Thalamocortical diaschisis: positron emission tomography in humans.
Identifieur interne : 000974 ( Pmc/Checkpoint ); précédent : 000973; suivant : 000975Thalamocortical diaschisis: positron emission tomography in humans.
Auteurs : J C Baron ; M. Levasseur ; B. Mazoyer ; F. Legault-Demare ; F. Mauguière ; S. Pappata ; P. Jedynak ; P. Derome ; J. Cambier ; S. Tran-DinhSource :
- Journal of Neurology, Neurosurgery, and Psychiatry [ 0022-3050 ] ; 1992.
Abstract
To investigate further the relations between cortical energy metabolism and neuropsychological impairment after unilateral thalamic lesion, 55 patients underwent positron emission tomography studies of either cortical oxygen consumption or glucose utilisation, including eight repeat studies, at times ranging from 4 days to 98 months after the onset of the lesion [stroke (n = 44) or stereotaxic VL-Vim thalamotomy performed for movement disorders (n = 11)]. Patients with thalamotomy were also studied preoperatively and the surgery induced a significant fall in cortical metabolism on both sides (more so ipsilaterally); post-operatively the magnitude of the ipsilateral cortex hypometabolism was positively correlated to the severity of global neuropsychological impairment; similar but less significant findings were obtained for the ipsilateral/contralateral cortical metabolic asymmetry. With respect to the whole patient sample, the cortical metabolic asymmetry was initially pronounced, with subsequent monoexponential recovery, in the cognitively impaired study group, but it was only mild and showed no meaningful trend for recovery in the cognitively unaffected study group; yet even soon (< 3 months) after thalamic lesion there was a noticeable overlap of individual asymmetry values among the two study groups. These results lend further support to the view that the neuropsychological impairment that frequently follows unilateral thalamic lesions is reflected in a depression of synaptic activity in both the overlying and the contralateral cerebral cortices. For individual patients, this study also illustrates the potentially misleading nature of the measured cortical metabolic asymmetry with respect to neuropsychological status, especially at late times after lesion, in part because side to side metabolic ratios do not reflect bilateral changes.
Url:
PubMed: 1431957
PubMed Central: 1015196
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:1015196Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Thalamocortical diaschisis: positron emission tomography in humans.</title>
<author><name sortKey="Baron, J C" sort="Baron, J C" uniqKey="Baron J" first="J C" last="Baron">J C Baron</name>
</author>
<author><name sortKey="Levasseur, M" sort="Levasseur, M" uniqKey="Levasseur M" first="M" last="Levasseur">M. Levasseur</name>
</author>
<author><name sortKey="Mazoyer, B" sort="Mazoyer, B" uniqKey="Mazoyer B" first="B" last="Mazoyer">B. Mazoyer</name>
</author>
<author><name sortKey="Legault Demare, F" sort="Legault Demare, F" uniqKey="Legault Demare F" first="F" last="Legault-Demare">F. Legault-Demare</name>
</author>
<author><name sortKey="Mauguiere, F" sort="Mauguiere, F" uniqKey="Mauguiere F" first="F" last="Mauguière">F. Mauguière</name>
</author>
<author><name sortKey="Pappata, S" sort="Pappata, S" uniqKey="Pappata S" first="S" last="Pappata">S. Pappata</name>
</author>
<author><name sortKey="Jedynak, P" sort="Jedynak, P" uniqKey="Jedynak P" first="P" last="Jedynak">P. Jedynak</name>
</author>
<author><name sortKey="Derome, P" sort="Derome, P" uniqKey="Derome P" first="P" last="Derome">P. Derome</name>
</author>
<author><name sortKey="Cambier, J" sort="Cambier, J" uniqKey="Cambier J" first="J" last="Cambier">J. Cambier</name>
</author>
<author><name sortKey="Tran Dinh, S" sort="Tran Dinh, S" uniqKey="Tran Dinh S" first="S" last="Tran-Dinh">S. Tran-Dinh</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">1431957</idno>
<idno type="pmc">1015196</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1015196</idno>
<idno type="RBID">PMC:1015196</idno>
<date when="1992">1992</date>
<idno type="wicri:Area/Pmc/Corpus">000275</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000275</idno>
<idno type="wicri:Area/Pmc/Curation">000273</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000273</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000974</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000974</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Thalamocortical diaschisis: positron emission tomography in humans.</title>
<author><name sortKey="Baron, J C" sort="Baron, J C" uniqKey="Baron J" first="J C" last="Baron">J C Baron</name>
</author>
<author><name sortKey="Levasseur, M" sort="Levasseur, M" uniqKey="Levasseur M" first="M" last="Levasseur">M. Levasseur</name>
</author>
<author><name sortKey="Mazoyer, B" sort="Mazoyer, B" uniqKey="Mazoyer B" first="B" last="Mazoyer">B. Mazoyer</name>
</author>
<author><name sortKey="Legault Demare, F" sort="Legault Demare, F" uniqKey="Legault Demare F" first="F" last="Legault-Demare">F. Legault-Demare</name>
</author>
<author><name sortKey="Mauguiere, F" sort="Mauguiere, F" uniqKey="Mauguiere F" first="F" last="Mauguière">F. Mauguière</name>
</author>
<author><name sortKey="Pappata, S" sort="Pappata, S" uniqKey="Pappata S" first="S" last="Pappata">S. Pappata</name>
</author>
<author><name sortKey="Jedynak, P" sort="Jedynak, P" uniqKey="Jedynak P" first="P" last="Jedynak">P. Jedynak</name>
</author>
<author><name sortKey="Derome, P" sort="Derome, P" uniqKey="Derome P" first="P" last="Derome">P. Derome</name>
</author>
<author><name sortKey="Cambier, J" sort="Cambier, J" uniqKey="Cambier J" first="J" last="Cambier">J. Cambier</name>
</author>
<author><name sortKey="Tran Dinh, S" sort="Tran Dinh, S" uniqKey="Tran Dinh S" first="S" last="Tran-Dinh">S. Tran-Dinh</name>
</author>
</analytic>
<series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title>
<idno type="ISSN">0022-3050</idno>
<idno type="eISSN">1468-330X</idno>
<imprint><date when="1992">1992</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>To investigate further the relations between cortical energy metabolism and neuropsychological impairment after unilateral thalamic lesion, 55 patients underwent positron emission tomography studies of either cortical oxygen consumption or glucose utilisation, including eight repeat studies, at times ranging from 4 days to 98 months after the onset of the lesion [stroke (n = 44) or stereotaxic VL-Vim thalamotomy performed for movement disorders (n = 11)]. Patients with thalamotomy were also studied preoperatively and the surgery induced a significant fall in cortical metabolism on both sides (more so ipsilaterally); post-operatively the magnitude of the ipsilateral cortex hypometabolism was positively correlated to the severity of global neuropsychological impairment; similar but less significant findings were obtained for the ipsilateral/contralateral cortical metabolic asymmetry. With respect to the whole patient sample, the cortical metabolic asymmetry was initially pronounced, with subsequent monoexponential recovery, in the cognitively impaired study group, but it was only mild and showed no meaningful trend for recovery in the cognitively unaffected study group; yet even soon (< 3 months) after thalamic lesion there was a noticeable overlap of individual asymmetry values among the two study groups. These results lend further support to the view that the neuropsychological impairment that frequently follows unilateral thalamic lesions is reflected in a depression of synaptic activity in both the overlying and the contralateral cerebral cortices. For individual patients, this study also illustrates the potentially misleading nature of the measured cortical metabolic asymmetry with respect to neuropsychological status, especially at late times after lesion, in part because side to side metabolic ratios do not reflect bilateral changes.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id>
<journal-title>Journal of Neurology, Neurosurgery, and Psychiatry</journal-title>
<issn pub-type="ppub">0022-3050</issn>
<issn pub-type="epub">1468-330X</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">1431957</article-id>
<article-id pub-id-type="pmc">1015196</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Thalamocortical diaschisis: positron emission tomography in humans.</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Baron</surname>
<given-names>J C</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Levasseur</surname>
<given-names>M</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Mazoyer</surname>
<given-names>B</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Legault-Demare</surname>
<given-names>F</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Mauguière</surname>
<given-names>F</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Pappata</surname>
<given-names>S</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Jedynak</surname>
<given-names>P</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Derome</surname>
<given-names>P</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Cambier</surname>
<given-names>J</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Tran-Dinh</surname>
<given-names>S</given-names>
</name>
</contrib>
<etal></etal>
</contrib-group>
<aff>INSERM U 320, Caen, France.</aff>
<pub-date pub-type="ppub"><month>10</month>
<year>1992</year>
</pub-date>
<volume>55</volume>
<issue>10</issue>
<fpage>935</fpage>
<lpage>942</lpage>
<abstract><p>To investigate further the relations between cortical energy metabolism and neuropsychological impairment after unilateral thalamic lesion, 55 patients underwent positron emission tomography studies of either cortical oxygen consumption or glucose utilisation, including eight repeat studies, at times ranging from 4 days to 98 months after the onset of the lesion [stroke (n = 44) or stereotaxic VL-Vim thalamotomy performed for movement disorders (n = 11)]. Patients with thalamotomy were also studied preoperatively and the surgery induced a significant fall in cortical metabolism on both sides (more so ipsilaterally); post-operatively the magnitude of the ipsilateral cortex hypometabolism was positively correlated to the severity of global neuropsychological impairment; similar but less significant findings were obtained for the ipsilateral/contralateral cortical metabolic asymmetry. With respect to the whole patient sample, the cortical metabolic asymmetry was initially pronounced, with subsequent monoexponential recovery, in the cognitively impaired study group, but it was only mild and showed no meaningful trend for recovery in the cognitively unaffected study group; yet even soon (< 3 months) after thalamic lesion there was a noticeable overlap of individual asymmetry values among the two study groups. These results lend further support to the view that the neuropsychological impairment that frequently follows unilateral thalamic lesions is reflected in a depression of synaptic activity in both the overlying and the contralateral cerebral cortices. For individual patients, this study also illustrates the potentially misleading nature of the measured cortical metabolic asymmetry with respect to neuropsychological status, especially at late times after lesion, in part because side to side metabolic ratios do not reflect bilateral changes.</p>
</abstract>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Baron, J C" sort="Baron, J C" uniqKey="Baron J" first="J C" last="Baron">J C Baron</name>
<name sortKey="Cambier, J" sort="Cambier, J" uniqKey="Cambier J" first="J" last="Cambier">J. Cambier</name>
<name sortKey="Derome, P" sort="Derome, P" uniqKey="Derome P" first="P" last="Derome">P. Derome</name>
<name sortKey="Jedynak, P" sort="Jedynak, P" uniqKey="Jedynak P" first="P" last="Jedynak">P. Jedynak</name>
<name sortKey="Legault Demare, F" sort="Legault Demare, F" uniqKey="Legault Demare F" first="F" last="Legault-Demare">F. Legault-Demare</name>
<name sortKey="Levasseur, M" sort="Levasseur, M" uniqKey="Levasseur M" first="M" last="Levasseur">M. Levasseur</name>
<name sortKey="Mauguiere, F" sort="Mauguiere, F" uniqKey="Mauguiere F" first="F" last="Mauguière">F. Mauguière</name>
<name sortKey="Mazoyer, B" sort="Mazoyer, B" uniqKey="Mazoyer B" first="B" last="Mazoyer">B. Mazoyer</name>
<name sortKey="Pappata, S" sort="Pappata, S" uniqKey="Pappata S" first="S" last="Pappata">S. Pappata</name>
<name sortKey="Tran Dinh, S" sort="Tran Dinh, S" uniqKey="Tran Dinh S" first="S" last="Tran-Dinh">S. Tran-Dinh</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000974 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000974 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Pmc |étape= Checkpoint |type= RBID |clé= PMC:1015196 |texte= Thalamocortical diaschisis: positron emission tomography in humans. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:1431957" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |