Progressive endothelial damage revealed by multilevel von Willebrand factor plasma concentrations in atrial fibrillation patients.
Identifieur interne : 000654 ( PubMed/Checkpoint ); précédent : 000653; suivant : 000655Progressive endothelial damage revealed by multilevel von Willebrand factor plasma concentrations in atrial fibrillation patients.
Auteurs : Alina Scridon [France] ; Nicolas Girerd ; Lucia Rugeri ; Emilie Nonin-Babary ; Philippe ChevalierSource :
- Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology [ 1532-2092 ] ; 2013.
English descriptors
- KwdEn :
- Atrial Fibrillation (blood), Atrial Fibrillation (physiopathology), Biomarkers (blood), Case-Control Studies, Cross-Sectional Studies, Disease Progression, Endothelium, Vascular (physiopathology), Female, Humans, Male, Middle Aged, Risk Factors, Sinoatrial Node (physiopathology), Stroke (epidemiology), Thromboembolism (epidemiology), Wolff-Parkinson-White Syndrome (blood), Wolff-Parkinson-White Syndrome (physiopathology), von Willebrand Factor (metabolism).
- MESH :
- chemical , blood : Biomarkers.
- blood : Atrial Fibrillation, Wolff-Parkinson-White Syndrome.
- epidemiology : Stroke, Thromboembolism.
- chemical , metabolism : von Willebrand Factor.
- physiopathology : Atrial Fibrillation, Endothelium, Vascular, Sinoatrial Node, Wolff-Parkinson-White Syndrome.
- Case-Control Studies, Cross-Sectional Studies, Disease Progression, Female, Humans, Male, Middle Aged, Risk Factors.
Abstract
Abnormal plasma concentrations of von Willebrand factor (vWF), a marker of prothrombotic risk, have been found in atrial fibrillation (AF) patients, but the extent of this variation is not clear. This study aimed to investigate the effect of different clinical forms of AF on plasma concentrations of vWF at different levels of the circulatory tree, both intracardiac and extracardiac.
DOI: 10.1093/europace/eut121
PubMed: 23689486
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Progressive endothelial damage revealed by multilevel von Willebrand factor plasma concentrations in atrial fibrillation patients.</title><author><name sortKey="Scridon, Alina" sort="Scridon, Alina" uniqKey="Scridon A" first="Alina" last="Scridon">Alina Scridon</name><affiliation wicri:level="3"><nlm:affiliation>Unité de Neurocardiologie EA4612, Université Lyon 1, Lyon F-69008, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité de Neurocardiologie EA4612, Université Lyon 1, Lyon F-69008</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Girerd, Nicolas" sort="Girerd, Nicolas" uniqKey="Girerd N" first="Nicolas" last="Girerd">Nicolas Girerd</name></author><author><name sortKey="Rugeri, Lucia" sort="Rugeri, Lucia" uniqKey="Rugeri L" first="Lucia" last="Rugeri">Lucia Rugeri</name></author><author><name sortKey="Nonin Babary, Emilie" sort="Nonin Babary, Emilie" uniqKey="Nonin Babary E" first="Emilie" last="Nonin-Babary">Emilie Nonin-Babary</name></author><author><name sortKey="Chevalier, Philippe" sort="Chevalier, Philippe" uniqKey="Chevalier P" first="Philippe" last="Chevalier">Philippe Chevalier</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23689486</idno><idno type="pmid">23689486</idno><idno type="doi">10.1093/europace/eut121</idno><idno type="wicri:Area/PubMed/Corpus">000667</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000667</idno><idno type="wicri:Area/PubMed/Curation">000639</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000639</idno><idno type="wicri:Area/PubMed/Checkpoint">000639</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000639</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Progressive endothelial damage revealed by multilevel von Willebrand factor plasma concentrations in atrial fibrillation patients.</title><author><name sortKey="Scridon, Alina" sort="Scridon, Alina" uniqKey="Scridon A" first="Alina" last="Scridon">Alina Scridon</name><affiliation wicri:level="3"><nlm:affiliation>Unité de Neurocardiologie EA4612, Université Lyon 1, Lyon F-69008, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité de Neurocardiologie EA4612, Université Lyon 1, Lyon F-69008</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Girerd, Nicolas" sort="Girerd, Nicolas" uniqKey="Girerd N" first="Nicolas" last="Girerd">Nicolas Girerd</name></author><author><name sortKey="Rugeri, Lucia" sort="Rugeri, Lucia" uniqKey="Rugeri L" first="Lucia" last="Rugeri">Lucia Rugeri</name></author><author><name sortKey="Nonin Babary, Emilie" sort="Nonin Babary, Emilie" uniqKey="Nonin Babary E" first="Emilie" last="Nonin-Babary">Emilie Nonin-Babary</name></author><author><name sortKey="Chevalier, Philippe" sort="Chevalier, Philippe" uniqKey="Chevalier P" first="Philippe" last="Chevalier">Philippe Chevalier</name></author></analytic><series><title level="j">Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology</title><idno type="eISSN">1532-2092</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atrial Fibrillation (blood)</term><term>Atrial Fibrillation (physiopathology)</term><term>Biomarkers (blood)</term><term>Case-Control Studies</term><term>Cross-Sectional Studies</term><term>Disease Progression</term><term>Endothelium, Vascular (physiopathology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term><term>Sinoatrial Node (physiopathology)</term><term>Stroke (epidemiology)</term><term>Thromboembolism (epidemiology)</term><term>Wolff-Parkinson-White Syndrome (blood)</term><term>Wolff-Parkinson-White Syndrome (physiopathology)</term><term>von Willebrand Factor (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Atrial Fibrillation</term><term>Wolff-Parkinson-White Syndrome</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Stroke</term><term>Thromboembolism</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>von Willebrand Factor</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Atrial Fibrillation</term><term>Endothelium, Vascular</term><term>Sinoatrial Node</term><term>Wolff-Parkinson-White Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Cross-Sectional Studies</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abnormal plasma concentrations of von Willebrand factor (vWF), a marker of prothrombotic risk, have been found in atrial fibrillation (AF) patients, but the extent of this variation is not clear. This study aimed to investigate the effect of different clinical forms of AF on plasma concentrations of vWF at different levels of the circulatory tree, both intracardiac and extracardiac.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23689486</PMID><DateCreated><Year>2013</Year><Month>10</Month><Day>30</Day></DateCreated><DateCompleted><Year>2014</Year><Month>09</Month><Day>30</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-2092</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>11</Issue><PubDate><Year>2013</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology</Title><ISOAbbreviation>Europace</ISOAbbreviation></Journal><ArticleTitle>Progressive endothelial damage revealed by multilevel von Willebrand factor plasma concentrations in atrial fibrillation patients.</ArticleTitle><Pagination><MedlinePgn>1562-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/europace/eut121</ELocationID><Abstract><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">Abnormal plasma concentrations of von Willebrand factor (vWF), a marker of prothrombotic risk, have been found in atrial fibrillation (AF) patients, but the extent of this variation is not clear. This study aimed to investigate the effect of different clinical forms of AF on plasma concentrations of vWF at different levels of the circulatory tree, both intracardiac and extracardiac.</AbstractText><AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Peripheral (Pf), left atrial (LA), and coronary sinus (CS) blood samples were obtained during cardiac catheterization from 52 patients with paroxysmal AF (PAF), 36 with persistent AF (PsAF), and 17 control subjects (Ct) with left-sided accessory pathway Wolff-Parkinson-White syndrome. Plasma concentrations of vWF were determined by immunoturbidimetry. Compared with Ct, patients with PAF had higher LA plasma levels of vWF (P = 0.004), but similar Pf and CS levels (both P > 0.30). In contrast, patients with PsAF had higher plasma concentrations of vWF in Pf (P = 0.04), LA (P < 0.001), and CS (P = 0.04) samples compared with Ct. Left atrial plasma concentrations of vWF in patients with PsAF were also higher than in the PAF group (P = 0.04).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Regardless of the clinical form of the arrhythmia, AF patients presented significantly higher plasma concentrations of vWF compared with sinus rhythm controls. Multilevel vWF plasma concentration assessment suggests an association between the clinical evolution of AF and the progression of endothelial dysfunction. Further studies will have to establish the exact mechanisms that link endothelial dysfunction and stroke in the context of AF.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Scridon</LastName><ForeName>Alina</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Unité de Neurocardiologie EA4612, Université Lyon 1, Lyon F-69008, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Girerd</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Rugeri</LastName><ForeName>Lucia</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Nonin-Babary</LastName><ForeName>Emilie</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Chevalier</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>05</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Europace</MedlineTA><NlmUniqueID>100883649</NlmUniqueID><ISSNLinking>1099-5129</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014841">von Willebrand Factor</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001281" MajorTopicYN="N">Atrial Fibrillation</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="Y">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004730" MajorTopicYN="N">Endothelium, Vascular</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012849" MajorTopicYN="N">Sinoatrial Node</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020521" MajorTopicYN="N">Stroke</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013923" MajorTopicYN="N">Thromboembolism</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014927" MajorTopicYN="N">Wolff-Parkinson-White Syndrome</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014841" MajorTopicYN="N">von Willebrand Factor</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Atrial fibrillation</Keyword><Keyword MajorTopicYN="N">Endothelial dysfunction</Keyword><Keyword MajorTopicYN="N">Stroke</Keyword><Keyword MajorTopicYN="N">von Willebrand factor</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>5</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>5</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>10</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23689486</ArticleId><ArticleId IdType="pii">eut121</ArticleId><ArticleId IdType="doi">10.1093/europace/eut121</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region></list><tree><noCountry><name sortKey="Chevalier, Philippe" sort="Chevalier, Philippe" uniqKey="Chevalier P" first="Philippe" last="Chevalier">Philippe Chevalier</name><name sortKey="Girerd, Nicolas" sort="Girerd, Nicolas" uniqKey="Girerd N" first="Nicolas" last="Girerd">Nicolas Girerd</name><name sortKey="Nonin Babary, Emilie" sort="Nonin Babary, Emilie" uniqKey="Nonin Babary E" first="Emilie" last="Nonin-Babary">Emilie Nonin-Babary</name><name sortKey="Rugeri, Lucia" sort="Rugeri, Lucia" uniqKey="Rugeri L" first="Lucia" last="Rugeri">Lucia Rugeri</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Scridon, Alina" sort="Scridon, Alina" uniqKey="Scridon A" first="Alina" last="Scridon">Alina 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