Experimental pain sensitivity in multiple system atrophy and Parkinson's disease at an early stage.
Identifieur interne : 000163 ( PubMed/Checkpoint ); précédent : 000162; suivant : 000164Experimental pain sensitivity in multiple system atrophy and Parkinson's disease at an early stage.
Auteurs : V. Mylius [Allemagne] ; S. Pee [Allemagne] ; H. Pape [Allemagne] ; M. Teepker [Allemagne] ; M. Stamelou [Allemagne] ; K. Eggert [Allemagne] ; J-P Lefaucheur [France] ; W H Oertel [Allemagne] ; J C Möller [Allemagne]Source :
- European journal of pain (London, England) [ 1532-2149 ] ; 2016.
Abstract
Chronic spontaneous pain is a clinically relevant non-motor symptom in multiple system atrophy (MSA) and Parkinson's disease (PD). Experimental pain sensitivity, reflecting the mechanisms of nociception and pain perception leading to clinical pain, is known to be enhanced in both diseases at advanced stages. Also, this study aimed at investigating experimental pain sensitivity already at an early stage (i.e. symptom duration ≤5 years).
DOI: 10.1002/ejp.846
PubMed: 26914528
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:26914528Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Experimental pain sensitivity in multiple system atrophy and Parkinson's disease at an early stage.</title><author><name sortKey="Mylius, V" sort="Mylius, V" uniqKey="Mylius V" first="V" last="Mylius">V. Mylius</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Pee, S" sort="Pee, S" uniqKey="Pee S" first="S" last="Pee">S. Pee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Pape, H" sort="Pape, H" uniqKey="Pape H" first="H" last="Pape">H. Pape</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Teepker, M" sort="Teepker, M" uniqKey="Teepker M" first="M" last="Teepker">M. Teepker</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Stamelou, M" sort="Stamelou, M" uniqKey="Stamelou M" first="M" last="Stamelou">M. Stamelou</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Eggert, K" sort="Eggert, K" uniqKey="Eggert K" first="K" last="Eggert">K. Eggert</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Lefaucheur, J P" sort="Lefaucheur, J P" uniqKey="Lefaucheur J" first="J-P" last="Lefaucheur">J-P Lefaucheur</name><affiliation wicri:level="3"><nlm:affiliation>Service de Physiologie - Explorations Fonctionnelles, Hôpital Henri-Mondor, AP-HP, Université Paris-Est, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Physiologie - Explorations Fonctionnelles, Hôpital Henri-Mondor, AP-HP, Université Paris-Est, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W H" last="Oertel">W H Oertel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Moller, J C" sort="Moller, J C" uniqKey="Moller J" first="J C" last="Möller">J C Möller</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26914528</idno><idno type="pmid">26914528</idno><idno type="doi">10.1002/ejp.846</idno><idno type="wicri:Area/PubMed/Corpus">000093</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000093</idno><idno type="wicri:Area/PubMed/Curation">000093</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000093</idno><idno type="wicri:Area/PubMed/Checkpoint">000093</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000093</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Experimental pain sensitivity in multiple system atrophy and Parkinson's disease at an early stage.</title><author><name sortKey="Mylius, V" sort="Mylius, V" uniqKey="Mylius V" first="V" last="Mylius">V. Mylius</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Pee, S" sort="Pee, S" uniqKey="Pee S" first="S" last="Pee">S. Pee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Pape, H" sort="Pape, H" uniqKey="Pape H" first="H" last="Pape">H. Pape</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Teepker, M" sort="Teepker, M" uniqKey="Teepker M" first="M" last="Teepker">M. Teepker</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Stamelou, M" sort="Stamelou, M" uniqKey="Stamelou M" first="M" last="Stamelou">M. Stamelou</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Eggert, K" sort="Eggert, K" uniqKey="Eggert K" first="K" last="Eggert">K. Eggert</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Lefaucheur, J P" sort="Lefaucheur, J P" uniqKey="Lefaucheur J" first="J-P" last="Lefaucheur">J-P Lefaucheur</name><affiliation wicri:level="3"><nlm:affiliation>Service de Physiologie - Explorations Fonctionnelles, Hôpital Henri-Mondor, AP-HP, Université Paris-Est, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Physiologie - Explorations Fonctionnelles, Hôpital Henri-Mondor, AP-HP, Université Paris-Est, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W H" last="Oertel">W H Oertel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Moller, J C" sort="Moller, J C" uniqKey="Moller J" first="J C" last="Möller">J C Möller</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author></analytic><series><title level="j">European journal of pain (London, England)</title><idno type="eISSN">1532-2149</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chronic spontaneous pain is a clinically relevant non-motor symptom in multiple system atrophy (MSA) and Parkinson's disease (PD). Experimental pain sensitivity, reflecting the mechanisms of nociception and pain perception leading to clinical pain, is known to be enhanced in both diseases at advanced stages. Also, this study aimed at investigating experimental pain sensitivity already at an early stage (i.e. symptom duration ≤5 years).</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">26914528</PMID><DateCreated><Year>2016</Year><Month>08</Month><Day>09</Day></DateCreated><DateRevised><Year>2016</Year><Month>08</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-2149</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>8</Issue><PubDate><Year>2016</Year><Month>Sep</Month></PubDate></JournalIssue><Title>European journal of pain (London, England)</Title><ISOAbbreviation>Eur J Pain</ISOAbbreviation></Journal><ArticleTitle>Experimental pain sensitivity in multiple system atrophy and Parkinson's disease at an early stage.</ArticleTitle><Pagination><MedlinePgn>1223-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/ejp.846</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Chronic spontaneous pain is a clinically relevant non-motor symptom in multiple system atrophy (MSA) and Parkinson's disease (PD). Experimental pain sensitivity, reflecting the mechanisms of nociception and pain perception leading to clinical pain, is known to be enhanced in both diseases at advanced stages. Also, this study aimed at investigating experimental pain sensitivity already at an early stage (i.e. symptom duration ≤5 years).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Experimental pain sensitivity was assessed by investigating the nociceptive flexion reflex (NFR, reflecting spinal nociception) and heat and electrical pain thresholds. 'Off-drug' MSA (n = 11) and PD (n = 14) patients selected at an early stage of the disease were compared to healthy controls (HC, n = 27). MSA patients had either parkinsonian (MSA-P, n = 5) or cerebellar (MSA-C, n = 6) subtypes.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Compared to HC, MSA patients had lower heat pain sensitivity, whereas PD patients had reduced NFR threshold. MSA and PD patients did not differ from HC regarding other variables. MSA-P and MSA-C patients did not differ, either.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Impaired sensory discrimination and attention deficits could contribute to the reduced perception of heat pain in MSA, whereas in PD, local changes in spinal excitability or a diminished dopaminergic descending inhibition might impact on the motor efference of the NFR to reduce its threshold to nociceptive afferent information. WHAT DOES THIS STUDY ADD?: This study investigated experimental pain sensitivity at an early stage in MSA and PD.</AbstractText><CopyrightInformation>© 2016 European Pain Federation - EFIC®</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mylius</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Neurology, Philipps University, Marburg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Neurorehabilitation, Valens, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pee</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, Philipps University, Marburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pape</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Neurology, Philipps University, Marburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teepker</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, Philipps University, Marburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stamelou</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, Philipps University, Marburg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Movement Disorders Clinic, Second Department of Neurology, University of Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eggert</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Neurology, Philipps University, Marburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lefaucheur</LastName><ForeName>J-P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Service de Physiologie - Explorations Fonctionnelles, Hôpital Henri-Mondor, AP-HP, Université Paris-Est, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oertel</LastName><ForeName>W H</ForeName><Initials>WH</Initials><AffiliationInfo><Affiliation>Department of Neurology, Philipps University, Marburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Möller</LastName><ForeName>J C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Neurology, Philipps University, Marburg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Parkinson Center, Center for Neurological Rehabilitation, Zihlschlacht, Switzerland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>02</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur J Pain</MedlineTA><NlmUniqueID>9801774</NlmUniqueID><ISSNLinking>1090-3801</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>12</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>2</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>2</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26914528</ArticleId><ArticleId IdType="doi">10.1002/ejp.846</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>France</li></country><region><li>District de Giessen</li><li>Hesse (Land)</li><li>Île-de-France</li></region><settlement><li>Créteil</li><li>Marbourg</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Mylius, V" sort="Mylius, V" uniqKey="Mylius V" first="V" last="Mylius">V. Mylius</name></region><name sortKey="Eggert, K" sort="Eggert, K" uniqKey="Eggert K" first="K" last="Eggert">K. Eggert</name><name sortKey="Moller, J C" sort="Moller, J C" uniqKey="Moller J" first="J C" last="Möller">J C Möller</name><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W H" last="Oertel">W H Oertel</name><name sortKey="Pape, H" sort="Pape, H" uniqKey="Pape H" first="H" last="Pape">H. Pape</name><name sortKey="Pee, S" sort="Pee, S" uniqKey="Pee S" first="S" last="Pee">S. Pee</name><name sortKey="Stamelou, M" sort="Stamelou, M" uniqKey="Stamelou M" first="M" last="Stamelou">M. Stamelou</name><name sortKey="Teepker, M" sort="Teepker, M" uniqKey="Teepker M" first="M" last="Teepker">M. Teepker</name></country><country name="France"><region name="Île-de-France"><name sortKey="Lefaucheur, J P" sort="Lefaucheur, J P" uniqKey="Lefaucheur J" first="J-P" last="Lefaucheur">J-P Lefaucheur</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000163 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000163 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:26914528
|texte= Experimental pain sensitivity in multiple system atrophy and Parkinson's disease at an early stage.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:26914528" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |