ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 000598

Melatonin is released in the third ventricle in humans. A study in movement disorders

Identifieur interne : 000598 ( PascalFrancis/Corpus ); précédent : 000597; suivant : 000599

Melatonin is released in the third ventricle in humans. A study in movement disorders

Auteurs : José Leston ; Catherine Harthe ; Jocelyne Brun ; Carmine Mottolese ; Patrick Mertens ; Marc Sindou ; Bruno Claustrat

Source :

Neuroscience letters [ 0304-3940 ] ; 2010.

RBID : Pascal:10-0147753

Descripteurs français

Pascal (Inist)
- Mélatonine, Liquide céphalorachidien, Maladie de Parkinson, Homme.

English descriptors

KwdEn :
- Cerebrospinal fluid, Human, Melatonin, Parkinson disease.

Abstract

In order to determine sources and metabolism of melatonin in human cerebrospinal fluid (CSF), melatonin and 6-sulfatoxymelatonin (aMT6S) concentrations were measured in CSF sampled during neurosurgery in both lateral and third ventricles in patients displaying movement disorder (Parkinson's disease, essential tremor, dystonia or dyskinesia) and compared with their plasma levels. Previous determinations in nocturnal urine had showed that the patients displayed melatonin excretion in the normal range, compared with healthy controls matched according to age. A significant difference in melatonin concentration was observed between lateral and third ventricles, with the highest levels in the third ventricle (8.75 ± 2.75 pg/ml vs. 3.20 ± 0.33 pg/ml, p = 0.01). CSF aMT6s levels were similar in both ventricles and of low magnitude, less than 5 pg/ml. They were not correlated with melatonin levels or influenced by the area of sampling. Melatonin levels were significantly higher in third ventricle than in the plasma, whereas there was no difference between plasma and lateral ventricle levels. These findings show that melatonin may enter directly the CSF through the pineal recess in humans. The physiological meaning of these data remains to be elucidated.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0304-3940`
A02	`01`			`@0 NELED5`
A03		`1`		`@0 Neurosci. lett.`
A05				`@2 469`
A06				`@2 3`
A08	`01`	`1`	`ENG`	`@1 Melatonin is released in the third ventricle in humans. A study in movement disorders`
A11	`01`	`1`		`@1 LESTON (José)`
A11	`02`	`1`		`@1 HARTHE (Catherine)`
A11	`03`	`1`		`@1 BRUN (Jocelyne)`
A11	`04`	`1`		`@1 MOTTOLESE (Carmine)`
A11	`05`	`1`		`@1 MERTENS (Patrick)`
A11	`06`	`1`		`@1 SINDOU (Marc)`
A11	`07`	`1`		`@1 CLAUSTRAT (Bruno)`
A14	`01`			`@1 Neurosurgical UnitA, Stem Cell and Brain Research Institute, Department of Chronobiology @2 Bron @3 FRA @Z 1 aut. @Z 5 aut. @Z 6 aut.`
A14	`02`			`@1 Hormone Laboratory, Centre of Nuclear Medicine, Stem Cell and Brain Research Institute, Department of Chronobiology @2 Bron @3 FRA @Z 2 aut. @Z 3 aut. @Z 7 aut.`
A14	`03`			`@1 Neurosurgical Unit B, Stem Cell and Brain Research Institute, Department of Chronobiology @2 Bron @3 FRA @Z 4 aut.`
A14	`04`			`@1 INSERM, U846, Stem Cell and Brain Research Institute, Department of Chronobiology @2 Bron @3 FRA @Z 1 aut. @Z 7 aut.`
A20				`@1 294-297`
A21				`@1 2010`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 17240 @5 354000181452510030`
A44				`@0 0000 @1 © 2010 INIST-CNRS. All rights reserved.`
A45				`@0 29 ref.`
A47	`01`	`1`		`@0 10-0147753`
A60				`@1 P @3 PR`
A61				`@0 A`
A64	`01`	`1`		`@0 Neuroscience letters`
A66	`01`			`@0 IRL`
C01	`01`		`ENG`	@0 In order to determine sources and metabolism of melatonin in human cerebrospinal fluid (CSF), melatonin and 6-sulfatoxymelatonin (aMT6S) concentrations were measured in CSF sampled during neurosurgery in both lateral and third ventricles in patients displaying movement disorder (Parkinson's disease, essential tremor, dystonia or dyskinesia) and compared with their plasma levels. Previous determinations in nocturnal urine had showed that the patients displayed melatonin excretion in the normal range, compared with healthy controls matched according to age. A significant difference in melatonin concentration was observed between lateral and third ventricles, with the highest levels in the third ventricle (8.75 ± 2.75 pg/ml vs. 3.20 ± 0.33 pg/ml, p = 0.01). CSF aMT6s levels were similar in both ventricles and of low magnitude, less than 5 pg/ml. They were not correlated with melatonin levels or influenced by the area of sampling. Melatonin levels were significantly higher in third ventricle than in the plasma, whereas there was no difference between plasma and lateral ventricle levels. These findings show that melatonin may enter directly the CSF through the pineal recess in humans. The physiological meaning of these data remains to be elucidated.
C02	`01`	`X`		`@0 002A25`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Mélatonine @5 01`
C03	`01`	`X`	`ENG`	`@0 Melatonin @5 01`
C03	`01`	`X`	`SPA`	`@0 Melatonina @5 01`
C03	`02`	`X`	`FRE`	`@0 Liquide céphalorachidien @5 02`
C03	`02`	`X`	`ENG`	`@0 Cerebrospinal fluid @5 02`
C03	`02`	`X`	`SPA`	`@0 Líquido cefalorraquídeo @5 02`
C03	`03`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 09`
C03	`03`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 09`
C03	`03`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 09`
C03	`04`	`X`	`FRE`	`@0 Homme @5 54`
C03	`04`	`X`	`ENG`	`@0 Human @5 54`
C03	`04`	`X`	`SPA`	`@0 Hombre @5 54`
C07	`01`	`X`	`FRE`	`@0 Hormone épiphysaire @5 20`
C07	`01`	`X`	`ENG`	`@0 Pineal hormone @5 20`
C07	`01`	`X`	`SPA`	`@0 Hormona epifisaria @5 20`
C07	`02`	`X`	`FRE`	`@0 Maladie dégénérative @5 21`
C07	`02`	`X`	`ENG`	`@0 Degenerative disease @5 21`
C07	`02`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 21`
C07	`03`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 22`
C07	`03`	`X`	`ENG`	`@0 Nervous system diseases @5 22`
C07	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 22`
C07	`04`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 23`
C07	`04`	`X`	`ENG`	`@0 Cerebral disorder @5 23`
C07	`04`	`X`	`SPA`	`@0 Encéfalo patología @5 23`
C07	`05`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 24`
C07	`05`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 24`
C07	`05`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 24`
C07	`06`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 25`
C07	`06`	`X`	`ENG`	`@0 Central nervous system disease @5 25`
C07	`06`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 25`
N21				`@1 095`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 10-0147753 INIST
ET :	Melatonin is released in the third ventricle in humans. A study in movement disorders
AU :	LESTON (José); HARTHE (Catherine); BRUN (Jocelyne); MOTTOLESE (Carmine); MERTENS (Patrick); SINDOU (Marc); CLAUSTRAT (Bruno)
AF :	Neurosurgical UnitA, Stem Cell and Brain Research Institute, Department of Chronobiology/Bron/France (1 aut., 5 aut., 6 aut.); Hormone Laboratory, Centre of Nuclear Medicine, Stem Cell and Brain Research Institute, Department of Chronobiology/Bron/France (2 aut., 3 aut., 7 aut.); Neurosurgical Unit B, Stem Cell and Brain Research Institute, Department of Chronobiology/Bron/France (4 aut.); INSERM, U846, Stem Cell and Brain Research Institute, Department of Chronobiology/Bron/France (1 aut., 7 aut.)
DT :	Publication en série; Papier de recherche; Niveau analytique
SO :	Neuroscience letters; ISSN 0304-3940; Coden NELED5; Irlande; Da. 2010; Vol. 469; No. 3; Pp. 294-297; Bibl. 29 ref.
LA :	Anglais
EA :	In order to determine sources and metabolism of melatonin in human cerebrospinal fluid (CSF), melatonin and 6-sulfatoxymelatonin (aMT6S) concentrations were measured in CSF sampled during neurosurgery in both lateral and third ventricles in patients displaying movement disorder (Parkinson's disease, essential tremor, dystonia or dyskinesia) and compared with their plasma levels. Previous determinations in nocturnal urine had showed that the patients displayed melatonin excretion in the normal range, compared with healthy controls matched according to age. A significant difference in melatonin concentration was observed between lateral and third ventricles, with the highest levels in the third ventricle (8.75 ± 2.75 pg/ml vs. 3.20 ± 0.33 pg/ml, p = 0.01). CSF aMT6s levels were similar in both ventricles and of low magnitude, less than 5 pg/ml. They were not correlated with melatonin levels or influenced by the area of sampling. Melatonin levels were significantly higher in third ventricle than in the plasma, whereas there was no difference between plasma and lateral ventricle levels. These findings show that melatonin may enter directly the CSF through the pineal recess in humans. The physiological meaning of these data remains to be elucidated.
CC :	002A25; 002B17G
FD :	Mélatonine; Liquide céphalorachidien; Maladie de Parkinson; Homme
FG :	Hormone épiphysaire; Maladie dégénérative; Pathologie du système nerveux; Pathologie de l'encéphale; Syndrome extrapyramidal; Pathologie du système nerveux central
ED :	Melatonin; Cerebrospinal fluid; Parkinson disease; Human
EG :	Pineal hormone; Degenerative disease; Nervous system diseases; Cerebral disorder; Extrapyramidal syndrome; Central nervous system disease
SD :	Melatonina; Líquido cefalorraquídeo; Parkinson enfermedad; Hombre
LO :	INIST-17240.354000181452510030
ID :	10-0147753

Links to Exploration step

Pascal:10-0147753

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Melatonin is released in the third ventricle in humans. A study in movement disorders</title>
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<author><name sortKey="Mottolese, Carmine" sort="Mottolese, Carmine" uniqKey="Mottolese C" first="Carmine" last="Mottolese">Carmine Mottolese</name>
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<front><div type="abstract" xml:lang="en">In order to determine sources and metabolism of melatonin in human cerebrospinal fluid (CSF), melatonin and 6-sulfatoxymelatonin (aMT6S) concentrations were measured in CSF sampled during neurosurgery in both lateral and third ventricles in patients displaying movement disorder (Parkinson's disease, essential tremor, dystonia or dyskinesia) and compared with their plasma levels. Previous determinations in nocturnal urine had showed that the patients displayed melatonin excretion in the normal range, compared with healthy controls matched according to age. A significant difference in melatonin concentration was observed between lateral and third ventricles, with the highest levels in the third ventricle (8.75 ± 2.75 pg/ml vs. 3.20 ± 0.33 pg/ml, p = 0.01). CSF aMT6s levels were similar in both ventricles and of low magnitude, less than 5 pg/ml. They were not correlated with melatonin levels or influenced by the area of sampling. Melatonin levels were significantly higher in third ventricle than in the plasma, whereas there was no difference between plasma and lateral ventricle levels. These findings show that melatonin may enter directly the CSF through the pineal recess in humans. The physiological meaning of these data remains to be elucidated.</div>
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<fA14 i1="02"><s1>Hormone Laboratory, Centre of Nuclear Medicine, Stem Cell and Brain Research Institute, Department of Chronobiology</s1>
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<fA64 i1="01" i2="1"><s0>Neuroscience letters</s0>
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<fA66 i1="01"><s0>IRL</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>In order to determine sources and metabolism of melatonin in human cerebrospinal fluid (CSF), melatonin and 6-sulfatoxymelatonin (aMT6S) concentrations were measured in CSF sampled during neurosurgery in both lateral and third ventricles in patients displaying movement disorder (Parkinson's disease, essential tremor, dystonia or dyskinesia) and compared with their plasma levels. Previous determinations in nocturnal urine had showed that the patients displayed melatonin excretion in the normal range, compared with healthy controls matched according to age. A significant difference in melatonin concentration was observed between lateral and third ventricles, with the highest levels in the third ventricle (8.75 ± 2.75 pg/ml vs. 3.20 ± 0.33 pg/ml, p = 0.01). CSF aMT6s levels were similar in both ventricles and of low magnitude, less than 5 pg/ml. They were not correlated with melatonin levels or influenced by the area of sampling. Melatonin levels were significantly higher in third ventricle than in the plasma, whereas there was no difference between plasma and lateral ventricle levels. These findings show that melatonin may enter directly the CSF through the pineal recess in humans. The physiological meaning of these data remains to be elucidated.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A25</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Mélatonine</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Melatonin</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Melatonina</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Liquide céphalorachidien</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Cerebrospinal fluid</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Líquido cefalorraquídeo</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Homme</s0>
<s5>54</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Human</s0>
<s5>54</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Hombre</s0>
<s5>54</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Hormone épiphysaire</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Pineal hormone</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Hormona epifisaria</s0>
<s5>20</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>21</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>22</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>22</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>22</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>23</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>23</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>23</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>24</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>24</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>24</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>25</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>25</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>25</s5>
</fC07>
<fN21><s1>095</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 10-0147753 INIST</NO>
<ET>Melatonin is released in the third ventricle in humans. A study in movement disorders</ET>
<AU>LESTON (José); HARTHE (Catherine); BRUN (Jocelyne); MOTTOLESE (Carmine); MERTENS (Patrick); SINDOU (Marc); CLAUSTRAT (Bruno)</AU>
<AF>Neurosurgical UnitA, Stem Cell and Brain Research Institute, Department of Chronobiology/Bron/France (1 aut., 5 aut., 6 aut.); Hormone Laboratory, Centre of Nuclear Medicine, Stem Cell and Brain Research Institute, Department of Chronobiology/Bron/France (2 aut., 3 aut., 7 aut.); Neurosurgical Unit B, Stem Cell and Brain Research Institute, Department of Chronobiology/Bron/France (4 aut.); INSERM, U846, Stem Cell and Brain Research Institute, Department of Chronobiology/Bron/France (1 aut., 7 aut.)</AF>
<DT>Publication en série; Papier de recherche; Niveau analytique</DT>
<SO>Neuroscience letters; ISSN 0304-3940; Coden NELED5; Irlande; Da. 2010; Vol. 469; No. 3; Pp. 294-297; Bibl. 29 ref.</SO>
<LA>Anglais</LA>
<EA>In order to determine sources and metabolism of melatonin in human cerebrospinal fluid (CSF), melatonin and 6-sulfatoxymelatonin (aMT6S) concentrations were measured in CSF sampled during neurosurgery in both lateral and third ventricles in patients displaying movement disorder (Parkinson's disease, essential tremor, dystonia or dyskinesia) and compared with their plasma levels. Previous determinations in nocturnal urine had showed that the patients displayed melatonin excretion in the normal range, compared with healthy controls matched according to age. A significant difference in melatonin concentration was observed between lateral and third ventricles, with the highest levels in the third ventricle (8.75 ± 2.75 pg/ml vs. 3.20 ± 0.33 pg/ml, p = 0.01). CSF aMT6s levels were similar in both ventricles and of low magnitude, less than 5 pg/ml. They were not correlated with melatonin levels or influenced by the area of sampling. Melatonin levels were significantly higher in third ventricle than in the plasma, whereas there was no difference between plasma and lateral ventricle levels. These findings show that melatonin may enter directly the CSF through the pineal recess in humans. The physiological meaning of these data remains to be elucidated.</EA>
<CC>002A25; 002B17G</CC>
<FD>Mélatonine; Liquide céphalorachidien; Maladie de Parkinson; Homme</FD>
<FG>Hormone épiphysaire; Maladie dégénérative; Pathologie du   système nerveux; Pathologie de l'encéphale; Syndrome extrapyramidal; Pathologie du système nerveux central</FG>
<ED>Melatonin; Cerebrospinal fluid; Parkinson disease; Human</ED>
<EG>Pineal hormone; Degenerative disease; Nervous system diseases; Cerebral disorder; Extrapyramidal syndrome; Central nervous system disease</EG>
<SD>Melatonina; Líquido cefalorraquídeo; Parkinson enfermedad; Hombre</SD>
<LO>INIST-17240.354000181452510030</LO>
<ID>10-0147753</ID>
</server>
</inist>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Melatonin is released in the third ventricle in humans. A study in movement disorders

Melatonin is released in the third ventricle in humans. A study in movement disorders

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