ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 001320

Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat

Identifieur interne : 001320 ( PascalFrancis/Corpus ); précédent : 001319; suivant : 001321

Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat

Auteurs : A. Benazzouz ; D. M. Gao ; Z. G. Ni ; B. Piallat ; R. Bouali-Benazzouz ; A. L. Benabid

Source :

Neuroscience [ 0306-4522 ] ; 2000.

RBID : Pascal:00-0457168

Descripteurs français

Pascal (Inist)
- Mode décharge, Locus niger, Noyau sousthalamique, Thalamus, Stimulus électrique, Haute fréquence, Parkinson maladie, Rat.

English descriptors

KwdEn :
- Discharge pattern, Electrical stimulus, High frequency, Locus niger, Parkinson disease, Rat, Subthalamic nucleus, Thalamus.

Abstract

Electrophysiological recordings were made in anaesthetized rats to investigate the mode of function of high-frequency stimulation of the subthalamic nucleus used as a therapeutic approach for Parkinson's disease. High-frequency electrical stimulation of the subthalamic nucleus (130 Hz) induced a net decrease in activity of all cells recorded around the site of stimulation in the subthalamic nucleus. It also caused an inhibition of the majority of neurons recorded in the substantia nigra pars reticulata in normal rats (94%) and in rats with 6-hydroxydopamine lesions of the substantia nigra pars compacta (90%) or with ibotenic acid lesions of the globus pallidus (79.5%). The majority of cells recorded in the ventrolateral nucleus of the thalamus responded with an increase in their activity (84%). These results show that high-frequency stimulation of the subthalamic nucleus induces a reduction of the excitatory glutamatergic output from the subthalamic nucleus which results in deactivation of substantia nigra pars reticulata neurons. The reduction in tonic inhibitory drive of nigral neurons induces a disinhibition of activity in the ventrolateral motor thalamic nucleus, which should result in activation of the motor cortical system.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 BENAZZOUZ (A.)`
A11	`02`	`1`		`@1 GAO (D. M.)`
A11	`03`	`1`		`@1 NI (Z. G.)`
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A11	`05`	`1`		`@1 BOUALI-BENAZZOUZ (R.)`
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A14	`01`			`@1 Laboratoire de Neurobiologie préclinique, INSERM U. 318, CHU-Pavillon B, BP 217 @2 38043 Grenoble @3 FRA @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut.`
A14	`02`			`@1 Department of Physiology, Jinzhou Medical College @2 121002 Jinzhou, Liaoning @3 CHN @Z 1 aut. @Z 2 aut.`
A20				`@1 289-295`
A21				`@1 2000`
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C01	`01`		`ENG`	@0 Electrophysiological recordings were made in anaesthetized rats to investigate the mode of function of high-frequency stimulation of the subthalamic nucleus used as a therapeutic approach for Parkinson's disease. High-frequency electrical stimulation of the subthalamic nucleus (130 Hz) induced a net decrease in activity of all cells recorded around the site of stimulation in the subthalamic nucleus. It also caused an inhibition of the majority of neurons recorded in the substantia nigra pars reticulata in normal rats (94%) and in rats with 6-hydroxydopamine lesions of the substantia nigra pars compacta (90%) or with ibotenic acid lesions of the globus pallidus (79.5%). The majority of cells recorded in the ventrolateral nucleus of the thalamus responded with an increase in their activity (84%). These results show that high-frequency stimulation of the subthalamic nucleus induces a reduction of the excitatory glutamatergic output from the subthalamic nucleus which results in deactivation of substantia nigra pars reticulata neurons. The reduction in tonic inhibitory drive of nigral neurons induces a disinhibition of activity in the ventrolateral motor thalamic nucleus, which should result in activation of the motor cortical system.
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C03	`03`	`X`	`SPA`	`@0 Núcleo subtalámico @5 03`
C03	`04`	`X`	`FRE`	`@0 Thalamus @5 04`
C03	`04`	`X`	`ENG`	`@0 Thalamus @5 04`
C03	`04`	`X`	`SPA`	`@0 Tálamo @5 04`
C03	`05`	`X`	`FRE`	`@0 Stimulus électrique @5 05`
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C03	`07`	`X`	`SPA`	`@0 Parkinson enfermedad @5 10`
C03	`08`	`X`	`FRE`	`@0 Rat @5 54`
C03	`08`	`X`	`ENG`	`@0 Rat @5 54`
C03	`08`	`X`	`SPA`	`@0 Rata @5 54`
C07	`01`	`X`	`FRE`	`@0 Electrophysiologie @5 20`
C07	`01`	`X`	`ENG`	`@0 Electrophysiology @5 20`
C07	`01`	`X`	`SPA`	`@0 Electrofisiología @5 20`
C07	`02`	`X`	`FRE`	`@0 Encéphale @5 26`
C07	`02`	`X`	`ENG`	`@0 Brain (vertebrata) @5 26`
C07	`02`	`X`	`SPA`	`@0 Encéfalo @5 26`
C07	`03`	`X`	`FRE`	`@0 Système nerveux central @5 27`
C07	`03`	`X`	`ENG`	`@0 Central nervous system @5 27`
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Format Inist (serveur)

NO :	PASCAL 00-0457168 INIST
ET :	Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat
AU :	BENAZZOUZ (A.); GAO (D. M.); NI (Z. G.); PIALLAT (B.); BOUALI-BENAZZOUZ (R.); BENABID (A. L.)
AF :	Laboratoire de Neurobiologie préclinique, INSERM U. 318, CHU-Pavillon B, BP 217/38043 Grenoble/France (1 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Department of Physiology, Jinzhou Medical College/121002 Jinzhou, Liaoning/Chine (1 aut., 2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Neuroscience; ISSN 0306-4522; Coden NRSCDN; Royaume-Uni; Da. 2000; Vol. 99; No. 2; Pp. 289-295; Bibl. 51 ref.
LA :	Anglais
EA :	Electrophysiological recordings were made in anaesthetized rats to investigate the mode of function of high-frequency stimulation of the subthalamic nucleus used as a therapeutic approach for Parkinson's disease. High-frequency electrical stimulation of the subthalamic nucleus (130 Hz) induced a net decrease in activity of all cells recorded around the site of stimulation in the subthalamic nucleus. It also caused an inhibition of the majority of neurons recorded in the substantia nigra pars reticulata in normal rats (94%) and in rats with 6-hydroxydopamine lesions of the substantia nigra pars compacta (90%) or with ibotenic acid lesions of the globus pallidus (79.5%). The majority of cells recorded in the ventrolateral nucleus of the thalamus responded with an increase in their activity (84%). These results show that high-frequency stimulation of the subthalamic nucleus induces a reduction of the excitatory glutamatergic output from the subthalamic nucleus which results in deactivation of substantia nigra pars reticulata neurons. The reduction in tonic inhibitory drive of nigral neurons induces a disinhibition of activity in the ventrolateral motor thalamic nucleus, which should result in activation of the motor cortical system.
CC :	002A25D03
FD :	Mode décharge; Locus niger; Noyau sousthalamique; Thalamus; Stimulus électrique; Haute fréquence; Parkinson maladie; Rat
FG :	Electrophysiologie; Encéphale; Système nerveux central; Rodentia; Mammalia; Vertebrata
ED :	Discharge pattern; Locus niger; Subthalamic nucleus; Thalamus; Electrical stimulus; High frequency; Parkinson disease; Rat
EG :	Electrophysiology; Brain (vertebrata); Central nervous system; Rodentia; Mammalia; Vertebrata
SD :	Forma descarga; Locus níger; Núcleo subtalámico; Tálamo; Estímulo eléctrico; Alta frecuencia; Parkinson enfermedad; Rata
LO :	INIST-17194.354000091179960100
ID :	00-0457168

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Pascal:00-0457168

Le document en format XML

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<front><div type="abstract" xml:lang="en">Electrophysiological recordings were made in anaesthetized rats to investigate the mode of function of high-frequency stimulation of the subthalamic nucleus used as a therapeutic approach for Parkinson's disease. High-frequency electrical stimulation of the subthalamic nucleus (130 Hz) induced a net decrease in activity of all cells recorded around the site of stimulation in the subthalamic nucleus. It also caused an inhibition of the majority of neurons recorded in the substantia nigra pars reticulata in normal rats (94%) and in rats with 6-hydroxydopamine lesions of the substantia nigra pars compacta (90%) or with ibotenic acid lesions of the globus pallidus (79.5%). The majority of cells recorded in the ventrolateral nucleus of the thalamus responded with an increase in their activity (84%). These results show that high-frequency stimulation of the subthalamic nucleus induces a reduction of the excitatory glutamatergic output from the subthalamic nucleus which results in deactivation of substantia nigra pars reticulata neurons. The reduction in tonic inhibitory drive of nigral neurons induces a disinhibition of activity in the ventrolateral motor thalamic nucleus, which should result in activation of the motor cortical system.</div>
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<fA14 i1="02"><s1>Department of Physiology, Jinzhou Medical College</s1>
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<fC01 i1="01" l="ENG"><s0>Electrophysiological recordings were made in anaesthetized rats to investigate the mode of function of high-frequency stimulation of the subthalamic nucleus used as a therapeutic approach for Parkinson's disease. High-frequency electrical stimulation of the subthalamic nucleus (130 Hz) induced a net decrease in activity of all cells recorded around the site of stimulation in the subthalamic nucleus. It also caused an inhibition of the majority of neurons recorded in the substantia nigra pars reticulata in normal rats (94%) and in rats with 6-hydroxydopamine lesions of the substantia nigra pars compacta (90%) or with ibotenic acid lesions of the globus pallidus (79.5%). The majority of cells recorded in the ventrolateral nucleus of the thalamus responded with an increase in their activity (84%). These results show that high-frequency stimulation of the subthalamic nucleus induces a reduction of the excitatory glutamatergic output from the subthalamic nucleus which results in deactivation of substantia nigra pars reticulata neurons. The reduction in tonic inhibitory drive of nigral neurons induces a disinhibition of activity in the ventrolateral motor thalamic nucleus, which should result in activation of the motor cortical system.</s0>
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<s5>04</s5>
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<fC03 i1="04" i2="X" l="SPA"><s0>Tálamo</s0>
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<fC07 i1="03" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>27</s5>
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<fC07 i1="04" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
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<s2>NS</s2>
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<s2>NS</s2>
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<fC07 i1="05" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
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<s2>NS</s2>
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<s2>NS</s2>
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<s2>NS</s2>
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<fC07 i1="06" i2="X" l="SPA"><s0>Vertebrata</s0>
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<server><NO>PASCAL 00-0457168 INIST</NO>
<ET>Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat</ET>
<AU>BENAZZOUZ (A.); GAO (D. M.); NI (Z. G.); PIALLAT (B.); BOUALI-BENAZZOUZ (R.); BENABID (A. L.)</AU>
<AF>Laboratoire de Neurobiologie préclinique, INSERM U. 318, CHU-Pavillon B, BP 217/38043 Grenoble/France (1 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Department of Physiology, Jinzhou Medical College/121002 Jinzhou, Liaoning/Chine (1 aut., 2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neuroscience; ISSN 0306-4522; Coden NRSCDN; Royaume-Uni; Da. 2000; Vol. 99; No. 2; Pp. 289-295; Bibl. 51 ref.</SO>
<LA>Anglais</LA>
<EA>Electrophysiological recordings were made in anaesthetized rats to investigate the mode of function of high-frequency stimulation of the subthalamic nucleus used as a therapeutic approach for Parkinson's disease. High-frequency electrical stimulation of the subthalamic nucleus (130 Hz) induced a net decrease in activity of all cells recorded around the site of stimulation in the subthalamic nucleus. It also caused an inhibition of the majority of neurons recorded in the substantia nigra pars reticulata in normal rats (94%) and in rats with 6-hydroxydopamine lesions of the substantia nigra pars compacta (90%) or with ibotenic acid lesions of the globus pallidus (79.5%). The majority of cells recorded in the ventrolateral nucleus of the thalamus responded with an increase in their activity (84%). These results show that high-frequency stimulation of the subthalamic nucleus induces a reduction of the excitatory glutamatergic output from the subthalamic nucleus which results in deactivation of substantia nigra pars reticulata neurons. The reduction in tonic inhibitory drive of nigral neurons induces a disinhibition of activity in the ventrolateral motor thalamic nucleus, which should result in activation of the motor cortical system.</EA>
<CC>002A25D03</CC>
<FD>Mode décharge; Locus niger; Noyau sousthalamique; Thalamus; Stimulus électrique; Haute fréquence; Parkinson maladie; Rat</FD>
<FG>Electrophysiologie; Encéphale; Système nerveux central; Rodentia; Mammalia; Vertebrata</FG>
<ED>Discharge pattern; Locus niger; Subthalamic nucleus; Thalamus; Electrical stimulus; High frequency; Parkinson disease; Rat</ED>
<EG>Electrophysiology; Brain (vertebrata); Central nervous system; Rodentia; Mammalia; Vertebrata</EG>
<SD>Forma descarga; Locus níger; Núcleo subtalámico; Tálamo; Estímulo eléctrico; Alta frecuencia; Parkinson enfermedad; Rata</SD>
<LO>INIST-17194.354000091179960100</LO>
<ID>00-0457168</ID>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat

Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat

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