Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method
Identifieur interne : 000C18 ( PascalFrancis/Corpus ); précédent : 000C17; suivant : 000C19Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method
Auteurs : C. Haegelen ; M. Verin ; B. Aubert Broche ; F. Prigent ; P. Jannin ; B. Gibaud ; X. MorandiSource :
- Surgical and radiologic anatomy : (Print) [ 0930-1038 ] ; 2005.
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- Pascal (Inist)
English descriptors
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Abstract
Among the basal ganglia nuclei, the subthalamic nucleus (STN) is considered to play a major role in output modulation. The STN represents a relay of the motor cortico-basal ganglia-thalamo-cortical circuit and has become the standard surgical target for treating Parkinson's patients with long-term motor fluctuations and dyskinesia. But chronic bilateral stimulation of the STN produces cognitive effects. According to animal and clinical studies, the STN also appears to have direct or indirect connections with the frontal associative and limbic areas. This prospective study was conducted to analyse regional cerebral blood flow changes in single-photon emission computed tomography imaging of six Parkinson's patients before and after STN stimulation. We particularly focused on the dorsolateral prefrontal cortex and the frontal limbic areas using a manual anatomical MRI segmentation method. We defined nine regions of interest, segmenting each MR slice to quantify the regional cerebral blood flow on pre- and postoperative SPECT images. We normalised the region-of-interest-based measurements to the entire brain volume. The, patients showed increased activation during STN stimulation in the dorsolateral prefrontal cortex bilaterally and no change in the anterior cingulate and orbitofrontal cortices. In our study, STN stimulation induced activation of premotor and associative frontal areas. Further studies are needed to underline involvement of the STN with the so-called limbic system.
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NO : | PASCAL 06-0041826 INIST |
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ET : | Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method |
AU : | HAEGELEN (C.); VERIN (M.); BROCHE (B. Aubert); PRIGENT (F.); JANNIN (P.); GIBAUD (B.); MORANDI (X.) |
AF : | Service de Neurochirurgie, Hôpital Pontchaillou, rue Henri Le Guilloux/35033 Rennes/France (1 aut.); Faculté de Médecine de Rennes, Avenue du Professeur Léon Bernard. Laboratoire IDM-UPRES-EA3192/35043 Rennes/France (1 aut., 3 aut., 5 aut., 6 aut., 7 aut.); Service de Neurologie, Hôpital Pontchaillou, rue Henri Le Guilloux/35033 Rennes/France (2 aut.); Département de Médecine Nucléaire, Centre Eugène Marquis, Avenue Bataille Flandres-Dunkerque/35042 Rennes/France (4 aut.); Faculté de Médecine de Rennes, Avenue du Professeur Léon Bernard, Laboratoire d'Anatomie et d'Organogenèse/35043 Rennes/France (7 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Surgical and radiologic anatomy : (Print); ISSN 0930-1038; Allemagne; Da. 2005; Vol. 27; No. 5; Pp. 389-394; Bibl. 41 ref. |
LA : | Anglais |
EA : | Among the basal ganglia nuclei, the subthalamic nucleus (STN) is considered to play a major role in output modulation. The STN represents a relay of the motor cortico-basal ganglia-thalamo-cortical circuit and has become the standard surgical target for treating Parkinson's patients with long-term motor fluctuations and dyskinesia. But chronic bilateral stimulation of the STN produces cognitive effects. According to animal and clinical studies, the STN also appears to have direct or indirect connections with the frontal associative and limbic areas. This prospective study was conducted to analyse regional cerebral blood flow changes in single-photon emission computed tomography imaging of six Parkinson's patients before and after STN stimulation. We particularly focused on the dorsolateral prefrontal cortex and the frontal limbic areas using a manual anatomical MRI segmentation method. We defined nine regions of interest, segmenting each MR slice to quantify the regional cerebral blood flow on pre- and postoperative SPECT images. We normalised the region-of-interest-based measurements to the entire brain volume. The, patients showed increased activation during STN stimulation in the dorsolateral prefrontal cortex bilaterally and no change in the anterior cingulate and orbitofrontal cortices. In our study, STN stimulation induced activation of premotor and associative frontal areas. Further studies are needed to underline involvement of the STN with the so-called limbic system. |
CC : | 002B01 |
FD : | Noyau sousthalamique; Stimulation; Frontal; Tomoscintigraphie émission monophotonique; Manuel; Segmentation; Méthodologie; Méthode; Encéphale; Cerveau; Système limbique; Imagerie RMN; Médecine; Chirurgie; Traitement |
FG : | Exploration radioisotopique; Imagerie médicale |
ED : | Subthalamic nucleus; Stimulation; Frontal; Single photon emission tomography; Manuals; Segmentation; Methodology; Method; Encephalon; Brain; Limbic system; Nuclear magnetic resonance imaging; Medicine; Surgery; Treatment |
EG : | Radionuclide study; Medical imagery |
SD : | Núcleo subtalámico; Estimulación; Frontal; Tomografía emisión fotón único; Manual; Segmentación; Metodología; Método; Encéfalo; Cerebro; Sistema límbico; Imaginería RMN; Medicina; Cirugía; Tratamiento |
LO : | INIST-26994.354000135413300070 |
ID : | 06-0041826 |
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<front><div type="abstract" xml:lang="en">Among the basal ganglia nuclei, the subthalamic nucleus (STN) is considered to play a major role in output modulation. The STN represents a relay of the motor cortico-basal ganglia-thalamo-cortical circuit and has become the standard surgical target for treating Parkinson's patients with long-term motor fluctuations and dyskinesia. But chronic bilateral stimulation of the STN produces cognitive effects. According to animal and clinical studies, the STN also appears to have direct or indirect connections with the frontal associative and limbic areas. This prospective study was conducted to analyse regional cerebral blood flow changes in single-photon emission computed tomography imaging of six Parkinson's patients before and after STN stimulation. We particularly focused on the dorsolateral prefrontal cortex and the frontal limbic areas using a manual anatomical MRI segmentation method. We defined nine regions of interest, segmenting each MR slice to quantify the regional cerebral blood flow on pre- and postoperative SPECT images. We normalised the region-of-interest-based measurements to the entire brain volume. The, patients showed increased activation during STN stimulation in the dorsolateral prefrontal cortex bilaterally and no change in the anterior cingulate and orbitofrontal cortices. In our study, STN stimulation induced activation of premotor and associative frontal areas. Further studies are needed to underline involvement of the STN with the so-called limbic system.</div>
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<s5>08</s5>
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<fC03 i1="05" i2="X" l="SPA"><s0>Manual</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Segmentation</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Segmentation</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Segmentación</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Méthodologie</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Methodology</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Metodología</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Méthode</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Method</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Método</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>14</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Cerveau</s0>
<s5>15</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Brain</s0>
<s5>15</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Cerebro</s0>
<s5>15</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Système limbique</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Limbic system</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Sistema límbico</s0>
<s5>17</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Imagerie RMN</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Nuclear magnetic resonance imaging</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Imaginería RMN</s0>
<s5>18</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Médecine</s0>
<s5>19</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Medicine</s0>
<s5>19</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Medicina</s0>
<s5>19</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Chirurgie</s0>
<s5>20</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Surgery</s0>
<s5>20</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Cirugía</s0>
<s5>20</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Traitement</s0>
<s5>25</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG"><s0>Treatment</s0>
<s5>25</s5>
</fC03>
<fC03 i1="15" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>25</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Exploration radioisotopique</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Radionuclide study</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Exploración radioisotópica</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Imagerie médicale</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Medical imagery</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Imaginería médica</s0>
<s5>38</s5>
</fC07>
<fN21><s1>016</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 06-0041826 INIST</NO>
<ET>Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method</ET>
<AU>HAEGELEN (C.); VERIN (M.); BROCHE (B. Aubert); PRIGENT (F.); JANNIN (P.); GIBAUD (B.); MORANDI (X.)</AU>
<AF>Service de Neurochirurgie, Hôpital Pontchaillou, rue Henri Le Guilloux/35033 Rennes/France (1 aut.); Faculté de Médecine de Rennes, Avenue du Professeur Léon Bernard. Laboratoire IDM-UPRES-EA3192/35043 Rennes/France (1 aut., 3 aut., 5 aut., 6 aut., 7 aut.); Service de Neurologie, Hôpital Pontchaillou, rue Henri Le Guilloux/35033 Rennes/France (2 aut.); Département de Médecine Nucléaire, Centre Eugène Marquis, Avenue Bataille Flandres-Dunkerque/35042 Rennes/France (4 aut.); Faculté de Médecine de Rennes, Avenue du Professeur Léon Bernard, Laboratoire d'Anatomie et d'Organogenèse/35043 Rennes/France (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Surgical and radiologic anatomy : (Print); ISSN 0930-1038; Allemagne; Da. 2005; Vol. 27; No. 5; Pp. 389-394; Bibl. 41 ref.</SO>
<LA>Anglais</LA>
<EA>Among the basal ganglia nuclei, the subthalamic nucleus (STN) is considered to play a major role in output modulation. The STN represents a relay of the motor cortico-basal ganglia-thalamo-cortical circuit and has become the standard surgical target for treating Parkinson's patients with long-term motor fluctuations and dyskinesia. But chronic bilateral stimulation of the STN produces cognitive effects. According to animal and clinical studies, the STN also appears to have direct or indirect connections with the frontal associative and limbic areas. This prospective study was conducted to analyse regional cerebral blood flow changes in single-photon emission computed tomography imaging of six Parkinson's patients before and after STN stimulation. We particularly focused on the dorsolateral prefrontal cortex and the frontal limbic areas using a manual anatomical MRI segmentation method. We defined nine regions of interest, segmenting each MR slice to quantify the regional cerebral blood flow on pre- and postoperative SPECT images. We normalised the region-of-interest-based measurements to the entire brain volume. The, patients showed increased activation during STN stimulation in the dorsolateral prefrontal cortex bilaterally and no change in the anterior cingulate and orbitofrontal cortices. In our study, STN stimulation induced activation of premotor and associative frontal areas. Further studies are needed to underline involvement of the STN with the so-called limbic system.</EA>
<CC>002B01</CC>
<FD>Noyau sousthalamique; Stimulation; Frontal; Tomoscintigraphie émission monophotonique; Manuel; Segmentation; Méthodologie; Méthode; Encéphale; Cerveau; Système limbique; Imagerie RMN; Médecine; Chirurgie; Traitement</FD>
<FG>Exploration radioisotopique; Imagerie médicale</FG>
<ED>Subthalamic nucleus; Stimulation; Frontal; Single photon emission tomography; Manuals; Segmentation; Methodology; Method; Encephalon; Brain; Limbic system; Nuclear magnetic resonance imaging; Medicine; Surgery; Treatment</ED>
<EG>Radionuclide study; Medical imagery</EG>
<SD>Núcleo subtalámico; Estimulación; Frontal; Tomografía emisión fotón único; Manual; Segmentación; Metodología; Método; Encéfalo; Cerebro; Sistema límbico; Imaginería RMN; Medicina; Cirugía; Tratamiento</SD>
<LO>INIST-26994.354000135413300070</LO>
<ID>06-0041826</ID>
</server>
</inist>
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