ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 000696

Resonance in subthalamo-cortical circuits in Parkinson's disease

Identifieur interne : 000696 ( PascalFrancis/Corpus ); précédent : 000695; suivant : 000697

Resonance in subthalamo-cortical circuits in Parkinson's disease

Auteurs : Alexandre Eusebio ; Alek Pogosyan ; SHOUYAN WANG ; Bruno Averbeck ; Louise Doyle Gaynor ; Stéphanie Cantiniaux ; Tatiana Witjas ; Patricia Limousin ; Jean-Philippe Azulay ; Peter Brown

Source :

Brain [ 0006-8950 ] ; 2009.

RBID : Pascal:09-0335175

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Synchronisation, Noyau gris central, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Basal ganglion, Deep brain stimulation, Nervous system diseases, Parkinson disease, Synchronization.

Abstract

Neuronal activity within and across the cortex and basal ganglia is pathologically synchronized, particularly at ∼20 Hz in patients with Parkinson's disease. Defining how activities in spatially distributed brain regions overtly synchronize in narrow frequency bands is critical for understanding disease processes like Parkinson's disease. To address this, we studied cortical responses to electrical stimulation of the subthalamic nucleus (STN) at various frequencies between 5 and 30 Hz in two cohorts of eight patients with Parkinson's disease from two different surgical centres. We found that evoked activity consisted of a series of diminishing waves with a peak latency of 21 ms for the first wave in the series. The cortical evoked potentials (cEPs) averaged in each group were well fitted by a damped oscillator function (r≥0.9, P<0.00001). Fits suggested that the natural frequency of the subthalamo-cortical circuit was around 20 Hz. When the system was forced at this frequency by stimulation of the STN at 20 Hz, the undamped amplitude of the modelled cortical response increased relative to that with 5 Hz stimulation in both groups (P≤0.005), consistent with resonance. Restoration of dopaminergic input by treatment with levodopa increased the damping of oscillatory activity (as measured by the modelled damping factor) in both patient groups (P ≤0.001). The increased damping would tend to limit resonance, as confirmed in simulations. Our results show that the basal ganglia-cortical network involving the STN has a tendency to resonate at ∼20Hz in Parkinsonian patients. This resonance phenomenon may underlie the propagation and amplification of activities synchronized around this frequency. Crucially, dopamine acts to increase damping and thereby limit resonance in this basal ganglia-cortical network.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A14	`01`			`@1 Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square @2 London @3 GBR @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 5 aut. @Z 8 aut. @Z 10 aut.`
A14	`02`			`@1 Department of Neurology and Movement Disorders, Timone University Hospital @2 Marseille @3 FRA @Z 1 aut. @Z 6 aut. @Z 7 aut. @Z 9 aut.`
A14	`03`			`@1 Hearing and Balance Centre, Institute of Sound and Vibration Research, University of Southampton @3 GBR @Z 3 aut.`
A14	`04`			`@1 Unit of Functional Neurosurgery, Institute of Neurology, Queen Square @2 London @3 GBR @Z 8 aut.`
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C01	`01`		`ENG`	@0 Neuronal activity within and across the cortex and basal ganglia is pathologically synchronized, particularly at ∼20 Hz in patients with Parkinson's disease. Defining how activities in spatially distributed brain regions overtly synchronize in narrow frequency bands is critical for understanding disease processes like Parkinson's disease. To address this, we studied cortical responses to electrical stimulation of the subthalamic nucleus (STN) at various frequencies between 5 and 30 Hz in two cohorts of eight patients with Parkinson's disease from two different surgical centres. We found that evoked activity consisted of a series of diminishing waves with a peak latency of 21 ms for the first wave in the series. The cortical evoked potentials (cEPs) averaged in each group were well fitted by a damped oscillator function (r≥0.9, P<0.00001). Fits suggested that the natural frequency of the subthalamo-cortical circuit was around 20 Hz. When the system was forced at this frequency by stimulation of the STN at 20 Hz, the undamped amplitude of the modelled cortical response increased relative to that with 5 Hz stimulation in both groups (P≤0.005), consistent with resonance. Restoration of dopaminergic input by treatment with levodopa increased the damping of oscillatory activity (as measured by the modelled damping factor) in both patient groups (P ≤0.001). The increased damping would tend to limit resonance, as confirmed in simulations. Our results show that the basal ganglia-cortical network involving the STN has a tendency to resonate at ∼20Hz in Parkinsonian patients. This resonance phenomenon may underlie the propagation and amplification of activities synchronized around this frequency. Crucially, dopamine acts to increase damping and thereby limit resonance in this basal ganglia-cortical network.
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C03	`01`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 01`
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C03	`04`	`X`	`SPA`	`@0 Núcleo basal @5 10`
C03	`05`	`X`	`FRE`	`@0 Stimulation cérébrale profonde @4 CD @5 96`
C03	`05`	`X`	`ENG`	`@0 Deep brain stimulation @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
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N21				`@1 243`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 09-0335175 INIST
ET :	Resonance in subthalamo-cortical circuits in Parkinson's disease
AU :	EUSEBIO (Alexandre); POGOSYAN (Alek); SHOUYAN WANG; AVERBECK (Bruno); DOYLE GAYNOR (Louise); CANTINIAUX (Stéphanie); WITJAS (Tatiana); LIMOUSIN (Patricia); AZULAY (Jean-Philippe); BROWN (Peter)
AF :	Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square/London/Royaume-Uni (1 aut., 2 aut., 4 aut., 5 aut., 8 aut., 10 aut.); Department of Neurology and Movement Disorders, Timone University Hospital/Marseille/France (1 aut., 6 aut., 7 aut., 9 aut.); Hearing and Balance Centre, Institute of Sound and Vibration Research, University of Southampton/Royaume-Uni (3 aut.); Unit of Functional Neurosurgery, Institute of Neurology, Queen Square/London/Royaume-Uni (8 aut.)
DT :	Publication en série; Niveau analytique
SO :	Brain; ISSN 0006-8950; Royaume-Uni; Da. 2009; Vol. 132; No. p. 8; Pp. 2139-2150; Bibl. 1 p.1/2
LA :	Anglais
EA :	Neuronal activity within and across the cortex and basal ganglia is pathologically synchronized, particularly at ∼20 Hz in patients with Parkinson's disease. Defining how activities in spatially distributed brain regions overtly synchronize in narrow frequency bands is critical for understanding disease processes like Parkinson's disease. To address this, we studied cortical responses to electrical stimulation of the subthalamic nucleus (STN) at various frequencies between 5 and 30 Hz in two cohorts of eight patients with Parkinson's disease from two different surgical centres. We found that evoked activity consisted of a series of diminishing waves with a peak latency of 21 ms for the first wave in the series. The cortical evoked potentials (cEPs) averaged in each group were well fitted by a damped oscillator function (r≥0.9, P<0.00001). Fits suggested that the natural frequency of the subthalamo-cortical circuit was around 20 Hz. When the system was forced at this frequency by stimulation of the STN at 20 Hz, the undamped amplitude of the modelled cortical response increased relative to that with 5 Hz stimulation in both groups (P≤0.005), consistent with resonance. Restoration of dopaminergic input by treatment with levodopa increased the damping of oscillatory activity (as measured by the modelled damping factor) in both patient groups (P ≤0.001). The increased damping would tend to limit resonance, as confirmed in simulations. Our results show that the basal ganglia-cortical network involving the STN has a tendency to resonate at ∼20Hz in Parkinsonian patients. This resonance phenomenon may underlie the propagation and amplification of activities synchronized around this frequency. Crucially, dopamine acts to increase damping and thereby limit resonance in this basal ganglia-cortical network.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Pathologie du système nerveux; Synchronisation; Noyau gris central; Stimulation cérébrale profonde
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Encéphale; Système nerveux central
ED :	Parkinson disease; Nervous system diseases; Synchronization; Basal ganglion; Deep brain stimulation
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Encephalon; Central nervous system
SD :	Parkinson enfermedad; Sistema nervioso patología; Sincronización; Núcleo basal
LO :	INIST-998.354000170853910130
ID :	09-0335175

Links to Exploration step

Pascal:09-0335175

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Resonance in subthalamo-cortical circuits in Parkinson's disease</title>
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<author><name sortKey="Witjas, Tatiana" sort="Witjas, Tatiana" uniqKey="Witjas T" first="Tatiana" last="Witjas">Tatiana Witjas</name>
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<author><name sortKey="Limousin, Patricia" sort="Limousin, Patricia" uniqKey="Limousin P" first="Patricia" last="Limousin">Patricia Limousin</name>
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<author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name>
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<front><div type="abstract" xml:lang="en">Neuronal activity within and across the cortex and basal ganglia is pathologically synchronized, particularly at ∼20 Hz in patients with Parkinson's disease. Defining how activities in spatially distributed brain regions overtly synchronize in narrow frequency bands is critical for understanding disease processes like Parkinson's disease. To address this, we studied cortical responses to electrical stimulation of the subthalamic nucleus (STN) at various frequencies between 5 and 30 Hz in two cohorts of eight patients with Parkinson's disease from two different surgical centres. We found that evoked activity consisted of a series of diminishing waves with a peak latency of 21 ms for the first wave in the series. The cortical evoked potentials (cEPs) averaged in each group were well fitted by a damped oscillator function (r≥0.9, P<0.00001). Fits suggested that the natural frequency of the subthalamo-cortical circuit was around 20 Hz. When the system was forced at this frequency by stimulation of the STN at 20 Hz, the undamped amplitude of the modelled cortical response increased relative to that with 5 Hz stimulation in both groups (P≤0.005), consistent with resonance. Restoration of dopaminergic input by treatment with levodopa increased the damping of oscillatory activity (as measured by the modelled damping factor) in both patient groups (P ≤0.001). The increased damping would tend to limit resonance, as confirmed in simulations. Our results show that the basal ganglia-cortical network involving the STN has a tendency to resonate at ∼20Hz in Parkinsonian patients. This resonance phenomenon may underlie the propagation and amplification of activities synchronized around this frequency. Crucially, dopamine acts to increase damping and thereby limit resonance in this basal ganglia-cortical network.</div>
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<AF>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square/London/Royaume-Uni (1 aut., 2 aut., 4 aut., 5 aut., 8 aut., 10 aut.); Department of Neurology and Movement Disorders, Timone University Hospital/Marseille/France (1 aut., 6 aut., 7 aut., 9 aut.); Hearing and Balance Centre, Institute of Sound and Vibration Research, University of Southampton/Royaume-Uni (3 aut.); Unit of Functional Neurosurgery, Institute of Neurology, Queen Square/London/Royaume-Uni (8 aut.)</AF>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Resonance in subthalamo-cortical circuits in Parkinson's disease

Resonance in subthalamo-cortical circuits in Parkinson's disease

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