Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe
Identifieur interne : 000A99 ( PascalFrancis/Checkpoint ); précédent : 000A98; suivant : 000B00Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe
Auteurs : Pierre Champy [France] ; Alice Melot [France] ; Vincent Guerineau [France] ; Christophe Gleye [France] ; Djibril Fall [France, Sénégal] ; Gunter U. Höglinger [France] ; Merle Ruberg [France] ; Annie Lannuzel [France] ; Olivier Laprevote [France] ; Alain Laurens [France] ; Reynald Hocquemiller [France]Source :
- Movement disorders [ 0885-3185 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Guadeloupe.
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Abstract
Atypical parkinsonism in Guadeloupe has been associated with the consumption of fruit and infusions or decoctions prepared from leaves of Annona muricata L. (Annonaceae), which contains annonaceous acetogenins, lipophilic inhibitors of complex I of the mitochondrial respiratory chain. We have determined the concentrations of annonacin, the major acetogenin in A. muricata, in extracts of fruit and leaves by matrix-assisted laser desorption-ionization mass spectrometry. An average fruit is estimated to contain about 15 mg of annonacin, a can of commercial nectar 36 mg, and a cup of infusion or decoction 140 μg. As an indication of its potential toxicity, an adult who consumes one fruit or can of nectar a day is estimated to ingest over 1 year the amount of annonacin that induced brain lesions in rats receiving purified annonacin by intravenous infusion.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe</title><author><name sortKey="Champy, Pierre" sort="Champy, Pierre" uniqKey="Champy P" first="Pierre" last="Champy">Pierre Champy</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de Pharmacie Paris XI</s1><s2>Châtenay-Malabry</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Châtenay-Malabry</wicri:noRegion><wicri:noRegion>Faculté de Pharmacie Paris XI</wicri:noRegion><wicri:noRegion>Châtenay-Malabry</wicri:noRegion></affiliation></author><author><name sortKey="Melot, Alice" sort="Melot, Alice" uniqKey="Melot A" first="Alice" last="Melot">Alice Melot</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de Pharmacie Paris XI</s1><s2>Châtenay-Malabry</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Châtenay-Malabry</wicri:noRegion><wicri:noRegion>Faculté de Pharmacie Paris XI</wicri:noRegion><wicri:noRegion>Châtenay-Malabry</wicri:noRegion></affiliation></author><author><name sortKey="Guerineau, Vincent" sort="Guerineau, Vincent" uniqKey="Guerineau V" first="Vincent" last="Guerineau">Vincent Guerineau</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratory of Mass Spectrometry, Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique (CNRS)</s1><s2>Gif-sur-Yvette</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Gif-sur-Yvette</settlement></placeName></affiliation></author><author><name sortKey="Gleye, Christophe" sort="Gleye, Christophe" uniqKey="Gleye C" first="Christophe" last="Gleye">Christophe Gleye</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de Pharmacie Paris XI</s1><s2>Châtenay-Malabry</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Châtenay-Malabry</wicri:noRegion><wicri:noRegion>Faculté de Pharmacie Paris XI</wicri:noRegion><wicri:noRegion>Châtenay-Malabry</wicri:noRegion></affiliation></author><author><name sortKey="Fall, Djibril" sort="Fall, Djibril" uniqKey="Fall D" first="Djibril" last="Fall">Djibril Fall</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de Pharmacie Paris XI</s1><s2>Châtenay-Malabry</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Châtenay-Malabry</wicri:noRegion><wicri:noRegion>Faculté de Pharmacie Paris XI</wicri:noRegion><wicri:noRegion>Châtenay-Malabry</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Laboratory of Therapeutic Chemistry, Faculté de Pharmacie, Université Cheikh Anta Diop</s1><s2>Dakar</s2><s3>SEN</s3><sZ>5 aut.</sZ></inist:fA14><country>Sénégal</country><wicri:noRegion>Dakar</wicri:noRegion></affiliation></author><author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Gunter U." last="Höglinger">Gunter U. Höglinger</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM) U679, Experimental Neurology and Therapeutics</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ruberg, Merle" sort="Ruberg, Merle" uniqKey="Ruberg M" first="Merle" last="Ruberg">Merle Ruberg</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM) U679, Experimental Neurology and Therapeutics</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lannuzel, Annie" sort="Lannuzel, Annie" uniqKey="Lannuzel A" first="Annie" last="Lannuzel">Annie Lannuzel</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM) U679, Experimental Neurology and Therapeutics</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, Centre Hospitalier Universitaire (CHU) Antilles-Guyane</s1><s2>Pointe-à-Pitre, Guadeloupe</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Guadeloupe</wicri:noRegion><wicri:noRegion>Centre Hospitalier Universitaire (CHU) Antilles-Guyane</wicri:noRegion><wicri:noRegion>Pointe-à-Pitre, Guadeloupe</wicri:noRegion></affiliation></author><author><name sortKey="Laprevote, Olivier" sort="Laprevote, Olivier" uniqKey="Laprevote O" first="Olivier" last="Laprevote">Olivier Laprevote</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratory of Mass Spectrometry, Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique (CNRS)</s1><s2>Gif-sur-Yvette</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Gif-sur-Yvette</settlement></placeName></affiliation></author><author><name sortKey="Laurens, Alain" sort="Laurens, Alain" uniqKey="Laurens A" first="Alain" last="Laurens">Alain Laurens</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de 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XI</wicri:noRegion><wicri:noRegion>Châtenay-Malabry</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0191534</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 06-0191534 INIST</idno><idno type="RBID">Pascal:06-0191534</idno><idno type="wicri:Area/PascalFrancis/Corpus">000B87</idno><idno type="wicri:Area/PascalFrancis/Curation">000847</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000A99</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000A99</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe</title><author><name sortKey="Champy, Pierre" sort="Champy, Pierre" uniqKey="Champy P" first="Pierre" last="Champy">Pierre Champy</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de Pharmacie Paris XI</s1><s2>Châtenay-Malabry</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Châtenay-Malabry</wicri:noRegion><wicri:noRegion>Faculté de Pharmacie Paris XI</wicri:noRegion><wicri:noRegion>Châtenay-Malabry</wicri:noRegion></affiliation></author><author><name sortKey="Melot, Alice" sort="Melot, Alice" uniqKey="Melot A" first="Alice" last="Melot">Alice Melot</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de Pharmacie Paris XI</s1><s2>Châtenay-Malabry</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Châtenay-Malabry</wicri:noRegion><wicri:noRegion>Faculté de Pharmacie Paris XI</wicri:noRegion><wicri:noRegion>Châtenay-Malabry</wicri:noRegion></affiliation></author><author><name sortKey="Guerineau, Vincent" sort="Guerineau, Vincent" uniqKey="Guerineau V" first="Vincent" last="Guerineau">Vincent Guerineau</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratory of Mass Spectrometry, Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique (CNRS)</s1><s2>Gif-sur-Yvette</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Gif-sur-Yvette</settlement></placeName></affiliation></author><author><name sortKey="Gleye, Christophe" sort="Gleye, Christophe" uniqKey="Gleye C" first="Christophe" last="Gleye">Christophe Gleye</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de Pharmacie Paris XI</s1><s2>Châtenay-Malabry</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Châtenay-Malabry</wicri:noRegion><wicri:noRegion>Faculté de Pharmacie Paris XI</wicri:noRegion><wicri:noRegion>Châtenay-Malabry</wicri:noRegion></affiliation></author><author><name sortKey="Fall, Djibril" sort="Fall, Djibril" uniqKey="Fall D" first="Djibril" last="Fall">Djibril Fall</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de Pharmacie Paris XI</s1><s2>Châtenay-Malabry</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Châtenay-Malabry</wicri:noRegion><wicri:noRegion>Faculté de Pharmacie Paris XI</wicri:noRegion><wicri:noRegion>Châtenay-Malabry</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Laboratory of Therapeutic Chemistry, Faculté de Pharmacie, Université Cheikh Anta Diop</s1><s2>Dakar</s2><s3>SEN</s3><sZ>5 aut.</sZ></inist:fA14><country>Sénégal</country><wicri:noRegion>Dakar</wicri:noRegion></affiliation></author><author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Gunter U." last="Höglinger">Gunter U. Höglinger</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM) U679, Experimental Neurology and Therapeutics</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ruberg, Merle" sort="Ruberg, Merle" uniqKey="Ruberg M" first="Merle" last="Ruberg">Merle Ruberg</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM) U679, Experimental Neurology and Therapeutics</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lannuzel, Annie" sort="Lannuzel, Annie" uniqKey="Lannuzel A" first="Annie" last="Lannuzel">Annie Lannuzel</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM) U679, Experimental Neurology and Therapeutics</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, Centre Hospitalier Universitaire (CHU) Antilles-Guyane</s1><s2>Pointe-à-Pitre, Guadeloupe</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Guadeloupe</wicri:noRegion><wicri:noRegion>Centre Hospitalier Universitaire (CHU) Antilles-Guyane</wicri:noRegion><wicri:noRegion>Pointe-à-Pitre, Guadeloupe</wicri:noRegion></affiliation></author><author><name sortKey="Laprevote, Olivier" sort="Laprevote, Olivier" uniqKey="Laprevote O" first="Olivier" last="Laprevote">Olivier Laprevote</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratory of Mass Spectrometry, Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique (CNRS)</s1><s2>Gif-sur-Yvette</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Gif-sur-Yvette</settlement></placeName></affiliation></author><author><name sortKey="Laurens, Alain" sort="Laurens, Alain" uniqKey="Laurens A" first="Alain" last="Laurens">Alain Laurens</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de Pharmacie Paris XI</s1><s2>Châtenay-Malabry</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Châtenay-Malabry</wicri:noRegion><wicri:noRegion>Faculté de Pharmacie Paris XI</wicri:noRegion><wicri:noRegion>Châtenay-Malabry</wicri:noRegion></affiliation></author><author><name sortKey="Hocquemiller, Reynald" sort="Hocquemiller, Reynald" uniqKey="Hocquemiller R" first="Reynald" last="Hocquemiller">Reynald Hocquemiller</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de Pharmacie Paris XI</s1><s2>Châtenay-Malabry</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Châtenay-Malabry</wicri:noRegion><wicri:noRegion>Faculté de Pharmacie Paris XI</wicri:noRegion><wicri:noRegion>Châtenay-Malabry</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Guadeloupe</term><term>Mitochondria</term><term>Nervous system diseases</term><term>Neurotoxin</term><term>Parkinson disease</term><term>Parkinsonism</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinsonisme</term><term>Parkinson maladie</term><term>Guadeloupe</term><term>Neurotoxine</term><term>Mitochondrie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Guadeloupe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Atypical parkinsonism in Guadeloupe has been associated with the consumption of fruit and infusions or decoctions prepared from leaves of Annona muricata L. (Annonaceae), which contains annonaceous acetogenins, lipophilic inhibitors of complex I of the mitochondrial respiratory chain. We have determined the concentrations of annonacin, the major acetogenin in A. muricata, in extracts of fruit and leaves by matrix-assisted laser desorption-ionization mass spectrometry. An average fruit is estimated to contain about 15 mg of annonacin, a can of commercial nectar 36 mg, and a cup of infusion or decoction 140 μg. As an indication of its potential toxicity, an adult who consumes one fruit or can of nectar a day is estimated to ingest over 1 year the amount of annonacin that induced brain lesions in rats receiving purified annonacin by intravenous infusion.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>20</s2></fA05><fA06><s2>12</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe</s1></fA08><fA11 i1="01" i2="1"><s1>CHAMPY (Pierre)</s1></fA11><fA11 i1="02" i2="1"><s1>MELOT (Alice)</s1></fA11><fA11 i1="03" i2="1"><s1>GUERINEAU (Vincent)</s1></fA11><fA11 i1="04" i2="1"><s1>GLEYE (Christophe)</s1></fA11><fA11 i1="05" i2="1"><s1>FALL (Djibril)</s1></fA11><fA11 i1="06" i2="1"><s1>HÖGLINGER (Gunter U.)</s1></fA11><fA11 i1="07" i2="1"><s1>RUBERG (Merle)</s1></fA11><fA11 i1="08" i2="1"><s1>LANNUZEL (Annie)</s1></fA11><fA11 i1="09" i2="1"><s1>LAPREVOTE (Olivier)</s1></fA11><fA11 i1="10" i2="1"><s1>LAURENS (Alain)</s1></fA11><fA11 i1="11" i2="1"><s1>HOCQUEMILLER (Reynald)</s1></fA11><fA14 i1="01"><s1>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de Pharmacie Paris XI</s1><s2>Châtenay-Malabry</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="02"><s1>Laboratory of Mass Spectrometry, Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique (CNRS)</s1><s2>Gif-sur-Yvette</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></fA14><fA14 i1="03"><s1>Laboratory of Therapeutic Chemistry, Faculté de Pharmacie, Université Cheikh Anta Diop</s1><s2>Dakar</s2><s3>SEN</s3><sZ>5 aut.</sZ></fA14><fA14 i1="04"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM) U679, Experimental Neurology and Therapeutics</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Neurology, Centre Hospitalier Universitaire (CHU) Antilles-Guyane</s1><s2>Pointe-à-Pitre, Guadeloupe</s2><s3>FRA</s3><sZ>8 aut.</sZ></fA14><fA20><s1>1629-1633</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000153322170190</s5></fA43><fA44><s0>0000</s0><s1>© 2006 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>18 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>06-0191534</s0></fA47><fA60><s1>P</s1><s3>CC</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Atypical parkinsonism in Guadeloupe has been associated with the consumption of fruit and infusions or decoctions prepared from leaves of Annona muricata L. (Annonaceae), which contains annonaceous acetogenins, lipophilic inhibitors of complex I of the mitochondrial respiratory chain. We have determined the concentrations of annonacin, the major acetogenin in A. muricata, in extracts of fruit and leaves by matrix-assisted laser desorption-ionization mass spectrometry. An average fruit is estimated to contain about 15 mg of annonacin, a can of commercial nectar 36 mg, and a cup of infusion or decoction 140 μg. As an indication of its potential toxicity, an adult who consumes one fruit or can of nectar a day is estimated to ingest over 1 year the amount of annonacin that induced brain lesions in rats receiving purified annonacin by intravenous infusion.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC02 i1="03" i2="X"><s0>002B22D02</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Parkinsonisme</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Parkinsonism</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Parkinson síndrome</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Guadeloupe</s0><s2>NG</s2><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Guadeloupe</s0><s2>NG</s2><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Guadalupe</s0><s2>NG</s2><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Neurotoxine</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Neurotoxin</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Neurotoxina</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Mitochondrie</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Mitochondria</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Mitocondria</s0><s5>11</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Antilles</s0><s2>NG</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>West Indies</s0><s2>NG</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Antillas</s0><s2>NG</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Amérique Centrale</s0><s2>NG</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Central America</s0><s2>NG</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>America central</s0><s2>NG</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Amérique</s0><s2>NG</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>America</s0><s2>NG</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>America</s0><s2>NG</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Toxine</s0></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Toxin</s0></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Toxina</s0></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>37</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>40</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fN21><s1>114</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>France</li><li>Sénégal</li></country><region><li>Île-de-France</li></region><settlement><li>Gif-sur-Yvette</li><li>Paris</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Champy, Pierre" sort="Champy, Pierre" uniqKey="Champy P" first="Pierre" last="Champy">Pierre Champy</name></noRegion><name sortKey="Fall, Djibril" sort="Fall, Djibril" uniqKey="Fall D" first="Djibril" last="Fall">Djibril Fall</name><name sortKey="Gleye, Christophe" sort="Gleye, Christophe" uniqKey="Gleye C" first="Christophe" last="Gleye">Christophe Gleye</name><name sortKey="Guerineau, Vincent" sort="Guerineau, Vincent" uniqKey="Guerineau V" first="Vincent" last="Guerineau">Vincent Guerineau</name><name sortKey="Hocquemiller, Reynald" sort="Hocquemiller, Reynald" uniqKey="Hocquemiller R" first="Reynald" last="Hocquemiller">Reynald Hocquemiller</name><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Gunter U." last="Höglinger">Gunter U. Höglinger</name><name sortKey="Lannuzel, Annie" sort="Lannuzel, Annie" uniqKey="Lannuzel A" first="Annie" last="Lannuzel">Annie Lannuzel</name><name sortKey="Lannuzel, Annie" sort="Lannuzel, Annie" uniqKey="Lannuzel A" first="Annie" last="Lannuzel">Annie Lannuzel</name><name sortKey="Laprevote, Olivier" sort="Laprevote, Olivier" uniqKey="Laprevote O" first="Olivier" last="Laprevote">Olivier Laprevote</name><name sortKey="Laurens, Alain" sort="Laurens, Alain" uniqKey="Laurens A" first="Alain" last="Laurens">Alain Laurens</name><name sortKey="Melot, Alice" sort="Melot, Alice" uniqKey="Melot A" first="Alice" last="Melot">Alice Melot</name><name sortKey="Ruberg, Merle" sort="Ruberg, Merle" uniqKey="Ruberg M" first="Merle" last="Ruberg">Merle Ruberg</name></country><country name="Sénégal"><noRegion><name sortKey="Fall, Djibril" sort="Fall, Djibril" uniqKey="Fall D" first="Djibril" last="Fall">Djibril Fall</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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