ParkinsonFranceV1, PascalFrancis, Curation, bibRecord, 000654

Assessment of Nurr1 nucleotide variations in familial Parkinson's disease

Identifieur interne : 000654 ( PascalFrancis/Curation ); précédent : 000653; suivant : 000655

Assessment of Nurr1 nucleotide variations in familial Parkinson's disease

Auteurs : C. Levecque [France] ; A. Destee [France] ; V. Mouroux [France] ; P. Amouyel [France] ; M.-C. Chartier-Harlin [France]

Source :

Neuroscience letters [ 0304-3940 ] ; 2004.

RBID : Pascal:04-0434137

Descripteurs français

Pascal (Inist)
- Maladie familiale, Parkinson maladie, Facteur transcription Nurr1.

English descriptors

KwdEn :
- Familial disease, Nurr1 transcription factor, Parkinson disease.

Abstract

Parkinson's disease (PD) is characterised by the death of dopaminergic neurons of the substantia nigra. As Nurr1 seems to regulate the development and maintenance of these neurons, we evaluated its potential role in Parkinson's disease using genetic methods. We genotyped two polymorphisms and screened a case-control sample for the presence/absence of two mutations recently described in exon 1. Our results failed to replicate the association initially observed and none of the mutations were present in our familial Parkinson's disease cases. These observations suggest that this gene is unlikely to play a major effect in French familial Parkinson Disease.

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Le document en format XML

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Assessment of Nurr1 nucleotide variations in familial Parkinson's disease

Assessment of Nurr1 nucleotide variations in familial Parkinson's disease

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Descripteurs français

English descriptors

Abstract

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