Subthalamic nucleus high-frequency stimulation modulates neuronal reactivity to cocaine within the reward circuit.
Identifieur interne : 000269 ( PubMed/Checkpoint ); précédent : 000268; suivant : 000270Subthalamic nucleus high-frequency stimulation modulates neuronal reactivity to cocaine within the reward circuit.
Auteurs : Sabira Hachem-Delaunay [France] ; Marie-Line Fournier [France] ; Candie Cohen [France] ; Nicolas Bonneau [France] ; Martine Cador [France] ; Christelle Baunez [France] ; Catherine Le Moine [France]Source :
- Neurobiology of disease [ 1095-953X ] ; 2015.
English descriptors
- KwdEn :
- Animals, Basolateral Nuclear Complex (metabolism), Cocaine (administration & dosage), Corpus Striatum (metabolism), Cytoskeletal Proteins (metabolism), Electric Stimulation, Globus Pallidus (metabolism), Male, Nerve Tissue Proteins (metabolism), Neurons (drug effects), Neurons (metabolism), Prefrontal Cortex (metabolism), Proto-Oncogene Proteins c-fos (metabolism), Rats, Rats, Long-Evans, Reward, Subthalamic Nucleus (cytology), Subthalamic Nucleus (drug effects), Subthalamic Nucleus (metabolism).
- MESH :
- chemical , administration & dosage : Cocaine.
- cytology : Subthalamic Nucleus.
- drug effects : Neurons, Subthalamic Nucleus.
- metabolism : Basolateral Nuclear Complex, Corpus Striatum, Cytoskeletal Proteins, Globus Pallidus, Nerve Tissue Proteins, Neurons, Prefrontal Cortex, Proto-Oncogene Proteins c-fos, Subthalamic Nucleus.
- Animals, Electric Stimulation, Male, Rats, Rats, Long-Evans, Reward.
Abstract
The subthalamic nucleus (STN) is a critical component of a complex network controlling motor, associative and limbic functions. High-frequency stimulation (HFS) of the STN is an effective therapy for motor symptoms in Parkinsonian patients and can also reduce their treatment-induced addictive behaviors. Preclinical studies have shown that STN HFS decreases motivation for cocaine while increasing that for food, highlighting its influence on rewarding and motivational circuits. However, the cellular substrates of these effects remain unknown. Our objectives were to characterize the cellular consequences of STN HFS with a special focus on limbic structures and to elucidate how STN HFS may interfere with acute cocaine effects in these brain areas. Male Long-Evans rats were subjected to STN HFS (130 Hz, 60 μs, 50-150 μA) for 30 min before an acute cocaine injection (15 mg/kg) and sacrificed 10 min following the injection. Neuronal reactivity was analyzed through the expression of two immediate early genes (Arc and c-Fos) to decipher cellular responses to STN HFS and cocaine. STN HFS only activated c-Fos in the globus pallidus and the basolateral amygdala, highlighting a possible role on emotional processes via the amygdala, with a limited effect by itself in other structures. Interestingly, and despite some differential effects on Arc and c-Fos expression, STN HFS diminished the c-Fos response induced by acute cocaine in the striatum. By preventing the cellular effect of cocaine in the striatum, STN HFS might thus decrease the reinforcing properties of the drug, which is in line with the inhibitory effect of STN HFS on the rewarding and reinforcing properties of cocaine.
DOI: 10.1016/j.nbd.2015.05.007
PubMed: 25982833
Affiliations:
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CNRS, INCIA, UMR 5287, Bordeaux F-33000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Bordeaux, INCIA, UMR 5287, Bordeaux F-33000, France; CNRS, INCIA, UMR 5287, Bordeaux F-33000</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName></affiliation></author><author><name sortKey="Fournier, Marie Line" sort="Fournier, Marie Line" uniqKey="Fournier M" first="Marie-Line" last="Fournier">Marie-Line Fournier</name><affiliation wicri:level="3"><nlm:affiliation>Université Bordeaux, INCIA, UMR 5287, Bordeaux F-33000, France; CNRS, INCIA, UMR 5287, Bordeaux F-33000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Bordeaux, INCIA, UMR 5287, Bordeaux F-33000, France; CNRS, INCIA, UMR 5287, Bordeaux F-33000</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName></affiliation></author><author><name sortKey="Cohen, Candie" sort="Cohen, Candie" uniqKey="Cohen C" first="Candie" last="Cohen">Candie Cohen</name><affiliation wicri:level="3"><nlm:affiliation>CNRS, INT, UMR 7289, Marseille F-13385, France; Aix Marseille Université, INT, UMR 7289, Marseille F-13385, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, INT, UMR 7289, Marseille F-13385, France; Aix Marseille Université, INT, UMR 7289, Marseille F-13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Bonneau, Nicolas" sort="Bonneau, Nicolas" uniqKey="Bonneau N" first="Nicolas" last="Bonneau">Nicolas Bonneau</name><affiliation wicri:level="3"><nlm:affiliation>Université Bordeaux, INCIA, UMR 5287, Bordeaux F-33000, France; CNRS, INCIA, UMR 5287, Bordeaux F-33000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Bordeaux, INCIA, UMR 5287, Bordeaux F-33000, France; CNRS, INCIA, UMR 5287, Bordeaux F-33000</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName></affiliation></author><author><name sortKey="Cador, Martine" sort="Cador, Martine" uniqKey="Cador M" first="Martine" last="Cador">Martine Cador</name><affiliation wicri:level="3"><nlm:affiliation>Université Bordeaux, INCIA, UMR 5287, Bordeaux F-33000, France; CNRS, INCIA, UMR 5287, Bordeaux F-33000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Bordeaux, INCIA, UMR 5287, Bordeaux F-33000, France; CNRS, INCIA, UMR 5287, Bordeaux F-33000</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName></affiliation></author><author><name sortKey="Baunez, Christelle" sort="Baunez, Christelle" uniqKey="Baunez C" first="Christelle" last="Baunez">Christelle Baunez</name><affiliation wicri:level="3"><nlm:affiliation>CNRS, INT, UMR 7289, Marseille F-13385, France; Aix Marseille Université, INT, UMR 7289, Marseille F-13385, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, INT, UMR 7289, Marseille F-13385, France; Aix Marseille Université, INT, UMR 7289, Marseille F-13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Le Moine, Catherine" sort="Le Moine, Catherine" uniqKey="Le Moine C" first="Catherine" last="Le Moine">Catherine Le Moine</name><affiliation wicri:level="3"><nlm:affiliation>Université Bordeaux, INCIA, UMR 5287, Bordeaux F-33000, France; CNRS, INCIA, UMR 5287, Bordeaux F-33000, France. Electronic address: catherine.le-moine@u-bordeaux.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Bordeaux, INCIA, UMR 5287, Bordeaux F-33000, France; CNRS, INCIA, UMR 5287, Bordeaux F-33000</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName></affiliation></author></analytic><series><title level="j">Neurobiology of disease</title><idno type="eISSN">1095-953X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Basolateral Nuclear Complex (metabolism)</term><term>Cocaine (administration & dosage)</term><term>Corpus Striatum (metabolism)</term><term>Cytoskeletal Proteins (metabolism)</term><term>Electric Stimulation</term><term>Globus Pallidus (metabolism)</term><term>Male</term><term>Nerve Tissue Proteins (metabolism)</term><term>Neurons (drug effects)</term><term>Neurons (metabolism)</term><term>Prefrontal Cortex (metabolism)</term><term>Proto-Oncogene Proteins c-fos (metabolism)</term><term>Rats</term><term>Rats, Long-Evans</term><term>Reward</term><term>Subthalamic Nucleus (cytology)</term><term>Subthalamic Nucleus (drug effects)</term><term>Subthalamic Nucleus (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Cocaine</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Neurons</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Basolateral Nuclear Complex</term><term>Corpus Striatum</term><term>Cytoskeletal Proteins</term><term>Globus Pallidus</term><term>Nerve Tissue Proteins</term><term>Neurons</term><term>Prefrontal Cortex</term><term>Proto-Oncogene Proteins c-fos</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Electric Stimulation</term><term>Male</term><term>Rats</term><term>Rats, Long-Evans</term><term>Reward</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The subthalamic nucleus (STN) is a critical component of a complex network controlling motor, associative and limbic functions. High-frequency stimulation (HFS) of the STN is an effective therapy for motor symptoms in Parkinsonian patients and can also reduce their treatment-induced addictive behaviors. Preclinical studies have shown that STN HFS decreases motivation for cocaine while increasing that for food, highlighting its influence on rewarding and motivational circuits. However, the cellular substrates of these effects remain unknown. Our objectives were to characterize the cellular consequences of STN HFS with a special focus on limbic structures and to elucidate how STN HFS may interfere with acute cocaine effects in these brain areas. Male Long-Evans rats were subjected to STN HFS (130 Hz, 60 μs, 50-150 μA) for 30 min before an acute cocaine injection (15 mg/kg) and sacrificed 10 min following the injection. Neuronal reactivity was analyzed through the expression of two immediate early genes (Arc and c-Fos) to decipher cellular responses to STN HFS and cocaine. STN HFS only activated c-Fos in the globus pallidus and the basolateral amygdala, highlighting a possible role on emotional processes via the amygdala, with a limited effect by itself in other structures. Interestingly, and despite some differential effects on Arc and c-Fos expression, STN HFS diminished the c-Fos response induced by acute cocaine in the striatum. By preventing the cellular effect of cocaine in the striatum, STN HFS might thus decrease the reinforcing properties of the drug, which is in line with the inhibitory effect of STN HFS on the rewarding and reinforcing properties of cocaine.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25982833</PMID><DateCreated><Year>2015</Year><Month>06</Month><Day>15</Day></DateCreated><DateCompleted><Year>2016</Year><Month>02</Month><Day>29</Day></DateCompleted><DateRevised><Year>2015</Year><Month>06</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-953X</ISSN><JournalIssue CitedMedium="Internet"><Volume>80</Volume><PubDate><Year>2015</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Neurobiology of disease</Title><ISOAbbreviation>Neurobiol. Dis.</ISOAbbreviation></Journal><ArticleTitle>Subthalamic nucleus high-frequency stimulation modulates neuronal reactivity to cocaine within the reward circuit.</ArticleTitle><Pagination><MedlinePgn>54-62</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.nbd.2015.05.007</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0969-9961(15)00169-2</ELocationID><Abstract><AbstractText>The subthalamic nucleus (STN) is a critical component of a complex network controlling motor, associative and limbic functions. High-frequency stimulation (HFS) of the STN is an effective therapy for motor symptoms in Parkinsonian patients and can also reduce their treatment-induced addictive behaviors. Preclinical studies have shown that STN HFS decreases motivation for cocaine while increasing that for food, highlighting its influence on rewarding and motivational circuits. However, the cellular substrates of these effects remain unknown. Our objectives were to characterize the cellular consequences of STN HFS with a special focus on limbic structures and to elucidate how STN HFS may interfere with acute cocaine effects in these brain areas. Male Long-Evans rats were subjected to STN HFS (130 Hz, 60 μs, 50-150 μA) for 30 min before an acute cocaine injection (15 mg/kg) and sacrificed 10 min following the injection. Neuronal reactivity was analyzed through the expression of two immediate early genes (Arc and c-Fos) to decipher cellular responses to STN HFS and cocaine. STN HFS only activated c-Fos in the globus pallidus and the basolateral amygdala, highlighting a possible role on emotional processes via the amygdala, with a limited effect by itself in other structures. Interestingly, and despite some differential effects on Arc and c-Fos expression, STN HFS diminished the c-Fos response induced by acute cocaine in the striatum. By preventing the cellular effect of cocaine in the striatum, STN HFS might thus decrease the reinforcing properties of the drug, which is in line with the inhibitory effect of STN HFS on the rewarding and reinforcing properties of cocaine.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hachem-Delaunay</LastName><ForeName>Sabira</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Université Bordeaux, INCIA, UMR 5287, Bordeaux F-33000, France; CNRS, INCIA, UMR 5287, Bordeaux F-33000, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fournier</LastName><ForeName>Marie-Line</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Université Bordeaux, INCIA, UMR 5287, Bordeaux F-33000, France; CNRS, INCIA, UMR 5287, Bordeaux F-33000, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cohen</LastName><ForeName>Candie</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>CNRS, INT, UMR 7289, Marseille F-13385, France; Aix Marseille Université, INT, UMR 7289, Marseille F-13385, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bonneau</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Université Bordeaux, INCIA, UMR 5287, Bordeaux F-33000, France; CNRS, INCIA, UMR 5287, Bordeaux F-33000, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cador</LastName><ForeName>Martine</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Université Bordeaux, INCIA, UMR 5287, Bordeaux F-33000, France; CNRS, INCIA, UMR 5287, Bordeaux F-33000, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baunez</LastName><ForeName>Christelle</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>CNRS, INT, UMR 7289, Marseille F-13385, France; Aix Marseille Université, INT, UMR 7289, Marseille F-13385, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Moine</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Université Bordeaux, INCIA, UMR 5287, Bordeaux F-33000, France; CNRS, INCIA, UMR 5287, Bordeaux F-33000, France. Electronic address: catherine.le-moine@u-bordeaux.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>05</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurobiol Dis</MedlineTA><NlmUniqueID>9500169</NlmUniqueID><ISSNLinking>0969-9961</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003598">Cytoskeletal Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009419">Nerve Tissue Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016760">Proto-Oncogene Proteins c-fos</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C092069">activity regulated cytoskeletal-associated protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>I5Y540LHVR</RegistryNumber><NameOfSubstance UI="D003042">Cocaine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D066272" MajorTopicYN="N">Basolateral Nuclear Complex</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003042" MajorTopicYN="N">Cocaine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003342" MajorTopicYN="N">Corpus Striatum</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003598" MajorTopicYN="N">Cytoskeletal Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004558" MajorTopicYN="N">Electric Stimulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005917" MajorTopicYN="N">Globus Pallidus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009419" MajorTopicYN="N">Nerve Tissue Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017397" MajorTopicYN="N">Prefrontal Cortex</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016760" MajorTopicYN="N">Proto-Oncogene Proteins c-fos</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020318" MajorTopicYN="N">Rats, Long-Evans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012201" MajorTopicYN="Y">Reward</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020531" MajorTopicYN="N">Subthalamic Nucleus</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Addiction</Keyword><Keyword MajorTopicYN="N">Arc</Keyword><Keyword MajorTopicYN="N">Basal ganglia</Keyword><Keyword MajorTopicYN="N">Deep brain stimulation</Keyword><Keyword MajorTopicYN="N">Nucleus accumbens</Keyword><Keyword MajorTopicYN="N">Parkinson</Keyword><Keyword MajorTopicYN="N">Striatum</Keyword><Keyword MajorTopicYN="N">c-Fos</Keyword><Keyword MajorTopicYN="N">catFISH</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>01</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>05</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>05</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>5</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>3</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25982833</ArticleId><ArticleId IdType="pii">S0969-9961(15)00169-2</ArticleId><ArticleId IdType="doi">10.1016/j.nbd.2015.05.007</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li><li>Provence-Alpes-Côte d'Azur</li></region></list><tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Hachem Delaunay, Sabira" sort="Hachem Delaunay, Sabira" uniqKey="Hachem Delaunay S" first="Sabira" last="Hachem-Delaunay">Sabira Hachem-Delaunay</name></region><name sortKey="Baunez, Christelle" sort="Baunez, Christelle" uniqKey="Baunez C" first="Christelle" last="Baunez">Christelle Baunez</name><name sortKey="Bonneau, Nicolas" sort="Bonneau, Nicolas" uniqKey="Bonneau N" first="Nicolas" last="Bonneau">Nicolas Bonneau</name><name sortKey="Cador, Martine" sort="Cador, Martine" uniqKey="Cador M" first="Martine" last="Cador">Martine Cador</name><name sortKey="Cohen, Candie" sort="Cohen, Candie" uniqKey="Cohen C" first="Candie" last="Cohen">Candie Cohen</name><name sortKey="Fournier, Marie Line" sort="Fournier, Marie Line" uniqKey="Fournier M" first="Marie-Line" last="Fournier">Marie-Line Fournier</name><name sortKey="Le Moine, Catherine" sort="Le Moine, Catherine" uniqKey="Le Moine C" first="Catherine" last="Le Moine">Catherine Le Moine</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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