Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death
Identifieur interne : 001067 ( PascalFrancis/Checkpoint ); précédent : 001066; suivant : 001068Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death
Auteurs : Zdenko Herceg [France] ; Zhao-Qi Wang [France]Source :
- Mutation research [ 0027-5107 ] ; 2001.
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Abstract
Poly(ADP-ribose) polymerase (PARP) is responsible for post-translational modification of proteins in the response to numerous endogenous and environmental genotoxic agents. PARP and poly(ADP-ribosyl)ation are proposed to be important for the regulation of many cellular processes such as DNA repair, cell death, chromatin functions and genomic stability. Activation of PARP is one of the early DNA damage responses, among other DNA sensing molecules, such as DNA-PK, ATM and p53. The generation and characterization of PARP deficient mouse models have been instrumental in defining the biological role of the molecule and its involvement in the pathogenesis of various diseases including diabetes, stroke, Parkinson disease, general inflammation as well as tumorigenesis, and have, therefore, provided information for the development of pharmaceutical strategies for the treatment of diseases.
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PARP and poly(ADP-ribosyl)ation are proposed to be important for the regulation of many cellular processes such as DNA repair, cell death, chromatin functions and genomic stability. Activation of PARP is one of the early DNA damage responses, among other DNA sensing molecules, such as DNA-PK, ATM and p53. The generation and characterization of PARP deficient mouse models have been instrumental in defining the biological role of the molecule and its involvement in the pathogenesis of various diseases including diabetes, stroke, Parkinson disease, general inflammation as well as tumorigenesis, and have, therefore, provided information for the development of pharmaceutical strategies for the treatment of diseases.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0027-5107</s0></fA01><fA02 i1="01"><s0>MUREAV</s0></fA02><fA03 i2="1"><s0>Mutat. res.</s0></fA03><fA05><s2>477</s2></fA05><fA06><s2>1-2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death</s1></fA08><fA09 i1="01" i2="1" l="ENG"><s1>Analysis and prevention of carcinogenesis in animal models</s1></fA09><fA11 i1="01" i2="1"><s1>HERCEG (Zdenko)</s1></fA11><fA11 i1="02" i2="1"><s1>WANG (Zhao-Qi)</s1></fA11><fA12 i1="01" i2="1"><s1>NAKAGAMA (H.)</s1><s9>ed.</s9></fA12><fA12 i1="02" i2="1"><s1>ISHIKAWA (T.)</s1><s9>ed.</s9></fA12><fA12 i1="03" i2="1"><s1>MIWA (M.)</s1><s9>ed.</s9></fA12><fA12 i1="04" i2="1"><s1>SETLOW (R. 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