Distinctive Features of NREM Parasomnia Behaviors in Parkinson’s Disease and Multiple System Atrophy
Identifieur interne : 000223 ( Pmc/Checkpoint ); précédent : 000222; suivant : 000224Distinctive Features of NREM Parasomnia Behaviors in Parkinson’s Disease and Multiple System Atrophy
Auteurs : Pietro-Luca Ratti [France, Suisse] ; Maria Sierra-Pe A [France] ; Raffaele Manni [Italie] ; Marion Simonetta-Moreau [France] ; Julien Bastin [France] ; Harrison Mace [France] ; Olivier Rascol [France] ; Olivier David [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
To characterize parasomnia behaviors on arousal from NREM sleep in Parkinson’s Disease (PD) and Multiple System Atrophy (MSA).
From 30 patients with PD, Dementia with Lewy Bodies/Dementia associated with PD, or MSA undergoing nocturnal video-polysomnography for presumed dream enactment behavior, we were able to select 2 PD and 2 MSA patients featuring NREM Parasomnia Behviors (NPBs). We identified episodes during which the subjects seemed to enact dreams or presumed dream-like mentation (NPB arousals) versus episodes with physiological movements (no-NPB arousals). A time-frequency analysis (Morlet Wavelet Transform) of the scalp EEG signals around each NPB and no- NPB arousal onset was performed, and the amplitudes of the spectral frequencies were compared between NPB and no-NPB arousals.
19 NPBs were identified, 12 of which consisting of ‘elementary’ NPBs while 7 resembling confusional arousals. With quantitative EEG analysis, we found an amplitude reduction in the 5-6 Hz band 40 seconds before NPBs arousal as compared to no-NPB arousals at F4 and C4 derivations (p<0.01).
Many PD and MSA patients feature various NREM sleep-related behaviors, with clinical and electrophysiological differences and similarities with arousal parasomnias in the general population.
This study help bring to attention an overlooked phenomenon in neurodegenerative diseases.
Url:
DOI: 10.1371/journal.pone.0120973
PubMed: 25756280
PubMed Central: 4355286
Affiliations:
- France, Italie, Suisse
- Auvergne-Rhône-Alpes, Midi-Pyrénées, Occitanie (région administrative), Rhône-Alpes
- Grenoble, Toulouse
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Atrophy</title><author><name sortKey="Ratti, Pietro Luca" sort="Ratti, Pietro Luca" uniqKey="Ratti P" first="Pietro-Luca" last="Ratti">Pietro-Luca Ratti</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Clinical Pharmacology, Toulouse University Hospital and Paul Sabatier University, Toulouse, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical Pharmacology, Toulouse University Hospital and Paul Sabatier University, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>UMR 825 Brain imaging and neurological dysfunctions, INSERM, Toulouse, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR 825 Brain imaging and neurological dysfunctions, INSERM, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Sleep and Epilepsy center, Neurocenter of Southern Switzerland, Civic Hospital (EOC) of Lugano, Lugano, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Sleep and Epilepsy center, Neurocenter of Southern Switzerland, Civic Hospital (EOC) of Lugano, Lugano</wicri:regionArea><wicri:noRegion>Lugano</wicri:noRegion></affiliation></author><author><name sortKey="Sierra Pe A, Maria" sort="Sierra Pe A, Maria" uniqKey="Sierra Pe A M" first="Maria" last="Sierra-Pe A">Maria Sierra-Pe A</name><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Department of Neurology, Toulouse University Hospital and Paul Sabatier University, Toulouse, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Toulouse University Hospital and Paul Sabatier University, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Manni, Raffaele" sort="Manni, Raffaele" uniqKey="Manni R" first="Raffaele" last="Manni">Raffaele Manni</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Sleep Medicine and Epilepsy unit, C. Mondino National Neurological Institute, Pavia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Sleep Medicine and Epilepsy unit, C. Mondino National Neurological Institute, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Simonetta Moreau, Marion" sort="Simonetta Moreau, Marion" uniqKey="Simonetta Moreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>UMR 825 Brain imaging and neurological dysfunctions, INSERM, Toulouse, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR 825 Brain imaging and neurological dysfunctions, INSERM, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Department of Neurology, Toulouse University Hospital and Paul Sabatier University, Toulouse, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Toulouse University Hospital and Paul Sabatier University, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Bastin, Julien" sort="Bastin, Julien" uniqKey="Bastin J" first="Julien" last="Bastin">Julien Bastin</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Brain Function & Neuromodulation, Grenoble Institute of Neuroscience, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Brain Function & Neuromodulation, Grenoble Institute of Neuroscience, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff007"><addr-line>Joseph Fourier University, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Joseph Fourier University, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Mace, Harrison" sort="Mace, Harrison" uniqKey="Mace H" first="Harrison" last="Mace">Harrison Mace</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Brain Function & Neuromodulation, Grenoble Institute of Neuroscience, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Brain Function & Neuromodulation, Grenoble Institute of Neuroscience, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Clinical Pharmacology, Toulouse University Hospital and Paul Sabatier University, Toulouse, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical Pharmacology, Toulouse University Hospital and Paul Sabatier University, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>UMR 825 Brain imaging and neurological dysfunctions, INSERM, Toulouse, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR 825 Brain imaging and neurological dysfunctions, INSERM, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>Reference Centre for Multiple System Atrophy, Toulouse University Hospital, Toulouse, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Reference Centre for Multiple System Atrophy, Toulouse University Hospital, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Brain Function & Neuromodulation, Grenoble Institute of Neuroscience, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Brain Function & Neuromodulation, Grenoble Institute of Neuroscience, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff007"><addr-line>Joseph Fourier University, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Joseph Fourier University, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Objective</title><p>To characterize parasomnia behaviors on arousal from NREM sleep in Parkinson’s Disease (PD) and Multiple System Atrophy (MSA).</p></sec><sec id="sec002"><title>Methods</title><p>From 30 patients with PD, Dementia with Lewy Bodies/Dementia associated with PD, or MSA undergoing nocturnal video-polysomnography for presumed dream enactment behavior, we were able to select 2 PD and 2 MSA patients featuring NREM Parasomnia Behviors (NPBs). We identified episodes during which the subjects seemed to enact dreams or presumed dream-like mentation (NPB arousals) versus episodes with physiological movements (no-NPB arousals). A time-frequency analysis (Morlet Wavelet Transform) of the scalp EEG signals around each NPB and no- NPB arousal onset was performed, and the amplitudes of the spectral frequencies were compared between NPB and no-NPB arousals.</p></sec><sec id="sec003"><title>Results</title><p>19 NPBs were identified, 12 of which consisting of ‘elementary’ NPBs while 7 resembling confusional arousals. With quantitative EEG analysis, we found an amplitude reduction in the 5-6 Hz band 40 seconds before NPBs arousal as compared to no-NPB arousals at F4 and C4 derivations (p<0.01).</p></sec><sec id="sec004"><title>Conclusions</title><p>Many PD and MSA patients feature various NREM sleep-related behaviors, with clinical and electrophysiological differences and similarities with arousal parasomnias in the general population.</p></sec><sec id="sec005"><title>Significance</title><p>This study help bring to attention an overlooked phenomenon in neurodegenerative diseases.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Manni, R" uniqKey="Manni R">R Manni</name></author><author><name sortKey="Terzaghi, M" uniqKey="Terzaghi M">M Terzaghi</name></author><author><name sortKey="Repetto, A" uniqKey="Repetto A">A Repetto</name></author><author><name sortKey="Zangaglia, R" uniqKey="Zangaglia R">R Zangaglia</name></author><author><name sortKey="Pacchetti, C" uniqKey="Pacchetti C">C Pacchetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Terzaghi, M" uniqKey="Terzaghi M">M Terzaghi</name></author><author><name sortKey="Rustioni, V" uniqKey="Rustioni V">V Rustioni</name></author><author><name sortKey="Manni, R" uniqKey="Manni R">R Manni</name></author><author><name sortKey="Pacchetti, C" uniqKey="Pacchetti C">C Pacchetti</name></author><author><name sortKey="Zangaglia, R" uniqKey="Zangaglia R">R Zangaglia</name></author><author><name sortKey="Ossola, M" uniqKey="Ossola M">M Ossola</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manni, R" uniqKey="Manni R">R Manni</name></author><author><name sortKey="Terzaghi, M" uniqKey="Terzaghi M">M Terzaghi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ratti, Pl" uniqKey="Ratti P">PL Ratti</name></author><author><name sortKey="Terzaghi, M" uniqKey="Terzaghi M">M 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25756280</article-id><article-id pub-id-type="pmc">4355286</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0120973</article-id><article-id pub-id-type="publisher-id">PONE-D-14-42859</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Distinctive Features of NREM Parasomnia Behaviors in Parkinson’s Disease and Multiple System Atrophy</article-title><alt-title alt-title-type="running-head">NREM Parasomnia Behaviors in Parkinson and Multiple System Atrophy</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ratti</surname><given-names>Pietro-Luca</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="aff" rid="aff002"><sup>2</sup></xref><xref ref-type="aff" rid="aff003"><sup>3</sup></xref><xref rid="cor001" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Sierra-Peña</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Manni</surname><given-names>Raffaele</given-names></name><xref ref-type="aff" rid="aff005"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Simonetta-Moreau</surname><given-names>Marion</given-names></name><xref ref-type="aff" rid="aff002"><sup>2</sup></xref><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bastin</surname><given-names>Julien</given-names></name><xref ref-type="aff" rid="aff006"><sup>6</sup></xref><xref ref-type="aff" rid="aff007"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mace</surname><given-names>Harrison</given-names></name><xref ref-type="aff" rid="aff006"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rascol</surname><given-names>Olivier</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="aff" rid="aff002"><sup>2</sup></xref><xref ref-type="aff" rid="aff008"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>David</surname><given-names>Olivier</given-names></name><xref ref-type="aff" rid="aff006"><sup>6</sup></xref><xref ref-type="aff" rid="aff007"><sup>7</sup></xref></contrib></contrib-group><aff id="aff001"><label>1</label><addr-line>Department of Clinical Pharmacology, Toulouse University Hospital and Paul Sabatier University, Toulouse, France</addr-line></aff><aff id="aff002"><label>2</label><addr-line>UMR 825 Brain imaging and neurological dysfunctions, INSERM, Toulouse, France</addr-line></aff><aff id="aff003"><label>3</label><addr-line>Sleep and Epilepsy center, Neurocenter of Southern Switzerland, Civic Hospital (EOC) of Lugano, Lugano, Switzerland</addr-line></aff><aff id="aff004"><label>4</label><addr-line>Department of Neurology, Toulouse University Hospital and Paul Sabatier University, Toulouse, France</addr-line></aff><aff id="aff005"><label>5</label><addr-line>Sleep Medicine and Epilepsy unit, C. Mondino National Neurological Institute, Pavia, Italy</addr-line></aff><aff id="aff006"><label>6</label><addr-line>Brain Function & Neuromodulation, Grenoble Institute of Neuroscience, Grenoble, France</addr-line></aff><aff id="aff007"><label>7</label><addr-line>Joseph Fourier University, Grenoble, France</addr-line></aff><aff id="aff008"><label>8</label><addr-line>Reference Centre for Multiple System Atrophy, Toulouse University Hospital, Toulouse, France</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Vyazovskiy</surname><given-names>Vladyslav</given-names></name><role>Academic Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Oxford, UNITED KINGDOM</addr-line></aff><author-notes><fn fn-type="conflict" id="coi001"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: PLR OD MSP RM JB. Performed the experiments: PLR MSP. Analyzed the data: PLR MSP JB OD HM. Contributed reagents/materials/analysis tools: OD. Wrote the paper: PLR RM OD HM MSM. Patients' recruitment: OR.</p></fn><corresp id="cor001">* E-mail: <email>pietroluca.ratti@eoc.ch</email></corresp></author-notes><pub-date pub-type="epub"><day>10</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>10</volume><issue>3</issue><elocation-id>e0120973</elocation-id><history><date date-type="received"><day>23</day><month>9</month><year>2014</year></date><date date-type="accepted"><day>28</day><month>1</month><year>2015</year></date></history><permissions><copyright-year>2015</copyright-year><copyright-holder>Ratti et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited</license-p></license></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="pone.0120973.pdf"></self-uri><abstract><sec id="sec001"><title>Objective</title><p>To characterize parasomnia behaviors on arousal from NREM sleep in Parkinson’s Disease (PD) and Multiple System Atrophy (MSA).</p></sec><sec id="sec002"><title>Methods</title><p>From 30 patients with PD, Dementia with Lewy Bodies/Dementia associated with PD, or MSA undergoing nocturnal video-polysomnography for presumed dream enactment behavior, we were able to select 2 PD and 2 MSA patients featuring NREM Parasomnia Behviors (NPBs). We identified episodes during which the subjects seemed to enact dreams or presumed dream-like mentation (NPB arousals) versus episodes with physiological movements (no-NPB arousals). A time-frequency analysis (Morlet Wavelet Transform) of the scalp EEG signals around each NPB and no- NPB arousal onset was performed, and the amplitudes of the spectral frequencies were compared between NPB and no-NPB arousals.</p></sec><sec id="sec003"><title>Results</title><p>19 NPBs were identified, 12 of which consisting of ‘elementary’ NPBs while 7 resembling confusional arousals. With quantitative EEG analysis, we found an amplitude reduction in the 5-6 Hz band 40 seconds before NPBs arousal as compared to no-NPB arousals at F4 and C4 derivations (p<0.01).</p></sec><sec id="sec004"><title>Conclusions</title><p>Many PD and MSA patients feature various NREM sleep-related behaviors, with clinical and electrophysiological differences and similarities with arousal parasomnias in the general population.</p></sec><sec id="sec005"><title>Significance</title><p>This study help bring to attention an overlooked phenomenon in neurodegenerative diseases.</p></sec></abstract><funding-group><funding-statement>These authors have no support or funding to report.</funding-statement></funding-group><counts><fig-count count="2"></fig-count><table-count count="2"></table-count><page-count count="15"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>Due to ethical restrictions involving sensitive clinical data, the anonymized European Data Format (EDF) of the PSG recording files from the final four patients included in the study are available upon request from the corresponding author: Pietro-Luca Ratti.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>Due to ethical restrictions involving sensitive clinical data, the anonymized European Data Format (EDF) of the PSG recording files from the final four patients included in the study are available upon request from the corresponding author: Pietro-Luca Ratti.</p></notes></front></pmc><affiliations><list><country><li>France</li><li>Italie</li><li>Suisse</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li><li>Toulouse</li></settlement></list><tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Ratti, Pietro Luca" sort="Ratti, Pietro Luca" uniqKey="Ratti P" first="Pietro-Luca" last="Ratti">Pietro-Luca Ratti</name></region><name sortKey="Bastin, Julien" sort="Bastin, Julien" uniqKey="Bastin J" first="Julien" last="Bastin">Julien Bastin</name><name sortKey="Bastin, Julien" sort="Bastin, Julien" uniqKey="Bastin J" first="Julien" last="Bastin">Julien Bastin</name><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name><name sortKey="Mace, Harrison" sort="Mace, Harrison" uniqKey="Mace H" first="Harrison" last="Mace">Harrison Mace</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><name sortKey="Ratti, Pietro Luca" sort="Ratti, Pietro Luca" uniqKey="Ratti P" first="Pietro-Luca" last="Ratti">Pietro-Luca Ratti</name><name sortKey="Sierra Pe A, Maria" sort="Sierra Pe A, Maria" uniqKey="Sierra Pe A M" first="Maria" last="Sierra-Pe A">Maria Sierra-Pe A</name><name sortKey="Simonetta Moreau, Marion" sort="Simonetta Moreau, Marion" uniqKey="Simonetta Moreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name><name sortKey="Simonetta Moreau, Marion" sort="Simonetta Moreau, Marion" uniqKey="Simonetta Moreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name></country><country name="Suisse"><noRegion><name sortKey="Ratti, Pietro Luca" sort="Ratti, Pietro Luca" uniqKey="Ratti P" first="Pietro-Luca" last="Ratti">Pietro-Luca Ratti</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Manni, Raffaele" sort="Manni, Raffaele" uniqKey="Manni R" first="Raffaele" last="Manni">Raffaele Manni</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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