Apomorphine in treatment of Parkinson's disease: comparison between subcutaneous and sublingual routes.
Identifieur interne : 000973 ( Pmc/Checkpoint ); précédent : 000972; suivant : 000974Apomorphine in treatment of Parkinson's disease: comparison between subcutaneous and sublingual routes.
Auteurs : D. Deffond ; F. Durif ; M. TournilhacSource :
- Journal of Neurology, Neurosurgery, and Psychiatry [ 0022-3050 ] ; 1993.
Abstract
The efficacy of two routes of apomorphine, subcutaneous (SC) and sublingual (SL), successively administered in 7 Parkinsonian patients with motor fluctuations, was compared in reducing the daily duration of "off" phases. The mean duration of SC and SL treatment was 7.7 and 6.8 months respectively. The mean time spent in "off" phase was 55% after SC and 68% after SL treatment. The mean time before turning "on" after an "off" period was 14 minutes after SC and 28 minutes after SL treatment. Two patients developed stomatitis after SL route. SL apomorphine may be helpful in the treatment of motor fluctuations in PD.
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PubMed: 8429309
PubMed Central: 1014775
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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id><journal-title>Journal of Neurology, Neurosurgery, and Psychiatry</journal-title><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">8429309</article-id><article-id pub-id-type="pmc">1014775</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Apomorphine in treatment of Parkinson's disease: comparison between subcutaneous and sublingual routes.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Deffond</surname><given-names>D</given-names></name></contrib><contrib contrib-type="author"><name><surname>Durif</surname><given-names>F</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tournilhac</surname><given-names>M</given-names></name></contrib></contrib-group><aff>Clinique Neurologique, Hôpital Fontmaure, Chamalieres, France.</aff><pub-date pub-type="ppub"><month>1</month><year>1993</year></pub-date><volume>56</volume><issue>1</issue><fpage>101</fpage><lpage>103</lpage><abstract><p>The efficacy of two routes of apomorphine, subcutaneous (SC) and sublingual (SL), successively administered in 7 Parkinsonian patients with motor fluctuations, was compared in reducing the daily duration of "off" phases. The mean duration of SC and SL treatment was 7.7 and 6.8 months respectively. The mean time spent in "off" phase was 55% after SC and 68% after SL treatment. The mean time before turning "on" after an "off" period was 14 minutes after SC and 28 minutes after SL treatment. Two patients developed stomatitis after SL route. SL apomorphine may be helpful in the treatment of motor fluctuations in PD.</p></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Deffond, D" sort="Deffond, D" uniqKey="Deffond D" first="D" last="Deffond">D. Deffond</name><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F" last="Durif">F. Durif</name><name sortKey="Tournilhac, M" sort="Tournilhac, M" uniqKey="Tournilhac M" first="M" last="Tournilhac">M. Tournilhac</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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