Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death
Identifieur interne : 001130 ( PascalFrancis/Corpus ); précédent : 001129; suivant : 001131Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death
Auteurs : Zdenko Herceg ; Zhao-Qi WangSource :
- Mutation research [ 0027-5107 ] ; 2001.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Poly(ADP-ribose) polymerase (PARP) is responsible for post-translational modification of proteins in the response to numerous endogenous and environmental genotoxic agents. PARP and poly(ADP-ribosyl)ation are proposed to be important for the regulation of many cellular processes such as DNA repair, cell death, chromatin functions and genomic stability. Activation of PARP is one of the early DNA damage responses, among other DNA sensing molecules, such as DNA-PK, ATM and p53. The generation and characterization of PARP deficient mouse models have been instrumental in defining the biological role of the molecule and its involvement in the pathogenesis of various diseases including diabetes, stroke, Parkinson disease, general inflammation as well as tumorigenesis, and have, therefore, provided information for the development of pharmaceutical strategies for the treatment of diseases.
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Format Inist (serveur)
NO : | PASCAL 02-0234959 INIST |
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ET : | Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death |
AU : | HERCEG (Zdenko); WANG (Zhao-Qi); NAKAGAMA (H.); ISHIKAWA (T.); MIWA (M.); SETLOW (R. B.) |
AF : | International Agency for Research on Cancer (IARC), 150 cours Albert-Thomas/69008 Lyon/France (1 aut., 2 aut.); Biochemistry Division, National Cancer Center Research Institute/Tokyo 104-0045/Japon (1 aut.); Faculty of Medicine, University of Tokyo/Tokyo/Japon (2 aut.); Department of Biochemistry and Molecular Oncology, Institute of Basic Medical Sciences, University of Tsukuba/Tsukuba, Ibaraki/Japon (3 aut.); Biology Department, Brookhaven National Laboratory/Upton, NY/Etats-Unis (4 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Mutation research; ISSN 0027-5107; Coden MUREAV; Pays-Bas; Da. 2001; Vol. 477; No. 1-2; Pp. 97-110; Bibl. 105 ref. |
LA : | Anglais |
EA : | Poly(ADP-ribose) polymerase (PARP) is responsible for post-translational modification of proteins in the response to numerous endogenous and environmental genotoxic agents. PARP and poly(ADP-ribosyl)ation are proposed to be important for the regulation of many cellular processes such as DNA repair, cell death, chromatin functions and genomic stability. Activation of PARP is one of the early DNA damage responses, among other DNA sensing molecules, such as DNA-PK, ATM and p53. The generation and characterization of PARP deficient mouse models have been instrumental in defining the biological role of the molecule and its involvement in the pathogenesis of various diseases including diabetes, stroke, Parkinson disease, general inflammation as well as tumorigenesis, and have, therefore, provided information for the development of pharmaceutical strategies for the treatment of diseases. |
CC : | 002A04C07 |
FD : | Mort cellulaire; Réparation; DNA; DNA-directed DNA polymerase; Génomique; Intégrité; Apoptose |
FG : | Nucleotidyltransferases; Transferases; Enzyme |
ED : | Cell death; Repair; DNA; DNA-directed DNA polymerase; Genomics; Integrity; Apoptosis |
EG : | Nucleotidyltransferases; Transferases; Enzyme |
SD : | Muerte celular; Reparación; DNA; DNA-directed DNA polymerase; Genómica; Integridad; Apoptosis |
LO : | INIST-12206A.354000095503940110 |
ID : | 02-0234959 |
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Pascal:02-0234959Le document en format XML
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<author><name sortKey="Herceg, Zdenko" sort="Herceg, Zdenko" uniqKey="Herceg Z" first="Zdenko" last="Herceg">Zdenko Herceg</name>
<affiliation><inist:fA14 i1="01"><s1>International Agency for Research on Cancer (IARC), 150 cours Albert-Thomas</s1>
<s2>69008 Lyon</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<author><name sortKey="Wang, Zhao Qi" sort="Wang, Zhao Qi" uniqKey="Wang Z" first="Zhao-Qi" last="Wang">Zhao-Qi Wang</name>
<affiliation><inist:fA14 i1="01"><s1>International Agency for Research on Cancer (IARC), 150 cours Albert-Thomas</s1>
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<front><div type="abstract" xml:lang="en">Poly(ADP-ribose) polymerase (PARP) is responsible for post-translational modification of proteins in the response to numerous endogenous and environmental genotoxic agents. PARP and poly(ADP-ribosyl)ation are proposed to be important for the regulation of many cellular processes such as DNA repair, cell death, chromatin functions and genomic stability. Activation of PARP is one of the early DNA damage responses, among other DNA sensing molecules, such as DNA-PK, ATM and p53. The generation and characterization of PARP deficient mouse models have been instrumental in defining the biological role of the molecule and its involvement in the pathogenesis of various diseases including diabetes, stroke, Parkinson disease, general inflammation as well as tumorigenesis, and have, therefore, provided information for the development of pharmaceutical strategies for the treatment of diseases.</div>
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<ET>Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death</ET>
<AU>HERCEG (Zdenko); WANG (Zhao-Qi); NAKAGAMA (H.); ISHIKAWA (T.); MIWA (M.); SETLOW (R. B.)</AU>
<AF>International Agency for Research on Cancer (IARC), 150 cours Albert-Thomas/69008 Lyon/France (1 aut., 2 aut.); Biochemistry Division, National Cancer Center Research Institute/Tokyo 104-0045/Japon (1 aut.); Faculty of Medicine, University of Tokyo/Tokyo/Japon (2 aut.); Department of Biochemistry and Molecular Oncology, Institute of Basic Medical Sciences, University of Tsukuba/Tsukuba, Ibaraki/Japon (3 aut.); Biology Department, Brookhaven National Laboratory/Upton, NY/Etats-Unis (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
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<LA>Anglais</LA>
<EA>Poly(ADP-ribose) polymerase (PARP) is responsible for post-translational modification of proteins in the response to numerous endogenous and environmental genotoxic agents. PARP and poly(ADP-ribosyl)ation are proposed to be important for the regulation of many cellular processes such as DNA repair, cell death, chromatin functions and genomic stability. Activation of PARP is one of the early DNA damage responses, among other DNA sensing molecules, such as DNA-PK, ATM and p53. The generation and characterization of PARP deficient mouse models have been instrumental in defining the biological role of the molecule and its involvement in the pathogenesis of various diseases including diabetes, stroke, Parkinson disease, general inflammation as well as tumorigenesis, and have, therefore, provided information for the development of pharmaceutical strategies for the treatment of diseases.</EA>
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