Deficit in evaluating pre-determined sequences of script events in patients with Parkinson's disease.
Identifieur interne : 001F45 ( Ncbi/Merge ); précédent : 001F44; suivant : 001F46Deficit in evaluating pre-determined sequences of script events in patients with Parkinson's disease.
Auteurs : T. Zalla [France] ; A. Sirigu ; B. Pillon ; B. Dubois ; J. Grafman ; Yves Agid [France]Source :
- Cortex; a journal devoted to the study of the nervous system and behavior [ 0010-9452 ] ; 1998.
English descriptors
- KwdEn :
- MESH :
- physiology : Cognition, Higher Nervous Activity, Memory, Reaction Time.
- physiopathology : Corpus Striatum, Frontal Lobe, Parkinson Disease.
- Adult, Aged, Female, Humans, Male, Middle Aged, Neuropsychological Tests.
Abstract
The purpose of the present study was to assess how the striato-frontal system contributes to the manipulation of goal-directed actions. We studied a group of ten patients with Parkinson's disease (PD) in order to investigate which aspects of action knowledge processing are impaired and to define the conditions under which the deficits may occur. PD patients committed errors of sequence and inserted distractors in tasks that required them to order pre-determined events belonging to a given script in a typical sequence. Rather than attributing errors of event sequencing to a deficit of script "syntax" knowledge, we suggest that the difficulties manifested by PD patients were due to an impairment of a switching mechanism that is necessary for processing information in parallel.
PubMed: 9800095
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pubmed:9800095Le document en format XML
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<front><div type="abstract" xml:lang="en">The purpose of the present study was to assess how the striato-frontal system contributes to the manipulation of goal-directed actions. We studied a group of ten patients with Parkinson's disease (PD) in order to investigate which aspects of action knowledge processing are impaired and to define the conditions under which the deficits may occur. PD patients committed errors of sequence and inserted distractors in tasks that required them to order pre-determined events belonging to a given script in a typical sequence. Rather than attributing errors of event sequencing to a deficit of script "syntax" knowledge, we suggest that the difficulties manifested by PD patients were due to an impairment of a switching mechanism that is necessary for processing information in parallel.</div>
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<Abstract><AbstractText>The purpose of the present study was to assess how the striato-frontal system contributes to the manipulation of goal-directed actions. We studied a group of ten patients with Parkinson's disease (PD) in order to investigate which aspects of action knowledge processing are impaired and to define the conditions under which the deficits may occur. PD patients committed errors of sequence and inserted distractors in tasks that required them to order pre-determined events belonging to a given script in a typical sequence. Rather than attributing errors of event sequencing to a deficit of script "syntax" knowledge, we suggest that the difficulties manifested by PD patients were due to an impairment of a switching mechanism that is necessary for processing information in parallel.</AbstractText>
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