ParkinsonFranceV1, PascalFrancis, Curation, bibRecord, 001B06

No pathogenic mutations in the persyn gene in Parkinson's disease

Identifieur interne : 001B06 ( PascalFrancis/Curation ); précédent : 001B05; suivant : 001B07

No pathogenic mutations in the persyn gene in Parkinson's disease

Auteurs : S. Lincoln [États-Unis] ; K. Gwinn-Hardy [États-Unis] ; J. Goudreau [États-Unis] ; M. C. Chartier-Harlin [France] ; M. Baker [États-Unis] ; V. Mouroux [France] ; F. Richard [France] ; A. Destee [France] ; E. Becquet [France] ; P. Amouyel [France] ; T. Lynch [Irlande (pays)] ; J. Hardy [États-Unis] ; M. Farrer [États-Unis]

Source :

Neuroscience letters [ 0304-3940 ] ; 1999.

RBID : Pascal:99-0103333

Descripteurs français

Pascal (Inist)
- Mutation, Génétique, Pathogénie, Parkinson maladie, Homme, Persyne, Synucléine.
Wicri :
- topic : Génétique, Homme.

English descriptors

KwdEn :
- Genetics, Human, Mutation, Parkinson disease, Pathogenesis, Synuclein.

Abstract

The persyn (γ-synuclein) gene is highly homologous to the α-synuclein gene and is highly expressed in the nervous system. It is therefore, an excellent candidate gene for Parkinson's disease. However, we have sequenced the gene in a large number of families with parkinsonism and failed to find pathogenic mutations.

A01	`01`	`1`		`@0 0304-3940`
A02	`01`			`@0 NELED5`
A03		`1`		`@0 Neurosci. lett.`
A05				`@2 259`
A06				`@2 1`
A08	`01`	`1`	`ENG`	`@1 No pathogenic mutations in the persyn gene in Parkinson's disease`
A11	`01`	`1`		`@1 LINCOLN (S.)`
A11	`02`	`1`		`@1 GWINN-HARDY (K.)`
A11	`03`	`1`		`@1 GOUDREAU (J.)`
A11	`04`	`1`		`@1 CHARTIER-HARLIN (M. C.)`
A11	`05`	`1`		`@1 BAKER (M.)`
A11	`06`	`1`		`@1 MOUROUX (V.)`
A11	`07`	`1`		`@1 RICHARD (F.)`
A11	`08`	`1`		`@1 DESTEE (A.)`
A11	`09`	`1`		`@1 BECQUET (E.)`
A11	`10`	`1`		`@1 AMOUYEL (P.)`
A11	`11`	`1`		`@1 LYNCH (T.)`
A11	`12`	`1`		`@1 HARDY (J.)`
A11	`13`	`1`		`@1 FARRER (M.)`
A14	`01`			`@1 Birdsall Building, Mayo Clinic Jacksonville, 4500 San Pablo Road @2 Jacksonville, FL 32084 @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 5 aut. @Z 12 aut. @Z 13 aut.`
A14	`02`			`@1 CJF 95-05 INSERM, Institut Pasteur de Lille, 1, Rue du Pr Calmette @2 59019, Lille @3 FRA @Z 4 aut. @Z 6 aut. @Z 7 aut.`
A14	`03`			`@1 Hopital Roget Salengro, Centre Hospitalier et Universitaire de Lille @2 59037, Lille @3 FRA @Z 4 aut. @Z 8 aut. @Z 9 aut. @Z 10 aut.`
A14	`04`			`@1 The Mater Misericordiae Hospital, Eccles Street @2 Dublin @3 IRL @Z 11 aut.`
A20				`@1 65-66`
A21				`@1 1999`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 17240 @5 354000074046100180`
A44				`@0 0000 @1 © 1999 INIST-CNRS. All rights reserved.`
A45				`@0 11 ref.`
A47	`01`	`1`		`@0 99-0103333`
A60				`@1 P`
A61				`@0 A`
A64		`1`		`@0 Neuroscience letters`
A66	`01`			`@0 IRL`
C01	`01`		`ENG`	`@0 The persyn (γ-synuclein) gene is highly homologous to the α-synuclein gene and is highly expressed in the nervous system. It is therefore, an excellent candidate gene for Parkinson's disease. However, we have sequenced the gene in a large number of families with parkinsonism and failed to find pathogenic mutations.`
C02	`01`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Mutation @5 01`
C03	`01`	`X`	`ENG`	`@0 Mutation @5 01`
C03	`01`	`X`	`SPA`	`@0 Mutación @5 01`
C03	`02`	`X`	`FRE`	`@0 Génétique @5 05`
C03	`02`	`X`	`ENG`	`@0 Genetics @5 05`
C03	`02`	`X`	`SPA`	`@0 Genética @5 05`
C03	`03`	`X`	`FRE`	`@0 Pathogénie @5 06`
C03	`03`	`X`	`ENG`	`@0 Pathogenesis @5 06`
C03	`03`	`X`	`SPA`	`@0 Patogenia @5 06`
C03	`04`	`X`	`FRE`	`@0 Parkinson maladie @5 09`
C03	`04`	`X`	`ENG`	`@0 Parkinson disease @5 09`
C03	`04`	`X`	`SPA`	`@0 Parkinson enfermedad @5 09`
C03	`05`	`X`	`FRE`	`@0 Homme @5 54`
C03	`05`	`X`	`ENG`	`@0 Human @5 54`
C03	`05`	`X`	`SPA`	`@0 Hombre @5 54`
C03	`06`	`X`	`FRE`	`@0 Persyne @4 INC @5 81`
C03	`07`	`X`	`FRE`	`@0 Synucléine @4 CD @5 96`
C03	`07`	`X`	`ENG`	`@0 Synuclein @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 38`
C07	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 38`
C07	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 38`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 39`
C07	`02`	`X`	`ENG`	`@0 Central nervous system disease @5 39`
C07	`02`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 39`
C07	`03`	`X`	`FRE`	`@0 Encéphale pathologie @5 40`
C07	`03`	`X`	`ENG`	`@0 Cerebral disorder @5 40`
C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 40`
C07	`04`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 41`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 41`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 41`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 42`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 42`
C07	`05`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 42`
N21				`@1 060`

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Pascal:99-0103333

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">No pathogenic mutations in the persyn gene in Parkinson's disease</title>
<author><name sortKey="Lincoln, S" sort="Lincoln, S" uniqKey="Lincoln S" first="S." last="Lincoln">S. Lincoln</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Birdsall Building, Mayo Clinic Jacksonville, 4500 San Pablo Road</s1>
<s2>Jacksonville, FL 32084</s2>
<s3>USA</s3>
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<author><name sortKey="Gwinn Hardy, K" sort="Gwinn Hardy, K" uniqKey="Gwinn Hardy K" first="K." last="Gwinn-Hardy">K. Gwinn-Hardy</name>
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<s3>USA</s3>
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<author><name sortKey="Goudreau, J" sort="Goudreau, J" uniqKey="Goudreau J" first="J." last="Goudreau">J. Goudreau</name>
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<author><name sortKey="Chartier Harlin, M C" sort="Chartier Harlin, M C" uniqKey="Chartier Harlin M" first="M. C." last="Chartier-Harlin">M. C. Chartier-Harlin</name>
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<sZ>4 aut.</sZ>
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<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hopital Roget Salengro, Centre Hospitalier et Universitaire de Lille</s1>
<s2>59037, Lille</s2>
<s3>FRA</s3>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Baker, M" sort="Baker, M" uniqKey="Baker M" first="M." last="Baker">M. Baker</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Birdsall Building, Mayo Clinic Jacksonville, 4500 San Pablo Road</s1>
<s2>Jacksonville, FL 32084</s2>
<s3>USA</s3>
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<author><name sortKey="Mouroux, V" sort="Mouroux, V" uniqKey="Mouroux V" first="V." last="Mouroux">V. Mouroux</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CJF 95-05 INSERM, Institut Pasteur de Lille, 1, Rue du Pr Calmette</s1>
<s2>59019, Lille</s2>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Richard, F" sort="Richard, F" uniqKey="Richard F" first="F." last="Richard">F. Richard</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CJF 95-05 INSERM, Institut Pasteur de Lille, 1, Rue du Pr Calmette</s1>
<s2>59019, Lille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Destee, A" sort="Destee, A" uniqKey="Destee A" first="A." last="Destee">A. Destee</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hopital Roget Salengro, Centre Hospitalier et Universitaire de Lille</s1>
<s2>59037, Lille</s2>
<s3>FRA</s3>
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</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Becquet, E" sort="Becquet, E" uniqKey="Becquet E" first="E." last="Becquet">E. Becquet</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hopital Roget Salengro, Centre Hospitalier et Universitaire de Lille</s1>
<s2>59037, Lille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Amouyel, P" sort="Amouyel, P" uniqKey="Amouyel P" first="P." last="Amouyel">P. Amouyel</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hopital Roget Salengro, Centre Hospitalier et Universitaire de Lille</s1>
<s2>59037, Lille</s2>
<s3>FRA</s3>
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<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Lynch, T" sort="Lynch, T" uniqKey="Lynch T" first="T." last="Lynch">T. Lynch</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>The Mater Misericordiae Hospital, Eccles Street</s1>
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<s3>IRL</s3>
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</author>
<author><name sortKey="Hardy, J" sort="Hardy, J" uniqKey="Hardy J" first="J." last="Hardy">J. Hardy</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Birdsall Building, Mayo Clinic Jacksonville, 4500 San Pablo Road</s1>
<s2>Jacksonville, FL 32084</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
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<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Farrer, M" sort="Farrer, M" uniqKey="Farrer M" first="M." last="Farrer">M. Farrer</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Birdsall Building, Mayo Clinic Jacksonville, 4500 San Pablo Road</s1>
<s2>Jacksonville, FL 32084</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neuroscience letters</title>
<title level="j" type="abbreviated">Neurosci. lett.</title>
<idno type="ISSN">0304-3940</idno>
<imprint><date when="1999">1999</date>
</imprint>
</series>
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</sourceDesc>
<seriesStmt><title level="j" type="main">Neuroscience letters</title>
<title level="j" type="abbreviated">Neurosci. lett.</title>
<idno type="ISSN">0304-3940</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Genetics</term>
<term>Human</term>
<term>Mutation</term>
<term>Parkinson disease</term>
<term>Pathogenesis</term>
<term>Synuclein</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Mutation</term>
<term>Génétique</term>
<term>Pathogénie</term>
<term>Parkinson maladie</term>
<term>Homme</term>
<term>Persyne</term>
<term>Synucléine</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term>
<term>Homme</term>
</keywords>
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<front><div type="abstract" xml:lang="en">The persyn (γ-synuclein) gene is highly homologous to the α-synuclein gene and is highly expressed in the nervous system. It is therefore, an excellent candidate gene for Parkinson's disease. However, we have sequenced the gene in a large number of families with parkinsonism and failed to find pathogenic mutations.</div>
</front>
</TEI>
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<fA03 i2="1"><s0>Neurosci. lett.</s0>
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<fA05><s2>259</s2>
</fA05>
<fA06><s2>1</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>No pathogenic mutations in the persyn gene in Parkinson's disease</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>LINCOLN (S.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>GWINN-HARDY (K.)</s1>
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<fA11 i1="03" i2="1"><s1>GOUDREAU (J.)</s1>
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<fA11 i1="04" i2="1"><s1>CHARTIER-HARLIN (M. C.)</s1>
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<fA11 i1="05" i2="1"><s1>BAKER (M.)</s1>
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<fA11 i1="06" i2="1"><s1>MOUROUX (V.)</s1>
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<fA11 i1="07" i2="1"><s1>RICHARD (F.)</s1>
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<fA11 i1="08" i2="1"><s1>DESTEE (A.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>BECQUET (E.)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>AMOUYEL (P.)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>LYNCH (T.)</s1>
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<fA11 i1="12" i2="1"><s1>HARDY (J.)</s1>
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<fA11 i1="13" i2="1"><s1>FARRER (M.)</s1>
</fA11>
<fA14 i1="01"><s1>Birdsall Building, Mayo Clinic Jacksonville, 4500 San Pablo Road</s1>
<s2>Jacksonville, FL 32084</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>CJF 95-05 INSERM, Institut Pasteur de Lille, 1, Rue du Pr Calmette</s1>
<s2>59019, Lille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Hopital Roget Salengro, Centre Hospitalier et Universitaire de Lille</s1>
<s2>59037, Lille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>The Mater Misericordiae Hospital, Eccles Street</s1>
<s2>Dublin</s2>
<s3>IRL</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA20><s1>65-66</s1>
</fA20>
<fA21><s1>1999</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
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<s1>© 1999 INIST-CNRS. All rights reserved.</s1>
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<fA47 i1="01" i2="1"><s0>99-0103333</s0>
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<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
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<fA64 i2="1"><s0>Neuroscience letters</s0>
</fA64>
<fA66 i1="01"><s0>IRL</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>The persyn (γ-synuclein) gene is highly homologous to the α-synuclein gene and is highly expressed in the nervous system. It is therefore, an excellent candidate gene for Parkinson's disease. However, we have sequenced the gene in a large number of families with parkinsonism and failed to find pathogenic mutations.</s0>
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<fC02 i1="01" i2="X"><s0>002B17G</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Mutation</s0>
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<s5>01</s5>
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<fC03 i1="01" i2="X" l="SPA"><s0>Mutación</s0>
<s5>01</s5>
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<s5>05</s5>
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<s5>05</s5>
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<s5>06</s5>
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<fC03 i1="03" i2="X" l="ENG"><s0>Pathogenesis</s0>
<s5>06</s5>
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<fC03 i1="03" i2="X" l="SPA"><s0>Patogenia</s0>
<s5>06</s5>
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<fC03 i1="04" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>09</s5>
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<fC03 i1="04" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
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<s5>54</s5>
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<fC03 i1="06" i2="X" l="FRE"><s0>Persyne</s0>
<s4>INC</s4>
<s5>81</s5>
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<fC03 i1="07" i2="X" l="FRE"><s0>Synucléine</s0>
<s4>CD</s4>
<s5>96</s5>
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<fC03 i1="07" i2="X" l="ENG"><s0>Synuclein</s0>
<s4>CD</s4>
<s5>96</s5>
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<s5>39</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>39</s5>
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<fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>40</s5>
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<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>40</s5>
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<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>41</s5>
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<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>42</s5>
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<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>42</s5>
</fC07>
<fN21><s1>060</s1>
</fN21>
</pA>
</standard>
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</record>

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	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

No pathogenic mutations in the persyn gene in Parkinson's disease

No pathogenic mutations in the persyn gene in Parkinson's disease

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