ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 000C18

Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method

Identifieur interne : 000C18 ( PascalFrancis/Corpus ); précédent : 000C17; suivant : 000C19

Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method

Auteurs : C. Haegelen ; M. Verin ; B. Aubert Broche ; F. Prigent ; P. Jannin ; B. Gibaud ; X. Morandi

Source :

Surgical and radiologic anatomy : (Print) [ 0930-1038 ] ; 2005.

RBID : Pascal:06-0041826

Descripteurs français

Pascal (Inist)
- Noyau sousthalamique, Stimulation, Frontal, Tomoscintigraphie émission monophotonique, Manuel, Segmentation, Méthodologie, Méthode, Encéphale, Cerveau, Système limbique, Imagerie RMN, Médecine, Chirurgie, Traitement.

English descriptors

KwdEn :
- Brain, Encephalon, Frontal, Limbic system, Manuals, Medicine, Method, Methodology, Nuclear magnetic resonance imaging, Segmentation, Single photon emission tomography, Stimulation, Subthalamic nucleus, Surgery, Treatment.

Abstract

Among the basal ganglia nuclei, the subthalamic nucleus (STN) is considered to play a major role in output modulation. The STN represents a relay of the motor cortico-basal ganglia-thalamo-cortical circuit and has become the standard surgical target for treating Parkinson's patients with long-term motor fluctuations and dyskinesia. But chronic bilateral stimulation of the STN produces cognitive effects. According to animal and clinical studies, the STN also appears to have direct or indirect connections with the frontal associative and limbic areas. This prospective study was conducted to analyse regional cerebral blood flow changes in single-photon emission computed tomography imaging of six Parkinson's patients before and after STN stimulation. We particularly focused on the dorsolateral prefrontal cortex and the frontal limbic areas using a manual anatomical MRI segmentation method. We defined nine regions of interest, segmenting each MR slice to quantify the regional cerebral blood flow on pre- and postoperative SPECT images. We normalised the region-of-interest-based measurements to the entire brain volume. The, patients showed increased activation during STN stimulation in the dorsolateral prefrontal cortex bilaterally and no change in the anterior cingulate and orbitofrontal cortices. In our study, STN stimulation induced activation of premotor and associative frontal areas. Further studies are needed to underline involvement of the STN with the so-called limbic system.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 06-0041826 INIST
ET :	Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method
AU :	HAEGELEN (C.); VERIN (M.); BROCHE (B. Aubert); PRIGENT (F.); JANNIN (P.); GIBAUD (B.); MORANDI (X.)
AF :	Service de Neurochirurgie, Hôpital Pontchaillou, rue Henri Le Guilloux/35033 Rennes/France (1 aut.); Faculté de Médecine de Rennes, Avenue du Professeur Léon Bernard. Laboratoire IDM-UPRES-EA3192/35043 Rennes/France (1 aut., 3 aut., 5 aut., 6 aut., 7 aut.); Service de Neurologie, Hôpital Pontchaillou, rue Henri Le Guilloux/35033 Rennes/France (2 aut.); Département de Médecine Nucléaire, Centre Eugène Marquis, Avenue Bataille Flandres-Dunkerque/35042 Rennes/France (4 aut.); Faculté de Médecine de Rennes, Avenue du Professeur Léon Bernard, Laboratoire d'Anatomie et d'Organogenèse/35043 Rennes/France (7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Surgical and radiologic anatomy : (Print); ISSN 0930-1038; Allemagne; Da. 2005; Vol. 27; No. 5; Pp. 389-394; Bibl. 41 ref.
LA :	Anglais
EA :	Among the basal ganglia nuclei, the subthalamic nucleus (STN) is considered to play a major role in output modulation. The STN represents a relay of the motor cortico-basal ganglia-thalamo-cortical circuit and has become the standard surgical target for treating Parkinson's patients with long-term motor fluctuations and dyskinesia. But chronic bilateral stimulation of the STN produces cognitive effects. According to animal and clinical studies, the STN also appears to have direct or indirect connections with the frontal associative and limbic areas. This prospective study was conducted to analyse regional cerebral blood flow changes in single-photon emission computed tomography imaging of six Parkinson's patients before and after STN stimulation. We particularly focused on the dorsolateral prefrontal cortex and the frontal limbic areas using a manual anatomical MRI segmentation method. We defined nine regions of interest, segmenting each MR slice to quantify the regional cerebral blood flow on pre- and postoperative SPECT images. We normalised the region-of-interest-based measurements to the entire brain volume. The, patients showed increased activation during STN stimulation in the dorsolateral prefrontal cortex bilaterally and no change in the anterior cingulate and orbitofrontal cortices. In our study, STN stimulation induced activation of premotor and associative frontal areas. Further studies are needed to underline involvement of the STN with the so-called limbic system.
CC :	002B01
FD :	Noyau sousthalamique; Stimulation; Frontal; Tomoscintigraphie émission monophotonique; Manuel; Segmentation; Méthodologie; Méthode; Encéphale; Cerveau; Système limbique; Imagerie RMN; Médecine; Chirurgie; Traitement
FG :	Exploration radioisotopique; Imagerie médicale
ED :	Subthalamic nucleus; Stimulation; Frontal; Single photon emission tomography; Manuals; Segmentation; Methodology; Method; Encephalon; Brain; Limbic system; Nuclear magnetic resonance imaging; Medicine; Surgery; Treatment
EG :	Radionuclide study; Medical imagery
SD :	Núcleo subtalámico; Estimulación; Frontal; Tomografía emisión fotón único; Manual; Segmentación; Metodología; Método; Encéfalo; Cerebro; Sistema límbico; Imaginería RMN; Medicina; Cirugía; Tratamiento
LO :	INIST-26994.354000135413300070
ID :	06-0041826

Links to Exploration step

Pascal:06-0041826

Le document en format XML

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<term>Medicine</term>
<term>Method</term>
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<term>Nuclear magnetic resonance imaging</term>
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<term>Single photon emission tomography</term>
<term>Stimulation</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Noyau sousthalamique</term>
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<term>Tomoscintigraphie émission monophotonique</term>
<term>Manuel</term>
<term>Segmentation</term>
<term>Méthodologie</term>
<term>Méthode</term>
<term>Encéphale</term>
<term>Cerveau</term>
<term>Système limbique</term>
<term>Imagerie RMN</term>
<term>Médecine</term>
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<front><div type="abstract" xml:lang="en">Among the basal ganglia nuclei, the subthalamic nucleus (STN) is considered to play a major role in output modulation. The STN represents a relay of the motor cortico-basal ganglia-thalamo-cortical circuit and has become the standard surgical target for treating Parkinson's patients with long-term motor fluctuations and dyskinesia. But chronic bilateral stimulation of the STN produces cognitive effects. According to animal and clinical studies, the STN also appears to have direct or indirect connections with the frontal associative and limbic areas. This prospective study was conducted to analyse regional cerebral blood flow changes in single-photon emission computed tomography imaging of six Parkinson's patients before and after STN stimulation. We particularly focused on the dorsolateral prefrontal cortex and the frontal limbic areas using a manual anatomical MRI segmentation method. We defined nine regions of interest, segmenting each MR slice to quantify the regional cerebral blood flow on pre- and postoperative SPECT images. We normalised the region-of-interest-based measurements to the entire brain volume. The, patients showed increased activation during STN stimulation in the dorsolateral prefrontal cortex bilaterally and no change in the anterior cingulate and orbitofrontal cortices. In our study, STN stimulation induced activation of premotor and associative frontal areas. Further studies are needed to underline involvement of the STN with the so-called limbic system.</div>
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<fA06><s2>5</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method</s1>
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<fA11 i1="01" i2="1"><s1>HAEGELEN (C.)</s1>
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<fA11 i1="02" i2="1"><s1>VERIN (M.)</s1>
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<fA11 i1="06" i2="1"><s1>GIBAUD (B.)</s1>
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<fA11 i1="07" i2="1"><s1>MORANDI (X.)</s1>
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<fA14 i1="01"><s1>Service de Neurochirurgie, Hôpital Pontchaillou, rue Henri Le Guilloux</s1>
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<s3>FRA</s3>
<sZ>1 aut.</sZ>
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<fA14 i1="02"><s1>Faculté de Médecine de Rennes, Avenue du Professeur Léon Bernard. Laboratoire IDM-UPRES-EA3192</s1>
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<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
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<fA14 i1="03"><s1>Service de Neurologie, Hôpital Pontchaillou, rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
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<fA14 i1="04"><s1>Département de Médecine Nucléaire, Centre Eugène Marquis, Avenue Bataille Flandres-Dunkerque</s1>
<s2>35042 Rennes</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
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<fA14 i1="05"><s1>Faculté de Médecine de Rennes, Avenue du Professeur Léon Bernard, Laboratoire d'Anatomie et d'Organogenèse</s1>
<s2>35043 Rennes</s2>
<s3>FRA</s3>
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<fA20><s1>389-394</s1>
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<fA21><s1>2005</s1>
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<fC03 i1="01" i2="X" l="FRE"><s0>Noyau sousthalamique</s0>
<s5>02</s5>
</fC03>
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<s5>02</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Núcleo subtalámico</s0>
<s5>02</s5>
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<s5>03</s5>
</fC03>
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<s5>03</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Estimulación</s0>
<s5>03</s5>
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<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Frontal</s0>
<s5>05</s5>
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<s5>05</s5>
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<s5>09</s5>
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<s5>12</s5>
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<s5>14</s5>
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<s5>14</s5>
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<s5>15</s5>
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<s5>15</s5>
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<s5>15</s5>
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<s5>17</s5>
</fC03>
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<s5>17</s5>
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<s5>17</s5>
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<s5>18</s5>
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<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Imaginería RMN</s0>
<s5>18</s5>
</fC03>
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<s5>19</s5>
</fC03>
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<s5>19</s5>
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<s5>19</s5>
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<s5>20</s5>
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<fC03 i1="14" i2="X" l="ENG"><s0>Surgery</s0>
<s5>20</s5>
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<fC03 i1="14" i2="X" l="SPA"><s0>Cirugía</s0>
<s5>20</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Traitement</s0>
<s5>25</s5>
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<fC03 i1="15" i2="X" l="ENG"><s0>Treatment</s0>
<s5>25</s5>
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<fC03 i1="15" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>25</s5>
</fC03>
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<s5>37</s5>
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<s5>37</s5>
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<s5>37</s5>
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<s5>38</s5>
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<fC07 i1="02" i2="X" l="SPA"><s0>Imaginería médica</s0>
<s5>38</s5>
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<ET>Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method</ET>
<AU>HAEGELEN (C.); VERIN (M.); BROCHE (B. Aubert); PRIGENT (F.); JANNIN (P.); GIBAUD (B.); MORANDI (X.)</AU>
<AF>Service de Neurochirurgie, Hôpital Pontchaillou, rue Henri Le Guilloux/35033 Rennes/France (1 aut.); Faculté de Médecine de Rennes, Avenue du Professeur Léon Bernard. Laboratoire IDM-UPRES-EA3192/35043 Rennes/France (1 aut., 3 aut., 5 aut., 6 aut., 7 aut.); Service de Neurologie, Hôpital Pontchaillou, rue Henri Le Guilloux/35033 Rennes/France (2 aut.); Département de Médecine Nucléaire, Centre Eugène Marquis, Avenue Bataille Flandres-Dunkerque/35042 Rennes/France (4 aut.); Faculté de Médecine de Rennes, Avenue du Professeur Léon Bernard, Laboratoire d'Anatomie et d'Organogenèse/35043 Rennes/France (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Surgical and radiologic anatomy : (Print); ISSN 0930-1038; Allemagne; Da. 2005; Vol. 27; No. 5; Pp. 389-394; Bibl. 41 ref.</SO>
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<EA>Among the basal ganglia nuclei, the subthalamic nucleus (STN) is considered to play a major role in output modulation. The STN represents a relay of the motor cortico-basal ganglia-thalamo-cortical circuit and has become the standard surgical target for treating Parkinson's patients with long-term motor fluctuations and dyskinesia. But chronic bilateral stimulation of the STN produces cognitive effects. According to animal and clinical studies, the STN also appears to have direct or indirect connections with the frontal associative and limbic areas. This prospective study was conducted to analyse regional cerebral blood flow changes in single-photon emission computed tomography imaging of six Parkinson's patients before and after STN stimulation. We particularly focused on the dorsolateral prefrontal cortex and the frontal limbic areas using a manual anatomical MRI segmentation method. We defined nine regions of interest, segmenting each MR slice to quantify the regional cerebral blood flow on pre- and postoperative SPECT images. We normalised the region-of-interest-based measurements to the entire brain volume. The, patients showed increased activation during STN stimulation in the dorsolateral prefrontal cortex bilaterally and no change in the anterior cingulate and orbitofrontal cortices. In our study, STN stimulation induced activation of premotor and associative frontal areas. Further studies are needed to underline involvement of the STN with the so-called limbic system.</EA>
<CC>002B01</CC>
<FD>Noyau sousthalamique; Stimulation; Frontal; Tomoscintigraphie émission monophotonique; Manuel; Segmentation; Méthodologie; Méthode; Encéphale; Cerveau; Système limbique; Imagerie RMN; Médecine; Chirurgie; Traitement</FD>
<FG>Exploration radioisotopique; Imagerie médicale</FG>
<ED>Subthalamic nucleus; Stimulation; Frontal; Single photon emission tomography; Manuals; Segmentation; Methodology; Method; Encephalon; Brain; Limbic system; Nuclear magnetic resonance imaging; Medicine; Surgery; Treatment</ED>
<EG>Radionuclide study; Medical imagery</EG>
<SD>Núcleo subtalámico; Estimulación; Frontal; Tomografía emisión fotón único; Manual; Segmentación; Metodología; Método; Encéfalo; Cerebro; Sistema límbico; Imaginería RMN; Medicina; Cirugía; Tratamiento</SD>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method

Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method

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