Is R2* a New MRI Biomarker for the Progression of Parkinson’s Disease? A Longitudinal Follow-Up
Identifieur interne : 000813 ( Pmc/Curation ); précédent : 000812; suivant : 000814Is R2* a New MRI Biomarker for the Progression of Parkinson’s Disease? A Longitudinal Follow-Up
Auteurs : Miguel Ulla [France] ; Jean Marie Bonny [France] ; Lemlih Ouchchane [France] ; Isabelle Rieu [France] ; Beatrice Claise [France] ; Franck Durif [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
To study changes of iron content in basal ganglia in Parkinson’s disease (PD) through a three-year longitudinal follow-up of the effective transverse relaxation rate R2*, a validated MRI marker of brain iron content which can be rapidly measured under clinical conditions.
Twenty-seven PD patients and 26 controls were investigated by a first MRI (t0). Longitudinal analysis was conducted among the 18 controls and 14 PD patients who underwent a second MRI (t1) 3 years after. The imaging protocol consisted in 6 gradient echo images obtained at different echo-times for mapping R2*. Quantitative exploration of basal ganglia was performed by measuring the variation of R2* [R2*(t1) – R2*(t0)] in several regions of interest.
During the three-year evolution of PD, R2* increased in Substantia nigra (SN) (by 10.2% in pars compacta, p = 0.001, and 8.1% in pars reticulata, p = 0.013) and in the caudal putamen (11.4%, p = 0.011), without significant change in controls. Furthermore, we showed a positive correlation between the variation of R2* and the worsening of motor symptoms of PD (p = 0.028).
Significant variation of R2* was longitudinally observed in the SN and caudal putamen of patients with PD evolving over a three-year period, emphasizing its interest as a biomarker of disease progression. Our results suggest that R2* MRI follow-up could be an interesting tool for individual assessment of neurodegeneration due to PD, and also be useful for testing the efficiency of disease-modifying treatments.
Url:
DOI: 10.1371/journal.pone.0057904
PubMed: 23469252
PubMed Central: 3585727
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* a New MRI Biomarker for the Progression of Parkinson’s Disease? A Longitudinal Follow-Up</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Purpose</title>
<p>To study changes of iron content in basal ganglia in Parkinson’s disease (PD) through a three-year longitudinal follow-up of the effective transverse relaxation rate R<sub>2</sub>
*, a validated MRI marker of brain iron content which can be rapidly measured under clinical conditions.</p>
</sec>
<sec><title>Methods</title>
<p>Twenty-seven PD patients and 26 controls were investigated by a first MRI (t<sub>0</sub>
). Longitudinal analysis was conducted among the 18 controls and 14 PD patients who underwent a second MRI (t<sub>1</sub>
) 3 years after. The imaging protocol consisted in 6 gradient echo images obtained at different echo-times for mapping R<sub>2</sub>
*. Quantitative exploration of basal ganglia was performed by measuring the variation of R<sub>2</sub>
* [R<sub>2</sub>
*(t<sub>1</sub>
) – R<sub>2</sub>
*(t<sub>0</sub>
)] in several regions of interest.</p>
</sec>
<sec><title>Results</title>
<p>During the three-year evolution of PD, R<sub>2</sub>
* increased in Substantia nigra (SN) (by 10.2% in pars compacta, p = 0.001, and 8.1% in pars reticulata, p = 0.013) and in the caudal putamen (11.4%, p = 0.011), without significant change in controls. Furthermore, we showed a positive correlation between the variation of R<sub>2</sub>
* and the worsening of motor symptoms of PD (p = 0.028).</p>
</sec>
<sec><title>Conclusion</title>
<p>Significant variation of R<sub>2</sub>
* was longitudinally observed in the SN and caudal putamen of patients with PD evolving over a three-year period, emphasizing its interest as a biomarker of disease progression. Our results suggest that R<sub>2</sub>
* MRI follow-up could be an interesting tool for individual assessment of neurodegeneration due to PD, and also be useful for testing the efficiency of disease-modifying treatments.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dexter, Dt" uniqKey="Dexter D">DT Dexter</name>
</author>
<author><name sortKey="Carayon, A" uniqKey="Carayon A">A Carayon</name>
</author>
<author><name sortKey="Javoy Agid, F" uniqKey="Javoy Agid F">F Javoy-Agid</name>
</author>
<author><name sortKey="Agid, Y" uniqKey="Agid Y">Y Agid</name>
</author>
<author><name sortKey="Wells, Fr" uniqKey="Wells F">FR Wells</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartzokis, G" uniqKey="Bartzokis G">G Bartzokis</name>
</author>
<author><name sortKey="Cummings, Jl" uniqKey="Cummings J">JL Cummings</name>
</author>
<author><name sortKey="Markham, Ch" uniqKey="Markham C">CH Markham</name>
</author>
<author><name sortKey="Marmarelis, Pz" uniqKey="Marmarelis P">PZ Marmarelis</name>
</author>
<author><name sortKey="Treciokas, Lj" uniqKey="Treciokas L">LJ Treciokas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baudrexel, S" uniqKey="Baudrexel S">S Baudrexel</name>
</author>
<author><name sortKey="Nurnberger, L" uniqKey="Nurnberger L">L Nurnberger</name>
</author>
<author><name sortKey="Rub, U" uniqKey="Rub U">U Rub</name>
</author>
<author><name sortKey="Seifried, C" uniqKey="Seifried C">C Seifried</name>
</author>
<author><name sortKey="Klein, Jc" uniqKey="Klein J">JC Klein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gorell, Jm" uniqKey="Gorell J">JM Gorell</name>
</author>
<author><name sortKey="Ordidge, Rj" uniqKey="Ordidge R">RJ Ordidge</name>
</author>
<author><name sortKey="Brown, Gg" uniqKey="Brown G">GG Brown</name>
</author>
<author><name sortKey="Deniau, Jc" uniqKey="Deniau J">JC Deniau</name>
</author>
<author><name sortKey="Buderer, Nm" uniqKey="Buderer N">NM Buderer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martin, Wr" uniqKey="Martin W">WR Martin</name>
</author>
<author><name sortKey="Wieler, M" uniqKey="Wieler M">M Wieler</name>
</author>
<author><name sortKey="Gee, M" uniqKey="Gee M">M Gee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Michaeli, S" uniqKey="Michaeli S">S Michaeli</name>
</author>
<author><name sortKey="Oz, G" uniqKey="Oz G">G Oz</name>
</author>
<author><name sortKey="Sorce, Dj" uniqKey="Sorce D">DJ Sorce</name>
</author>
<author><name sortKey="Garwood, M" uniqKey="Garwood M">M Garwood</name>
</author>
<author><name sortKey="Ugurbil, K" uniqKey="Ugurbil K">K Ugurbil</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peran, P" uniqKey="Peran P">P Peran</name>
</author>
<author><name sortKey="Cherubini, A" uniqKey="Cherubini A">A Cherubini</name>
</author>
<author><name sortKey="Assogna, F" uniqKey="Assogna F">F Assogna</name>
</author>
<author><name sortKey="Piras, F" uniqKey="Piras F">F Piras</name>
</author>
<author><name sortKey="Quattrocchi, C" uniqKey="Quattrocchi C">C Quattrocchi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Behnke, S" uniqKey="Behnke S">S Behnke</name>
</author>
<author><name sortKey="Schroeder, U" uniqKey="Schroeder U">U Schroeder</name>
</author>
<author><name sortKey="Dillmann, U" uniqKey="Dillmann U">U Dillmann</name>
</author>
<author><name sortKey="Buchholz, Hg" uniqKey="Buchholz H">HG Buchholz</name>
</author>
<author><name sortKey="Schreckenberger, M" uniqKey="Schreckenberger M">M Schreckenberger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Graham, Jm" uniqKey="Graham J">JM Graham</name>
</author>
<author><name sortKey="Paley, Mn" uniqKey="Paley M">MN Paley</name>
</author>
<author><name sortKey="Grunewald, Ra" uniqKey="Grunewald R">RA Grunewald</name>
</author>
<author><name sortKey="Hoggard, N" uniqKey="Hoggard N">N Hoggard</name>
</author>
<author><name sortKey="Griffiths, Pd" uniqKey="Griffiths P">PD Griffiths</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ryvlin, P" uniqKey="Ryvlin P">P Ryvlin</name>
</author>
<author><name sortKey="Broussolle, E" uniqKey="Broussolle E">E Broussolle</name>
</author>
<author><name sortKey="Piollet, H" uniqKey="Piollet H">H Piollet</name>
</author>
<author><name sortKey="Viallet, F" uniqKey="Viallet F">F Viallet</name>
</author>
<author><name sortKey="Khalfallah, Y" uniqKey="Khalfallah Y">Y Khalfallah</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wallis, Li" uniqKey="Wallis L">LI Wallis</name>
</author>
<author><name sortKey="Paley, Mn" uniqKey="Paley M">MN Paley</name>
</author>
<author><name sortKey="Graham, Jm" uniqKey="Graham J">JM Graham</name>
</author>
<author><name sortKey="Grunewald, Ra" uniqKey="Grunewald R">RA Grunewald</name>
</author>
<author><name sortKey="Wignall, El" uniqKey="Wignall E">EL Wignall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kosta, P" uniqKey="Kosta P">P Kosta</name>
</author>
<author><name sortKey="Argyropoulou, Mi" uniqKey="Argyropoulou M">MI Argyropoulou</name>
</author>
<author><name sortKey="Markoula, S" uniqKey="Markoula S">S Markoula</name>
</author>
<author><name sortKey="Konitsiotis, S" uniqKey="Konitsiotis S">S Konitsiotis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartzokis, G" uniqKey="Bartzokis G">G Bartzokis</name>
</author>
<author><name sortKey="Tishler, Ta" uniqKey="Tishler T">TA Tishler</name>
</author>
<author><name sortKey="Lu, Ph" uniqKey="Lu P">PH Lu</name>
</author>
<author><name sortKey="Villablanca, P" uniqKey="Villablanca P">P Villablanca</name>
</author>
<author><name sortKey="Altshuler, Ll" uniqKey="Altshuler L">LL Altshuler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hallgren, B" uniqKey="Hallgren B">B Hallgren</name>
</author>
<author><name sortKey="Sourander, P" uniqKey="Sourander P">P Sourander</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martin, Wr" uniqKey="Martin W">WR Martin</name>
</author>
<author><name sortKey="Roberts, Te" uniqKey="Roberts T">TE Roberts</name>
</author>
<author><name sortKey="Ye, Fq" uniqKey="Ye F">FQ Ye</name>
</author>
<author><name sortKey="Allen, Ps" uniqKey="Allen P">PS Allen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name>
</author>
<author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
<author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Siemonsen, S" uniqKey="Siemonsen S">S Siemonsen</name>
</author>
<author><name sortKey="Finsterbusch, J" uniqKey="Finsterbusch J">J Finsterbusch</name>
</author>
<author><name sortKey="Matschke, J" uniqKey="Matschke J">J Matschke</name>
</author>
<author><name sortKey="Lorenzen, A" uniqKey="Lorenzen A">A Lorenzen</name>
</author>
<author><name sortKey="Ding, Xq" uniqKey="Ding X">XQ Ding</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yablonskiy, Da" uniqKey="Yablonskiy D">DA Yablonskiy</name>
</author>
<author><name sortKey="Haacke, Em" uniqKey="Haacke E">EM Haacke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ma, J" uniqKey="Ma J">J Ma</name>
</author>
<author><name sortKey="Wehrli, Fw" uniqKey="Wehrli F">FW Wehrli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gelman, N" uniqKey="Gelman N">N Gelman</name>
</author>
<author><name sortKey="Gorell, Jm" uniqKey="Gorell J">JM Gorell</name>
</author>
<author><name sortKey="Barker, Pb" uniqKey="Barker P">PB Barker</name>
</author>
<author><name sortKey="Savage, Rm" uniqKey="Savage R">RM Savage</name>
</author>
<author><name sortKey="Spickler, Em" uniqKey="Spickler E">EM Spickler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gibb, Wr" uniqKey="Gibb W">WR Gibb</name>
</author>
<author><name sortKey="Lees, Aj" uniqKey="Lees A">AJ Lees</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thobois, S" uniqKey="Thobois S">S Thobois</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Eapen, M" uniqKey="Eapen M">M Eapen</name>
</author>
<author><name sortKey="Zald, Dh" uniqKey="Zald D">DH Zald</name>
</author>
<author><name sortKey="Gatenby, Jc" uniqKey="Gatenby J">JC Gatenby</name>
</author>
<author><name sortKey="Ding, Z" uniqKey="Ding Z">Z Ding</name>
</author>
<author><name sortKey="Gore, Jc" uniqKey="Gore J">JC Gore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Du, G" uniqKey="Du G">G Du</name>
</author>
<author><name sortKey="Lewis, Mm" uniqKey="Lewis M">MM Lewis</name>
</author>
<author><name sortKey="Styner, M" uniqKey="Styner M">M Styner</name>
</author>
<author><name sortKey="Shaffer, Ml" uniqKey="Shaffer M">ML Shaffer</name>
</author>
<author><name sortKey="Sen, S" uniqKey="Sen S">S Sen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Evans, Jr" uniqKey="Evans J">JR Evans</name>
</author>
<author><name sortKey="Mason, Sl" uniqKey="Mason S">SL Mason</name>
</author>
<author><name sortKey="Williams Gray, Ch" uniqKey="Williams Gray C">CH Williams-Gray</name>
</author>
<author><name sortKey="Foltynie, T" uniqKey="Foltynie T">T Foltynie</name>
</author>
<author><name sortKey="Brayne, C" uniqKey="Brayne C">C Brayne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jankovic, J" uniqKey="Jankovic J">J Jankovic</name>
</author>
<author><name sortKey="Kapadia, As" uniqKey="Kapadia A">AS Kapadia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartzokis, G" uniqKey="Bartzokis G">G Bartzokis</name>
</author>
<author><name sortKey="Beckson, M" uniqKey="Beckson M">M Beckson</name>
</author>
<author><name sortKey="Hance, Db" uniqKey="Hance D">DB Hance</name>
</author>
<author><name sortKey="Marx, P" uniqKey="Marx P">P Marx</name>
</author>
<author><name sortKey="Foster, Ja" uniqKey="Foster J">JA Foster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Agid, Y" uniqKey="Agid Y">Y Agid</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Kortekaas, R" uniqKey="Kortekaas R">R Kortekaas</name>
</author>
<author><name sortKey="Leenders, Kl" uniqKey="Leenders K">KL Leenders</name>
</author>
<author><name sortKey="Van Oostrom, Jc" uniqKey="Van Oostrom J">JC van Oostrom</name>
</author>
<author><name sortKey="Vaalburg, W" uniqKey="Vaalburg W">W Vaalburg</name>
</author>
<author><name sortKey="Bart, J" uniqKey="Bart J">J Bart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salazar, J" uniqKey="Salazar J">J Salazar</name>
</author>
<author><name sortKey="Mena, N" uniqKey="Mena N">N Mena</name>
</author>
<author><name sortKey="Hunot, S" uniqKey="Hunot S">S Hunot</name>
</author>
<author><name sortKey="Prigent, A" uniqKey="Prigent A">A Prigent</name>
</author>
<author><name sortKey="Alvarez Fischer, D" uniqKey="Alvarez Fischer D">D Alvarez-Fischer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Connor, Jr" uniqKey="Connor J">JR Connor</name>
</author>
<author><name sortKey="Boeshore, Kl" uniqKey="Boeshore K">KL Boeshore</name>
</author>
<author><name sortKey="Benkovic, Sa" uniqKey="Benkovic S">SA Benkovic</name>
</author>
<author><name sortKey="Menzies, Sl" uniqKey="Menzies S">SL Menzies</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hirsch, Ec" uniqKey="Hirsch E">EC Hirsch</name>
</author>
<author><name sortKey="Hunot, S" uniqKey="Hunot S">S Hunot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zecca, L" uniqKey="Zecca L">L Zecca</name>
</author>
<author><name sortKey="Youdim, Mb" uniqKey="Youdim M">MB Youdim</name>
</author>
<author><name sortKey="Riederer, P" uniqKey="Riederer P">P Riederer</name>
</author>
<author><name sortKey="Connor, Jr" uniqKey="Connor J">JR Connor</name>
</author>
<author><name sortKey="Crichton, Rr" uniqKey="Crichton R">RR Crichton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name>
</author>
<author><name sortKey="Thong, Ps" uniqKey="Thong P">PS Thong</name>
</author>
<author><name sortKey="Lee, T" uniqKey="Lee T">T Lee</name>
</author>
<author><name sortKey="Leong, Sk" uniqKey="Leong S">SK Leong</name>
</author>
<author><name sortKey="Mao, By" uniqKey="Mao B">BY Mao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mitsumori, F" uniqKey="Mitsumori F">F Mitsumori</name>
</author>
<author><name sortKey="Watanabe, H" uniqKey="Watanabe H">H Watanabe</name>
</author>
<author><name sortKey="Takaya, N" uniqKey="Takaya N">N Takaya</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Punwani, S" uniqKey="Punwani S">S Punwani</name>
</author>
<author><name sortKey="Cooper, Ce" uniqKey="Cooper C">CE Cooper</name>
</author>
<author><name sortKey="Clemence, M" uniqKey="Clemence M">M Clemence</name>
</author>
<author><name sortKey="Penrice, J" uniqKey="Penrice J">J Penrice</name>
</author>
<author><name sortKey="Amess, P" uniqKey="Amess P">P Amess</name>
</author>
</analytic>
</biblStruct>
</listBibl>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23469252</article-id>
<article-id pub-id-type="pmc">3585727</article-id>
<article-id pub-id-type="publisher-id">PONE-D-12-23939</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0057904</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject>
<subj-group><subject>Anatomy and Physiology</subject>
<subj-group><subject>Neurological System</subject>
<subj-group><subject>Ganglia</subject>
<subject>Neural Pathways</subject>
<subject>Neuroanatomy</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group><subject>Clinical Research Design</subject>
<subj-group><subject>Cohort Studies</subject>
<subject>Longitudinal Studies</subject>
</subj-group>
</subj-group>
<subj-group><subject>Epidemiology</subject>
<subj-group><subject>Biomarker Epidemiology</subject>
</subj-group>
</subj-group>
<subj-group><subject>Neurology</subject>
<subj-group><subject>Movement Disorders</subject>
<subject>Neuroimaging</subject>
<subject>Parkinson Disease</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Physics</subject>
<subj-group><subject>Medical Physics</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Is R<sub>2</sub>
* a New MRI Biomarker for the Progression of Parkinson’s Disease? A Longitudinal Follow-Up</article-title>
<alt-title alt-title-type="running-head">R<sub>2</sub>
* for Parkinson’s Disease Follow-Up</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Ulla</surname>
<given-names>Miguel</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>*</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bonny</surname>
<given-names>Jean Marie</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ouchchane</surname>
<given-names>Lemlih</given-names>
</name>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rieu</surname>
<given-names>Isabelle</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Claise</surname>
<given-names>Beatrice</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Durif</surname>
<given-names>Franck</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<addr-line>CHU Clermont-Ferrand, Service de Neurologie A, Clermont-Ferrand, France</addr-line>
</aff>
<aff id="aff2"><label>2</label>
<addr-line>University Clermont 1, EA3845, Clermont-Ferrand, France</addr-line>
</aff>
<aff id="aff3"><label>3</label>
<addr-line>INRA, UR370 Qualité des Produits Animaux, Saint Genès Champanelle, France</addr-line>
</aff>
<aff id="aff4"><label>4</label>
<addr-line>CHU Clermont-Ferrand, Pôle Santé Publique Médecine Légale Qualité Vigilances, Unité de Biostatistique Informatique Médicale et Technologies de Communication, Clermont-Ferrand, France</addr-line>
</aff>
<aff id="aff5"><label>5</label>
<addr-line>University Clermont1, Laboratoire de Biostatistique Informatique Médicale et Technologies de Communication, Clermont-Ferrand, France</addr-line>
</aff>
<aff id="aff6"><label>6</label>
<addr-line>CHU Clermont-Ferrand, Service de Radiologie B, Clermont-Ferrand, France</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Duda</surname>
<given-names>John</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>Philadelphia VA Medical Center, United States of America</addr-line>
</aff>
<author-notes><corresp id="cor1">* E-mail: <email>mulla@chu-clermontferrand.fr</email>
</corresp>
<fn fn-type="conflict"><p><bold>Competing Interests: </bold>
The authors have declared that no competing interests exist.</p>
</fn>
<fn fn-type="con"><p>Conceived and designed the experiments: MU JMB FD. Performed the experiments: MU IR BC. Analyzed the data: MU JMB LO. Contributed reagents/materials/analysis tools: MU JMB. Wrote the paper: MU JMB LO FD.</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>1</day>
<month>3</month>
<year>2013</year>
</pub-date>
<volume>8</volume>
<issue>3</issue>
<elocation-id>e57904</elocation-id>
<history><date date-type="received"><day>7</day>
<month>8</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>29</day>
<month>1</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-year>2013</copyright-year>
<copyright-holder>Ulla et al</copyright-holder>
<license><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
</license>
</permissions>
<abstract><sec><title>Purpose</title>
<p>To study changes of iron content in basal ganglia in Parkinson’s disease (PD) through a three-year longitudinal follow-up of the effective transverse relaxation rate R<sub>2</sub>
*, a validated MRI marker of brain iron content which can be rapidly measured under clinical conditions.</p>
</sec>
<sec><title>Methods</title>
<p>Twenty-seven PD patients and 26 controls were investigated by a first MRI (t<sub>0</sub>
). Longitudinal analysis was conducted among the 18 controls and 14 PD patients who underwent a second MRI (t<sub>1</sub>
) 3 years after. The imaging protocol consisted in 6 gradient echo images obtained at different echo-times for mapping R<sub>2</sub>
*. Quantitative exploration of basal ganglia was performed by measuring the variation of R<sub>2</sub>
* [R<sub>2</sub>
*(t<sub>1</sub>
) – R<sub>2</sub>
*(t<sub>0</sub>
)] in several regions of interest.</p>
</sec>
<sec><title>Results</title>
<p>During the three-year evolution of PD, R<sub>2</sub>
* increased in Substantia nigra (SN) (by 10.2% in pars compacta, p = 0.001, and 8.1% in pars reticulata, p = 0.013) and in the caudal putamen (11.4%, p = 0.011), without significant change in controls. Furthermore, we showed a positive correlation between the variation of R<sub>2</sub>
* and the worsening of motor symptoms of PD (p = 0.028).</p>
</sec>
<sec><title>Conclusion</title>
<p>Significant variation of R<sub>2</sub>
* was longitudinally observed in the SN and caudal putamen of patients with PD evolving over a three-year period, emphasizing its interest as a biomarker of disease progression. Our results suggest that R<sub>2</sub>
* MRI follow-up could be an interesting tool for individual assessment of neurodegeneration due to PD, and also be useful for testing the efficiency of disease-modifying treatments.</p>
</sec>
</abstract>
<funding-group><funding-statement>The authors have no funding or support to report.</funding-statement>
</funding-group>
<counts><page-count count="8"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
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