Melatonin is released in the third ventricle in humans. A study in movement disorders
Identifieur interne : 000598 ( PascalFrancis/Corpus ); précédent : 000597; suivant : 000599Melatonin is released in the third ventricle in humans. A study in movement disorders
Auteurs : José Leston ; Catherine Harthe ; Jocelyne Brun ; Carmine Mottolese ; Patrick Mertens ; Marc Sindou ; Bruno ClaustratSource :
- Neuroscience letters [ 0304-3940 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
In order to determine sources and metabolism of melatonin in human cerebrospinal fluid (CSF), melatonin and 6-sulfatoxymelatonin (aMT6S) concentrations were measured in CSF sampled during neurosurgery in both lateral and third ventricles in patients displaying movement disorder (Parkinson's disease, essential tremor, dystonia or dyskinesia) and compared with their plasma levels. Previous determinations in nocturnal urine had showed that the patients displayed melatonin excretion in the normal range, compared with healthy controls matched according to age. A significant difference in melatonin concentration was observed between lateral and third ventricles, with the highest levels in the third ventricle (8.75 ± 2.75 pg/ml vs. 3.20 ± 0.33 pg/ml, p = 0.01). CSF aMT6s levels were similar in both ventricles and of low magnitude, less than 5 pg/ml. They were not correlated with melatonin levels or influenced by the area of sampling. Melatonin levels were significantly higher in third ventricle than in the plasma, whereas there was no difference between plasma and lateral ventricle levels. These findings show that melatonin may enter directly the CSF through the pineal recess in humans. The physiological meaning of these data remains to be elucidated.
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Format Inist (serveur)
NO : | PASCAL 10-0147753 INIST |
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ET : | Melatonin is released in the third ventricle in humans. A study in movement disorders |
AU : | LESTON (José); HARTHE (Catherine); BRUN (Jocelyne); MOTTOLESE (Carmine); MERTENS (Patrick); SINDOU (Marc); CLAUSTRAT (Bruno) |
AF : | Neurosurgical UnitA, Stem Cell and Brain Research Institute, Department of Chronobiology/Bron/France (1 aut., 5 aut., 6 aut.); Hormone Laboratory, Centre of Nuclear Medicine, Stem Cell and Brain Research Institute, Department of Chronobiology/Bron/France (2 aut., 3 aut., 7 aut.); Neurosurgical Unit B, Stem Cell and Brain Research Institute, Department of Chronobiology/Bron/France (4 aut.); INSERM, U846, Stem Cell and Brain Research Institute, Department of Chronobiology/Bron/France (1 aut., 7 aut.) |
DT : | Publication en série; Papier de recherche; Niveau analytique |
SO : | Neuroscience letters; ISSN 0304-3940; Coden NELED5; Irlande; Da. 2010; Vol. 469; No. 3; Pp. 294-297; Bibl. 29 ref. |
LA : | Anglais |
EA : | In order to determine sources and metabolism of melatonin in human cerebrospinal fluid (CSF), melatonin and 6-sulfatoxymelatonin (aMT6S) concentrations were measured in CSF sampled during neurosurgery in both lateral and third ventricles in patients displaying movement disorder (Parkinson's disease, essential tremor, dystonia or dyskinesia) and compared with their plasma levels. Previous determinations in nocturnal urine had showed that the patients displayed melatonin excretion in the normal range, compared with healthy controls matched according to age. A significant difference in melatonin concentration was observed between lateral and third ventricles, with the highest levels in the third ventricle (8.75 ± 2.75 pg/ml vs. 3.20 ± 0.33 pg/ml, p = 0.01). CSF aMT6s levels were similar in both ventricles and of low magnitude, less than 5 pg/ml. They were not correlated with melatonin levels or influenced by the area of sampling. Melatonin levels were significantly higher in third ventricle than in the plasma, whereas there was no difference between plasma and lateral ventricle levels. These findings show that melatonin may enter directly the CSF through the pineal recess in humans. The physiological meaning of these data remains to be elucidated. |
CC : | 002A25; 002B17G |
FD : | Mélatonine; Liquide céphalorachidien; Maladie de Parkinson; Homme |
FG : | Hormone épiphysaire; Maladie dégénérative; Pathologie du système nerveux; Pathologie de l'encéphale; Syndrome extrapyramidal; Pathologie du système nerveux central |
ED : | Melatonin; Cerebrospinal fluid; Parkinson disease; Human |
EG : | Pineal hormone; Degenerative disease; Nervous system diseases; Cerebral disorder; Extrapyramidal syndrome; Central nervous system disease |
SD : | Melatonina; Líquido cefalorraquídeo; Parkinson enfermedad; Hombre |
LO : | INIST-17240.354000181452510030 |
ID : | 10-0147753 |
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Pascal:10-0147753Le document en format XML
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<front><div type="abstract" xml:lang="en">In order to determine sources and metabolism of melatonin in human cerebrospinal fluid (CSF), melatonin and 6-sulfatoxymelatonin (aMT6S) concentrations were measured in CSF sampled during neurosurgery in both lateral and third ventricles in patients displaying movement disorder (Parkinson's disease, essential tremor, dystonia or dyskinesia) and compared with their plasma levels. Previous determinations in nocturnal urine had showed that the patients displayed melatonin excretion in the normal range, compared with healthy controls matched according to age. A significant difference in melatonin concentration was observed between lateral and third ventricles, with the highest levels in the third ventricle (8.75 ± 2.75 pg/ml vs. 3.20 ± 0.33 pg/ml, p = 0.01). CSF aMT6s levels were similar in both ventricles and of low magnitude, less than 5 pg/ml. They were not correlated with melatonin levels or influenced by the area of sampling. Melatonin levels were significantly higher in third ventricle than in the plasma, whereas there was no difference between plasma and lateral ventricle levels. These findings show that melatonin may enter directly the CSF through the pineal recess in humans. The physiological meaning of these data remains to be elucidated.</div>
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<ET>Melatonin is released in the third ventricle in humans. A study in movement disorders</ET>
<AU>LESTON (José); HARTHE (Catherine); BRUN (Jocelyne); MOTTOLESE (Carmine); MERTENS (Patrick); SINDOU (Marc); CLAUSTRAT (Bruno)</AU>
<AF>Neurosurgical UnitA, Stem Cell and Brain Research Institute, Department of Chronobiology/Bron/France (1 aut., 5 aut., 6 aut.); Hormone Laboratory, Centre of Nuclear Medicine, Stem Cell and Brain Research Institute, Department of Chronobiology/Bron/France (2 aut., 3 aut., 7 aut.); Neurosurgical Unit B, Stem Cell and Brain Research Institute, Department of Chronobiology/Bron/France (4 aut.); INSERM, U846, Stem Cell and Brain Research Institute, Department of Chronobiology/Bron/France (1 aut., 7 aut.)</AF>
<DT>Publication en série; Papier de recherche; Niveau analytique</DT>
<SO>Neuroscience letters; ISSN 0304-3940; Coden NELED5; Irlande; Da. 2010; Vol. 469; No. 3; Pp. 294-297; Bibl. 29 ref.</SO>
<LA>Anglais</LA>
<EA>In order to determine sources and metabolism of melatonin in human cerebrospinal fluid (CSF), melatonin and 6-sulfatoxymelatonin (aMT6S) concentrations were measured in CSF sampled during neurosurgery in both lateral and third ventricles in patients displaying movement disorder (Parkinson's disease, essential tremor, dystonia or dyskinesia) and compared with their plasma levels. Previous determinations in nocturnal urine had showed that the patients displayed melatonin excretion in the normal range, compared with healthy controls matched according to age. A significant difference in melatonin concentration was observed between lateral and third ventricles, with the highest levels in the third ventricle (8.75 ± 2.75 pg/ml vs. 3.20 ± 0.33 pg/ml, p = 0.01). CSF aMT6s levels were similar in both ventricles and of low magnitude, less than 5 pg/ml. They were not correlated with melatonin levels or influenced by the area of sampling. Melatonin levels were significantly higher in third ventricle than in the plasma, whereas there was no difference between plasma and lateral ventricle levels. These findings show that melatonin may enter directly the CSF through the pineal recess in humans. The physiological meaning of these data remains to be elucidated.</EA>
<CC>002A25; 002B17G</CC>
<FD>Mélatonine; Liquide céphalorachidien; Maladie de Parkinson; Homme</FD>
<FG>Hormone épiphysaire; Maladie dégénérative; Pathologie du système nerveux; Pathologie de l'encéphale; Syndrome extrapyramidal; Pathologie du système nerveux central</FG>
<ED>Melatonin; Cerebrospinal fluid; Parkinson disease; Human</ED>
<EG>Pineal hormone; Degenerative disease; Nervous system diseases; Cerebral disorder; Extrapyramidal syndrome; Central nervous system disease</EG>
<SD>Melatonina; Líquido cefalorraquídeo; Parkinson enfermedad; Hombre</SD>
<LO>INIST-17240.354000181452510030</LO>
<ID>10-0147753</ID>
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