The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease.
Identifieur interne : 000253 ( PubMed/Checkpoint ); précédent : 000252; suivant : 000254The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease.
Auteurs : Christina M. Lill [Allemagne] ; Aina Rengmark [Norvège] ; Lasse Pihlstr M [Norvège] ; Isabella Fogh [Royaume-Uni] ; Aleksey Shatunov [Royaume-Uni] ; Patrick M. Sleiman [États-Unis] ; Li-San Wang [États-Unis] ; Tian Liu [Allemagne] ; Christina F. Lassen [Danemark] ; Esther Meissner [Allemagne] ; Panos Alexopoulos [Allemagne] ; Andrea Calvo [Italie] ; Adriano Chio [Italie] ; Nil Dizdar [Suède] ; Frank Faltraco [Allemagne] ; Lars Forsgren [Suède] ; Julia Kirchheiner [Allemagne] ; Alexander Kurz [Allemagne] ; Jan P. Larsen [Norvège] ; Maria Liebsch [Allemagne] ; Jan Linder [Suède] ; Karen E. Morrison [Royaume-Uni] ; Hans Nissbrandt [Suède] ; Markus Otto [Allemagne] ; Jens Pahnke [Allemagne] ; Amanda Partch [États-Unis] ; Gabriella Restagno [Italie] ; Dan Rujescu [Allemagne] ; Cathrin Schnack [Allemagne] ; Christopher E. Shaw [Royaume-Uni] ; Pamela J. Shaw [Royaume-Uni] ; Hayrettin Tumani [Allemagne] ; Ole-Bj Rn Tysnes [Norvège] ; Otto Valladares [États-Unis] ; Vincenzo Silani [Italie] ; Leonard H. Van Den Berg [Pays-Bas] ; Wouter Van Rheenen [Pays-Bas] ; Jan H. Veldink [Pays-Bas] ; Ulman Lindenberger [Allemagne] ; Elisabeth Steinhagen-Thiessen [Allemagne] ; Stefan Teipel [Allemagne] ; Robert Perneczky [Royaume-Uni] ; Hakon Hakonarson [États-Unis] ; Harald Hampel [France] ; Christine A F. Von Arnim [Allemagne] ; J Rgen H. Olsen [Danemark] ; Vivianna M. Van Deerlin [États-Unis] ; Ammar Al-Chalabi [Royaume-Uni] ; Mathias Toft [Norvège] ; Beate Ritz [États-Unis] ; Lars Bertram [Royaume-Uni]Source :
- Alzheimer's & dementia : the journal of the Alzheimer's Association [ 1552-5279 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Alleles, Alzheimer Disease (genetics), Amyotrophic Lateral Sclerosis (genetics), Case-Control Studies, European Continental Ancestry Group, Female, Frontotemporal Lobar Degeneration (genetics), Genetic Predisposition to Disease, Genotype, Humans, Male, Membrane Glycoproteins (genetics), Middle Aged, Neurodegenerative Diseases (genetics), Parkinson Disease (genetics), Quantitative Trait Loci, Receptors, Immunologic (genetics), Risk Factors, tau Proteins (cerebrospinal fluid).
- MESH :
- chemical , cerebrospinal fluid : tau Proteins.
- chemical , genetics : Membrane Glycoproteins, Receptors, Immunologic.
- genetics : Alzheimer Disease, Amyotrophic Lateral Sclerosis, Frontotemporal Lobar Degeneration, Neurodegenerative Diseases, Parkinson Disease.
- Aged, Alleles, Case-Control Studies, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Quantitative Trait Loci, Risk Factors.
Abstract
A rare variant in TREM2 (p.R47H, rs75932628) was recently reported to increase the risk of Alzheimer's disease (AD) and, subsequently, other neurodegenerative diseases, i.e. frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease (PD). Here we comprehensively assessed TREM2 rs75932628 for association with these diseases in a total of 19,940 previously untyped subjects of European descent. These data were combined with those from 28 published data sets by meta-analysis. Furthermore, we tested whether rs75932628 shows association with amyloid beta (Aβ42) and total-tau protein levels in the cerebrospinal fluid (CSF) of 828 individuals with AD or mild cognitive impairment. Our data show that rs75932628 is highly significantly associated with the risk of AD across 24,086 AD cases and 148,993 controls of European descent (odds ratio or OR = 2.71, P = 4.67 × 10(-25)). No consistent evidence for association was found between this marker and the risk of FTLD (OR = 2.24, P = .0113 across 2673 cases/9283 controls), PD (OR = 1.36, P = .0767 across 8311 cases/79,938 controls) and ALS (OR = 1.41, P = .198 across 5544 cases/7072 controls). Furthermore, carriers of the rs75932628 risk allele showed significantly increased levels of CSF-total-tau (P = .0110) but not Aβ42 suggesting that TREM2's role in AD may involve tau dysfunction.
DOI: 10.1016/j.jalz.2014.12.009
PubMed: 25936935
Affiliations:
- Allemagne, Danemark, France, Italie, Norvège, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Angleterre, Bade-Wurtemberg, Bavière, Berlin, Californie, District de Darmstadt, District de Haute-Bavière, District de Tübingen, Grand Londres, Hesse (Land), Hovedstaden, Midlands de l'Ouest, Pennsylvanie, Piémont, Utrecht (province), Île-de-France, Østlandet
- Berlin, Birmingham, Copenhague, Francfort-sur-le-Main, Londres, Munich, Oslo, Paris, Turin, Ulm, Utrecht
- Université d'Ulm, Université de Birmingham, Université technique de Munich
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Electronic address: christina.lill@gmx.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Rengmark, Aina" sort="Rengmark, Aina" uniqKey="Rengmark A" first="Aina" last="Rengmark">Aina Rengmark</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Pihlstr M, Lasse" sort="Pihlstr M, Lasse" uniqKey="Pihlstr M L" first="Lasse" last="Pihlstr M">Lasse Pihlstr M</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Fogh, Isabella" sort="Fogh, Isabella" uniqKey="Fogh I" first="Isabella" last="Fogh">Isabella Fogh</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Shatunov, Aleksey" sort="Shatunov, Aleksey" uniqKey="Shatunov A" first="Aleksey" last="Shatunov">Aleksey Shatunov</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sleiman, Patrick M" sort="Sleiman, Patrick M" uniqKey="Sleiman P" first="Patrick M" last="Sleiman">Patrick M. Sleiman</name><affiliation wicri:level="2"><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Human Genetics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Human Genetics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Wang, Li San" sort="Wang, Li San" uniqKey="Wang L" first="Li-San" last="Wang">Li-San Wang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Liu, Tian" sort="Liu, Tian" uniqKey="Liu T" first="Tian" last="Liu">Tian Liu</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute for Human Development, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute for Human Development, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Lassen, Christina F" sort="Lassen, Christina F" uniqKey="Lassen C" first="Christina F" last="Lassen">Christina F. Lassen</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Meissner, Esther" sort="Meissner, Esther" uniqKey="Meissner E" first="Esther" last="Meissner">Esther Meissner</name><affiliation wicri:level="3"><nlm:affiliation>Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Alexopoulos, Panos" sort="Alexopoulos, Panos" uniqKey="Alexopoulos P" first="Panos" last="Alexopoulos">Panos Alexopoulos</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Technische Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Calvo, Andrea" sort="Calvo, Andrea" uniqKey="Calvo A" first="Andrea" last="Calvo">Andrea Calvo</name><affiliation wicri:level="3"><nlm:affiliation>Rita Levi Montalcini Department of Neuroscience, ALS Center, University of Torino, Torino, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Rita Levi Montalcini Department of Neuroscience, ALS Center, University of Torino, Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Chio, Adriano" sort="Chio, Adriano" uniqKey="Chio A" first="Adriano" last="Chio">Adriano Chio</name><affiliation wicri:level="3"><nlm:affiliation>Rita Levi Montalcini Department of Neuroscience, ALS Center, University of Torino, Torino, Italy; Neuroscience Institute of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Rita Levi Montalcini Department of Neuroscience, ALS Center, University of Torino, Torino, Italy; Neuroscience Institute of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Dizdar, Nil" sort="Dizdar, Nil" uniqKey="Dizdar N" first="Nil" last="Dizdar">Nil Dizdar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Linköping University, Linköping, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurology, Linköping University, Linköping</wicri:regionArea><wicri:noRegion>Linköping</wicri:noRegion></affiliation></author><author><name sortKey="Faltraco, Frank" sort="Faltraco, Frank" uniqKey="Faltraco F" first="Frank" last="Faltraco">Frank Faltraco</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University of Frankfurt, Frankfurt, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University of Frankfurt, Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Forsgren, Lars" sort="Forsgren, Lars" uniqKey="Forsgren L" first="Lars" last="Forsgren">Lars Forsgren</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Kirchheiner, Julia" sort="Kirchheiner, Julia" uniqKey="Kirchheiner J" first="Julia" last="Kirchheiner">Julia Kirchheiner</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Kurz, Alexander" sort="Kurz, Alexander" uniqKey="Kurz A" first="Alexander" last="Kurz">Alexander Kurz</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Technische Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P" last="Larsen">Jan P. Larsen</name><affiliation wicri:level="1"><nlm:affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Liebsch, Maria" sort="Liebsch, Maria" uniqKey="Liebsch M" first="Maria" last="Liebsch">Maria Liebsch</name><affiliation wicri:level="3"><nlm:affiliation>Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Linder, Jan" sort="Linder, Jan" uniqKey="Linder J" first="Jan" last="Linder">Jan Linder</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E" last="Morrison">Karen E. Morrison</name><affiliation wicri:level="4"><nlm:affiliation>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Neurosciences Division, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Neurosciences Division, University Hospitals Birmingham NHS Foundation Trust, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Nissbrandt, Hans" sort="Nissbrandt, Hans" uniqKey="Nissbrandt H" first="Hans" last="Nissbrandt">Hans Nissbrandt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pharmacology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Otto, Markus" sort="Otto, Markus" uniqKey="Otto M" first="Markus" last="Otto">Markus Otto</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Pahnke, Jens" sort="Pahnke, Jens" uniqKey="Pahnke J" first="Jens" last="Pahnke">Jens Pahnke</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuro-/Pathology, University of Oslo and Oslo University Hospital, Oslo, Norway; Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuro-/Pathology, University of Oslo and Oslo University Hospital, Oslo, Norway; Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Partch, Amanda" sort="Partch, Amanda" uniqKey="Partch A" first="Amanda" last="Partch">Amanda Partch</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Restagno, Gabriella" sort="Restagno, Gabriella" uniqKey="Restagno G" first="Gabriella" last="Restagno">Gabriella Restagno</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Pathology, Molecular Genetics Unit, Azienda Ospedaliera Città della Salute e della Scienza, Torino, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical Pathology, Molecular Genetics Unit, Azienda Ospedaliera Città della Salute e della Scienza, Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Rujescu, Dan" sort="Rujescu, Dan" uniqKey="Rujescu D" first="Dan" last="Rujescu">Dan Rujescu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Halle-Wittenberg, Halle, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, University of Halle-Wittenberg, Halle</wicri:regionArea><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion></affiliation></author><author><name sortKey="Schnack, Cathrin" sort="Schnack, Cathrin" uniqKey="Schnack C" first="Cathrin" last="Schnack">Cathrin Schnack</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Shaw, Christopher E" sort="Shaw, Christopher E" uniqKey="Shaw C" first="Christopher E" last="Shaw">Christopher E. Shaw</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Shaw, Pamela J" sort="Shaw, Pamela J" uniqKey="Shaw P" first="Pamela J" last="Shaw">Pamela J. Shaw</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Tumani, Hayrettin" sort="Tumani, Hayrettin" uniqKey="Tumani H" first="Hayrettin" last="Tumani">Hayrettin Tumani</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Tysnes, Ole Bj Rn" sort="Tysnes, Ole Bj Rn" uniqKey="Tysnes O" first="Ole-Bj Rn" last="Tysnes">Ole-Bj Rn Tysnes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Valladares, Otto" sort="Valladares, Otto" uniqKey="Valladares O" first="Otto" last="Valladares">Otto Valladares</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Silani, Vincenzo" sort="Silani, Vincenzo" uniqKey="Silani V" first="Vincenzo" last="Silani">Vincenzo Silani</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano, Italy; Department of Pathophysiology and Tranplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano, Italy; Department of Pathophysiology and Tranplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H" last="Van Den Berg">Leonard H. Van Den Berg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Van Rheenen, Wouter" sort="Van Rheenen, Wouter" uniqKey="Van Rheenen W" first="Wouter" last="Van Rheenen">Wouter Van Rheenen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Veldink, Jan H" sort="Veldink, Jan H" uniqKey="Veldink J" first="Jan H" last="Veldink">Jan H. Veldink</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Lindenberger, Ulman" sort="Lindenberger, Ulman" uniqKey="Lindenberger U" first="Ulman" last="Lindenberger">Ulman Lindenberger</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute for Human Development, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute for Human Development, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Steinhagen Thiessen, Elisabeth" sort="Steinhagen Thiessen, Elisabeth" uniqKey="Steinhagen Thiessen E" first="Elisabeth" last="Steinhagen-Thiessen">Elisabeth Steinhagen-Thiessen</name><affiliation wicri:level="3"><nlm:affiliation>Interdisciplinary Metabolic Center, Lipids Clinic, Charité University Medicine, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interdisciplinary Metabolic Center, Lipids Clinic, Charité University Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Teipel, Stefan" sort="Teipel, Stefan" uniqKey="Teipel S" first="Stefan" last="Teipel">Stefan Teipel</name><affiliation wicri:level="1"><nlm:affiliation>German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany; Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany; Department of Psychosomatic Medicine, University of Rostock, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Perneczky, Robert" sort="Perneczky, Robert" uniqKey="Perneczky R" first="Robert" last="Perneczky">Robert Perneczky</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany; Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London, UK; West London Cognitive Disorders Treatment and Research Unit, West London Mental Health Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany; Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London, UK; West London Cognitive Disorders Treatment and Research Unit, West London Mental Health Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation wicri:level="2"><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Human Genetics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Human Genetics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><affiliation wicri:level="3"><nlm:affiliation>AXA Research Fund & UPMC Chair, Paris, France; Département de Neurologie, Sorbonne Universités, Université Pierre et Marie Curie, Institut de la Mémoire et de la Maladie d'Alzheimer & Institut du Cerveau et de la Moelle épinière (ICM), Hôpital de la Pitié-Salpétrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AXA Research Fund & UPMC Chair, Paris, France; Département de Neurologie, Sorbonne Universités, Université Pierre et Marie Curie, Institut de la Mémoire et de la Maladie d'Alzheimer & Institut du Cerveau et de la Moelle épinière (ICM), Hôpital de la Pitié-Salpétrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Von Arnim, Christine A F" sort="Von Arnim, Christine A F" uniqKey="Von Arnim C" first="Christine A F" last="Von Arnim">Christine A F. Von Arnim</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Olsen, J Rgen H" sort="Olsen, J Rgen H" uniqKey="Olsen J" first="J Rgen H" last="Olsen">J Rgen H. Olsen</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Van Deerlin, Vivianna M" sort="Van Deerlin, Vivianna M" uniqKey="Van Deerlin V" first="Vivianna M" last="Van Deerlin">Vivianna M. Van Deerlin</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Al Chalabi, Ammar" sort="Al Chalabi, Ammar" uniqKey="Al Chalabi A" first="Ammar" last="Al-Chalabi">Ammar Al-Chalabi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Toft, Mathias" sort="Toft, Mathias" uniqKey="Toft M" first="Mathias" last="Toft">Mathias Toft</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Environmental Sciences, School of Public Health, University of California, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Environmental Sciences, School of Public Health, University of California, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><affiliation wicri:level="3"><nlm:affiliation>Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany; Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany; Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25936935</idno><idno type="pmid">25936935</idno><idno type="doi">10.1016/j.jalz.2014.12.009</idno><idno type="wicri:Area/PubMed/Corpus">000241</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000241</idno><idno type="wicri:Area/PubMed/Curation">000240</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000240</idno><idno type="wicri:Area/PubMed/Checkpoint">000240</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000240</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease.</title><author><name sortKey="Lill, Christina M" sort="Lill, Christina M" uniqKey="Lill C" first="Christina M" last="Lill">Christina M. Lill</name><affiliation wicri:level="3"><nlm:affiliation>Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany. Electronic address: christina.lill@gmx.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Rengmark, Aina" sort="Rengmark, Aina" uniqKey="Rengmark A" first="Aina" last="Rengmark">Aina Rengmark</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Pihlstr M, Lasse" sort="Pihlstr M, Lasse" uniqKey="Pihlstr M L" first="Lasse" last="Pihlstr M">Lasse Pihlstr M</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Fogh, Isabella" sort="Fogh, Isabella" uniqKey="Fogh I" first="Isabella" last="Fogh">Isabella Fogh</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Shatunov, Aleksey" sort="Shatunov, Aleksey" uniqKey="Shatunov A" first="Aleksey" last="Shatunov">Aleksey Shatunov</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sleiman, Patrick M" sort="Sleiman, Patrick M" uniqKey="Sleiman P" first="Patrick M" last="Sleiman">Patrick M. Sleiman</name><affiliation wicri:level="2"><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Human Genetics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Human Genetics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Wang, Li San" sort="Wang, Li San" uniqKey="Wang L" first="Li-San" last="Wang">Li-San Wang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Liu, Tian" sort="Liu, Tian" uniqKey="Liu T" first="Tian" last="Liu">Tian Liu</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute for Human Development, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute for Human Development, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Lassen, Christina F" sort="Lassen, Christina F" uniqKey="Lassen C" first="Christina F" last="Lassen">Christina F. Lassen</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Meissner, Esther" sort="Meissner, Esther" uniqKey="Meissner E" first="Esther" last="Meissner">Esther Meissner</name><affiliation wicri:level="3"><nlm:affiliation>Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Alexopoulos, Panos" sort="Alexopoulos, Panos" uniqKey="Alexopoulos P" first="Panos" last="Alexopoulos">Panos Alexopoulos</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Technische Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Calvo, Andrea" sort="Calvo, Andrea" uniqKey="Calvo A" first="Andrea" last="Calvo">Andrea Calvo</name><affiliation wicri:level="3"><nlm:affiliation>Rita Levi Montalcini Department of Neuroscience, ALS Center, University of Torino, Torino, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Rita Levi Montalcini Department of Neuroscience, ALS Center, University of Torino, Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Chio, Adriano" sort="Chio, Adriano" uniqKey="Chio A" first="Adriano" last="Chio">Adriano Chio</name><affiliation wicri:level="3"><nlm:affiliation>Rita Levi Montalcini Department of Neuroscience, ALS Center, University of Torino, Torino, Italy; Neuroscience Institute of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Rita Levi Montalcini Department of Neuroscience, ALS Center, University of Torino, Torino, Italy; Neuroscience Institute of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Dizdar, Nil" sort="Dizdar, Nil" uniqKey="Dizdar N" first="Nil" last="Dizdar">Nil Dizdar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Linköping University, Linköping, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurology, Linköping University, Linköping</wicri:regionArea><wicri:noRegion>Linköping</wicri:noRegion></affiliation></author><author><name sortKey="Faltraco, Frank" sort="Faltraco, Frank" uniqKey="Faltraco F" first="Frank" last="Faltraco">Frank Faltraco</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University of Frankfurt, Frankfurt, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University of Frankfurt, Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Forsgren, Lars" sort="Forsgren, Lars" uniqKey="Forsgren L" first="Lars" last="Forsgren">Lars Forsgren</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Kirchheiner, Julia" sort="Kirchheiner, Julia" uniqKey="Kirchheiner J" first="Julia" last="Kirchheiner">Julia Kirchheiner</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Kurz, Alexander" sort="Kurz, Alexander" uniqKey="Kurz A" first="Alexander" last="Kurz">Alexander Kurz</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Technische Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P" last="Larsen">Jan P. Larsen</name><affiliation wicri:level="1"><nlm:affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Liebsch, Maria" sort="Liebsch, Maria" uniqKey="Liebsch M" first="Maria" last="Liebsch">Maria Liebsch</name><affiliation wicri:level="3"><nlm:affiliation>Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Linder, Jan" sort="Linder, Jan" uniqKey="Linder J" first="Jan" last="Linder">Jan Linder</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E" last="Morrison">Karen E. Morrison</name><affiliation wicri:level="4"><nlm:affiliation>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Neurosciences Division, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Neurosciences Division, University Hospitals Birmingham NHS Foundation Trust, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Nissbrandt, Hans" sort="Nissbrandt, Hans" uniqKey="Nissbrandt H" first="Hans" last="Nissbrandt">Hans Nissbrandt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pharmacology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Otto, Markus" sort="Otto, Markus" uniqKey="Otto M" first="Markus" last="Otto">Markus Otto</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Pahnke, Jens" sort="Pahnke, Jens" uniqKey="Pahnke J" first="Jens" last="Pahnke">Jens Pahnke</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuro-/Pathology, University of Oslo and Oslo University Hospital, Oslo, Norway; Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuro-/Pathology, University of Oslo and Oslo University Hospital, Oslo, Norway; Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Partch, Amanda" sort="Partch, Amanda" uniqKey="Partch A" first="Amanda" last="Partch">Amanda Partch</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Restagno, Gabriella" sort="Restagno, Gabriella" uniqKey="Restagno G" first="Gabriella" last="Restagno">Gabriella Restagno</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Pathology, Molecular Genetics Unit, Azienda Ospedaliera Città della Salute e della Scienza, Torino, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical Pathology, Molecular Genetics Unit, Azienda Ospedaliera Città della Salute e della Scienza, Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Rujescu, Dan" sort="Rujescu, Dan" uniqKey="Rujescu D" first="Dan" last="Rujescu">Dan Rujescu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Halle-Wittenberg, Halle, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, University of Halle-Wittenberg, Halle</wicri:regionArea><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion></affiliation></author><author><name sortKey="Schnack, Cathrin" sort="Schnack, Cathrin" uniqKey="Schnack C" first="Cathrin" last="Schnack">Cathrin Schnack</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Shaw, Christopher E" sort="Shaw, Christopher E" uniqKey="Shaw C" first="Christopher E" last="Shaw">Christopher E. Shaw</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Shaw, Pamela J" sort="Shaw, Pamela J" uniqKey="Shaw P" first="Pamela J" last="Shaw">Pamela J. Shaw</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Tumani, Hayrettin" sort="Tumani, Hayrettin" uniqKey="Tumani H" first="Hayrettin" last="Tumani">Hayrettin Tumani</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Tysnes, Ole Bj Rn" sort="Tysnes, Ole Bj Rn" uniqKey="Tysnes O" first="Ole-Bj Rn" last="Tysnes">Ole-Bj Rn Tysnes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Valladares, Otto" sort="Valladares, Otto" uniqKey="Valladares O" first="Otto" last="Valladares">Otto Valladares</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Silani, Vincenzo" sort="Silani, Vincenzo" uniqKey="Silani V" first="Vincenzo" last="Silani">Vincenzo Silani</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano, Italy; Department of Pathophysiology and Tranplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano, Italy; Department of Pathophysiology and Tranplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H" last="Van Den Berg">Leonard H. Van Den Berg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Van Rheenen, Wouter" sort="Van Rheenen, Wouter" uniqKey="Van Rheenen W" first="Wouter" last="Van Rheenen">Wouter Van Rheenen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Veldink, Jan H" sort="Veldink, Jan H" uniqKey="Veldink J" first="Jan H" last="Veldink">Jan H. Veldink</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Lindenberger, Ulman" sort="Lindenberger, Ulman" uniqKey="Lindenberger U" first="Ulman" last="Lindenberger">Ulman Lindenberger</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute for Human Development, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute for Human Development, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Steinhagen Thiessen, Elisabeth" sort="Steinhagen Thiessen, Elisabeth" uniqKey="Steinhagen Thiessen E" first="Elisabeth" last="Steinhagen-Thiessen">Elisabeth Steinhagen-Thiessen</name><affiliation wicri:level="3"><nlm:affiliation>Interdisciplinary Metabolic Center, Lipids Clinic, Charité University Medicine, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interdisciplinary Metabolic Center, Lipids Clinic, Charité University Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Teipel, Stefan" sort="Teipel, Stefan" uniqKey="Teipel S" first="Stefan" last="Teipel">Stefan Teipel</name><affiliation wicri:level="1"><nlm:affiliation>German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany; Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany; Department of Psychosomatic Medicine, University of Rostock, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Perneczky, Robert" sort="Perneczky, Robert" uniqKey="Perneczky R" first="Robert" last="Perneczky">Robert Perneczky</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany; Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London, UK; West London Cognitive Disorders Treatment and Research Unit, West London Mental Health Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany; Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London, UK; West London Cognitive Disorders Treatment and Research Unit, West London Mental Health Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation wicri:level="2"><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Human Genetics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Human Genetics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><affiliation wicri:level="3"><nlm:affiliation>AXA Research Fund & UPMC Chair, Paris, France; Département de Neurologie, Sorbonne Universités, Université Pierre et Marie Curie, Institut de la Mémoire et de la Maladie d'Alzheimer & Institut du Cerveau et de la Moelle épinière (ICM), Hôpital de la Pitié-Salpétrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AXA Research Fund & UPMC Chair, Paris, France; Département de Neurologie, Sorbonne Universités, Université Pierre et Marie Curie, Institut de la Mémoire et de la Maladie d'Alzheimer & Institut du Cerveau et de la Moelle épinière (ICM), Hôpital de la Pitié-Salpétrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Von Arnim, Christine A F" sort="Von Arnim, Christine A F" uniqKey="Von Arnim C" first="Christine A F" last="Von Arnim">Christine A F. Von Arnim</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Olsen, J Rgen H" sort="Olsen, J Rgen H" uniqKey="Olsen J" first="J Rgen H" last="Olsen">J Rgen H. Olsen</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Van Deerlin, Vivianna M" sort="Van Deerlin, Vivianna M" uniqKey="Van Deerlin V" first="Vivianna M" last="Van Deerlin">Vivianna M. Van Deerlin</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Al Chalabi, Ammar" sort="Al Chalabi, Ammar" uniqKey="Al Chalabi A" first="Ammar" last="Al-Chalabi">Ammar Al-Chalabi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Toft, Mathias" sort="Toft, Mathias" uniqKey="Toft M" first="Mathias" last="Toft">Mathias Toft</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Environmental Sciences, School of Public Health, University of California, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Environmental Sciences, School of Public Health, University of California, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><affiliation wicri:level="3"><nlm:affiliation>Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany; Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany; Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Alzheimer's & dementia : the journal of the Alzheimer's Association</title><idno type="eISSN">1552-5279</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alleles</term><term>Alzheimer Disease (genetics)</term><term>Amyotrophic Lateral Sclerosis (genetics)</term><term>Case-Control Studies</term><term>European Continental Ancestry Group</term><term>Female</term><term>Frontotemporal Lobar Degeneration (genetics)</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Membrane Glycoproteins (genetics)</term><term>Middle Aged</term><term>Neurodegenerative Diseases (genetics)</term><term>Parkinson Disease (genetics)</term><term>Quantitative Trait Loci</term><term>Receptors, Immunologic (genetics)</term><term>Risk Factors</term><term>tau Proteins (cerebrospinal fluid)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>tau Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term><term>Receptors, Immunologic</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alzheimer Disease</term><term>Amyotrophic Lateral Sclerosis</term><term>Frontotemporal Lobar Degeneration</term><term>Neurodegenerative Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Alleles</term><term>Case-Control Studies</term><term>European Continental Ancestry Group</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Quantitative Trait Loci</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A rare variant in TREM2 (p.R47H, rs75932628) was recently reported to increase the risk of Alzheimer's disease (AD) and, subsequently, other neurodegenerative diseases, i.e. frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease (PD). Here we comprehensively assessed TREM2 rs75932628 for association with these diseases in a total of 19,940 previously untyped subjects of European descent. These data were combined with those from 28 published data sets by meta-analysis. Furthermore, we tested whether rs75932628 shows association with amyloid beta (Aβ42) and total-tau protein levels in the cerebrospinal fluid (CSF) of 828 individuals with AD or mild cognitive impairment. Our data show that rs75932628 is highly significantly associated with the risk of AD across 24,086 AD cases and 148,993 controls of European descent (odds ratio or OR = 2.71, P = 4.67 × 10(-25)). No consistent evidence for association was found between this marker and the risk of FTLD (OR = 2.24, P = .0113 across 2673 cases/9283 controls), PD (OR = 1.36, P = .0767 across 8311 cases/79,938 controls) and ALS (OR = 1.41, P = .198 across 5544 cases/7072 controls). Furthermore, carriers of the rs75932628 risk allele showed significantly increased levels of CSF-total-tau (P = .0110) but not Aβ42 suggesting that TREM2's role in AD may involve tau dysfunction.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25936935</PMID><DateCreated><Year>2015</Year><Month>12</Month><Day>24</Day></DateCreated><DateCompleted><Year>2016</Year><Month>09</Month><Day>08</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1552-5279</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>12</Issue><PubDate><Year>2015</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Alzheimer's & dementia : the journal of the Alzheimer's Association</Title><ISOAbbreviation>Alzheimers Dement</ISOAbbreviation></Journal><ArticleTitle>The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1407-16</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jalz.2014.12.009</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1552-5260(15)00122-3</ELocationID><Abstract><AbstractText>A rare variant in TREM2 (p.R47H, rs75932628) was recently reported to increase the risk of Alzheimer's disease (AD) and, subsequently, other neurodegenerative diseases, i.e. frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease (PD). Here we comprehensively assessed TREM2 rs75932628 for association with these diseases in a total of 19,940 previously untyped subjects of European descent. These data were combined with those from 28 published data sets by meta-analysis. Furthermore, we tested whether rs75932628 shows association with amyloid beta (Aβ42) and total-tau protein levels in the cerebrospinal fluid (CSF) of 828 individuals with AD or mild cognitive impairment. Our data show that rs75932628 is highly significantly associated with the risk of AD across 24,086 AD cases and 148,993 controls of European descent (odds ratio or OR = 2.71, P = 4.67 × 10(-25)). No consistent evidence for association was found between this marker and the risk of FTLD (OR = 2.24, P = .0113 across 2673 cases/9283 controls), PD (OR = 1.36, P = .0767 across 8311 cases/79,938 controls) and ALS (OR = 1.41, P = .198 across 5544 cases/7072 controls). Furthermore, carriers of the rs75932628 risk allele showed significantly increased levels of CSF-total-tau (P = .0110) but not Aβ42 suggesting that TREM2's role in AD may involve tau dysfunction.</AbstractText><CopyrightInformation>Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lill</LastName><ForeName>Christina M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany. Electronic address: christina.lill@gmx.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rengmark</LastName><ForeName>Aina</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, Oslo University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pihlstrøm</LastName><ForeName>Lasse</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Neurology, Oslo University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fogh</LastName><ForeName>Isabella</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shatunov</LastName><ForeName>Aleksey</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sleiman</LastName><ForeName>Patrick M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Human Genetics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Li-San</ForeName><Initials>LS</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Tian</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Max Planck Institute for Human Development, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lassen</LastName><ForeName>Christina F</ForeName><Initials>CF</Initials><AffiliationInfo><Affiliation>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meissner</LastName><ForeName>Esther</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alexopoulos</LastName><ForeName>Panos</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calvo</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Rita Levi Montalcini Department of Neuroscience, ALS Center, University of Torino, Torino, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chio</LastName><ForeName>Adriano</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Rita Levi Montalcini Department of Neuroscience, ALS Center, University of Torino, Torino, Italy; Neuroscience Institute of Turin, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dizdar</LastName><ForeName>Nil</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Neurology, Linköping University, Linköping, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Faltraco</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University of Frankfurt, Frankfurt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Forsgren</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kirchheiner</LastName><ForeName>Julia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kurz</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Larsen</LastName><ForeName>Jan P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liebsch</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Linder</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morrison</LastName><ForeName>Karen E</ForeName><Initials>KE</Initials><AffiliationInfo><Affiliation>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Neurosciences Division, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nissbrandt</LastName><ForeName>Hans</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Otto</LastName><ForeName>Markus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pahnke</LastName><ForeName>Jens</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neuro-/Pathology, University of Oslo and Oslo University Hospital, Oslo, Norway; Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Partch</LastName><ForeName>Amanda</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Restagno</LastName><ForeName>Gabriella</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Clinical Pathology, Molecular Genetics Unit, Azienda Ospedaliera Città della Salute e della Scienza, Torino, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rujescu</LastName><ForeName>Dan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Halle-Wittenberg, Halle, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schnack</LastName><ForeName>Cathrin</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shaw</LastName><ForeName>Christopher E</ForeName><Initials>CE</Initials><AffiliationInfo><Affiliation>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shaw</LastName><ForeName>Pamela J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Department of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tumani</LastName><ForeName>Hayrettin</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tysnes</LastName><ForeName>Ole-Bjørn</ForeName><Initials>OB</Initials><AffiliationInfo><Affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valladares</LastName><ForeName>Otto</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silani</LastName><ForeName>Vincenzo</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano, Italy; Department of Pathophysiology and Tranplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Milano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van den Berg</LastName><ForeName>Leonard H</ForeName><Initials>LH</Initials><AffiliationInfo><Affiliation>Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Rheenen</LastName><ForeName>Wouter</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Veldink</LastName><ForeName>Jan H</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lindenberger</LastName><ForeName>Ulman</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Max Planck Institute for Human Development, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steinhagen-Thiessen</LastName><ForeName>Elisabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Interdisciplinary Metabolic Center, Lipids Clinic, Charité University Medicine, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>SLAGEN Consortium</CollectiveName></Author><Author ValidYN="Y"><LastName>Teipel</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany; Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perneczky</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany; Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London, UK; West London Cognitive Disorders Treatment and Research Unit, West London Mental Health Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hakonarson</LastName><ForeName>Hakon</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Human Genetics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hampel</LastName><ForeName>Harald</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>AXA Research Fund & UPMC Chair, Paris, France; Département de Neurologie, Sorbonne Universités, Université Pierre et Marie Curie, Institut de la Mémoire et de la Maladie d'Alzheimer & Institut du Cerveau et de la Moelle épinière (ICM), Hôpital de la Pitié-Salpétrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>von Arnim</LastName><ForeName>Christine A F</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olsen</LastName><ForeName>Jørgen H</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van Deerlin</LastName><ForeName>Vivianna M</ForeName><Initials>VM</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Chalabi</LastName><ForeName>Ammar</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Toft</LastName><ForeName>Mathias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, Oslo University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ritz</LastName><ForeName>Beate</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Environmental Sciences, School of Public Health, University of California, Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bertram</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany; Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>089701</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MR/L501529/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>P01 AG017586</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 ES013508</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01ES013717</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 ES013717</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>04</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Alzheimers Dement</MedlineTA><NlmUniqueID>101231978</NlmUniqueID><ISSNLinking>1552-5260</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance 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MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016875" MajorTopicYN="N">tau Proteins</DescriptorName><QualifierName UI="Q000134" MajorTopicYN="N">cerebrospinal fluid</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS692224 [Available on 12/01/16]</OtherID><OtherID Source="NLM">PMC4627856 [Available on 12/01/16]</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Alzheimer disease</Keyword><Keyword MajorTopicYN="N">Amyotrophic lateral sclerosis</Keyword><Keyword MajorTopicYN="N">Frontotemporal lobar degeneration</Keyword><Keyword MajorTopicYN="N">GWAS</Keyword><Keyword MajorTopicYN="N">Genetic association</Keyword><Keyword MajorTopicYN="N">Imputation</Keyword><Keyword MajorTopicYN="N">Meta-analysis</Keyword><Keyword MajorTopicYN="N">Neurodegenerative disease</Keyword><Keyword MajorTopicYN="N">Parkinson 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ValidYN="Y"><LastName>Sorarù</LastName><ForeName>Gianni</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cereda</LastName><ForeName>Cristina</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Comi</LastName><ForeName>Giacomo</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Del Bo</LastName><ForeName>Roberto</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gellera</LastName><ForeName>Cinzia</ForeName><Initials>C</Initials></Investigator></InvestigatorList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>06</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>10</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>12</Month><Day>02</Day></PubMedPubDate><PubMedPubDate 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Munich</li></orgName></list><tree><country name="Allemagne"><region name="Berlin"><name sortKey="Lill, Christina M" sort="Lill, Christina M" uniqKey="Lill C" first="Christina M" last="Lill">Christina M. 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Morrison</name><name sortKey="Perneczky, Robert" sort="Perneczky, Robert" uniqKey="Perneczky R" first="Robert" last="Perneczky">Robert Perneczky</name><name sortKey="Shatunov, Aleksey" sort="Shatunov, Aleksey" uniqKey="Shatunov A" first="Aleksey" last="Shatunov">Aleksey Shatunov</name><name sortKey="Shaw, Christopher E" sort="Shaw, Christopher E" uniqKey="Shaw C" first="Christopher E" last="Shaw">Christopher E. Shaw</name><name sortKey="Shaw, Pamela J" sort="Shaw, Pamela J" uniqKey="Shaw P" first="Pamela J" last="Shaw">Pamela J. Shaw</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Sleiman, Patrick M" sort="Sleiman, Patrick M" uniqKey="Sleiman P" first="Patrick M" last="Sleiman">Patrick M. Sleiman</name></region><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><name sortKey="Partch, Amanda" sort="Partch, Amanda" uniqKey="Partch A" first="Amanda" last="Partch">Amanda Partch</name><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name><name sortKey="Valladares, Otto" sort="Valladares, Otto" uniqKey="Valladares O" first="Otto" last="Valladares">Otto Valladares</name><name sortKey="Van Deerlin, Vivianna M" sort="Van Deerlin, Vivianna M" uniqKey="Van Deerlin V" first="Vivianna M" last="Van Deerlin">Vivianna M. Van Deerlin</name><name sortKey="Wang, Li San" sort="Wang, Li San" uniqKey="Wang L" first="Li-San" last="Wang">Li-San Wang</name></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Lassen, Christina F" sort="Lassen, Christina F" uniqKey="Lassen C" first="Christina F" last="Lassen">Christina F. Lassen</name></region><name sortKey="Olsen, J Rgen H" sort="Olsen, J Rgen H" uniqKey="Olsen J" first="J Rgen H" last="Olsen">J Rgen H. Olsen</name></country><country name="Italie"><region name="Piémont"><name sortKey="Calvo, Andrea" sort="Calvo, Andrea" uniqKey="Calvo A" first="Andrea" last="Calvo">Andrea Calvo</name></region><name sortKey="Chio, Adriano" sort="Chio, Adriano" uniqKey="Chio A" first="Adriano" last="Chio">Adriano Chio</name><name sortKey="Restagno, Gabriella" sort="Restagno, Gabriella" uniqKey="Restagno G" first="Gabriella" last="Restagno">Gabriella Restagno</name><name sortKey="Silani, Vincenzo" sort="Silani, Vincenzo" uniqKey="Silani V" first="Vincenzo" last="Silani">Vincenzo Silani</name></country><country name="Suède"><noRegion><name sortKey="Dizdar, Nil" sort="Dizdar, Nil" uniqKey="Dizdar N" first="Nil" last="Dizdar">Nil Dizdar</name></noRegion><name sortKey="Forsgren, Lars" sort="Forsgren, Lars" uniqKey="Forsgren L" first="Lars" last="Forsgren">Lars Forsgren</name><name sortKey="Linder, Jan" sort="Linder, Jan" uniqKey="Linder J" first="Jan" last="Linder">Jan Linder</name><name sortKey="Nissbrandt, Hans" sort="Nissbrandt, Hans" uniqKey="Nissbrandt H" first="Hans" last="Nissbrandt">Hans Nissbrandt</name></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H" last="Van Den Berg">Leonard H. Van Den Berg</name></region><name sortKey="Van Rheenen, Wouter" sort="Van Rheenen, Wouter" uniqKey="Van Rheenen W" first="Wouter" last="Van Rheenen">Wouter Van Rheenen</name><name sortKey="Veldink, Jan H" sort="Veldink, Jan H" uniqKey="Veldink J" first="Jan H" last="Veldink">Jan H. Veldink</name></country><country name="France"><region name="Île-de-France"><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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