ParkinsonFranceV1, PascalFrancis, Checkpoint, bibRecord, 001795

Mitochondrial respiratory failure in skeletal muscle from patients with Parkinson's disease and multiple system atrophy

Identifieur interne : 001795 ( PascalFrancis/Checkpoint ); précédent : 001794; suivant : 001796

Mitochondrial respiratory failure in skeletal muscle from patients with Parkinson's disease and multiple system atrophy

Auteurs : O. Blin [France] ; C. Desnuelle ; O. Rascol ; M. Borg ; H. Peyro Saint Paul ; J. P. Azulay [France] ; F. Bille [France] ; D. Figarella [France] ; F. Coulom [France] ; J. F. Pellissier [France] ; J. L. Montastruc ; M. Chatel ; G. Serratrice [France]

Source :

Journal of the neurological sciences [ 0022-510X ] ; 1994.

RBID : Pascal:94-0624765

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Chaîne respiratoire, Mitochondrie, Muscle strié, Exploration, Homme, Atrophie multisystématisée.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Exploration, Human, Mitochondria, Multiple system atrophy, Parkinson disease, Respiratory chain, Striated muscle.

Abstract

We studied mitochondrial respiratory chain function in skeletal muscle taken from 27 patients with idiopathic Parkinson's disease (PD; 21 Dopa-treated PD patients and 6 de novo patients), 5 patients with multiple system atrophy (MSA) and from 43 age-matched controls in order to determine the occurrence of mitochondrial respiratory chain abnormalities in parkinsonian syndromes. In our control subjects, we found a significant age-related decrease in the activity of respiratory chain complex I. As compared to carefully age-matched control subjects, activity of complex (NADH: ubiquinone reductase) was significantly lower in muscle mitochondria from patients with PD and MSA and a mean remaining activity <30% of controls was observed

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001948
to stream PascalFrancis, to step Curation: 001704

Links to Exploration step

Pascal:94-0624765

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Exploration</term>
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<term>Striated muscle</term>
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<front><div type="abstract" xml:lang="en">We studied mitochondrial respiratory chain function in skeletal muscle taken from 27 patients with idiopathic Parkinson's disease (PD; 21 Dopa-treated PD patients and 6 de novo patients), 5 patients with multiple system atrophy (MSA) and from 43 age-matched controls in order to determine the occurrence of mitochondrial respiratory chain abnormalities in parkinsonian syndromes. In our control subjects, we found a significant age-related decrease in the activity of respiratory chain complex I. As compared to carefully age-matched control subjects, activity of complex (NADH: ubiquinone reductase) was significantly lower in muscle mitochondria from patients with PD and MSA and a mean remaining activity <30% of controls was observed</div>
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<fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>41</s5>
</fC07>
<fN21><s1>300</s1>
</fN21>
</pA>
</standard>
</inist>
<affiliations><list><country><li>France</li>
</country>
<region><li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Marseille</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Borg, M" sort="Borg, M" uniqKey="Borg M" first="M." last="Borg">M. Borg</name>
<name sortKey="Chatel, M" sort="Chatel, M" uniqKey="Chatel M" first="M." last="Chatel">M. Chatel</name>
<name sortKey="Desnuelle, C" sort="Desnuelle, C" uniqKey="Desnuelle C" first="C." last="Desnuelle">C. Desnuelle</name>
<name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J. L." last="Montastruc">J. L. Montastruc</name>
<name sortKey="Peyro Saint Paul, H" sort="Peyro Saint Paul, H" uniqKey="Peyro Saint Paul H" first="H." last="Peyro Saint Paul">H. Peyro Saint Paul</name>
<name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O." last="Rascol">O. Rascol</name>
</noCountry>
<country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Blin, O" sort="Blin, O" uniqKey="Blin O" first="O." last="Blin">O. Blin</name>
</region>
<name sortKey="Azulay, J P" sort="Azulay, J P" uniqKey="Azulay J" first="J. P." last="Azulay">J. P. Azulay</name>
<name sortKey="Bille, F" sort="Bille, F" uniqKey="Bille F" first="F." last="Bille">F. Bille</name>
<name sortKey="Coulom, F" sort="Coulom, F" uniqKey="Coulom F" first="F." last="Coulom">F. Coulom</name>
<name sortKey="Figarella, D" sort="Figarella, D" uniqKey="Figarella D" first="D." last="Figarella">D. Figarella</name>
<name sortKey="Pellissier, J F" sort="Pellissier, J F" uniqKey="Pellissier J" first="J. F." last="Pellissier">J. F. Pellissier</name>
<name sortKey="Serratrice, G" sort="Serratrice, G" uniqKey="Serratrice G" first="G." last="Serratrice">G. Serratrice</name>
</country>
</tree>
</affiliations>
</record>

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This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Mitochondrial respiratory failure in skeletal muscle from patients with Parkinson's disease and multiple system atrophy

Mitochondrial respiratory failure in skeletal muscle from patients with Parkinson's disease and multiple system atrophy

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