Increased prenatal exposure to methylmercury does not affect the risk of Parkinson's disease
Identifieur interne : 000754 ( PascalFrancis/Checkpoint ); précédent : 000753; suivant : 000755Increased prenatal exposure to methylmercury does not affect the risk of Parkinson's disease
Auteurs : Maria Skaalum Petersen [Danemark] ; Pal Weihe [Danemark] ; Anna Choi [États-Unis] ; Philippe Grandjean [Danemark, États-Unis]Source :
- Neurotoxicology : (Park Forest South) [ 0161-813X ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
This study aimed to determine whether prenatal methylmercury (MeHg) exposure is a risk factor for Parkinson's disease (PD). A total of 172 clinically confirmed PD cases and 1018 controls matched by vital status, sex and age were included. The cases were ascertained in 1995 or were diagnosed during 1995-2005 in the Faroe Islands where the prevalence of PD is twice as high as elsewhere in northern Europe. Because the main single source of increased MeHg exposure in the Faroes is whale meat, retrospective exposure assessment was possible using detailed whaling records, rules of whale meat distribution and census lists. The share for each resident was calculated from the total amount of whale meat landed divided by the number of residents in the district entitled to a share. Utilizing the calculated share per resident at the mother's residence prior to the date of parturition, maternal body burden profiles were calculated as the average hair Hg concentration during the whole pregnancy, during the third trimester, and at the beginning of the third trimester. The exposures were compared between cases and controls using Mantel-Haenszel odds ratios (ORs), X2 and logistic regressions. All analytical methods gave ORs close to 1.0, none of them approaching statistical significance. The upper confidence limit was clearly below 2.0 in all analyses. No significant association between PD and prenatal MeHg exposure was found in this study, thus providing no support for prenatal MeHg exposure as an important risk factor that might explain the doubling of PD prevalence in this population.
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i1="01"><s1>Institute of Public Health, Environmental Medicine, University of Southern Denmark, Winslowparken 17</s1><s2>5000 Odense</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>5000 Odense</wicri:noRegion></affiliation><affiliation><inist:fA14 i1="02"><s1>The Faroese Hospital System, Department of Occupational and Public Health, Sigmundargota 5</s1><s2>100 Tdrshavn</s2><s3>FRO</s3><sZ>2 aut.</sZ></inist:fA14><wicri:noCountry>FRO</wicri:noCountry></affiliation></author><author><name sortKey="Choi, Anna" sort="Choi, Anna" uniqKey="Choi A" first="Anna" last="Choi">Anna Choi</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Environmental Health, Harvard School of Public Health</s1><s2>Boston, MA 02215</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Grandjean, Philippe" sort="Grandjean, Philippe" uniqKey="Grandjean P" first="Philippe" last="Grandjean">Philippe Grandjean</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Public Health, Environmental Medicine, University of Southern Denmark, Winslowparken 17</s1><s2>5000 Odense</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>5000 Odense</wicri:noRegion></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Environmental Health, Harvard School of Public Health</s1><s2>Boston, MA 02215</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Neurotoxicology : (Park Forest South)</title><title level="j" type="abbreviated">Neurotoxicology : (Park Forest South)</title><idno type="ISSN">0161-813X</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurotoxicology : (Park Forest South)</title><title level="j" type="abbreviated">Neurotoxicology : (Park Forest South)</title><idno type="ISSN">0161-813X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Exposure</term><term>Mercury Organic compounds</term><term>Parkinson disease</term><term>Prenatal</term><term>Risk</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Prénatal</term><term>Exposition</term><term>Mercure Composé organique</term><term>Facteur risque</term><term>Risque</term><term>Maladie de Parkinson</term><term>Mercure(méthyl)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study aimed to determine whether prenatal methylmercury (MeHg) exposure is a risk factor for Parkinson's disease (PD). A total of 172 clinically confirmed PD cases and 1018 controls matched by vital status, sex and age were included. The cases were ascertained in 1995 or were diagnosed during 1995-2005 in the Faroe Islands where the prevalence of PD is twice as high as elsewhere in northern Europe. Because the main single source of increased MeHg exposure in the Faroes is whale meat, retrospective exposure assessment was possible using detailed whaling records, rules of whale meat distribution and census lists. The share for each resident was calculated from the total amount of whale meat landed divided by the number of residents in the district entitled to a share. Utilizing the calculated share per resident at the mother's residence prior to the date of parturition, maternal body burden profiles were calculated as the average hair Hg concentration during the whole pregnancy, during the third trimester, and at the beginning of the third trimester. The exposures were compared between cases and controls using Mantel-Haenszel odds ratios (ORs), X<sup>2</sup> and logistic regressions. All analytical methods gave ORs close to 1.0, none of them approaching statistical significance. The upper confidence limit was clearly below 2.0 in all analyses. No significant association between PD and prenatal MeHg exposure was found in this study, thus providing no support for prenatal MeHg exposure as an important risk factor that might explain the doubling of PD prevalence in this population.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0161-813X</s0></fA01><fA03 i2="1"><s0>Neurotoxicology : (Park Forest South)</s0></fA03><fA05><s2>29</s2></fA05><fA06><s2>4</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Increased prenatal exposure to methylmercury does not affect the risk of Parkinson's disease</s1></fA08><fA11 i1="01" i2="1"><s1>PETERSEN (Maria Skaalum)</s1></fA11><fA11 i1="02" i2="1"><s1>WEIHE (Pal)</s1></fA11><fA11 i1="03" i2="1"><s1>CHOI (Anna)</s1></fA11><fA11 i1="04" i2="1"><s1>GRANDJEAN (Philippe)</s1></fA11><fA14 i1="01"><s1>Institute of Public Health, Environmental Medicine, University of Southern Denmark, Winslowparken 17</s1><s2>5000 Odense</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="02"><s1>The Faroese Hospital System, Department of Occupational and Public Health, Sigmundargota 5</s1><s2>100 Tdrshavn</s2><s3>FRO</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Environmental Health, Harvard School of Public Health</s1><s2>Boston, MA 02215</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></fA14><fA20><s1>591-595</s1></fA20><fA21><s1>2008</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>18397</s2><s5>354000197693560040</s5></fA43><fA44><s0>0000</s0><s1>© 2008 INIST-CNRS. 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The share for each resident was calculated from the total amount of whale meat landed divided by the number of residents in the district entitled to a share. Utilizing the calculated share per resident at the mother's residence prior to the date of parturition, maternal body burden profiles were calculated as the average hair Hg concentration during the whole pregnancy, during the third trimester, and at the beginning of the third trimester. The exposures were compared between cases and controls using Mantel-Haenszel odds ratios (ORs), X<sup>2</sup> and logistic regressions. All analytical methods gave ORs close to 1.0, none of them approaching statistical significance. The upper confidence limit was clearly below 2.0 in all analyses. 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