ParkinsonFranceV1, PascalFrancis, Curation, bibRecord, 000140

Expression of Trk isoforms in brain regions and in the striatum of patients with Alzheimer's disease

Identifieur interne : 000140 ( PascalFrancis/Curation ); précédent : 000139; suivant : 000141

Expression of Trk isoforms in brain regions and in the striatum of patients with Alzheimer's disease

Auteurs : Pierre Dubus [France] ; Baptiste Faucheux [France] ; Florence Boissiere [France] ; Alexis Groppi [France] ; Claude Vital [France] ; T. Anne Vital [France] ; Yves Agid [France] ; Etienne C. Hirsch [France] ; Jean Philippe Merlio [France]

Source :

Experimental neurology : (Print) [ 0014-4886 ] ; 2000.

RBID : Pascal:00-0529868

Descripteurs français

Pascal (Inist)
- Démence Alzheimer, Parkinson maladie, Forme moléculaire, Corps strié, Localisation, Homme, Protein-tyrosine kinase, Rat, Animal, Personne âgée, Expression génique, Facteur croissance nerf, Aminoacide, Cholérétique, Hépatoprotecteur, Site fixation, Récepteur trk.
Wicri :
- topic : Homme, Personne âgée.

English descriptors

KwdEn :
- Alzheimer disease, Aminoacid, Animal, Binding site, Choleretic, Corpus striatum, Elderly, Gene expression, Hepatoprotector, Human, Localization, Molecular form, Nerve growth factor, Parkinson disease, Protein-tyrosine kinase, Rat.

Abstract

The TrkAII tyrosine kinase receptor differs from the TrkAI isoform by an insertion of six amino acids in the extracellular domain. We used RT-PCR to determine their respective distribution in rat and human brain. Only trkAII transcripts were detected in 12 rat brain regions, while both trkAI and trkAII transcripts were detected in the cerebellum and pituitary gland. In human, both trkAI and trkAII transcripts were detected in the frontal, temporal, and occipital cortex and thalamus, while only trkAI transcripts were detected in the hippocampus and cerebellum. In the caudate and putamen, trkAII transcripts were exclusively detected. Thereafter, we studied the expression of TrkA isoforms in the striatum of five patients with Alzheimer's disease (AD), four patients with non-AD dementia, seven patients with Parkinson's disease, and six paired nondemented elderly control individuals. In controls and non-AD patients, a constant expression of trkAII transcripts was detected within all striatum parts. In AD patients, a heterogeneous decrease in trkAII expression was observed in the caudate, putamen, and ventral striatum, resulting either in a drop of trkAII transcript levels or in a weak coamplification of trkAII and trkAI transcripts. The alteration of TrkAII gene expression paralleled those of choline acetyltransferase. Together with previous data, this suggests that the alteration of trk gene expression could contribute to a decrease in NGF binding sites and its protective effects on cholinergic neurons of AD patients.

A01	`01`	`1`		`@0 0014-4886`
A02	`01`			`@0 EXNEAC`
A03		`1`		`@0 Exp. neurol. : (Print)`
A05				`@2 165`
A06				`@2 2`
A08	`01`	`1`	`ENG`	`@1 Expression of Trk isoforms in brain regions and in the striatum of patients with Alzheimer's disease`
A11	`01`	`1`		`@1 DUBUS (Pierre)`
A11	`02`	`1`		`@1 FAUCHEUX (Baptiste)`
A11	`03`	`1`		`@1 BOISSIERE (Florence)`
A11	`04`	`1`		`@1 GROPPI (Alexis)`
A11	`05`	`1`		`@1 VITAL (Claude)`
A11	`06`	`1`		`@1 VITAL (T. Anne)`
A11	`07`	`1`		`@1 AGID (Yves)`
A11	`08`	`1`		`@1 HIRSCH (Etienne C.)`
A11	`09`	`1`		`@1 MERLIO (Jean Philippe)`
A14	`01`			`@1 Laboratoire d'Histologie-Embryologie, EA 2406 Université de Bordeaux 2, BP 8 @2 33076 Bordeaux @3 FRA @Z 1 aut. @Z 4 aut. @Z 9 aut.`
A14	`02`			`@1 INSERM U289, Hôpital de la Salpêtrière @2 75651 Paris @3 FRA @Z 2 aut. @Z 3 aut. @Z 7 aut. @Z 8 aut.`
A14	`03`			`@1 Service d'Anatomie Pathologique, Hôpital Pellegrin @2 33076 Bordeaux @3 FRA @Z 5 aut. @Z 6 aut.`
A20				`@1 285-294`
A21				`@1 2000`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 9181 @5 354000091146470090`
A44				`@0 0000 @1 © 2000 INIST-CNRS. All rights reserved.`
A45				`@0 61 ref.`
A47	`01`	`1`		`@0 00-0529868`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Experimental neurology : (Print)`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 The TrkAII tyrosine kinase receptor differs from the TrkAI isoform by an insertion of six amino acids in the extracellular domain. We used RT-PCR to determine their respective distribution in rat and human brain. Only trkAII transcripts were detected in 12 rat brain regions, while both trkAI and trkAII transcripts were detected in the cerebellum and pituitary gland. In human, both trkAI and trkAII transcripts were detected in the frontal, temporal, and occipital cortex and thalamus, while only trkAI transcripts were detected in the hippocampus and cerebellum. In the caudate and putamen, trkAII transcripts were exclusively detected. Thereafter, we studied the expression of TrkA isoforms in the striatum of five patients with Alzheimer's disease (AD), four patients with non-AD dementia, seven patients with Parkinson's disease, and six paired nondemented elderly control individuals. In controls and non-AD patients, a constant expression of trkAII transcripts was detected within all striatum parts. In AD patients, a heterogeneous decrease in trkAII expression was observed in the caudate, putamen, and ventral striatum, resulting either in a drop of trkAII transcript levels or in a weak coamplification of trkAII and trkAI transcripts. The alteration of TrkAII gene expression paralleled those of choline acetyltransferase. Together with previous data, this suggests that the alteration of trk gene expression could contribute to a decrease in NGF binding sites and its protective effects on cholinergic neurons of AD patients.
C02	`01`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Démence Alzheimer @5 01`
C03	`01`	`X`	`ENG`	`@0 Alzheimer disease @5 01`
C03	`01`	`X`	`SPA`	`@0 Demencia Alzheimer @5 01`
C03	`02`	`X`	`FRE`	`@0 Parkinson maladie @5 04`
C03	`02`	`X`	`ENG`	`@0 Parkinson disease @5 04`
C03	`02`	`X`	`SPA`	`@0 Parkinson enfermedad @5 04`
C03	`03`	`X`	`FRE`	`@0 Forme moléculaire @5 07`
C03	`03`	`X`	`ENG`	`@0 Molecular form @5 07`
C03	`03`	`X`	`SPA`	`@0 Forma molecular @5 07`
C03	`04`	`X`	`FRE`	`@0 Corps strié @5 10`
C03	`04`	`X`	`ENG`	`@0 Corpus striatum @5 10`
C03	`04`	`X`	`SPA`	`@0 Cuerpo estriado @5 10`
C03	`05`	`X`	`FRE`	`@0 Localisation @5 13`
C03	`05`	`X`	`ENG`	`@0 Localization @5 13`
C03	`05`	`X`	`SPA`	`@0 Localización @5 13`
C03	`06`	`X`	`FRE`	`@0 Homme @5 17`
C03	`06`	`X`	`ENG`	`@0 Human @5 17`
C03	`06`	`X`	`SPA`	`@0 Hombre @5 17`
C03	`07`	`X`	`FRE`	`@0 Protein-tyrosine kinase @2 FE @5 19`
C03	`07`	`X`	`ENG`	`@0 Protein-tyrosine kinase @2 FE @5 19`
C03	`07`	`X`	`SPA`	`@0 Protein-tyrosine kinase @2 FE @5 19`
C03	`08`	`X`	`FRE`	`@0 Rat @5 20`
C03	`08`	`X`	`ENG`	`@0 Rat @5 20`
C03	`08`	`X`	`SPA`	`@0 Rata @5 20`
C03	`09`	`X`	`FRE`	`@0 Animal @5 21`
C03	`09`	`X`	`ENG`	`@0 Animal @5 21`
C03	`09`	`X`	`SPA`	`@0 Animal @5 21`
C03	`10`	`X`	`FRE`	`@0 Personne âgée @5 22`
C03	`10`	`X`	`ENG`	`@0 Elderly @5 22`
C03	`10`	`X`	`SPA`	`@0 Anciano @5 22`
C03	`11`	`X`	`FRE`	`@0 Expression génique @5 23`
C03	`11`	`X`	`ENG`	`@0 Gene expression @5 23`
C03	`11`	`X`	`SPA`	`@0 Expresión genética @5 23`
C03	`12`	`X`	`FRE`	`@0 Facteur croissance nerf @5 24`
C03	`12`	`X`	`ENG`	`@0 Nerve growth factor @5 24`
C03	`12`	`X`	`SPA`	`@0 Factor crecimiento nervio @5 24`
C03	`13`	`X`	`FRE`	`@0 Aminoacide @5 25`
C03	`13`	`X`	`ENG`	`@0 Aminoacid @5 25`
C03	`13`	`X`	`SPA`	`@0 Aminoácido @5 25`
C03	`14`	`X`	`FRE`	`@0 Cholérétique @5 26`
C03	`14`	`X`	`ENG`	`@0 Choleretic @5 26`
C03	`14`	`X`	`SPA`	`@0 Colerético @5 26`
C03	`15`	`X`	`FRE`	`@0 Hépatoprotecteur @5 27`
C03	`15`	`X`	`ENG`	`@0 Hepatoprotector @5 27`
C03	`15`	`X`	`SPA`	`@0 Hepatoprotector @5 27`
C03	`16`	`X`	`FRE`	`@0 Site fixation @5 35`
C03	`16`	`X`	`ENG`	`@0 Binding site @5 35`
C03	`16`	`X`	`SPA`	`@0 Sitio fijación @5 35`
C03	`17`	`X`	`FRE`	`@0 Récepteur trk @4 INC @5 86`
C07	`01`	`X`	`FRE`	`@0 Transferases @2 FE`
C07	`01`	`X`	`ENG`	`@0 Transferases @2 FE`
C07	`01`	`X`	`SPA`	`@0 Transferases @2 FE`
C07	`02`	`X`	`FRE`	`@0 Enzyme`
C07	`02`	`X`	`ENG`	`@0 Enzyme`
C07	`02`	`X`	`SPA`	`@0 Enzima`
C07	`03`	`X`	`FRE`	`@0 Rodentia @2 NS`
C07	`03`	`X`	`ENG`	`@0 Rodentia @2 NS`
C07	`03`	`X`	`SPA`	`@0 Rodentia @2 NS`
C07	`04`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`04`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`04`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`05`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`05`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`05`	`X`	`SPA`	`@0 Vertebrata @2 NS`
C07	`06`	`X`	`FRE`	`@0 Encéphale pathologie @5 37`
C07	`06`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`06`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`07`	`X`	`FRE`	`@0 Système nerveux pathologie @5 38`
C07	`07`	`X`	`ENG`	`@0 Nervous system diseases @5 38`
C07	`07`	`X`	`SPA`	`@0 Sistema nervioso patología @5 38`
C07	`08`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 39`
C07	`08`	`X`	`ENG`	`@0 Central nervous system disease @5 39`
C07	`08`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 39`
C07	`09`	`X`	`FRE`	`@0 Maladie dégénérative @5 40`
C07	`09`	`X`	`ENG`	`@0 Degenerative disease @5 40`
C07	`09`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 40`
C07	`10`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 41`
C07	`10`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 41`
C07	`10`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 41`
N21				`@1 353`

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001298

Links to Exploration step

Pascal:00-0529868

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Expression of Trk isoforms in brain regions and in the striatum of patients with Alzheimer's disease</title>
<author><name sortKey="Dubus, Pierre" sort="Dubus, Pierre" uniqKey="Dubus P" first="Pierre" last="Dubus">Pierre Dubus</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratoire d'Histologie-Embryologie, EA 2406 Université de Bordeaux 2, BP 8</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Faucheux, Baptiste" sort="Faucheux, Baptiste" uniqKey="Faucheux B" first="Baptiste" last="Faucheux">Baptiste Faucheux</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s2>75651 Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Boissiere, Florence" sort="Boissiere, Florence" uniqKey="Boissiere F" first="Florence" last="Boissiere">Florence Boissiere</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s2>75651 Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Groppi, Alexis" sort="Groppi, Alexis" uniqKey="Groppi A" first="Alexis" last="Groppi">Alexis Groppi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratoire d'Histologie-Embryologie, EA 2406 Université de Bordeaux 2, BP 8</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Vital, Claude" sort="Vital, Claude" uniqKey="Vital C" first="Claude" last="Vital">Claude Vital</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service d'Anatomie Pathologique, Hôpital Pellegrin</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Vital, T Anne" sort="Vital, T Anne" uniqKey="Vital T" first="T. Anne" last="Vital">T. Anne Vital</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service d'Anatomie Pathologique, Hôpital Pellegrin</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s2>75651 Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s2>75651 Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Merlio, Jean Philippe" sort="Merlio, Jean Philippe" uniqKey="Merlio J" first="Jean Philippe" last="Merlio">Jean Philippe Merlio</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratoire d'Histologie-Embryologie, EA 2406 Université de Bordeaux 2, BP 8</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">00-0529868</idno>
<date when="2000">2000</date>
<idno type="stanalyst">PASCAL 00-0529868 INIST</idno>
<idno type="RBID">Pascal:00-0529868</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001298</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000140</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Expression of Trk isoforms in brain regions and in the striatum of patients with Alzheimer's disease</title>
<author><name sortKey="Dubus, Pierre" sort="Dubus, Pierre" uniqKey="Dubus P" first="Pierre" last="Dubus">Pierre Dubus</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratoire d'Histologie-Embryologie, EA 2406 Université de Bordeaux 2, BP 8</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Faucheux, Baptiste" sort="Faucheux, Baptiste" uniqKey="Faucheux B" first="Baptiste" last="Faucheux">Baptiste Faucheux</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s2>75651 Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Boissiere, Florence" sort="Boissiere, Florence" uniqKey="Boissiere F" first="Florence" last="Boissiere">Florence Boissiere</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s2>75651 Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Groppi, Alexis" sort="Groppi, Alexis" uniqKey="Groppi A" first="Alexis" last="Groppi">Alexis Groppi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratoire d'Histologie-Embryologie, EA 2406 Université de Bordeaux 2, BP 8</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Vital, Claude" sort="Vital, Claude" uniqKey="Vital C" first="Claude" last="Vital">Claude Vital</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service d'Anatomie Pathologique, Hôpital Pellegrin</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Vital, T Anne" sort="Vital, T Anne" uniqKey="Vital T" first="T. Anne" last="Vital">T. Anne Vital</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service d'Anatomie Pathologique, Hôpital Pellegrin</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s2>75651 Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s2>75651 Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Merlio, Jean Philippe" sort="Merlio, Jean Philippe" uniqKey="Merlio J" first="Jean Philippe" last="Merlio">Jean Philippe Merlio</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratoire d'Histologie-Embryologie, EA 2406 Université de Bordeaux 2, BP 8</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Experimental neurology : (Print)</title>
<title level="j" type="abbreviated">Exp. neurol. : (Print)</title>
<idno type="ISSN">0014-4886</idno>
<imprint><date when="2000">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Experimental neurology : (Print)</title>
<title level="j" type="abbreviated">Exp. neurol. : (Print)</title>
<idno type="ISSN">0014-4886</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term>
<term>Aminoacid</term>
<term>Animal</term>
<term>Binding site</term>
<term>Choleretic</term>
<term>Corpus striatum</term>
<term>Elderly</term>
<term>Gene expression</term>
<term>Hepatoprotector</term>
<term>Human</term>
<term>Localization</term>
<term>Molecular form</term>
<term>Nerve growth factor</term>
<term>Parkinson disease</term>
<term>Protein-tyrosine kinase</term>
<term>Rat</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Démence Alzheimer</term>
<term>Parkinson maladie</term>
<term>Forme moléculaire</term>
<term>Corps strié</term>
<term>Localisation</term>
<term>Homme</term>
<term>Protein-tyrosine kinase</term>
<term>Rat</term>
<term>Animal</term>
<term>Personne âgée</term>
<term>Expression génique</term>
<term>Facteur croissance nerf</term>
<term>Aminoacide</term>
<term>Cholérétique</term>
<term>Hépatoprotecteur</term>
<term>Site fixation</term>
<term>Récepteur trk</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
<term>Personne âgée</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The TrkAII tyrosine kinase receptor differs from the TrkAI isoform by an insertion of six amino acids in the extracellular domain. We used RT-PCR to determine their respective distribution in rat and human brain. Only trkAII transcripts were detected in 12 rat brain regions, while both trkAI and trkAII transcripts were detected in the cerebellum and pituitary gland. In human, both trkAI and trkAII transcripts were detected in the frontal, temporal, and occipital cortex and thalamus, while only trkAI transcripts were detected in the hippocampus and cerebellum. In the caudate and putamen, trkAII transcripts were exclusively detected. Thereafter, we studied the expression of TrkA isoforms in the striatum of five patients with Alzheimer's disease (AD), four patients with non-AD dementia, seven patients with Parkinson's disease, and six paired nondemented elderly control individuals. In controls and non-AD patients, a constant expression of trkAII transcripts was detected within all striatum parts. In AD patients, a heterogeneous decrease in trkAII expression was observed in the caudate, putamen, and ventral striatum, resulting either in a drop of trkAII transcript levels or in a weak coamplification of trkAII and trkAI transcripts. The alteration of TrkAII gene expression paralleled those of choline acetyltransferase. Together with previous data, this suggests that the alteration of trk gene expression could contribute to a decrease in NGF binding sites and its protective effects on cholinergic neurons of AD patients.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0014-4886</s0>
</fA01>
<fA02 i1="01"><s0>EXNEAC</s0>
</fA02>
<fA03 i2="1"><s0>Exp. neurol. : (Print)</s0>
</fA03>
<fA05><s2>165</s2>
</fA05>
<fA06><s2>2</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Expression of Trk isoforms in brain regions and in the striatum of patients with Alzheimer's disease</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>DUBUS (Pierre)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>FAUCHEUX (Baptiste)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>BOISSIERE (Florence)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>GROPPI (Alexis)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>VITAL (Claude)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>VITAL (T. Anne)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>AGID (Yves)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>HIRSCH (Etienne C.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>MERLIO (Jean Philippe)</s1>
</fA11>
<fA14 i1="01"><s1>Laboratoire d'Histologie-Embryologie, EA 2406 Université de Bordeaux 2, BP 8</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s2>75651 Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Service d'Anatomie Pathologique, Hôpital Pellegrin</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA20><s1>285-294</s1>
</fA20>
<fA21><s1>2000</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>9181</s2>
<s5>354000091146470090</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2000 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>61 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>00-0529868</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Experimental neurology : (Print)</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>The TrkAII tyrosine kinase receptor differs from the TrkAI isoform by an insertion of six amino acids in the extracellular domain. We used RT-PCR to determine their respective distribution in rat and human brain. Only trkAII transcripts were detected in 12 rat brain regions, while both trkAI and trkAII transcripts were detected in the cerebellum and pituitary gland. In human, both trkAI and trkAII transcripts were detected in the frontal, temporal, and occipital cortex and thalamus, while only trkAI transcripts were detected in the hippocampus and cerebellum. In the caudate and putamen, trkAII transcripts were exclusively detected. Thereafter, we studied the expression of TrkA isoforms in the striatum of five patients with Alzheimer's disease (AD), four patients with non-AD dementia, seven patients with Parkinson's disease, and six paired nondemented elderly control individuals. In controls and non-AD patients, a constant expression of trkAII transcripts was detected within all striatum parts. In AD patients, a heterogeneous decrease in trkAII expression was observed in the caudate, putamen, and ventral striatum, resulting either in a drop of trkAII transcript levels or in a weak coamplification of trkAII and trkAI transcripts. The alteration of TrkAII gene expression paralleled those of choline acetyltransferase. Together with previous data, this suggests that the alteration of trk gene expression could contribute to a decrease in NGF binding sites and its protective effects on cholinergic neurons of AD patients.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Démence Alzheimer</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Alzheimer disease</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Demencia Alzheimer</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>04</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Forme moléculaire</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Molecular form</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Forma molecular</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Corps strié</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Corpus striatum</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Cuerpo estriado</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Localisation</s0>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Localization</s0>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Localización</s0>
<s5>13</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Homme</s0>
<s5>17</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Human</s0>
<s5>17</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Hombre</s0>
<s5>17</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Protein-tyrosine kinase</s0>
<s2>FE</s2>
<s5>19</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Protein-tyrosine kinase</s0>
<s2>FE</s2>
<s5>19</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Protein-tyrosine kinase</s0>
<s2>FE</s2>
<s5>19</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Rat</s0>
<s5>20</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Rat</s0>
<s5>20</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Rata</s0>
<s5>20</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Animal</s0>
<s5>21</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Animal</s0>
<s5>21</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Animal</s0>
<s5>21</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Personne âgée</s0>
<s5>22</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Elderly</s0>
<s5>22</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Anciano</s0>
<s5>22</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Expression génique</s0>
<s5>23</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Gene expression</s0>
<s5>23</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Expresión genética</s0>
<s5>23</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Facteur croissance nerf</s0>
<s5>24</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Nerve growth factor</s0>
<s5>24</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Factor crecimiento nervio</s0>
<s5>24</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Aminoacide</s0>
<s5>25</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Aminoacid</s0>
<s5>25</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Aminoácido</s0>
<s5>25</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Cholérétique</s0>
<s5>26</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Choleretic</s0>
<s5>26</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Colerético</s0>
<s5>26</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Hépatoprotecteur</s0>
<s5>27</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG"><s0>Hepatoprotector</s0>
<s5>27</s5>
</fC03>
<fC03 i1="15" i2="X" l="SPA"><s0>Hepatoprotector</s0>
<s5>27</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>Site fixation</s0>
<s5>35</s5>
</fC03>
<fC03 i1="16" i2="X" l="ENG"><s0>Binding site</s0>
<s5>35</s5>
</fC03>
<fC03 i1="16" i2="X" l="SPA"><s0>Sitio fijación</s0>
<s5>35</s5>
</fC03>
<fC03 i1="17" i2="X" l="FRE"><s0>Récepteur trk</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Transferases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Transferases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Transferases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Enzyme</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Enzyme</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Enzima</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>40</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>40</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>41</s5>
</fC07>
<fN21><s1>353</s1>
</fN21>
</pA>
</standard>
</inist>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PascalFrancis/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000140 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Curation/biblio.hfd -nk 000140 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    PascalFrancis
   |étape=   Curation
   |type=    RBID
   |clé=     Pascal:00-0529868
   |texte=   Expression of Trk isoforms in brain regions and in the striatum of patients with Alzheimer's disease
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Expression of Trk isoforms in brain regions and in the striatum of patients with Alzheimer's disease

Expression of Trk isoforms in brain regions and in the striatum of patients with Alzheimer's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri