Striatal Molecular Signature of Subchronic Subthalamic Nucleus High Frequency Stimulation in Parkinsonian Rat
Identifieur interne : 000814 ( Pmc/Curation ); précédent : 000813; suivant : 000815Striatal Molecular Signature of Subchronic Subthalamic Nucleus High Frequency Stimulation in Parkinsonian Rat
Auteurs : Sylviane Lortet [France] ; Emilie Lacombe [France] ; Nicolas Boulanger [France] ; Pascal Rihet [France] ; Catherine Nguyen [France] ; Lydia Kerkerian-Le Goff [France] ; Pascal Salin [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
This study addresses the molecular mechanisms underlying the action of subthalamic nucleus high frequency stimulation (STN-HFS) in the treatment of Parkinson's disease and its interaction with levodopa (L-DOPA), focusing on the striatum. Striatal gene expression profile was assessed in rats with nigral dopamine neuron lesion, either treated or not, using agilent microarrays and qPCR verification. The treatments consisted in anti-akinetic STN-HFS (5 days), chronic L-DOPA treatment inducing dyskinesia (LIDs) or the combination of the two treatments that exacerbated LIDs. STN-HFS modulated 71 striatal genes. The main biological processes associated with the differentially expressed gene products include regulation of growth, of apoptosis and of synaptic transmission, and extracellular region is a major cellular component implicated. In particular, several of these genes have been shown to support survival or differentiation of striatal or of dopaminergic neurons. These results indicate that STN HFS may induce widespread anatomo-functional rearrangements in the striatum and create a molecular environment favorable for neuroprotection and neuroplasticity. STN-HFS and L-DOPA treatment share very few common gene regulation features indicating that the molecular substrates underlying their striatal action are mostly different; among the common effects is the down-regulation of
Url:
DOI: 10.1371/journal.pone.0060447
PubMed: 23593219
PubMed Central: 3617149
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<front><div type="abstract" xml:lang="en"><p>This study addresses the molecular mechanisms underlying the action of subthalamic nucleus high frequency stimulation (STN-HFS) in the treatment of Parkinson's disease and its interaction with levodopa (L-DOPA), focusing on the striatum. Striatal gene expression profile was assessed in rats with nigral dopamine neuron lesion, either treated or not, using agilent microarrays and qPCR verification. The treatments consisted in anti-akinetic STN-HFS (5 days), chronic L-DOPA treatment inducing dyskinesia (LIDs) or the combination of the two treatments that exacerbated LIDs. STN-HFS modulated 71 striatal genes. The main biological processes associated with the differentially expressed gene products include regulation of growth, of apoptosis and of synaptic transmission, and extracellular region is a major cellular component implicated. In particular, several of these genes have been shown to support survival or differentiation of striatal or of dopaminergic neurons. These results indicate that STN HFS may induce widespread anatomo-functional rearrangements in the striatum and create a molecular environment favorable for neuroprotection and neuroplasticity. STN-HFS and L-DOPA treatment share very few common gene regulation features indicating that the molecular substrates underlying their striatal action are mostly different; among the common effects is the down-regulation of <italic>Adrb1</italic>
, which encodes the adrenergic beta-1- receptor, supporting a major role of this receptor in Parkinson's disease. In addition to genes already reported to be associated with LIDs (preprodynorphin, thyrotropin-releasing hormone, metabotropic glutamate receptor 4, cannabinoid receptor 1), the comparison between DOPA and DOPA/HFS identifies immunity-related genes as potential players in L-DOPA side effects.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dauer, W" uniqKey="Dauer W">W Dauer</name>
</author>
<author><name sortKey="Przedborski, S" uniqKey="Przedborski S">S Przedborski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Delong, M" uniqKey="Delong M">M DeLong</name>
</author>
<author><name sortKey="Wichmann, T" uniqKey="Wichmann T">T Wichmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bezard, E" uniqKey="Bezard E">E Bezard</name>
</author>
<author><name sortKey="Brotchie, Jm" uniqKey="Brotchie J">JM Brotchie</name>
</author>
<author><name sortKey="Gross, Ce" uniqKey="Gross C">CE Gross</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cenci, Ma" uniqKey="Cenci M">MA Cenci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Iravani, Mm" uniqKey="Iravani M">MM Iravani</name>
</author>
<author><name sortKey="Jenner, P" uniqKey="Jenner P">P Jenner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gottwald, Md" uniqKey="Gottwald M">MD Gottwald</name>
</author>
<author><name sortKey="Aminoff, Mj" uniqKey="Aminoff M">MJ Aminoff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Benabid, Al" uniqKey="Benabid A">AL Benabid</name>
</author>
<author><name sortKey="Chabardes, S" uniqKey="Chabardes S">S Chabardes</name>
</author>
<author><name sortKey="Mitrofanis, J" uniqKey="Mitrofanis J">J Mitrofanis</name>
</author>
<author><name sortKey="Pollak, P" uniqKey="Pollak P">P Pollak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Katayama, Y" uniqKey="Katayama Y">Y Katayama</name>
</author>
<author><name sortKey="Oshima, H" uniqKey="Oshima H">H Oshima</name>
</author>
<author><name sortKey="Kano, T" uniqKey="Kano T">T Kano</name>
</author>
<author><name sortKey="Kobayashi, K" uniqKey="Kobayashi K">K Kobayashi</name>
</author>
<author><name sortKey="Fukaya, C" uniqKey="Fukaya C">C Fukaya</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gubellini, P" uniqKey="Gubellini P">P Gubellini</name>
</author>
<author><name sortKey="Eusebio, A" uniqKey="Eusebio A">A Eusebio</name>
</author>
<author><name sortKey="Oueslati, A" uniqKey="Oueslati A">A Oueslati</name>
</author>
<author><name sortKey="Melon, C" uniqKey="Melon C">C Melon</name>
</author>
<author><name sortKey="Kerkerian Le, Gl" uniqKey="Kerkerian Le G">GL Kerkerian-Le</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oueslati, A" uniqKey="Oueslati A">A Oueslati</name>
</author>
<author><name sortKey="Sgambato Faure, V" uniqKey="Sgambato Faure V">V Sgambato-Faure</name>
</author>
<author><name sortKey="Melon, C" uniqKey="Melon C">C Melon</name>
</author>
<author><name sortKey="Kachidian, P" uniqKey="Kachidian P">P Kachidian</name>
</author>
<author><name sortKey="Gubellini, P" uniqKey="Gubellini P">P Gubellini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lacombe, E" uniqKey="Lacombe E">E Lacombe</name>
</author>
<author><name sortKey="Carcenac, C" uniqKey="Carcenac C">C Carcenac</name>
</author>
<author><name sortKey="Boulet, S" uniqKey="Boulet S">S Boulet</name>
</author>
<author><name sortKey="Feuerstein, C" uniqKey="Feuerstein C">C Feuerstein</name>
</author>
<author><name sortKey="Bertrand, A" uniqKey="Bertrand A">A Bertrand</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gubellini, P" uniqKey="Gubellini P">P Gubellini</name>
</author>
<author><name sortKey="Salin, P" uniqKey="Salin P">P Salin</name>
</author>
<author><name sortKey="Kerkerian Le, Gl" uniqKey="Kerkerian Le G">GL Kerkerian-Le</name>
</author>
<author><name sortKey="Baunez, C" uniqKey="Baunez C">C Baunez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khaindrava, V" uniqKey="Khaindrava V">V Khaindrava</name>
</author>
<author><name sortKey="Salin, P" uniqKey="Salin P">P Salin</name>
</author>
<author><name sortKey="Melon, C" uniqKey="Melon C">C Melon</name>
</author>
<author><name sortKey="Ugrumov, M" uniqKey="Ugrumov M">M Ugrumov</name>
</author>
<author><name sortKey="Kerkerian Le Goff, L" uniqKey="Kerkerian Le Goff L">L Kerkerian-Le-Goff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Konradi, C" uniqKey="Konradi C">C Konradi</name>
</author>
<author><name sortKey="Westin, Je" uniqKey="Westin J">JE Westin</name>
</author>
<author><name sortKey="Carta, M" uniqKey="Carta M">M Carta</name>
</author>
<author><name sortKey="Eaton, Me" uniqKey="Eaton M">ME Eaton</name>
</author>
<author><name sortKey="Kuter, K" uniqKey="Kuter K">K Kuter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="El Atifi Borel, M" uniqKey="El Atifi Borel M">M El Atifi-Borel</name>
</author>
<author><name sortKey="Buggia Prevot, V" uniqKey="Buggia Prevot V">V Buggia-Prevot</name>
</author>
<author><name sortKey="Platet, N" uniqKey="Platet N">N Platet</name>
</author>
<author><name sortKey="Benabid, Al" uniqKey="Benabid A">AL Benabid</name>
</author>
<author><name sortKey="Berger, F" uniqKey="Berger F">F Berger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grunblatt, E" uniqKey="Grunblatt E">E Grunblatt</name>
</author>
<author><name sortKey="Schmidt, Wj" uniqKey="Schmidt W">WJ Schmidt</name>
</author>
<author><name sortKey="Scheller, Dk" uniqKey="Scheller D">DK Scheller</name>
</author>
<author><name sortKey="Riederer, P" uniqKey="Riederer P">P Riederer</name>
</author>
<author><name sortKey="Gerlach, M" uniqKey="Gerlach M">M Gerlach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Naydenov, Av" uniqKey="Naydenov A">AV Naydenov</name>
</author>
<author><name sortKey="Vassoler, F" uniqKey="Vassoler F">F Vassoler</name>
</author>
<author><name sortKey="Luksik, As" uniqKey="Luksik A">AS Luksik</name>
</author>
<author><name sortKey="Kaczmarska, J" uniqKey="Kaczmarska J">J Kaczmarska</name>
</author>
<author><name sortKey="Konradi, C" uniqKey="Konradi C">C Konradi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferrario, Je" uniqKey="Ferrario J">JE Ferrario</name>
</author>
<author><name sortKey="Taravini, Ir" uniqKey="Taravini I">IR Taravini</name>
</author>
<author><name sortKey="Mourlevat, S" uniqKey="Mourlevat S">S Mourlevat</name>
</author>
<author><name sortKey="Stefano, A" uniqKey="Stefano A">A Stefano</name>
</author>
<author><name sortKey="Delfino, Ma" uniqKey="Delfino M">MA Delfino</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Robelet, S" uniqKey="Robelet S">S Robelet</name>
</author>
<author><name sortKey="Melon, C" uniqKey="Melon C">C Melon</name>
</author>
<author><name sortKey="Guillet, B" uniqKey="Guillet B">B Guillet</name>
</author>
<author><name sortKey="Salin, P" uniqKey="Salin P">P Salin</name>
</author>
<author><name sortKey="Kerkerian Le, Gl" uniqKey="Kerkerian Le G">GL Kerkerian-Le</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cenci, Ma" uniqKey="Cenci M">MA Cenci</name>
</author>
<author><name sortKey="Lee, Cs" uniqKey="Lee C">CS Lee</name>
</author>
<author><name sortKey="Bjorklund, A" uniqKey="Bjorklund A">A Bjorklund</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salin, P" uniqKey="Salin P">P Salin</name>
</author>
<author><name sortKey="Manrique, C" uniqKey="Manrique C">C Manrique</name>
</author>
<author><name sortKey="Forni, C" uniqKey="Forni C">C Forni</name>
</author>
<author><name sortKey="Kerkerian Le, Gl" uniqKey="Kerkerian Le G">GL Kerkerian-Le</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kerr, Mk" uniqKey="Kerr M">MK Kerr</name>
</author>
<author><name sortKey="Martin, M" uniqKey="Martin M">M Martin</name>
</author>
<author><name sortKey="Churchill, Ga" uniqKey="Churchill G">GA Churchill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reiner, A" uniqKey="Reiner A">A Reiner</name>
</author>
<author><name sortKey="Yekutieli, D" uniqKey="Yekutieli D">D Yekutieli</name>
</author>
<author><name sortKey="Benjamini, Y" uniqKey="Benjamini Y">Y Benjamini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dennis, G" uniqKey="Dennis G">G Dennis</name>
</author>
<author><name sortKey="Sherman, Bt" uniqKey="Sherman B">BT Sherman</name>
</author>
<author><name sortKey="Hosack, Da" uniqKey="Hosack D">DA Hosack</name>
</author>
<author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name>
</author>
<author><name sortKey="Gao, W" uniqKey="Gao W">W Gao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lacombe, E" uniqKey="Lacombe E">E Lacombe</name>
</author>
<author><name sortKey="Khaindrava, V" uniqKey="Khaindrava V">V Khaindrava</name>
</author>
<author><name sortKey="Melon, C" uniqKey="Melon C">C Melon</name>
</author>
<author><name sortKey="Oueslati, A" uniqKey="Oueslati A">A Oueslati</name>
</author>
<author><name sortKey="Kerkerian Le, Gl" uniqKey="Kerkerian Le G">GL Kerkerian-Le</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aviles Olmos, I" uniqKey="Aviles Olmos I">I Aviles-Olmos</name>
</author>
<author><name sortKey="Limousin, P" uniqKey="Limousin P">P Limousin</name>
</author>
<author><name sortKey="Lees, A" uniqKey="Lees A">A Lees</name>
</author>
<author><name sortKey="Foltynie, T" uniqKey="Foltynie T">T Foltynie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Masliah, E" uniqKey="Masliah E">E Masliah</name>
</author>
<author><name sortKey="Reixach, N" uniqKey="Reixach N">N Reixach</name>
</author>
<author><name sortKey="Buxbaum, Jn" uniqKey="Buxbaum J">JN Buxbaum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brouillette, J" uniqKey="Brouillette J">J Brouillette</name>
</author>
<author><name sortKey="Quirion, R" uniqKey="Quirion R">R Quirion</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Toresson, H" uniqKey="Toresson H">H Toresson</name>
</author>
<author><name sortKey="Mata De, Ua" uniqKey="Mata De U">UA Mata de</name>
</author>
<author><name sortKey="Fagerstrom, C" uniqKey="Fagerstrom C">C Fagerstrom</name>
</author>
<author><name sortKey="Perlmann, T" uniqKey="Perlmann T">T Perlmann</name>
</author>
<author><name sortKey="Campbell, K" uniqKey="Campbell K">K Campbell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Tw" uniqKey="Wang T">TW Wang</name>
</author>
<author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name>
</author>
<author><name sortKey="Parent, Jm" uniqKey="Parent J">JM Parent</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Plane, Jm" uniqKey="Plane J">JM Plane</name>
</author>
<author><name sortKey="Whitney, Jt" uniqKey="Whitney J">JT Whitney</name>
</author>
<author><name sortKey="Schallert, T" uniqKey="Schallert T">T Schallert</name>
</author>
<author><name sortKey="Parent, Jm" uniqKey="Parent J">JM Parent</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liz, Ma" uniqKey="Liz M">MA Liz</name>
</author>
<author><name sortKey="Leite, Sc" uniqKey="Leite S">SC Leite</name>
</author>
<author><name sortKey="Juliano, L" uniqKey="Juliano L">L Juliano</name>
</author>
<author><name sortKey="Saraiva, Mj" uniqKey="Saraiva M">MJ Saraiva</name>
</author>
<author><name sortKey="Damas, Am" uniqKey="Damas A">AM Damas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kawaguchi, Y" uniqKey="Kawaguchi Y">Y Kawaguchi</name>
</author>
<author><name sortKey="Wilson, Cj" uniqKey="Wilson C">CJ Wilson</name>
</author>
<author><name sortKey="Augood, Sj" uniqKey="Augood S">SJ Augood</name>
</author>
<author><name sortKey="Emson, Pc" uniqKey="Emson P">PC Emson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cannizzaro, C" uniqKey="Cannizzaro C">C Cannizzaro</name>
</author>
<author><name sortKey="Tel, Bc" uniqKey="Tel B">BC Tel</name>
</author>
<author><name sortKey="Rose, S" uniqKey="Rose S">S Rose</name>
</author>
<author><name sortKey="Zeng, By" uniqKey="Zeng B">BY Zeng</name>
</author>
<author><name sortKey="Jenner, P" uniqKey="Jenner P">P Jenner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kerkerian, L" uniqKey="Kerkerian L">L Kerkerian</name>
</author>
<author><name sortKey="Bosler, O" uniqKey="Bosler O">O Bosler</name>
</author>
<author><name sortKey="Pelletier, G" uniqKey="Pelletier G">G Pelletier</name>
</author>
<author><name sortKey="Nieoullon, A" uniqKey="Nieoullon A">A Nieoullon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lindefors, N" uniqKey="Lindefors N">N Lindefors</name>
</author>
<author><name sortKey="Brene, S" uniqKey="Brene S">S Brene</name>
</author>
<author><name sortKey="Herrera Marschitz, M" uniqKey="Herrera Marschitz M">M Herrera-Marschitz</name>
</author>
<author><name sortKey="Persson, H" uniqKey="Persson H">H Persson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bassilana, F" uniqKey="Bassilana F">F Bassilana</name>
</author>
<author><name sortKey="Mace, N" uniqKey="Mace N">N Mace</name>
</author>
<author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name>
</author>
<author><name sortKey="Stutzmann, Jm" uniqKey="Stutzmann J">JM Stutzmann</name>
</author>
<author><name sortKey="Gross, Ce" uniqKey="Gross C">CE Gross</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cabeza Arvelaiz, Y" uniqKey="Cabeza Arvelaiz Y">Y Cabeza-Arvelaiz</name>
</author>
<author><name sortKey="Fleming, Sm" uniqKey="Fleming S">SM Fleming</name>
</author>
<author><name sortKey="Richter, F" uniqKey="Richter F">F Richter</name>
</author>
<author><name sortKey="Masliah, E" uniqKey="Masliah E">E Masliah</name>
</author>
<author><name sortKey="Chesselet, Mf" uniqKey="Chesselet M">MF Chesselet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Md" uniqKey="Li M">MD Li</name>
</author>
<author><name sortKey="Kane, Jk" uniqKey="Kane J">JK Kane</name>
</author>
<author><name sortKey="Matta, Sg" uniqKey="Matta S">SG Matta</name>
</author>
<author><name sortKey="Blaner, Ws" uniqKey="Blaner W">WS Blaner</name>
</author>
<author><name sortKey="Sharp, Bm" uniqKey="Sharp B">BM Sharp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Quik, M" uniqKey="Quik M">M Quik</name>
</author>
<author><name sortKey="Huang, Lz" uniqKey="Huang L">LZ Huang</name>
</author>
<author><name sortKey="Parameswaran, N" uniqKey="Parameswaran N">N Parameswaran</name>
</author>
<author><name sortKey="Bordia, T" uniqKey="Bordia T">T Bordia</name>
</author>
<author><name sortKey="Campos, C" uniqKey="Campos C">C Campos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fernandez, Am" uniqKey="Fernandez A">AM Fernandez</name>
</author>
<author><name sortKey="Torres Aleman, I" uniqKey="Torres Aleman I">I Torres-Aleman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bracko, O" uniqKey="Bracko O">O Bracko</name>
</author>
<author><name sortKey="Singer, T" uniqKey="Singer T">T Singer</name>
</author>
<author><name sortKey="Aigner, S" uniqKey="Aigner S">S Aigner</name>
</author>
<author><name sortKey="Knobloch, M" uniqKey="Knobloch M">M Knobloch</name>
</author>
<author><name sortKey="Winner, B" uniqKey="Winner B">B Winner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vazin, T" uniqKey="Vazin T">T Vazin</name>
</author>
<author><name sortKey="Becker, Kg" uniqKey="Becker K">KG Becker</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name>
</author>
<author><name sortKey="Spivak, Ce" uniqKey="Spivak C">CE Spivak</name>
</author>
<author><name sortKey="Lupica, Cr" uniqKey="Lupica C">CR Lupica</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schmeisser, Mj" uniqKey="Schmeisser M">MJ Schmeisser</name>
</author>
<author><name sortKey="Baumann, B" uniqKey="Baumann B">B Baumann</name>
</author>
<author><name sortKey="Johannsen, S" uniqKey="Johannsen S">S Johannsen</name>
</author>
<author><name sortKey="Vindedal, Gf" uniqKey="Vindedal G">GF Vindedal</name>
</author>
<author><name sortKey="Jensen, V" uniqKey="Jensen V">V Jensen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Y" uniqKey="Smith Y">Y Smith</name>
</author>
<author><name sortKey="Villalba, Rm" uniqKey="Villalba R">RM Villalba</name>
</author>
<author><name sortKey="Raju, Dv" uniqKey="Raju D">DV Raju</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lim, Da" uniqKey="Lim D">DA Lim</name>
</author>
<author><name sortKey="Tramontin, Ad" uniqKey="Tramontin A">AD Tramontin</name>
</author>
<author><name sortKey="Trevejo, Jm" uniqKey="Trevejo J">JM Trevejo</name>
</author>
<author><name sortKey="Herrera, Dg" uniqKey="Herrera D">DG Herrera</name>
</author>
<author><name sortKey="Garcia Verdugo, Jm" uniqKey="Garcia Verdugo J">JM Garcia-Verdugo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chmielnicki, E" uniqKey="Chmielnicki E">E Chmielnicki</name>
</author>
<author><name sortKey="Benraiss, A" uniqKey="Benraiss A">A Benraiss</name>
</author>
<author><name sortKey="Economides, An" uniqKey="Economides A">AN Economides</name>
</author>
<author><name sortKey="Goldman, Sa" uniqKey="Goldman S">SA Goldman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maxwell, Ma" uniqKey="Maxwell M">MA Maxwell</name>
</author>
<author><name sortKey="Muscat, Ge" uniqKey="Muscat G">GE Muscat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Werme, M" uniqKey="Werme M">M Werme</name>
</author>
<author><name sortKey="Ringholm, A" uniqKey="Ringholm A">A Ringholm</name>
</author>
<author><name sortKey="Olson, L" uniqKey="Olson L">L Olson</name>
</author>
<author><name sortKey="Brene, S" uniqKey="Brene S">S Brene</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eells, Jb" uniqKey="Eells J">JB Eells</name>
</author>
<author><name sortKey="Wilcots, J" uniqKey="Wilcots J">J Wilcots</name>
</author>
<author><name sortKey="Sisk, S" uniqKey="Sisk S">S Sisk</name>
</author>
<author><name sortKey="Guo Ross, Sx" uniqKey="Guo Ross S">SX Guo-Ross</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garcia Dominguez, M" uniqKey="Garcia Dominguez M">M Garcia-Dominguez</name>
</author>
<author><name sortKey="Poquet, C" uniqKey="Poquet C">C Poquet</name>
</author>
<author><name sortKey="Garel, S" uniqKey="Garel S">S Garel</name>
</author>
<author><name sortKey="Charnay, P" uniqKey="Charnay P">P Charnay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lobo, Mk" uniqKey="Lobo M">MK Lobo</name>
</author>
<author><name sortKey="Karsten, Sl" uniqKey="Karsten S">SL Karsten</name>
</author>
<author><name sortKey="Gray, M" uniqKey="Gray M">M Gray</name>
</author>
<author><name sortKey="Geschwind, Dh" uniqKey="Geschwind D">DH Geschwind</name>
</author>
<author><name sortKey="Yang, Xw" uniqKey="Yang X">XW Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bruet, N" uniqKey="Bruet N">N Bruet</name>
</author>
<author><name sortKey="Windels, F" uniqKey="Windels F">F Windels</name>
</author>
<author><name sortKey="Bertrand, A" uniqKey="Bertrand A">A Bertrand</name>
</author>
<author><name sortKey="Feuerstein, C" uniqKey="Feuerstein C">C Feuerstein</name>
</author>
<author><name sortKey="Poupard, A" uniqKey="Poupard A">A Poupard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meissner, W" uniqKey="Meissner W">W Meissner</name>
</author>
<author><name sortKey="Harnack, D" uniqKey="Harnack D">D Harnack</name>
</author>
<author><name sortKey="Reese, R" uniqKey="Reese R">R Reese</name>
</author>
<author><name sortKey="Paul, G" uniqKey="Paul G">G Paul</name>
</author>
<author><name sortKey="Reum, T" uniqKey="Reum T">T Reum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, Xd" uniqKey="Zhao X">XD Zhao</name>
</author>
<author><name sortKey="Cao, Yq" uniqKey="Cao Y">YQ Cao</name>
</author>
<author><name sortKey="Liu, Hh" uniqKey="Liu H">HH Liu</name>
</author>
<author><name sortKey="Li, Fq" uniqKey="Li F">FQ Li</name>
</author>
<author><name sortKey="You, Bm" uniqKey="You B">BM You</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jin, H" uniqKey="Jin H">H Jin</name>
</author>
<author><name sortKey="Kanthasamy, A" uniqKey="Kanthasamy A">A Kanthasamy</name>
</author>
<author><name sortKey="Anantharam, V" uniqKey="Anantharam V">V Anantharam</name>
</author>
<author><name sortKey="Rana, A" uniqKey="Rana A">A Rana</name>
</author>
<author><name sortKey="Kanthasamy, Ag" uniqKey="Kanthasamy A">AG Kanthasamy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hanrott, K" uniqKey="Hanrott K">K Hanrott</name>
</author>
<author><name sortKey="Gudmunsen, L" uniqKey="Gudmunsen L">L Gudmunsen</name>
</author>
<author><name sortKey="O Neill, Mj" uniqKey="O Neill M">MJ O'Neill</name>
</author>
<author><name sortKey="Wonnacott, S" uniqKey="Wonnacott S">S Wonnacott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, D" uniqKey="Zhang D">D Zhang</name>
</author>
<author><name sortKey="Anantharam, V" uniqKey="Anantharam V">V Anantharam</name>
</author>
<author><name sortKey="Kanthasamy, A" uniqKey="Kanthasamy A">A Kanthasamy</name>
</author>
<author><name sortKey="Kanthasamy, Ag" uniqKey="Kanthasamy A">AG Kanthasamy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steckley, D" uniqKey="Steckley D">D Steckley</name>
</author>
<author><name sortKey="Karajgikar, M" uniqKey="Karajgikar M">M Karajgikar</name>
</author>
<author><name sortKey="Dale, Lb" uniqKey="Dale L">LB Dale</name>
</author>
<author><name sortKey="Fuerth, B" uniqKey="Fuerth B">B Fuerth</name>
</author>
<author><name sortKey="Swan, P" uniqKey="Swan P">P Swan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gomez Lazaro, M" uniqKey="Gomez Lazaro M">M Gomez-Lazaro</name>
</author>
<author><name sortKey="Galindo, Mf" uniqKey="Galindo M">MF Galindo</name>
</author>
<author><name sortKey="Concannon, Cg" uniqKey="Concannon C">CG Concannon</name>
</author>
<author><name sortKey="Segura, Mf" uniqKey="Segura M">MF Segura</name>
</author>
<author><name sortKey="Fernandez Gomez, Fj" uniqKey="Fernandez Gomez F">FJ Fernandez-Gomez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gertz, M" uniqKey="Gertz M">M Gertz</name>
</author>
<author><name sortKey="Steegborn, C" uniqKey="Steegborn C">C Steegborn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pfister, Ja" uniqKey="Pfister J">JA Pfister</name>
</author>
<author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name>
</author>
<author><name sortKey="Morrison, Be" uniqKey="Morrison B">BE Morrison</name>
</author>
<author><name sortKey="D Mello, Sr" uniqKey="D Mello S">SR D'Mello</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Toulorge, D" uniqKey="Toulorge D">D Toulorge</name>
</author>
<author><name sortKey="Guerreiro, S" uniqKey="Guerreiro S">S Guerreiro</name>
</author>
<author><name sortKey="Hild, A" uniqKey="Hild A">A Hild</name>
</author>
<author><name sortKey="Maskos, U" uniqKey="Maskos U">U Maskos</name>
</author>
<author><name sortKey="Hirsch, Ec" uniqKey="Hirsch E">EC Hirsch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Azam, L" uniqKey="Azam L">L Azam</name>
</author>
<author><name sortKey="Winzer Serhan, U" uniqKey="Winzer Serhan U">U Winzer-Serhan</name>
</author>
<author><name sortKey="Leslie, Fm" uniqKey="Leslie F">FM Leslie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kita, Y" uniqKey="Kita Y">Y Kita</name>
</author>
<author><name sortKey="Ago, Y" uniqKey="Ago Y">Y Ago</name>
</author>
<author><name sortKey="Takano, E" uniqKey="Takano E">E Takano</name>
</author>
<author><name sortKey="Fukada, A" uniqKey="Fukada A">A Fukada</name>
</author>
<author><name sortKey="Takuma, K" uniqKey="Takuma K">K Takuma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roux, Pp" uniqKey="Roux P">PP Roux</name>
</author>
<author><name sortKey="Barker, Pa" uniqKey="Barker P">PA Barker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Sj" uniqKey="Zhang S">SJ Zhang</name>
</author>
<author><name sortKey="Zou, M" uniqKey="Zou M">M Zou</name>
</author>
<author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name>
</author>
<author><name sortKey="Lau, D" uniqKey="Lau D">D Lau</name>
</author>
<author><name sortKey="Ditzel, Da" uniqKey="Ditzel D">DA Ditzel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pfeiffer, Jr" uniqKey="Pfeiffer J">JR Pfeiffer</name>
</author>
<author><name sortKey="Mcavoy, Bl" uniqKey="Mcavoy B">BL McAvoy</name>
</author>
<author><name sortKey="Fecteau, Re" uniqKey="Fecteau R">RE Fecteau</name>
</author>
<author><name sortKey="Deleault, Km" uniqKey="Deleault K">KM Deleault</name>
</author>
<author><name sortKey="Brooks, Sa" uniqKey="Brooks S">SA Brooks</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aubert, I" uniqKey="Aubert I">I Aubert</name>
</author>
<author><name sortKey="Guigoni, C" uniqKey="Guigoni C">C Guigoni</name>
</author>
<author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name>
</author>
<author><name sortKey="Dovero, S" uniqKey="Dovero S">S Dovero</name>
</author>
<author><name sortKey="Bioulac, Bh" uniqKey="Bioulac B">BH Bioulac</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Henry, B" uniqKey="Henry B">B Henry</name>
</author>
<author><name sortKey="Duty, S" uniqKey="Duty S">S Duty</name>
</author>
<author><name sortKey="Fox, Sh" uniqKey="Fox S">SH Fox</name>
</author>
<author><name sortKey="Crossman, Ar" uniqKey="Crossman A">AR Crossman</name>
</author>
<author><name sortKey="Brotchie, Jm" uniqKey="Brotchie J">JM Brotchie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lundblad, M" uniqKey="Lundblad M">M Lundblad</name>
</author>
<author><name sortKey="Picconi, B" uniqKey="Picconi B">B Picconi</name>
</author>
<author><name sortKey="Lindgren, H" uniqKey="Lindgren H">H Lindgren</name>
</author>
<author><name sortKey="Cenci, Ma" uniqKey="Cenci M">MA Cenci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Calabresi, P" uniqKey="Calabresi P">P Calabresi</name>
</author>
<author><name sortKey="Giacomini, P" uniqKey="Giacomini P">P Giacomini</name>
</author>
<author><name sortKey="Centonze, D" uniqKey="Centonze D">D Centonze</name>
</author>
<author><name sortKey="Bernardi, G" uniqKey="Bernardi G">G Bernardi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sgambato Faure, V" uniqKey="Sgambato Faure V">V Sgambato-Faure</name>
</author>
<author><name sortKey="Cenci, Ma" uniqKey="Cenci M">MA Cenci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zeng, By" uniqKey="Zeng B">BY Zeng</name>
</author>
<author><name sortKey="Dass, B" uniqKey="Dass B">B Dass</name>
</author>
<author><name sortKey="Owen, A" uniqKey="Owen A">A Owen</name>
</author>
<author><name sortKey="Rose, S" uniqKey="Rose S">S Rose</name>
</author>
<author><name sortKey="Cannizzaro, C" uniqKey="Cannizzaro C">C Cannizzaro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cantuti Castelvetri, I" uniqKey="Cantuti Castelvetri I">I Cantuti-Castelvetri</name>
</author>
<author><name sortKey="Hernandez, Lf" uniqKey="Hernandez L">LF Hernandez</name>
</author>
<author><name sortKey="Keller Mcgandy, Ce" uniqKey="Keller Mcgandy C">CE Keller-McGandy</name>
</author>
<author><name sortKey="Kett, Lr" uniqKey="Kett L">LR Kett</name>
</author>
<author><name sortKey="Landy, A" uniqKey="Landy A">A Landy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fabbrini, G" uniqKey="Fabbrini G">G Fabbrini</name>
</author>
<author><name sortKey="Brotchie, Jm" uniqKey="Brotchie J">JM Brotchie</name>
</author>
<author><name sortKey="Grandas, F" uniqKey="Grandas F">F Grandas</name>
</author>
<author><name sortKey="Nomoto, M" uniqKey="Nomoto M">M Nomoto</name>
</author>
<author><name sortKey="Goetz, Cg" uniqKey="Goetz C">CG Goetz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nicholson, Sl" uniqKey="Nicholson S">SL Nicholson</name>
</author>
<author><name sortKey="Brotchie, Jm" uniqKey="Brotchie J">JM Brotchie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lindgren, Hs" uniqKey="Lindgren H">HS Lindgren</name>
</author>
<author><name sortKey="Ohlin, Ke" uniqKey="Ohlin K">KE Ohlin</name>
</author>
<author><name sortKey="Cenci, Ma" uniqKey="Cenci M">MA Cenci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name>
</author>
<author><name sortKey="Halliday, Gm" uniqKey="Halliday G">GM Halliday</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sarkar, C" uniqKey="Sarkar C">C Sarkar</name>
</author>
<author><name sortKey="Basu, B" uniqKey="Basu B">B Basu</name>
</author>
<author><name sortKey="Chakroborty, D" uniqKey="Chakroborty D">D Chakroborty</name>
</author>
<author><name sortKey="Dasgupta, Ps" uniqKey="Dasgupta P">PS Dasgupta</name>
</author>
<author><name sortKey="Basu, S" uniqKey="Basu S">S Basu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y Ding</name>
</author>
<author><name sortKey="Won, L" uniqKey="Won L">L Won</name>
</author>
<author><name sortKey="Britt, Jp" uniqKey="Britt J">JP Britt</name>
</author>
<author><name sortKey="Lim, Sa" uniqKey="Lim S">SA Lim</name>
</author>
<author><name sortKey="Mcgehee, Ds" uniqKey="Mcgehee D">DS McGehee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pisani, A" uniqKey="Pisani A">A Pisani</name>
</author>
<author><name sortKey="Bonsi, P" uniqKey="Bonsi P">P Bonsi</name>
</author>
<author><name sortKey="Centonze, D" uniqKey="Centonze D">D Centonze</name>
</author>
<author><name sortKey="Martorana, A" uniqKey="Martorana A">A Martorana</name>
</author>
<author><name sortKey="Fusco, F" uniqKey="Fusco F">F Fusco</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hara, M" uniqKey="Hara M">M Hara</name>
</author>
<author><name sortKey="Fukui, R" uniqKey="Fukui R">R Fukui</name>
</author>
<author><name sortKey="Hieda, E" uniqKey="Hieda E">E Hieda</name>
</author>
<author><name sortKey="Kuroiwa, M" uniqKey="Kuroiwa M">M Kuroiwa</name>
</author>
<author><name sortKey="Bateup, Hs" uniqKey="Bateup H">HS Bateup</name>
</author>
</analytic>
</biblStruct>
</listBibl>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23593219</article-id>
<article-id pub-id-type="pmc">3617149</article-id>
<article-id pub-id-type="publisher-id">PONE-D-12-36103</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0060447</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Biology</subject>
<subj-group><subject>Model Organisms</subject>
<subj-group><subject>Animal Models</subject>
<subj-group><subject>Rat</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group><subject>Molecular Cell Biology</subject>
<subj-group><subject>Gene Expression</subject>
<subj-group><subject>DNA transcription</subject>
</subj-group>
</subj-group>
<subj-group><subject>Nucleic Acids</subject>
<subj-group><subject>RNA</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group><subject>Neuroscience</subject>
<subj-group><subject>Molecular Neuroscience</subject>
<subject>Neurobiology of Disease and Regeneration</subject>
<subject>Neurotransmitters</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject>
<subj-group><subject>Neurology</subject>
<subj-group><subject>Movement Disorders</subject>
<subject>Parkinson Disease</subject>
</subj-group>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Striatal Molecular Signature of Subchronic Subthalamic Nucleus High Frequency Stimulation in Parkinsonian Rat</article-title>
<alt-title alt-title-type="running-head">Striatal Gene Profiling after STN-HFS</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lortet</surname>
<given-names>Sylviane</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>*</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lacombe</surname>
<given-names>Emilie</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Boulanger</surname>
<given-names>Nicolas</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rihet</surname>
<given-names>Pascal</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nguyen</surname>
<given-names>Catherine</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Goff</surname>
<given-names>Lydia Kerkerian-Le</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Salin</surname>
<given-names>Pascal</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<addr-line>Aix-Marseille Université, CNRS, IBDM UMR 7288, Marseille, France</addr-line>
</aff>
<aff id="aff2"><label>2</label>
<addr-line>Aix-Marseille Université, INSERM, TAGC U1090, Marseille, France</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Svenningsson</surname>
<given-names>Per</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>Karolinska Institute, Sweden</addr-line>
</aff>
<author-notes><corresp id="cor1">* E-mail: <email>sylviane.lortet@univ-amu.fr</email>
</corresp>
<fn fn-type="conflict"><p><bold>Competing Interests: </bold>
The authors have declared that no competing interests exist.</p>
</fn>
<fn fn-type="con"><p>Conceived and designed the experiments: LK-L PS. Performed the experiments: SL EL NB. Analyzed the data: SL PR CN PS. Contributed reagents/materials/analysis tools: SL NB CN. Wrote the paper: SL LK-L PS.</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>4</day>
<month>4</month>
<year>2013</year>
</pub-date>
<volume>8</volume>
<issue>4</issue>
<elocation-id>e60447</elocation-id>
<history><date date-type="received"><day>6</day>
<month>11</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>26</day>
<month>2</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-year>2013</copyright-year>
<copyright-holder>Lortet et al</copyright-holder>
<license><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
</license>
</permissions>
<abstract><p>This study addresses the molecular mechanisms underlying the action of subthalamic nucleus high frequency stimulation (STN-HFS) in the treatment of Parkinson's disease and its interaction with levodopa (L-DOPA), focusing on the striatum. Striatal gene expression profile was assessed in rats with nigral dopamine neuron lesion, either treated or not, using agilent microarrays and qPCR verification. The treatments consisted in anti-akinetic STN-HFS (5 days), chronic L-DOPA treatment inducing dyskinesia (LIDs) or the combination of the two treatments that exacerbated LIDs. STN-HFS modulated 71 striatal genes. The main biological processes associated with the differentially expressed gene products include regulation of growth, of apoptosis and of synaptic transmission, and extracellular region is a major cellular component implicated. In particular, several of these genes have been shown to support survival or differentiation of striatal or of dopaminergic neurons. These results indicate that STN HFS may induce widespread anatomo-functional rearrangements in the striatum and create a molecular environment favorable for neuroprotection and neuroplasticity. STN-HFS and L-DOPA treatment share very few common gene regulation features indicating that the molecular substrates underlying their striatal action are mostly different; among the common effects is the down-regulation of <italic>Adrb1</italic>
, which encodes the adrenergic beta-1- receptor, supporting a major role of this receptor in Parkinson's disease. In addition to genes already reported to be associated with LIDs (preprodynorphin, thyrotropin-releasing hormone, metabotropic glutamate receptor 4, cannabinoid receptor 1), the comparison between DOPA and DOPA/HFS identifies immunity-related genes as potential players in L-DOPA side effects.</p>
</abstract>
<funding-group><funding-statement>This work was supported by the Centre National de la Recherche Scientifique (CNRS), Aix- Marseille University, and Fédération pour la Recherche sur le Cerveau (FRC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement>
</funding-group>
<counts><page-count count="14"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
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