Non-apoptotic functions of apoptosis-regulatory proteins
Identifieur interne : 000585 ( Pmc/Checkpoint ); précédent : 000584; suivant : 000586Non-apoptotic functions of apoptosis-regulatory proteins
Auteurs : Lorenzo Galluzzi [France] ; Oliver Kepp [France] ; Christina Trojel-Hansen [France] ; Guido Kroemer [France]Source :
- EMBO Reports [ 1469-221X ] ; 2012.
Abstract
Galluzzi, Kroemer and colleagues summarize the important roles of apoptotic regulators and executioners in non-lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation.
Url:
DOI: 10.1038/embor.2012.19
PubMed: 22402666
PubMed Central: 3321152
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>Galluzzi, Kroemer and colleagues summarize the important roles of apoptotic regulators and executioners in non-lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation.</p>
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Tel: +33 1 4211 6046; Fax: +33 1 4211 6047;
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<abstract abstract-type="hidden-editorial-summary"><p>Galluzzi, Kroemer and colleagues summarize the important roles of apoptotic regulators and executioners in non-lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation.</p>
</abstract>
<abstract><p>During the past two decades, apoptotic cell death has been the subject of an intense wave of investigation, leading to the discovery of multiple gene products that govern both its induction and execution. In parallel, it has progressively become evident that most, if not all, proteins that had initially been discovered for their essential role in apoptosis also mediate a wide range of non-apoptotic functions. On the one hand, apoptotic regulators and executioners are involved in non-lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation. On the other hand, pro-apoptotic proteins can control other modalities of programmed cell death, in particular regulated necrosis. In this review, we summarize the unconventional roles of the apoptotic core machinery from a functional perspective and discuss their pathophysiological implications.
<italic>EMBO reports</italic>
advance online publication 9 March 2012; doi:10.1038/embor.2012.19</p>
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