Non-apoptotic functions of apoptosis-regulatory proteins
Identifieur interne : 000E66 ( Ncbi/Merge ); précédent : 000E65; suivant : 000E67Non-apoptotic functions of apoptosis-regulatory proteins
Auteurs : Lorenzo Galluzzi [France] ; Oliver Kepp [France] ; Christina Trojel-Hansen [France] ; Guido Kroemer [France]Source :
- EMBO Reports [ 1469-221X ] ; 2012.
Abstract
Galluzzi, Kroemer and colleagues summarize the important roles of apoptotic regulators and executioners in non-lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation.
Url:
DOI: 10.1038/embor.2012.19
PubMed: 22402666
PubMed Central: 3321152
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Galluzzi</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U848, IGR, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F-94805 Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institut Gustave Roussy</institution>, Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Université Paris Sud</institution>, Paris 11, Le Kremlin-Bicêtre,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U848, IGR, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F-94805 Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institut Gustave Roussy</institution>, Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Université Paris Sud</institution>, Paris 11, Le Kremlin-Bicêtre,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Trojel Hansen, Christina" sort="Trojel Hansen, Christina" uniqKey="Trojel Hansen C" first="Christina" last="Trojel-Hansen">Christina Trojel-Hansen</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U848, IGR, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F-94805 Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institut Gustave Roussy</institution>, Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Université Paris Sud</institution>, Paris 11, Le Kremlin-Bicêtre,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>INSERM</institution>, U848, IGR, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F-94805 Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Metabolomics Platform, Institut Gustave Roussy</institution>, Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="a5"><institution>Centre de Recherche des Cordeliers</institution>, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Université Paris Descartes, Sorbonne Paris Cité</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">EMBO Reports</title><idno type="ISSN">1469-221X</idno><idno type="eISSN">1469-3178</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Galluzzi, Kroemer and colleagues summarize the important roles of apoptotic regulators and executioners in non-lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">EMBO Rep</journal-id><journal-id journal-id-type="iso-abbrev">EMBO Rep</journal-id><journal-title-group><journal-title>EMBO Reports</journal-title></journal-title-group><issn pub-type="ppub">1469-221X</issn><issn pub-type="epub">1469-3178</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22402666</article-id><article-id pub-id-type="pmc">3321152</article-id><article-id pub-id-type="pii">embor201219</article-id><article-id pub-id-type="doi">10.1038/embor.2012.19</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>Non-apoptotic functions of apoptosis-regulatory proteins</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Galluzzi</surname><given-names>Lorenzo</given-names></name><xref ref-type="aff" rid="a1">1</xref><xref ref-type="aff" rid="a2">2</xref><xref ref-type="aff" rid="a3">3</xref></contrib><contrib contrib-type="author"><name><surname>Kepp</surname><given-names>Oliver</given-names></name><xref ref-type="aff" rid="a1">1</xref><xref ref-type="aff" rid="a2">2</xref><xref ref-type="aff" rid="a3">3</xref></contrib><contrib contrib-type="author"><name><surname>Trojel-Hansen</surname><given-names>Christina</given-names></name><xref ref-type="aff" rid="a1">1</xref><xref ref-type="aff" rid="a2">2</xref><xref ref-type="aff" rid="a3">3</xref></contrib><contrib contrib-type="author"><name><surname>Kroemer</surname><given-names>Guido</given-names></name><xref ref-type="corresp" rid="c1">a</xref><xref ref-type="aff" rid="a1">1</xref><xref ref-type="aff" rid="a4">4</xref><xref ref-type="aff" rid="a5">5</xref><xref ref-type="aff" rid="a6">6</xref><xref ref-type="aff" rid="a7">7</xref></contrib><aff id="a1"><label>1</label><institution>INSERM</institution>, U848, IGR, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F-94805 Villejuif,<country>France</country></aff><aff id="a2"><label>2</label><institution>Institut Gustave Roussy</institution>, Villejuif,<country>France</country></aff><aff id="a3"><label>3</label><institution>Université Paris Sud</institution>, Paris 11, Le Kremlin-Bicêtre,<country>France</country></aff><aff id="a4"><label>4</label><institution>Metabolomics Platform, Institut Gustave Roussy</institution>, Villejuif,<country>France</country></aff><aff id="a5"><label>5</label><institution>Centre de Recherche des Cordeliers</institution>, Paris, France</aff><aff id="a6"><label>6</label><institution>Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP</institution>, Paris,<country>France</country></aff><aff id="a7"><label>7</label><institution>Université Paris Descartes, Sorbonne Paris Cité</institution>, Paris,<country>France</country></aff></contrib-group><author-notes><corresp id="c1"><label>a</label>Tel: +33 1 4211 6046; Fax: +33 1 4211 6047;
E-mail: <email>kroemer@orange.fr</email></corresp><fn><p><xref ref-type="fig" rid="illus1"></xref></p></fn></author-notes><pub-date pub-type="ppub"><month>04</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>09</day><month>03</month><year>2012</year></pub-date><volume>13</volume><issue>4</issue><fpage>322</fpage><lpage>330</lpage><history><date date-type="received"><day>26</day><month>11</month><year>2011</year></date><date date-type="accepted"><day>23</day><month>01</month><year>2012</year></date></history><permissions><copyright-statement>Copyright © 2012, European Molecular Biology Organization</copyright-statement><copyright-year>2012</copyright-year><copyright-holder>European Molecular Biology Organization</copyright-holder></permissions><abstract abstract-type="hidden-editorial-summary"><p>Galluzzi, Kroemer and colleagues summarize the important roles of apoptotic regulators and executioners in non-lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation.</p></abstract><abstract><p>During the past two decades, apoptotic cell death has been the subject of an intense wave of investigation, leading to the discovery of multiple gene products that govern both its induction and execution. In parallel, it has progressively become evident that most, if not all, proteins that had initially been discovered for their essential role in apoptosis also mediate a wide range of non-apoptotic functions. On the one hand, apoptotic regulators and executioners are involved in non-lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation. On the other hand, pro-apoptotic proteins can control other modalities of programmed cell death, in particular regulated necrosis. In this review, we summarize the unconventional roles of the apoptotic core machinery from a functional perspective and discuss their pathophysiological implications.
<italic>EMBO reports</italic> advance online publication 9 March 2012; doi:10.1038/embor.2012.19</p></abstract><kwd-group><kwd>AIF</kwd><kwd>apoptosome</kwd><kwd>BCL-2</kwd><kwd>caspase</kwd><kwd>death receptor</kwd><kwd>mitochondrial membrane permeabilization</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name></noRegion><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Trojel Hansen, Christina" sort="Trojel Hansen, Christina" uniqKey="Trojel Hansen C" first="Christina" last="Trojel-Hansen">Christina Trojel-Hansen</name><name sortKey="Trojel Hansen, Christina" sort="Trojel Hansen, Christina" uniqKey="Trojel Hansen C" first="Christina" last="Trojel-Hansen">Christina Trojel-Hansen</name><name sortKey="Trojel Hansen, Christina" sort="Trojel Hansen, Christina" uniqKey="Trojel Hansen C" first="Christina" last="Trojel-Hansen">Christina Trojel-Hansen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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