ParkinsonFranceV1, PascalFrancis, Curation, bibRecord, 001770

Inactivation of protease nexin-1 by xanthine oxidase-derived free radicals

Identifieur interne : 001770 ( PascalFrancis/Curation ); précédent : 001769; suivant : 001771

Inactivation of protease nexin-1 by xanthine oxidase-derived free radicals

Auteurs : F. N. Bolkenius [France] ; D. Monard

Source :

Neurochemistry international [ 0197-0186 ] ; 1995.

RBID : Pascal:95-0402708

Descripteurs français

Pascal (Inist)
- Proteinases, Activité enzymatique, Inhibiteur enzyme, Thrombin, Radical libre, Xanthine oxidase, Antioxydant, In vitro, Oxydation, Rat, Nexin-1, Serpin.

English descriptors

KwdEn :
- Antioxidant, Enzymatic activity, Enzyme inhibitor, Free radical, In vitro, Oxidation, Proteinases, Rat, Thrombin, Xanthine oxidase.

Abstract

Neuronal viability is affected by reactive oxygen species. Lipid peroxidation is often defined as a major reason for cellular breakdown. Additionally, certain indispensable proteins are possible targets for excessively formed reactive oxygen species. Evidence is given here that protease nexin-1 (PN-1), an endogenous thrombin inhibitor and neurite outgrowth promoter, is inactivated by xanthine oxidase-derived free radicals. Varying protection by superoxide dismutase and catalase was observed, depending on the reaction conditions. The water-soluble α-analogues-analogues MDL 74,406 (R(+ )-3,4-dihydro-6-hydroxy-N,N,N2,5,7,8-heptamethyl-2H-1-benzopyran-2-ethanaminium 4-methylbenzenesulfonate), MDL 74,180DA (2,3dihydro-2,2,4,6,7-pentamethyl-3-(4-methyl-piperazino)-I-benzofuran-5-ol dihydro-chloride) and trolox also protected PN-I. Neurodegeneration may be triggered by oxidative inactivation of protease inhibitors such as PN-I. Protection of PN-1 in Alzheimer's or Parkinson's diseases, could be a possible target for a therapeutic function of antioxidants in these diseases.

A01	`01`	`1`		`@0 0197-0186`
A02	`01`			`@0 NEUIDS`
A03		`1`		`@0 Neurochem. int.`
A05				`@2 26`
A06				`@2 6`
A08	`01`	`1`	`ENG`	`@1 Inactivation of protease nexin-1 by xanthine oxidase-derived free radicals`
A11	`01`	`1`		`@1 BOLKENIUS (F. N.)`
A11	`02`	`1`		`@1 MONARD (D.)`
A14	`01`			`@1 Marion Merrell Dow res. inst. @2 67080 Strasbourg @3 FRA @Z 1 aut.`
A20				`@1 587-592`
A21				`@1 1995`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 18809 @5 354000051043110050`
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A45				`@0 1 p.1/4`
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A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Neurochemistry international`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Neuronal viability is affected by reactive oxygen species. Lipid peroxidation is often defined as a major reason for cellular breakdown. Additionally, certain indispensable proteins are possible targets for excessively formed reactive oxygen species. Evidence is given here that protease nexin-1 (PN-1), an endogenous thrombin inhibitor and neurite outgrowth promoter, is inactivated by xanthine oxidase-derived free radicals. Varying protection by superoxide dismutase and catalase was observed, depending on the reaction conditions. The water-soluble α-analogues-analogues MDL 74,406 (R(+ )-3,4-dihydro-6-hydroxy-N,N,N2,5,7,8-heptamethyl-2H-1-benzopyran-2-ethanaminium 4-methylbenzenesulfonate), MDL 74,180DA (2,3dihydro-2,2,4,6,7-pentamethyl-3-(4-methyl-piperazino)-I-benzofuran-5-ol dihydro-chloride) and trolox also protected PN-I. Neurodegeneration may be triggered by oxidative inactivation of protease inhibitors such as PN-I. Protection of PN-1 in Alzheimer's or Parkinson's diseases, could be a possible target for a therapeutic function of antioxidants in these diseases.
C02	`01`	`X`		`@0 002A25D02`
C03	`01`	`X`	`FRE`	`@0 Proteinases @2 FE @5 01`
C03	`01`	`X`	`ENG`	`@0 Proteinases @2 FE @5 01`
C03	`01`	`X`	`SPA`	`@0 Proteinases @2 FE @5 01`
C03	`02`	`X`	`FRE`	`@0 Activité enzymatique @5 02`
C03	`02`	`X`	`ENG`	`@0 Enzymatic activity @5 02`
C03	`02`	`X`	`SPA`	`@0 Actividad enzimática @5 02`
C03	`03`	`X`	`FRE`	`@0 Inhibiteur enzyme @5 03`
C03	`03`	`X`	`ENG`	`@0 Enzyme inhibitor @5 03`
C03	`03`	`X`	`SPA`	`@0 Inhibidor enzima @5 03`
C03	`04`	`X`	`FRE`	`@0 Thrombin @2 NK @2 FE @2 FR @5 04`
C03	`04`	`X`	`ENG`	`@0 Thrombin @2 NK @2 FE @2 FR @5 04`
C03	`04`	`X`	`SPA`	`@0 Thrombin @2 NK @2 FE @2 FR @5 04`
C03	`05`	`X`	`FRE`	`@0 Radical libre @2 FX @5 05`
C03	`05`	`X`	`ENG`	`@0 Free radical @2 FX @5 05`
C03	`05`	`X`	`SPA`	`@0 Radical libre @2 FX @5 05`
C03	`06`	`X`	`FRE`	`@0 Xanthine oxidase @2 FE @5 06`
C03	`06`	`X`	`ENG`	`@0 Xanthine oxidase @2 FE @5 06`
C03	`06`	`X`	`SPA`	`@0 Xanthine oxidase @2 FE @5 06`
C03	`07`	`X`	`FRE`	`@0 Antioxydant @5 07`
C03	`07`	`X`	`ENG`	`@0 Antioxidant @5 07`
C03	`07`	`X`	`SPA`	`@0 Antioxidante @5 07`
C03	`08`	`X`	`FRE`	`@0 In vitro @5 08`
C03	`08`	`X`	`ENG`	`@0 In vitro @5 08`
C03	`08`	`X`	`SPA`	`@0 In vitro @5 08`
C03	`09`	`X`	`FRE`	`@0 Oxydation @5 10`
C03	`09`	`X`	`ENG`	`@0 Oxidation @5 10`
C03	`09`	`X`	`GER`	`@0 Oxidation @5 10`
C03	`09`	`X`	`SPA`	`@0 Oxidación @5 10`
C03	`10`	`X`	`FRE`	`@0 Rat @5 54`
C03	`10`	`X`	`ENG`	`@0 Rat @5 54`
C03	`10`	`X`	`SPA`	`@0 Rata @5 54`
C03	`11`	`X`	`FRE`	`@0 Nexin-1 @4 INC @5 78`
C03	`12`	`X`	`FRE`	`@0 Serpin @4 INC @5 81`
C07	`01`	`X`	`FRE`	`@0 Hydrolases @2 FE`
C07	`01`	`X`	`ENG`	`@0 Hydrolases @2 FE`
C07	`01`	`X`	`SPA`	`@0 Hydrolases @2 FE`
C07	`02`	`X`	`FRE`	`@0 Enzyme`
C07	`02`	`X`	`ENG`	`@0 Enzyme`
C07	`02`	`X`	`SPA`	`@0 Enzima`
C07	`03`	`X`	`FRE`	`@0 Serine endopeptidases @2 FE`
C07	`03`	`X`	`ENG`	`@0 Serine endopeptidases @2 FE`
C07	`03`	`X`	`SPA`	`@0 Serine endopeptidases @2 FE`
C07	`04`	`X`	`FRE`	`@0 Oxidoreductases @2 FE`
C07	`04`	`X`	`ENG`	`@0 Oxidoreductases @2 FE`
C07	`04`	`X`	`SPA`	`@0 Oxidoreductases @2 FE`
C07	`05`	`X`	`FRE`	`@0 Rodentia @2 NS`
C07	`05`	`X`	`ENG`	`@0 Rodentia @2 NS`
C07	`05`	`X`	`SPA`	`@0 Rodentia @2 NS`
C07	`06`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`06`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`06`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`07`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`07`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`07`	`X`	`SPA`	`@0 Vertebrata @2 NS`
N21				`@1 225`

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Pascal:95-0402708

Le document en format XML

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<front><div type="abstract" xml:lang="en">Neuronal viability is affected by reactive oxygen species. Lipid peroxidation is often defined as a major reason for cellular breakdown. Additionally, certain indispensable proteins are possible targets for excessively formed reactive oxygen species. Evidence is given here that protease nexin-1 (PN-1), an endogenous thrombin inhibitor and neurite outgrowth promoter, is inactivated by xanthine oxidase-derived free radicals. Varying protection by superoxide dismutase and catalase was observed, depending on the reaction conditions. The water-soluble α-analogues-analogues MDL 74,406 (R(+ )-3,4-dihydro-6-hydroxy-N,N,N2,5,7,8-heptamethyl-2H-1-benzopyran-2-ethanaminium 4-methylbenzenesulfonate), MDL 74,180DA (2,3dihydro-2,2,4,6,7-pentamethyl-3-(4-methyl-piperazino)-I-benzofuran-5-ol dihydro-chloride) and trolox also protected PN-I. Neurodegeneration may be triggered by oxidative inactivation of protease inhibitors such as PN-I. Protection of PN-1 in Alzheimer's or Parkinson's diseases, could be a possible target for a therapeutic function of antioxidants in these diseases.</div>
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<fC02 i1="01" i2="X"><s0>002A25D02</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Proteinases</s0>
<s2>FE</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Proteinases</s0>
<s2>FE</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Proteinases</s0>
<s2>FE</s2>
<s5>01</s5>
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<fC03 i1="02" i2="X" l="FRE"><s0>Activité enzymatique</s0>
<s5>02</s5>
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<fC03 i1="02" i2="X" l="ENG"><s0>Enzymatic activity</s0>
<s5>02</s5>
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<s5>03</s5>
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<fC03 i1="03" i2="X" l="ENG"><s0>Enzyme inhibitor</s0>
<s5>03</s5>
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<fC03 i1="03" i2="X" l="SPA"><s0>Inhibidor enzima</s0>
<s5>03</s5>
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<fC03 i1="04" i2="X" l="FRE"><s0>Thrombin</s0>
<s2>NK</s2>
<s2>FE</s2>
<s2>FR</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Thrombin</s0>
<s2>NK</s2>
<s2>FE</s2>
<s2>FR</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Thrombin</s0>
<s2>NK</s2>
<s2>FE</s2>
<s2>FR</s2>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Radical libre</s0>
<s2>FX</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Free radical</s0>
<s2>FX</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Radical libre</s0>
<s2>FX</s2>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Xanthine oxidase</s0>
<s2>FE</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Xanthine oxidase</s0>
<s2>FE</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Xanthine oxidase</s0>
<s2>FE</s2>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Antioxydant</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Antioxidant</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Antioxidante</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>In vitro</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>In vitro</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>In vitro</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Oxydation</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Oxidation</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="GER"><s0>Oxidation</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Oxidación</s0>
<s5>10</s5>
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<fC03 i1="10" i2="X" l="FRE"><s0>Rat</s0>
<s5>54</s5>
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<fC03 i1="10" i2="X" l="ENG"><s0>Rat</s0>
<s5>54</s5>
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<fC03 i1="10" i2="X" l="SPA"><s0>Rata</s0>
<s5>54</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Nexin-1</s0>
<s4>INC</s4>
<s5>78</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Serpin</s0>
<s4>INC</s4>
<s5>81</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Hydrolases</s0>
<s2>FE</s2>
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<fC07 i1="02" i2="X" l="FRE"><s0>Enzyme</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Enzyme</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Enzima</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Serine endopeptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Serine endopeptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Serine endopeptidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Oxidoreductases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Oxidoreductases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Oxidoreductases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Vertebrata</s0>
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   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    PascalFrancis
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   |clé=     Pascal:95-0402708
   |texte=   Inactivation of protease nexin-1 by xanthine oxidase-derived free radicals
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This area was generated with Dilib version V0.6.29.
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	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Inactivation of protease nexin-1 by xanthine oxidase-derived free radicals

Inactivation of protease nexin-1 by xanthine oxidase-derived free radicals

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