Is R2* a New MRI Biomarker for the Progression of Parkinson’s Disease? A Longitudinal Follow-Up
Identifieur interne : 000813 ( Pmc/Curation ); précédent : 000812; suivant : 000814Is R2* a New MRI Biomarker for the Progression of Parkinson’s Disease? A Longitudinal Follow-Up
Auteurs : Miguel Ulla [France] ; Jean Marie Bonny [France] ; Lemlih Ouchchane [France] ; Isabelle Rieu [France] ; Beatrice Claise [France] ; Franck Durif [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
To study changes of iron content in basal ganglia in Parkinson’s disease (PD) through a three-year longitudinal follow-up of the effective transverse relaxation rate R2*, a validated MRI marker of brain iron content which can be rapidly measured under clinical conditions.
Twenty-seven PD patients and 26 controls were investigated by a first MRI (t0). Longitudinal analysis was conducted among the 18 controls and 14 PD patients who underwent a second MRI (t1) 3 years after. The imaging protocol consisted in 6 gradient echo images obtained at different echo-times for mapping R2*. Quantitative exploration of basal ganglia was performed by measuring the variation of R2* [R2*(t1) – R2*(t0)] in several regions of interest.
During the three-year evolution of PD, R2* increased in Substantia nigra (SN) (by 10.2% in pars compacta, p = 0.001, and 8.1% in pars reticulata, p = 0.013) and in the caudal putamen (11.4%, p = 0.011), without significant change in controls. Furthermore, we showed a positive correlation between the variation of R2* and the worsening of motor symptoms of PD (p = 0.028).
Significant variation of R2* was longitudinally observed in the SN and caudal putamen of patients with PD evolving over a three-year period, emphasizing its interest as a biomarker of disease progression. Our results suggest that R2* MRI follow-up could be an interesting tool for individual assessment of neurodegeneration due to PD, and also be useful for testing the efficiency of disease-modifying treatments.
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DOI: 10.1371/journal.pone.0057904
PubMed: 23469252
PubMed Central: 3585727
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A Longitudinal Follow-Up</title><author><name sortKey="Ulla, Miguel" sort="Ulla, Miguel" uniqKey="Ulla M" first="Miguel" last="Ulla">Miguel Ulla</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>CHU Clermont-Ferrand, Service de Neurologie A, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU Clermont-Ferrand, Service de Neurologie A, Clermont-Ferrand</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>University Clermont 1, EA3845, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Clermont 1, EA3845, Clermont-Ferrand</wicri:regionArea></affiliation></author><author><name sortKey="Bonny, Jean Marie" sort="Bonny, Jean Marie" uniqKey="Bonny J" first="Jean Marie" last="Bonny">Jean Marie Bonny</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>INRA, UR370 Qualité des Produits Animaux, Saint Genès Champanelle, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRA, UR370 Qualité des Produits Animaux, Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Ouchchane, Lemlih" sort="Ouchchane, Lemlih" uniqKey="Ouchchane L" first="Lemlih" last="Ouchchane">Lemlih Ouchchane</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>CHU Clermont-Ferrand, Pôle Santé Publique Médecine Légale Qualité Vigilances, Unité de Biostatistique Informatique Médicale et Technologies de Communication, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU Clermont-Ferrand, Pôle Santé Publique Médecine Légale Qualité Vigilances, Unité de Biostatistique Informatique Médicale et Technologies de Communication, Clermont-Ferrand</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>University Clermont1, Laboratoire de Biostatistique Informatique Médicale et Technologies de Communication, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Clermont1, Laboratoire de Biostatistique Informatique Médicale et Technologies de Communication, Clermont-Ferrand</wicri:regionArea></affiliation></author><author><name sortKey="Rieu, Isabelle" sort="Rieu, Isabelle" uniqKey="Rieu I" first="Isabelle" last="Rieu">Isabelle Rieu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>CHU Clermont-Ferrand, Service de Neurologie A, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU Clermont-Ferrand, Service de Neurologie A, Clermont-Ferrand</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>University Clermont 1, EA3845, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Clermont 1, EA3845, Clermont-Ferrand</wicri:regionArea></affiliation></author><author><name sortKey="Claise, Beatrice" sort="Claise, Beatrice" uniqKey="Claise B" first="Beatrice" last="Claise">Beatrice Claise</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>University Clermont 1, EA3845, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Clermont 1, EA3845, Clermont-Ferrand</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>CHU Clermont-Ferrand, Service de Radiologie B, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU Clermont-Ferrand, Service de Radiologie B, Clermont-Ferrand</wicri:regionArea></affiliation></author><author><name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>CHU Clermont-Ferrand, Service de Neurologie A, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU Clermont-Ferrand, Service de Neurologie A, Clermont-Ferrand</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>University Clermont 1, EA3845, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Clermont 1, EA3845, Clermont-Ferrand</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>To study changes of iron content in basal ganglia in Parkinson’s disease (PD) through a three-year longitudinal follow-up of the effective transverse relaxation rate R<sub>2</sub>*, a validated MRI marker of brain iron content which can be rapidly measured under clinical conditions.</p></sec><sec><title>Methods</title><p>Twenty-seven PD patients and 26 controls were investigated by a first MRI (t<sub>0</sub>). Longitudinal analysis was conducted among the 18 controls and 14 PD patients who underwent a second MRI (t<sub>1</sub>) 3 years after. The imaging protocol consisted in 6 gradient echo images obtained at different echo-times for mapping R<sub>2</sub>*. Quantitative exploration of basal ganglia was performed by measuring the variation of R<sub>2</sub>* [R<sub>2</sub>*(t<sub>1</sub>) – R<sub>2</sub>*(t<sub>0</sub>)] in several regions of interest.</p></sec><sec><title>Results</title><p>During the three-year evolution of PD, R<sub>2</sub>* increased in Substantia nigra (SN) (by 10.2% in pars compacta, p = 0.001, and 8.1% in pars reticulata, p = 0.013) and in the caudal putamen (11.4%, p = 0.011), without significant change in controls. Furthermore, we showed a positive correlation between the variation of R<sub>2</sub>* and the worsening of motor symptoms of PD (p = 0.028).</p></sec><sec><title>Conclusion</title><p>Significant variation of R<sub>2</sub>* was longitudinally observed in the SN and caudal putamen of patients with PD evolving over a three-year period, emphasizing its interest as a biomarker of disease progression. Our results suggest that R<sub>2</sub>* MRI follow-up could be an interesting tool for individual assessment of neurodegeneration due to PD, and also be useful for testing the efficiency of disease-modifying treatments.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dexter, Dt" uniqKey="Dexter D">DT Dexter</name></author><author><name sortKey="Carayon, A" uniqKey="Carayon A">A Carayon</name></author><author><name sortKey="Javoy Agid, F" uniqKey="Javoy Agid F">F Javoy-Agid</name></author><author><name sortKey="Agid, Y" uniqKey="Agid Y">Y Agid</name></author><author><name sortKey="Wells, Fr" uniqKey="Wells F">FR Wells</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bartzokis, G" uniqKey="Bartzokis G">G Bartzokis</name></author><author><name sortKey="Cummings, Jl" uniqKey="Cummings J">JL Cummings</name></author><author><name sortKey="Markham, Ch" uniqKey="Markham C">CH 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23469252</article-id><article-id pub-id-type="pmc">3585727</article-id><article-id pub-id-type="publisher-id">PONE-D-12-23939</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0057904</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject><subj-group><subject>Anatomy and Physiology</subject><subj-group><subject>Neurological System</subject><subj-group><subject>Ganglia</subject><subject>Neural Pathways</subject><subject>Neuroanatomy</subject></subj-group></subj-group></subj-group><subj-group><subject>Clinical Research Design</subject><subj-group><subject>Cohort Studies</subject><subject>Longitudinal Studies</subject></subj-group></subj-group><subj-group><subject>Epidemiology</subject><subj-group><subject>Biomarker Epidemiology</subject></subj-group></subj-group><subj-group><subject>Neurology</subject><subj-group><subject>Movement Disorders</subject><subject>Neuroimaging</subject><subject>Parkinson Disease</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Physics</subject><subj-group><subject>Medical Physics</subject></subj-group></subj-group></article-categories><title-group><article-title>Is R<sub>2</sub>* a New MRI Biomarker for the Progression of Parkinson’s Disease? A Longitudinal Follow-Up</article-title><alt-title alt-title-type="running-head">R<sub>2</sub>* for Parkinson’s Disease Follow-Up</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ulla</surname><given-names>Miguel</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bonny</surname><given-names>Jean Marie</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ouchchane</surname><given-names>Lemlih</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rieu</surname><given-names>Isabelle</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Claise</surname><given-names>Beatrice</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Durif</surname><given-names>Franck</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>CHU Clermont-Ferrand, Service de Neurologie A, Clermont-Ferrand, France</addr-line></aff><aff id="aff2"><label>2</label><addr-line>University Clermont 1, EA3845, Clermont-Ferrand, France</addr-line></aff><aff id="aff3"><label>3</label><addr-line>INRA, UR370 Qualité des Produits Animaux, Saint Genès Champanelle, France</addr-line></aff><aff id="aff4"><label>4</label><addr-line>CHU Clermont-Ferrand, Pôle Santé Publique Médecine Légale Qualité Vigilances, Unité de Biostatistique Informatique Médicale et Technologies de Communication, Clermont-Ferrand, France</addr-line></aff><aff id="aff5"><label>5</label><addr-line>University Clermont1, Laboratoire de Biostatistique Informatique Médicale et Technologies de Communication, Clermont-Ferrand, France</addr-line></aff><aff id="aff6"><label>6</label><addr-line>CHU Clermont-Ferrand, Service de Radiologie B, Clermont-Ferrand, France</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Duda</surname><given-names>John</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Philadelphia VA Medical Center, United States of America</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>mulla@chu-clermontferrand.fr</email></corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: MU JMB FD. Performed the experiments: MU IR BC. Analyzed the data: MU JMB LO. Contributed reagents/materials/analysis tools: MU JMB. Wrote the paper: MU JMB LO FD.</p></fn></author-notes><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>1</day><month>3</month><year>2013</year></pub-date><volume>8</volume><issue>3</issue><elocation-id>e57904</elocation-id><history><date date-type="received"><day>7</day><month>8</month><year>2012</year></date><date date-type="accepted"><day>29</day><month>1</month><year>2013</year></date></history><permissions><copyright-year>2013</copyright-year><copyright-holder>Ulla et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><sec><title>Purpose</title><p>To study changes of iron content in basal ganglia in Parkinson’s disease (PD) through a three-year longitudinal follow-up of the effective transverse relaxation rate R<sub>2</sub>*, a validated MRI marker of brain iron content which can be rapidly measured under clinical conditions.</p></sec><sec><title>Methods</title><p>Twenty-seven PD patients and 26 controls were investigated by a first MRI (t<sub>0</sub>). Longitudinal analysis was conducted among the 18 controls and 14 PD patients who underwent a second MRI (t<sub>1</sub>) 3 years after. The imaging protocol consisted in 6 gradient echo images obtained at different echo-times for mapping R<sub>2</sub>*. Quantitative exploration of basal ganglia was performed by measuring the variation of R<sub>2</sub>* [R<sub>2</sub>*(t<sub>1</sub>) – R<sub>2</sub>*(t<sub>0</sub>)] in several regions of interest.</p></sec><sec><title>Results</title><p>During the three-year evolution of PD, R<sub>2</sub>* increased in Substantia nigra (SN) (by 10.2% in pars compacta, p = 0.001, and 8.1% in pars reticulata, p = 0.013) and in the caudal putamen (11.4%, p = 0.011), without significant change in controls. Furthermore, we showed a positive correlation between the variation of R<sub>2</sub>* and the worsening of motor symptoms of PD (p = 0.028).</p></sec><sec><title>Conclusion</title><p>Significant variation of R<sub>2</sub>* was longitudinally observed in the SN and caudal putamen of patients with PD evolving over a three-year period, emphasizing its interest as a biomarker of disease progression. Our results suggest that R<sub>2</sub>* MRI follow-up could be an interesting tool for individual assessment of neurodegeneration due to PD, and also be useful for testing the efficiency of disease-modifying treatments.</p></sec></abstract><funding-group><funding-statement>The authors have no funding or support to report.</funding-statement></funding-group><counts><page-count count="8"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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