (AEs) in relation to antiparkinsonian drugs in PD patients using two different data collection methods: patient's spontaneous reporting versus a predefined investigator-driven structured interview. Secondary objectives were to assess factors related to spontaneous reporting and to compare the rate of AE reporting in PD patients with that of a group of non-parkinsonian post-stroke patients.</AbstractText>
<AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">Cross-sectional study.</AbstractText>
<AbstractText Label="PATIENTS" NlmCategory="METHODS">Ambulatory, cognitively intact PD or post-stroke outpatients.</AbstractText>
<AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">None.</AbstractText>
<AbstractText Label="OUTCOME MEASURES" NlmCategory="METHODS">Patients were first asked by means of an an open question to disclose any unpleasant effects in connection with their current medications that had occurred during the previous week. Afterwards, a predefined questionnaire listing the most common AEs known to be related to antiparkinsonian drugs was used to question the same patients in a systematic manner about the presence of any AE during the same week. Chronological and semiological criteria were used to classify the reported AEs as "unrelated" or "possibly/plausibly related" to the antiparkinsonian treatment.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 203 PD and 52 post-stroke patients of comparable age and sex were recruited. Eighty-five PD and five post-stroke patients reported spontaneously at least one AE (42 vs. 10%, p < 0.01), while 203 PD and 47 post-stroke patients reported at least one AE following the structured questionnaire (100 vs. 90%, p < 0.001). In PD patients, there were a total of 112 spontaneously reported AEs as compared with 1,574 according to the structured questionnaire (7%). Spontaneous disclosure of AEs was associated with experiencing >2 AEs [OR = 1.2 (1.1-3.2)], logistic regression). Seventy-four percent of PD patients had ≥1 AE possibly/plausibly related to antiparkinsonian drugs.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Results showed that only 7% of AEs were reported spontaneously by patients, thus underscoring the importance of systematically asking about AEs in PD patients.</AbstractText>
</Abstract>
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