Cell death induced by MPTP, a substrate for monoamine oxidase B
Identifieur interne : 001237 ( PascalFrancis/Checkpoint ); précédent : 001236; suivant : 001238Cell death induced by MPTP, a substrate for monoamine oxidase B
Auteurs : A. Nicotra [Italie] ; S. H. Parvez [France]Source :
- Toxicology : (Amsterdam) [ 0300-483X ] ; 2000.
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Abstract
MPTP is known to cause PD symptoms in primates and in rodents. In order to exert its neurotoxicity MPTP must be converted by monoamine oxidase B into MPP+ which is the true toxic agent. MPP' is taken up by the dopaminergic neurons of the substantia nigra in which it induces cell death. The present work reviews and discusses papers in which specific methods were used to determine whether cell death induced by MPTP/MPP + should be considered as apoptosis or necrosis. These two cell death modes may be distinguished using morphological and biochemical criteria. The effect of MPTP/MPP was studied in vitro and in vivo. The results show that no univocal answer is possible. The most widespread interpretation is that MPTP/MPP + causes apoptosis when its neurotoxic effect is only sligh and necrosis when it is stronger. Similar considerations may be made also concerning the type of cell death occurring in the dopaminergic neurons in the substantia nigra of PD patients.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Cell death induced by MPTP, a substrate for monoamine oxidase B</title><author><name sortKey="Nicotra, A" sort="Nicotra, A" uniqKey="Nicotra A" first="A." last="Nicotra">A. Nicotra</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dipartimento di Biologia Animale e dell'Uomo, Università di Roma I, Viale dell'Università 32</s1><s2>00185 Ronte</s2><s3>ITA</s3><sZ>1 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>00185 Ronte</wicri:noRegion></affiliation></author><author><name sortKey="Parvez, S H" sort="Parvez, S H" uniqKey="Parvez S" first="S. H." last="Parvez">S. H. Parvez</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institut Alfred Fessard of Neurosciences, CNRS UPR 2212-Bât 5, Chateau CNRS</s1><s2>91190 Gif Sur Yvette</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Gif Sur Yvette</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">01-0079379</idno><date when="2000">2000</date><idno type="stanalyst">PASCAL 01-0079379 INIST</idno><idno type="RBID">Pascal:01-0079379</idno><idno type="wicri:Area/PascalFrancis/Corpus">001276</idno><idno type="wicri:Area/PascalFrancis/Curation">000162</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001237</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001237</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cell death induced by MPTP, a substrate for monoamine oxidase B</title><author><name sortKey="Nicotra, A" sort="Nicotra, A" uniqKey="Nicotra A" first="A." last="Nicotra">A. Nicotra</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dipartimento di Biologia Animale e dell'Uomo, Università di Roma I, Viale dell'Università 32</s1><s2>00185 Ronte</s2><s3>ITA</s3><sZ>1 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>00185 Ronte</wicri:noRegion></affiliation></author><author><name sortKey="Parvez, S H" sort="Parvez, S H" uniqKey="Parvez S" first="S. H." last="Parvez">S. H. Parvez</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institut Alfred Fessard of Neurosciences, CNRS UPR 2212-Bât 5, Chateau CNRS</s1><s2>91190 Gif Sur Yvette</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Gif Sur Yvette</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Toxicology : (Amsterdam)</title><title level="j" type="abbreviated">Toxicology : (Amst.)</title><idno type="ISSN">0300-483X</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Toxicology : (Amsterdam)</title><title level="j" type="abbreviated">Toxicology : (Amst.)</title><idno type="ISSN">0300-483X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amine oxidase (flavin-containing)</term><term>Apoptosis</term><term>Cell death</term><term>Comparative study</term><term>Dopaminergic neuron</term><term>Locus niger</term><term>Mechanism of action</term><term>Metabolite</term><term>Necrosis</term><term>Parkinson disease</term><term>Review</term><term>Substrate</term><term>Toxicity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Article synthèse</term><term>Toxicité</term><term>Pyridine(1-méthyl-4-phényl-1,2,3,6-tétrahydro)</term><term>Substrat</term><term>Amine oxidase (flavin-containing)</term><term>Métabolite</term><term>Mécanisme action</term><term>Mort cellulaire</term><term>Etude comparative</term><term>Nécrose</term><term>Apoptose</term><term>Neurone dopaminergique</term><term>Locus niger</term><term>Parkinson maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">MPTP is known to cause PD symptoms in primates and in rodents. In order to exert its neurotoxicity MPTP must be converted by monoamine oxidase B into MPP<sup>+</sup> which is the true toxic agent. MPP' is taken up by the dopaminergic neurons of the substantia nigra in which it induces cell death. The present work reviews and discusses papers in which specific methods were used to determine whether cell death induced by MPTP/MPP <sup>+</sup> should be considered as apoptosis or necrosis. These two cell death modes may be distinguished using morphological and biochemical criteria. The effect of MPTP/MPP was studied in vitro and in vivo. The results show that no univocal answer is possible. The most widespread interpretation is that MPTP/MPP <sup>+</sup> causes apoptosis when its neurotoxic effect is only sligh and necrosis when it is stronger. Similar considerations may be made also concerning the type of cell death occurring in the dopaminergic neurons in the substantia nigra of PD patients.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0300-483X</s0></fA01><fA02 i1="01"><s0>TXICDD</s0></fA02><fA03 i2="1"><s0>Toxicology : (Amst.)</s0></fA03><fA05><s2>153</s2></fA05><fA06><s2>1-3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Cell death induced by MPTP, a substrate for monoamine oxidase B</s1></fA08><fA09 i1="01" i2="1" l="ENG"><s1>Molecular Responses to Xenobiotics</s1></fA09><fA11 i1="01" i2="1"><s1>NICOTRA (A.)</s1></fA11><fA11 i1="02" i2="1"><s1>PARVEZ (S. H.)</s1></fA11><fA12 i1="01" i2="1"><s1>PARVEZ (S. 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Nicotra</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Parvez, S H" sort="Parvez, S H" uniqKey="Parvez S" first="S. H." last="Parvez">S. H. Parvez</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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