Cell death induced by MPTP, a substrate for monoamine oxidase B
Identifieur interne : 001276 ( PascalFrancis/Corpus ); précédent : 001275; suivant : 001277Cell death induced by MPTP, a substrate for monoamine oxidase B
Auteurs : A. Nicotra ; S. H. ParvezSource :
- Toxicology : (Amsterdam) [ 0300-483X ] ; 2000.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
MPTP is known to cause PD symptoms in primates and in rodents. In order to exert its neurotoxicity MPTP must be converted by monoamine oxidase B into MPP+ which is the true toxic agent. MPP' is taken up by the dopaminergic neurons of the substantia nigra in which it induces cell death. The present work reviews and discusses papers in which specific methods were used to determine whether cell death induced by MPTP/MPP + should be considered as apoptosis or necrosis. These two cell death modes may be distinguished using morphological and biochemical criteria. The effect of MPTP/MPP was studied in vitro and in vivo. The results show that no univocal answer is possible. The most widespread interpretation is that MPTP/MPP + causes apoptosis when its neurotoxic effect is only sligh and necrosis when it is stronger. Similar considerations may be made also concerning the type of cell death occurring in the dopaminergic neurons in the substantia nigra of PD patients.
Notice en format standard (ISO 2709)
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Format Inist (serveur)
NO : | PASCAL 01-0079379 INIST |
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ET : | Cell death induced by MPTP, a substrate for monoamine oxidase B |
AU : | NICOTRA (A.); PARVEZ (S. H.); PARVEZ (S. H.); REISS (C.) |
AF : | Dipartimento di Biologia Animale e dell'Uomo, Università di Roma I, Viale dell'Università 32/00185 Ronte/Italie (1 aut.); Institut Alfred Fessard of Neurosciences, CNRS UPR 2212-Bât 5, Chateau CNRS/91190 Gif Sur Yvette/France (2 aut.); Unité de Neuropharmacologie, Institut Alfred Fessard de Neuroscience, CNRS/Paris/France (1 aut.); Centre de Génétique Moléculaire, CNRS/91198 Gif-sur-Yvette/France (2 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Toxicology : (Amsterdam); ISSN 0300-483X; Coden TXICDD; Irlande; Da. 2000; Vol. 153; No. 1-3; Pp. 157-166; Bibl. 1 p.3/4 |
LA : | Anglais |
EA : | MPTP is known to cause PD symptoms in primates and in rodents. In order to exert its neurotoxicity MPTP must be converted by monoamine oxidase B into MPP+ which is the true toxic agent. MPP' is taken up by the dopaminergic neurons of the substantia nigra in which it induces cell death. The present work reviews and discusses papers in which specific methods were used to determine whether cell death induced by MPTP/MPP + should be considered as apoptosis or necrosis. These two cell death modes may be distinguished using morphological and biochemical criteria. The effect of MPTP/MPP was studied in vitro and in vivo. The results show that no univocal answer is possible. The most widespread interpretation is that MPTP/MPP + causes apoptosis when its neurotoxic effect is only sligh and necrosis when it is stronger. Similar considerations may be made also concerning the type of cell death occurring in the dopaminergic neurons in the substantia nigra of PD patients. |
CC : | 002B03L06 |
FD : | Article synthèse; Toxicité; Pyridine(1-méthyl-4-phényl-1,2,3,6-tétrahydro); Substrat; Amine oxidase (flavin-containing); Métabolite; Mécanisme action; Mort cellulaire; Etude comparative; Nécrose; Apoptose; Neurone dopaminergique; Locus niger; Parkinson maladie |
FG : | Oxidoreductases; Enzyme |
ED : | Review; Toxicity; Substrate; Amine oxidase (flavin-containing); Metabolite; Mechanism of action; Cell death; Comparative study; Necrosis; Apoptosis; Dopaminergic neuron; Locus niger; Parkinson disease |
EG : | Oxidoreductases; Enzyme |
SD : | Artículo síntesis; Toxicidad; Substrato; Amine oxidase (flavin-containing); Metabolito; Mecanismo acción; Muerte celular; Estudio comparativo; Necrosis; Apoptosis; Neurona dopaminérgica; Locus níger; Parkinson enfermedad |
LO : | INIST-15984.354000093313990120 |
ID : | 01-0079379 |
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Pascal:01-0079379Le document en format XML
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<front><div type="abstract" xml:lang="en">MPTP is known to cause PD symptoms in primates and in rodents. In order to exert its neurotoxicity MPTP must be converted by monoamine oxidase B into MPP<sup>+</sup>
which is the true toxic agent. MPP' is taken up by the dopaminergic neurons of the substantia nigra in which it induces cell death. The present work reviews and discusses papers in which specific methods were used to determine whether cell death induced by MPTP/MPP <sup>+</sup>
should be considered as apoptosis or necrosis. These two cell death modes may be distinguished using morphological and biochemical criteria. The effect of MPTP/MPP was studied in vitro and in vivo. The results show that no univocal answer is possible. The most widespread interpretation is that MPTP/MPP <sup>+</sup>
causes apoptosis when its neurotoxic effect is only sligh and necrosis when it is stronger. Similar considerations may be made also concerning the type of cell death occurring in the dopaminergic neurons in the substantia nigra of PD patients.</div>
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<ET>Cell death induced by MPTP, a substrate for monoamine oxidase B</ET>
<AU>NICOTRA (A.); PARVEZ (S. H.); PARVEZ (S. H.); REISS (C.)</AU>
<AF>Dipartimento di Biologia Animale e dell'Uomo, Università di Roma I, Viale dell'Università 32/00185 Ronte/Italie (1 aut.); Institut Alfred Fessard of Neurosciences, CNRS UPR 2212-Bât 5, Chateau CNRS/91190 Gif Sur Yvette/France (2 aut.); Unité de Neuropharmacologie, Institut Alfred Fessard de Neuroscience, CNRS/Paris/France (1 aut.); Centre de Génétique Moléculaire, CNRS/91198 Gif-sur-Yvette/France (2 aut.)</AF>
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<EA>MPTP is known to cause PD symptoms in primates and in rodents. In order to exert its neurotoxicity MPTP must be converted by monoamine oxidase B into MPP<sup>+</sup>
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