ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 000865

Increased prenatal exposure to methylmercury does not affect the risk of Parkinson's disease

Identifieur interne : 000865 ( PascalFrancis/Corpus ); précédent : 000864; suivant : 000866

Increased prenatal exposure to methylmercury does not affect the risk of Parkinson's disease

Auteurs : Maria Skaalum Petersen ; Pal Weihe ; Anna Choi ; Philippe Grandjean

Source :

Neurotoxicology : (Park Forest South) [ 0161-813X ] ; 2008.

RBID : Pascal:08-0390970

Descripteurs français

Pascal (Inist)
- Prénatal, Exposition, Mercure Composé organique, Facteur risque, Risque, Maladie de Parkinson, Mercure(méthyl).

English descriptors

KwdEn :
- Exposure, Mercury Organic compounds, Parkinson disease, Prenatal, Risk, Risk factor.

Abstract

This study aimed to determine whether prenatal methylmercury (MeHg) exposure is a risk factor for Parkinson's disease (PD). A total of 172 clinically confirmed PD cases and 1018 controls matched by vital status, sex and age were included. The cases were ascertained in 1995 or were diagnosed during 1995-2005 in the Faroe Islands where the prevalence of PD is twice as high as elsewhere in northern Europe. Because the main single source of increased MeHg exposure in the Faroes is whale meat, retrospective exposure assessment was possible using detailed whaling records, rules of whale meat distribution and census lists. The share for each resident was calculated from the total amount of whale meat landed divided by the number of residents in the district entitled to a share. Utilizing the calculated share per resident at the mother's residence prior to the date of parturition, maternal body burden profiles were calculated as the average hair Hg concentration during the whole pregnancy, during the third trimester, and at the beginning of the third trimester. The exposures were compared between cases and controls using Mantel-Haenszel odds ratios (ORs), X² and logistic regressions. All analytical methods gave ORs close to 1.0, none of them approaching statistical significance. The upper confidence limit was clearly below 2.0 in all analyses. No significant association between PD and prenatal MeHg exposure was found in this study, thus providing no support for prenatal MeHg exposure as an important risk factor that might explain the doubling of PD prevalence in this population.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 PETERSEN (Maria Skaalum)`
A11	`02`	`1`		`@1 WEIHE (Pal)`
A11	`03`	`1`		`@1 CHOI (Anna)`
A11	`04`	`1`		`@1 GRANDJEAN (Philippe)`
A14	`01`			`@1 Institute of Public Health, Environmental Medicine, University of Southern Denmark, Winslowparken 17 @2 5000 Odense @3 DNK @Z 1 aut. @Z 2 aut. @Z 4 aut.`
A14	`02`			`@1 The Faroese Hospital System, Department of Occupational and Public Health, Sigmundargota 5 @2 100 Tdrshavn @3 FRO @Z 2 aut.`
A14	`03`			`@1 Department of Environmental Health, Harvard School of Public Health @2 Boston, MA 02215 @3 USA @Z 3 aut. @Z 4 aut.`
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A21				`@1 2008`
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C01	`01`		`ENG`	@0 This study aimed to determine whether prenatal methylmercury (MeHg) exposure is a risk factor for Parkinson's disease (PD). A total of 172 clinically confirmed PD cases and 1018 controls matched by vital status, sex and age were included. The cases were ascertained in 1995 or were diagnosed during 1995-2005 in the Faroe Islands where the prevalence of PD is twice as high as elsewhere in northern Europe. Because the main single source of increased MeHg exposure in the Faroes is whale meat, retrospective exposure assessment was possible using detailed whaling records, rules of whale meat distribution and census lists. The share for each resident was calculated from the total amount of whale meat landed divided by the number of residents in the district entitled to a share. Utilizing the calculated share per resident at the mother's residence prior to the date of parturition, maternal body burden profiles were calculated as the average hair Hg concentration during the whole pregnancy, during the third trimester, and at the beginning of the third trimester. The exposures were compared between cases and controls using Mantel-Haenszel odds ratios (ORs), X² and logistic regressions. All analytical methods gave ORs close to 1.0, none of them approaching statistical significance. The upper confidence limit was clearly below 2.0 in all analyses. No significant association between PD and prenatal MeHg exposure was found in this study, thus providing no support for prenatal MeHg exposure as an important risk factor that might explain the doubling of PD prevalence in this population.
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C03	`02`	`X`	`SPA`	`@0 Exposición @5 03`
C03	`03`	`X`	`FRE`	`@0 Mercure Composé organique @2 NC @2 FX @2 NA @5 05`
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C03	`04`	`X`	`ENG`	`@0 Risk factor @5 06`
C03	`04`	`X`	`SPA`	`@0 Factor riesgo @5 06`
C03	`05`	`X`	`FRE`	`@0 Risque @5 08`
C03	`05`	`X`	`ENG`	`@0 Risk @5 08`
C03	`05`	`X`	`SPA`	`@0 Riesgo @5 08`
C03	`06`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 10`
C03	`06`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 10`
C03	`06`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 10`
C03	`07`	`X`	`FRE`	`@0 Mercure(méthyl) @4 INC @5 86`
C07	`01`	`X`	`FRE`	`@0 Métal lourd @5 61`
C07	`01`	`X`	`ENG`	`@0 Heavy metal @5 61`
C07	`01`	`X`	`SPA`	`@0 Metal pesado @5 61`
C07	`02`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 62`
C07	`02`	`X`	`ENG`	`@0 Cerebral disorder @5 62`
C07	`02`	`X`	`SPA`	`@0 Encéfalo patología @5 62`
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Format Inist (serveur)

NO :	PASCAL 08-0390970 INIST
ET :	Increased prenatal exposure to methylmercury does not affect the risk of Parkinson's disease
AU :	PETERSEN (Maria Skaalum); WEIHE (Pal); CHOI (Anna); GRANDJEAN (Philippe)
AF :	Institute of Public Health, Environmental Medicine, University of Southern Denmark, Winslowparken 17/5000 Odense/Danemark (1 aut., 2 aut., 4 aut.); The Faroese Hospital System, Department of Occupational and Public Health, Sigmundargota 5/100 Tdrshavn/Féroé, Iles (2 aut.); Department of Environmental Health, Harvard School of Public Health/Boston, MA 02215/Etats-Unis (3 aut., 4 aut.)
DT :	Publication en série; Papier de recherche; Niveau analytique
SO :	Neurotoxicology : (Park Forest South); ISSN 0161-813X; Etats-Unis; Da. 2008; Vol. 29; No. 4; Pp. 591-595; Bibl. 1/2 p.
LA :	Anglais
EA :	This study aimed to determine whether prenatal methylmercury (MeHg) exposure is a risk factor for Parkinson's disease (PD). A total of 172 clinically confirmed PD cases and 1018 controls matched by vital status, sex and age were included. The cases were ascertained in 1995 or were diagnosed during 1995-2005 in the Faroe Islands where the prevalence of PD is twice as high as elsewhere in northern Europe. Because the main single source of increased MeHg exposure in the Faroes is whale meat, retrospective exposure assessment was possible using detailed whaling records, rules of whale meat distribution and census lists. The share for each resident was calculated from the total amount of whale meat landed divided by the number of residents in the district entitled to a share. Utilizing the calculated share per resident at the mother's residence prior to the date of parturition, maternal body burden profiles were calculated as the average hair Hg concentration during the whole pregnancy, during the third trimester, and at the beginning of the third trimester. The exposures were compared between cases and controls using Mantel-Haenszel odds ratios (ORs), X² and logistic regressions. All analytical methods gave ORs close to 1.0, none of them approaching statistical significance. The upper confidence limit was clearly below 2.0 in all analyses. No significant association between PD and prenatal MeHg exposure was found in this study, thus providing no support for prenatal MeHg exposure as an important risk factor that might explain the doubling of PD prevalence in this population.
CC :	002B03L05; 002B17G; 002B17A01
FD :	Prénatal; Exposition; Mercure Composé organique; Facteur risque; Risque; Maladie de Parkinson; Mercure(méthyl)
FG :	Métal lourd; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Pathologie du système nerveux
ED :	Prenatal; Exposure; Mercury Organic compounds; Risk factor; Risk; Parkinson disease
EG :	Heavy metal; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases
SD :	Prenatal; Exposición; Mercurio Compuesto orgánico; Factor riesgo; Riesgo; Parkinson enfermedad
LO :	INIST-18397.354000197693560040
ID :	08-0390970

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Pascal:08-0390970

Le document en format XML

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<front><div type="abstract" xml:lang="en">This study aimed to determine whether prenatal methylmercury (MeHg) exposure is a risk factor for Parkinson's disease (PD). A total of 172 clinically confirmed PD cases and 1018 controls matched by vital status, sex and age were included. The cases were ascertained in 1995 or were diagnosed during 1995-2005 in the Faroe Islands where the prevalence of PD is twice as high as elsewhere in northern Europe. Because the main single source of increased MeHg exposure in the Faroes is whale meat, retrospective exposure assessment was possible using detailed whaling records, rules of whale meat distribution and census lists. The share for each resident was calculated from the total amount of whale meat landed divided by the number of residents in the district entitled to a share. Utilizing the calculated share per resident at the mother's residence prior to the date of parturition, maternal body burden profiles were calculated as the average hair Hg concentration during the whole pregnancy, during the third trimester, and at the beginning of the third trimester. The exposures were compared between cases and controls using Mantel-Haenszel odds ratios (ORs), X<sup>2</sup>
 and logistic regressions. All analytical methods gave ORs close to 1.0, none of them approaching statistical significance. The upper confidence limit was clearly below 2.0 in all analyses. No significant association between PD and prenatal MeHg exposure was found in this study, thus providing no support for prenatal MeHg exposure as an important risk factor that might explain the doubling of PD prevalence in this population.</div>
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<fC01 i1="01" l="ENG"><s0>This study aimed to determine whether prenatal methylmercury (MeHg) exposure is a risk factor for Parkinson's disease (PD). A total of 172 clinically confirmed PD cases and 1018 controls matched by vital status, sex and age were included. The cases were ascertained in 1995 or were diagnosed during 1995-2005 in the Faroe Islands where the prevalence of PD is twice as high as elsewhere in northern Europe. Because the main single source of increased MeHg exposure in the Faroes is whale meat, retrospective exposure assessment was possible using detailed whaling records, rules of whale meat distribution and census lists. The share for each resident was calculated from the total amount of whale meat landed divided by the number of residents in the district entitled to a share. Utilizing the calculated share per resident at the mother's residence prior to the date of parturition, maternal body burden profiles were calculated as the average hair Hg concentration during the whole pregnancy, during the third trimester, and at the beginning of the third trimester. The exposures were compared between cases and controls using Mantel-Haenszel odds ratios (ORs), X<sup>2</sup>
 and logistic regressions. All analytical methods gave ORs close to 1.0, none of them approaching statistical significance. The upper confidence limit was clearly below 2.0 in all analyses. No significant association between PD and prenatal MeHg exposure was found in this study, thus providing no support for prenatal MeHg exposure as an important risk factor that might explain the doubling of PD prevalence in this population.</s0>
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<s2>NA</s2>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Mercurio Compuesto orgánico</s0>
<s2>NC</s2>
<s2>FX</s2>
<s2>NA</s2>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Facteur risque</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Risk factor</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Factor riesgo</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Risque</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Risk</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Riesgo</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Mercure(méthyl)</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Métal lourd</s0>
<s5>61</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Heavy metal</s0>
<s5>61</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Metal pesado</s0>
<s5>61</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>62</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>62</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>62</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>63</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>63</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>63</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>64</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>64</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>64</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>65</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>65</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>65</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>66</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>66</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>66</s5>
</fC07>
<fN21><s1>252</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 08-0390970 INIST</NO>
<ET>Increased prenatal exposure to methylmercury does not affect the risk of Parkinson's disease</ET>
<AU>PETERSEN (Maria Skaalum); WEIHE (Pal); CHOI (Anna); GRANDJEAN (Philippe)</AU>
<AF>Institute of Public Health, Environmental Medicine, University of Southern Denmark, Winslowparken 17/5000 Odense/Danemark (1 aut., 2 aut., 4 aut.); The Faroese Hospital System, Department of Occupational and Public Health, Sigmundargota 5/100 Tdrshavn/Féroé, Iles (2 aut.); Department of Environmental Health, Harvard School of Public Health/Boston, MA 02215/Etats-Unis (3 aut., 4 aut.)</AF>
<DT>Publication en série; Papier de recherche; Niveau analytique</DT>
<SO>Neurotoxicology : (Park Forest South); ISSN 0161-813X; Etats-Unis; Da. 2008; Vol. 29; No. 4; Pp. 591-595; Bibl. 1/2 p.</SO>
<LA>Anglais</LA>
<EA>This study aimed to determine whether prenatal methylmercury (MeHg) exposure is a risk factor for Parkinson's disease (PD). A total of 172 clinically confirmed PD cases and 1018 controls matched by vital status, sex and age were included. The cases were ascertained in 1995 or were diagnosed during 1995-2005 in the Faroe Islands where the prevalence of PD is twice as high as elsewhere in northern Europe. Because the main single source of increased MeHg exposure in the Faroes is whale meat, retrospective exposure assessment was possible using detailed whaling records, rules of whale meat distribution and census lists. The share for each resident was calculated from the total amount of whale meat landed divided by the number of residents in the district entitled to a share. Utilizing the calculated share per resident at the mother's residence prior to the date of parturition, maternal body burden profiles were calculated as the average hair Hg concentration during the whole pregnancy, during the third trimester, and at the beginning of the third trimester. The exposures were compared between cases and controls using Mantel-Haenszel odds ratios (ORs), X<sup>2</sup>
 and logistic regressions. All analytical methods gave ORs close to 1.0, none of them approaching statistical significance. The upper confidence limit was clearly below 2.0 in all analyses. No significant association between PD and prenatal MeHg exposure was found in this study, thus providing no support for prenatal MeHg exposure as an important risk factor that might explain the doubling of PD prevalence in this population.</EA>
<CC>002B03L05; 002B17G; 002B17A01</CC>
<FD>Prénatal; Exposition; Mercure Composé organique; Facteur risque; Risque; Maladie de Parkinson; Mercure(méthyl)</FD>
<FG>Métal lourd; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central; Pathologie du   système nerveux</FG>
<ED>Prenatal; Exposure; Mercury Organic compounds; Risk factor; Risk; Parkinson disease</ED>
<EG>Heavy metal; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases</EG>
<SD>Prenatal; Exposición; Mercurio Compuesto orgánico; Factor riesgo; Riesgo; Parkinson enfermedad</SD>
<LO>INIST-18397.354000197693560040</LO>
<ID>08-0390970</ID>
</server>
</inist>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Increased prenatal exposure to methylmercury does not affect the risk of Parkinson's disease

Increased prenatal exposure to methylmercury does not affect the risk of Parkinson's disease

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