ParkinsonFranceV1, PascalFrancis, Checkpoint, bibRecord, 001223

Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat

Identifieur interne : 001223 ( PascalFrancis/Checkpoint ); précédent : 001222; suivant : 001224

Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat

Auteurs : A. Benazzouz [France, République populaire de Chine] ; D. M. Gao [République populaire de Chine] ; Z. G. Ni [France] ; B. Piallat [France] ; R. Bouali-Benazzouz [France] ; A. L. Benabid [France]

Source :

Neuroscience [ 0306-4522 ] ; 2000.

RBID : Pascal:00-0457168

Descripteurs français

Pascal (Inist)
- Mode décharge, Locus niger, Noyau sousthalamique, Thalamus, Stimulus électrique, Haute fréquence, Parkinson maladie, Rat.

English descriptors

KwdEn :
- Discharge pattern, Electrical stimulus, High frequency, Locus niger, Parkinson disease, Rat, Subthalamic nucleus, Thalamus.

Abstract

Electrophysiological recordings were made in anaesthetized rats to investigate the mode of function of high-frequency stimulation of the subthalamic nucleus used as a therapeutic approach for Parkinson's disease. High-frequency electrical stimulation of the subthalamic nucleus (130 Hz) induced a net decrease in activity of all cells recorded around the site of stimulation in the subthalamic nucleus. It also caused an inhibition of the majority of neurons recorded in the substantia nigra pars reticulata in normal rats (94%) and in rats with 6-hydroxydopamine lesions of the substantia nigra pars compacta (90%) or with ibotenic acid lesions of the globus pallidus (79.5%). The majority of cells recorded in the ventrolateral nucleus of the thalamus responded with an increase in their activity (84%). These results show that high-frequency stimulation of the subthalamic nucleus induces a reduction of the excitatory glutamatergic output from the subthalamic nucleus which results in deactivation of substantia nigra pars reticulata neurons. The reduction in tonic inhibitory drive of nigral neurons induces a disinhibition of activity in the ventrolateral motor thalamic nucleus, which should result in activation of the motor cortical system.

Affiliations:

Links toward previous steps (curation, corpus...)

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Pascal:00-0457168

Le document en format XML

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<front><div type="abstract" xml:lang="en">Electrophysiological recordings were made in anaesthetized rats to investigate the mode of function of high-frequency stimulation of the subthalamic nucleus used as a therapeutic approach for Parkinson's disease. High-frequency electrical stimulation of the subthalamic nucleus (130 Hz) induced a net decrease in activity of all cells recorded around the site of stimulation in the subthalamic nucleus. It also caused an inhibition of the majority of neurons recorded in the substantia nigra pars reticulata in normal rats (94%) and in rats with 6-hydroxydopamine lesions of the substantia nigra pars compacta (90%) or with ibotenic acid lesions of the globus pallidus (79.5%). The majority of cells recorded in the ventrolateral nucleus of the thalamus responded with an increase in their activity (84%). These results show that high-frequency stimulation of the subthalamic nucleus induces a reduction of the excitatory glutamatergic output from the subthalamic nucleus which results in deactivation of substantia nigra pars reticulata neurons. The reduction in tonic inhibitory drive of nigral neurons induces a disinhibition of activity in the ventrolateral motor thalamic nucleus, which should result in activation of the motor cortical system.</div>
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<s5>20</s5>
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<s5>26</s5>
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<fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>26</s5>
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<s2>NS</s2>
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<fC07 i1="04" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
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<fC07 i1="05" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
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<s2>NS</s2>
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<fC07 i1="05" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
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<fC07 i1="06" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
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<fC07 i1="06" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>304</s1>
</fN21>
</pA>
</standard>
</inist>
<affiliations><list><country><li>France</li>
<li>République populaire de Chine</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Grenoble</li>
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<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Benazzouz, A" sort="Benazzouz, A" uniqKey="Benazzouz A" first="A." last="Benazzouz">A. Benazzouz</name>
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<name sortKey="Ni, Z G" sort="Ni, Z G" uniqKey="Ni Z" first="Z. G." last="Ni">Z. G. Ni</name>
<name sortKey="Piallat, B" sort="Piallat, B" uniqKey="Piallat B" first="B." last="Piallat">B. Piallat</name>
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<country name="République populaire de Chine"><noRegion><name sortKey="Benazzouz, A" sort="Benazzouz, A" uniqKey="Benazzouz A" first="A." last="Benazzouz">A. Benazzouz</name>
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<name sortKey="Gao, D M" sort="Gao, D M" uniqKey="Gao D" first="D. M." last="Gao">D. M. Gao</name>
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</tree>
</affiliations>
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	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat

Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat

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