Mitochondria and the autophagy-inflammation-cell death axis in organismal aging
Identifieur interne : 000675 ( Pmc/Checkpoint ); précédent : 000674; suivant : 000676Mitochondria and the autophagy-inflammation-cell death axis in organismal aging
Auteurs : Douglas R. Green [États-Unis] ; Lorenzo Galluzzi [France] ; Guido Kroemer [France]Source :
- Science (New York, N.y.) [ 0036-8075 ] ; 2011.
Abstract
Alterations of mitochondrial functions are linked to multiple degenerative or acute diseases. As mitochondria age in our cells, they become progressively inefficient and potentially toxic, and acute damage can trigger the permeabilization of mitochondrial membranes to initiate apoptosis or necrosis. Moreover, mitochondria have an important role in pro-inflammatory signaling. Autophagic turnover of cellular constituents, be it general or specific for mitochondria (mitophagy), eliminates dysfunctional or damaged mitochondria, thus counteracting degeneration, dampening inflammation, and preventing unwarranted cell loss. Decreased expression of genes that regulate autophagy or mitophagy can cause degenerative diseases in which deficient quality control results in inflammation and the death of cell populations. Thus, a combination of mitochondrial dysfunction and insufficient autophagy may contribute to multiple aging-associated pathologies.
Url:
DOI: 10.1126/science.1201940
PubMed: 21868666
PubMed Central: 3405151
Affiliations:
- France, États-Unis
- Tennessee, Île-de-France
- Paris, Villejuif
- Université Paris-Descartes, Université Paris-Sud
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:3405151Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mitochondria and the autophagy-inflammation-cell death axis in organismal aging</title>
<author><name sortKey="Green, Douglas R" sort="Green, Douglas R" uniqKey="Green D" first="Douglas R." last="Green">Douglas R. Green</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Immunology, St Jude Children’s Research Hospital, Memphis, TN 38105, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Immunology, St Jude Children’s Research Hospital, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name>
<affiliation wicri:level="3"><nlm:aff id="A2">INSERM, U848, F-94805 Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U848, F-94805 Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">Institut Gustave Roussy, F94805 Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Gustave Roussy, F94805 Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A4">Université Paris-Sud, Paris 11, F-94805 Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Paris-Sud, Paris 11, F-94805 Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
<orgName type="university">Université Paris-Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<affiliation wicri:level="3"><nlm:aff id="A2">INSERM, U848, F-94805 Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U848, F-94805 Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A5">Metabolomics Platform, Institut Gustave Roussy, F-94805 Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Metabolomics Platform, Institut Gustave Roussy, F-94805 Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A6">Centre de Recherche des Cordeliers, F-75005 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Recherche des Cordeliers, F-75005 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A7">Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, F-75908 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, F-75908 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A8">Université Paris Descartes, Paris 5, F-75270 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Paris Descartes, Paris 5, F-75270 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21868666</idno>
<idno type="pmc">3405151</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405151</idno>
<idno type="RBID">PMC:3405151</idno>
<idno type="doi">10.1126/science.1201940</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">000583</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000583</idno>
<idno type="wicri:Area/Pmc/Curation">000580</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000580</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000675</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000675</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mitochondria and the autophagy-inflammation-cell death axis in organismal aging</title>
<author><name sortKey="Green, Douglas R" sort="Green, Douglas R" uniqKey="Green D" first="Douglas R." last="Green">Douglas R. Green</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Immunology, St Jude Children’s Research Hospital, Memphis, TN 38105, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Immunology, St Jude Children’s Research Hospital, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name>
<affiliation wicri:level="3"><nlm:aff id="A2">INSERM, U848, F-94805 Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U848, F-94805 Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">Institut Gustave Roussy, F94805 Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Gustave Roussy, F94805 Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A4">Université Paris-Sud, Paris 11, F-94805 Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Paris-Sud, Paris 11, F-94805 Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
<orgName type="university">Université Paris-Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<affiliation wicri:level="3"><nlm:aff id="A2">INSERM, U848, F-94805 Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U848, F-94805 Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A5">Metabolomics Platform, Institut Gustave Roussy, F-94805 Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Metabolomics Platform, Institut Gustave Roussy, F-94805 Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A6">Centre de Recherche des Cordeliers, F-75005 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Recherche des Cordeliers, F-75005 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A7">Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, F-75908 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, F-75908 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A8">Université Paris Descartes, Paris 5, F-75270 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Paris Descartes, Paris 5, F-75270 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Science (New York, N.y.)</title>
<idno type="ISSN">0036-8075</idno>
<idno type="eISSN">1095-9203</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p id="P2">Alterations of mitochondrial functions are linked to multiple degenerative or acute diseases. As mitochondria age in our cells, they become progressively inefficient and potentially toxic, and acute damage can trigger the permeabilization of mitochondrial membranes to initiate apoptosis or necrosis. Moreover, mitochondria have an important role in pro-inflammatory signaling. Autophagic turnover of cellular constituents, be it general or specific for mitochondria (mitophagy), eliminates dysfunctional or damaged mitochondria, thus counteracting degeneration, dampening inflammation, and preventing unwarranted cell loss. Decreased expression of genes that regulate autophagy or mitophagy can cause degenerative diseases in which deficient quality control results in inflammation and the death of cell populations. Thus, a combination of mitochondrial dysfunction and insufficient autophagy may contribute to multiple aging-associated pathologies.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0404511</journal-id>
<journal-id journal-id-type="pubmed-jr-id">7473</journal-id>
<journal-id journal-id-type="nlm-ta">Science</journal-id>
<journal-id journal-id-type="iso-abbrev">Science</journal-id>
<journal-title-group><journal-title>Science (New York, N.y.)</journal-title>
</journal-title-group>
<issn pub-type="ppub">0036-8075</issn>
<issn pub-type="epub">1095-9203</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21868666</article-id>
<article-id pub-id-type="pmc">3405151</article-id>
<article-id pub-id-type="doi">10.1126/science.1201940</article-id>
<article-id pub-id-type="manuscript">NIHMS392891</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Mitochondria and the autophagy-inflammation-cell death axis in organismal aging</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Green</surname>
<given-names>Douglas R.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Galluzzi</surname>
<given-names>Lorenzo</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kroemer</surname>
<given-names>Guido</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A5">5</xref>
<xref ref-type="aff" rid="A6">6</xref>
<xref ref-type="aff" rid="A7">7</xref>
<xref ref-type="aff" rid="A8">8</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Immunology, St Jude Children’s Research Hospital, Memphis, TN 38105, USA</aff>
<aff id="A2"><label>2</label>
INSERM, U848, F-94805 Villejuif, France</aff>
<aff id="A3"><label>3</label>
Institut Gustave Roussy, F94805 Villejuif, France</aff>
<aff id="A4"><label>4</label>
Université Paris-Sud, Paris 11, F-94805 Villejuif, France</aff>
<aff id="A5"><label>5</label>
Metabolomics Platform, Institut Gustave Roussy, F-94805 Villejuif, France</aff>
<aff id="A6"><label>6</label>
Centre de Recherche des Cordeliers, F-75005 Paris, France</aff>
<aff id="A7"><label>7</label>
Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, F-75908 Paris, France</aff>
<aff id="A8"><label>8</label>
Université Paris Descartes, Paris 5, F-75270 Paris, France</aff>
<author-notes><corresp id="FN1"><label>*</label>
To whom correspondence should be addressed: <email>douglas.green@stjude.org</email>
or <email>kroemer@orange.fr</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>11</day>
<month>7</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="ppub"><day>26</day>
<month>8</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>25</day>
<month>7</month>
<year>2012</year>
</pub-date>
<volume>333</volume>
<issue>6046</issue>
<fpage>1109</fpage>
<lpage>1112</lpage>
<abstract><title>Summary</title>
<p id="P2">Alterations of mitochondrial functions are linked to multiple degenerative or acute diseases. As mitochondria age in our cells, they become progressively inefficient and potentially toxic, and acute damage can trigger the permeabilization of mitochondrial membranes to initiate apoptosis or necrosis. Moreover, mitochondria have an important role in pro-inflammatory signaling. Autophagic turnover of cellular constituents, be it general or specific for mitochondria (mitophagy), eliminates dysfunctional or damaged mitochondria, thus counteracting degeneration, dampening inflammation, and preventing unwarranted cell loss. Decreased expression of genes that regulate autophagy or mitophagy can cause degenerative diseases in which deficient quality control results in inflammation and the death of cell populations. Thus, a combination of mitochondrial dysfunction and insufficient autophagy may contribute to multiple aging-associated pathologies.</p>
</abstract>
<funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source>
<award-id>R01 AI047891 || AI</award-id>
</award-group>
<award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source>
<award-id>R01 AI040646 || AI</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>France</li>
<li>États-Unis</li>
</country>
<region><li>Tennessee</li>
<li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
<li>Villejuif</li>
</settlement>
<orgName><li>Université Paris-Descartes</li>
<li>Université Paris-Sud</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Green, Douglas R" sort="Green, Douglas R" uniqKey="Green D" first="Douglas R." last="Green">Douglas R. Green</name>
</region>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name>
</region>
<name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name>
<name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000675 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000675 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Pmc |étape= Checkpoint |type= RBID |clé= PMC:3405151 |texte= Mitochondria and the autophagy-inflammation-cell death axis in organismal aging }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:21868666" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |