ParkinsonFranceV1, PascalFrancis, Checkpoint, bibRecord, 000A98

REM Sleep behavior disorder and REM Sleep without atonia in patients with progressive supranuclear palsy

Identifieur interne : 000A98 ( PascalFrancis/Checkpoint ); précédent : 000A97; suivant : 000A99

REM Sleep behavior disorder and REM Sleep without atonia in patients with progressive supranuclear palsy

Auteurs : Isabelle Arnulf [France] ; Milagros Merino-Andreu [France] ; Frédéric Bloch [France] ; Eric Konofal [France] ; Marie Vidailhet [France] ; Valérie Cochen [France] ; Jean-Philippe Derenne [France] ; Yves Agid [France]

Source :

Sleep : (New York, NY) [ 0161-8105 ] ; 2005.

RBID : Pascal:05-0193219

Descripteurs français

Pascal (Inist)
- Paralysie susnucléaire, Etude comparative, Individu sain, Parkinson maladie, Sommeil paradoxal, Polysomnographie, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Comparative study, Healthy subject, Human, Parkinson disease, Polysomnography, Rapid eye movement sleep, Supranuclear paralysis.

Abstract

Study Objective: To compare sleep characteristics, rapid eye movement (REM) sleep without atonia, and REM sleep behavior disorder (RBD) in patients with progressive supranuclear palsy (tauopathy), patients with Parkinson's disease (a synucleinopathy), and control subjects. Design: Sleep interview, overnight polysomnography, and Multiple Sleep Latency Tests. Patients: Forty-five age- and sex-matched patients with probable progressive supranuclear palsy, (n = 15, aged 68 ± 8 years, 7 men), patients with Parkinson disease (n = 15), and control subjects (n = 15). Settings: Tertiary-care academic hospital. Intervention: N/A. Results: Compared to the 2 other groups, patients with progressive supranuclear palsy had a longer duration of wakefulness after sleep onset and twice as much sleep fragmentation and percentage of stage 1 sleep but had similar apnea-hypopnea indexes, periodic leg movements indexes, and mean daytime sleep latencies. REM sleep percentage was as low in patients with progressive supranuclear palsy (8% ± 6% of total sleep time) as in patients with Parkinson disease (10% ± 4%), versus 20% ± 6% in controls (analysis of variance, P <.0001). Interestingly, patients with progressive supranuclear palsy had percentages of REM sleep without atonia (chin muscle activity: 33% ± 36% of REM sleep) similar to those of patients with Parkinson disease (28% ± 35%) and dramatically higher than those of controls (0.5% ± 1%, analysis of variance, P =.008). Four (27%) patients with progressive supranuclear palsy had more than 50% REM sleep without atonia (as did a similar number of patients with Parkinson disease), and 2 of them (13%, vs 20% of patients with Parkinson disease) had clinical RBD. The four patients with progressive supranuclear palsy with excessive daytime sleepiness slept longer at night than the 11 patients with progressive supranuclear palsy who were alert (442 ± 14 minutes vs 312 ± 74 minutes, student t tests, P =.004), suggesting a primary nonnarcoleptic hypersomnia. Conclusion: REM sleep without atonia and RBD were as frequent in patients with progressive supranuclear palsy as in patients with Parkinson disease. It suggests that the downstream cause of parkinsonism, rather than its primary neuropathology (synucleinopathy vs tauopathy), is a key factor for REM sleep behavior disorder.

Affiliations:

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<front><div type="abstract" xml:lang="en">Study Objective: To compare sleep characteristics, rapid eye movement (REM) sleep without atonia, and REM sleep behavior disorder (RBD) in patients with progressive supranuclear palsy (tauopathy), patients with Parkinson's disease (a synucleinopathy), and control subjects. Design: Sleep interview, overnight polysomnography, and Multiple Sleep Latency Tests. Patients: Forty-five age- and sex-matched patients with probable progressive supranuclear palsy, (n = 15, aged 68 ± 8 years, 7 men), patients with Parkinson disease (n = 15), and control subjects (n = 15). Settings: Tertiary-care academic hospital. Intervention: N/A. Results: Compared to the 2 other groups, patients with progressive supranuclear palsy had a longer duration of wakefulness after sleep onset and twice as much sleep fragmentation and percentage of stage 1 sleep but had similar apnea-hypopnea indexes, periodic leg movements indexes, and mean daytime sleep latencies. REM sleep percentage was as low in patients with progressive supranuclear palsy (8% ± 6% of total sleep time) as in patients with Parkinson disease (10% ± 4%), versus 20% ± 6% in controls (analysis of variance, P <.0001). Interestingly, patients with progressive supranuclear palsy had percentages of REM sleep without atonia (chin muscle activity: 33% ± 36% of REM sleep) similar to those of patients with Parkinson disease (28% ± 35%) and dramatically higher than those of controls (0.5% ± 1%, analysis of variance, P =.008). Four (27%) patients with progressive supranuclear palsy had more than 50% REM sleep without atonia (as did a similar number of patients with Parkinson disease), and 2 of them (13%, vs 20% of patients with Parkinson disease) had clinical RBD. The four patients with progressive supranuclear palsy with excessive daytime sleepiness slept longer at night than the 11 patients with progressive supranuclear palsy who were alert (442 ± 14 minutes vs 312 ± 74 minutes, student t tests, P =.004), suggesting a primary nonnarcoleptic hypersomnia. Conclusion: REM sleep without atonia and RBD were as frequent in patients with progressive supranuclear palsy as in patients with Parkinson disease. It suggests that the downstream cause of parkinsonism, rather than its primary neuropathology (synucleinopathy vs tauopathy), is a key factor for REM sleep behavior disorder.</div>
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<fC01 i1="01" l="ENG"><s0>Study Objective: To compare sleep characteristics, rapid eye movement (REM) sleep without atonia, and REM sleep behavior disorder (RBD) in patients with progressive supranuclear palsy (tauopathy), patients with Parkinson's disease (a synucleinopathy), and control subjects. Design: Sleep interview, overnight polysomnography, and Multiple Sleep Latency Tests. Patients: Forty-five age- and sex-matched patients with probable progressive supranuclear palsy, (n = 15, aged 68 ± 8 years, 7 men), patients with Parkinson disease (n = 15), and control subjects (n = 15). Settings: Tertiary-care academic hospital. Intervention: N/A. Results: Compared to the 2 other groups, patients with progressive supranuclear palsy had a longer duration of wakefulness after sleep onset and twice as much sleep fragmentation and percentage of stage 1 sleep but had similar apnea-hypopnea indexes, periodic leg movements indexes, and mean daytime sleep latencies. REM sleep percentage was as low in patients with progressive supranuclear palsy (8% ± 6% of total sleep time) as in patients with Parkinson disease (10% ± 4%), versus 20% ± 6% in controls (analysis of variance, P <.0001). Interestingly, patients with progressive supranuclear palsy had percentages of REM sleep without atonia (chin muscle activity: 33% ± 36% of REM sleep) similar to those of patients with Parkinson disease (28% ± 35%) and dramatically higher than those of controls (0.5% ± 1%, analysis of variance, P =.008). Four (27%) patients with progressive supranuclear palsy had more than 50% REM sleep without atonia (as did a similar number of patients with Parkinson disease), and 2 of them (13%, vs 20% of patients with Parkinson disease) had clinical RBD. The four patients with progressive supranuclear palsy with excessive daytime sleepiness slept longer at night than the 11 patients with progressive supranuclear palsy who were alert (442 ± 14 minutes vs 312 ± 74 minutes, student t tests, P =.004), suggesting a primary nonnarcoleptic hypersomnia. Conclusion: REM sleep without atonia and RBD were as frequent in patients with progressive supranuclear palsy as in patients with Parkinson disease. It suggests that the downstream cause of parkinsonism, rather than its primary neuropathology (synucleinopathy vs tauopathy), is a key factor for REM sleep behavior disorder.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17I</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002A26D05</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Paralysie susnucléaire</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Supranuclear paralysis</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Parálisis supranuclear</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Etude comparative</s0>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Comparative study</s0>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Estudio comparativo</s0>
<s5>04</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Individu sain</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Healthy subject</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Individuo sano</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Sommeil paradoxal</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Rapid eye movement sleep</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Sueño paradojal</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Polysomnographie</s0>
<s5>13</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Polysomnography</s0>
<s5>13</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Polisomnografía</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Homme</s0>
<s5>20</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Human</s0>
<s5>20</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Hombre</s0>
<s5>20</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>53</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>53</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>53</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>54</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>54</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>54</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>55</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>55</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>55</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>56</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>56</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>56</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>57</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>57</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>57</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Electrodiagnostic</s0>
<s5>69</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Electrodiagnosis</s0>
<s5>69</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Electrodiagnóstico</s0>
<s5>69</s5>
</fC07>
<fN21><s1>136</s1>
</fN21>
<fN44 i1="01"><s1>PSI</s1>
</fN44>
<fN82><s1>PSI</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
</settlement>
<orgName><li>Hôpital de la Salpêtrière</li>
</orgName>
</list>
<tree><country name="France"><noRegion><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
</noRegion>
<name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<name sortKey="Bloch, Frederic" sort="Bloch, Frederic" uniqKey="Bloch F" first="Frédéric" last="Bloch">Frédéric Bloch</name>
<name sortKey="Cochen, Valerie" sort="Cochen, Valerie" uniqKey="Cochen V" first="Valérie" last="Cochen">Valérie Cochen</name>
<name sortKey="Derenne, Jean Philippe" sort="Derenne, Jean Philippe" uniqKey="Derenne J" first="Jean-Philippe" last="Derenne">Jean-Philippe Derenne</name>
<name sortKey="Konofal, Eric" sort="Konofal, Eric" uniqKey="Konofal E" first="Eric" last="Konofal">Eric Konofal</name>
<name sortKey="Merino Andreu, Milagros" sort="Merino Andreu, Milagros" uniqKey="Merino Andreu M" first="Milagros" last="Merino-Andreu">Milagros Merino-Andreu</name>
<name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name>
<name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name>
</country>
</tree>
</affiliations>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

REM Sleep behavior disorder and REM Sleep without atonia in patients with progressive supranuclear palsy

REM Sleep behavior disorder and REM Sleep without atonia in patients with progressive supranuclear palsy

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