Low-dose clozapine improves dyskinesias in Parkinson's disease.
Identifieur interne : 001E53 ( Ncbi/Curation ); précédent : 001E52; suivant : 001E54Low-dose clozapine improves dyskinesias in Parkinson's disease.
Auteurs : F. Durif [France] ; M. Vidailhet ; F. Assal ; C. Roche ; A M Bonnet ; Yves Agid [France]Source :
- Neurology [ 0028-3878 ] ; 1997.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Antipsychotic Agents, Clozapine.
- drug therapy : Parkinson Disease.
- prevention & control : Movement Disorders.
- Aged, Humans, Middle Aged, Pilot Projects, Treatment Outcome.
Abstract
The severity of parkinsonian motor disability and dyskinesias was evaluated in seven levodopa-responsive patients with Parkinson's disease after an acute challenge with the mixed dopamine agonist apomorphine, before and after low-dose clozapine (50 mg) for 18 +/- 2 days. There was a significant 59% improvement (p < 0.05) of apomorphine-induced dyskinesias without aggravation of parkinsonian motor disability following clozapine treatment. The results suggest that low-dose clozapine, already shown to improve psychotic symptoms, may help to reduce severe levodopa-induced dyskinesias in parkinsonian patients.
PubMed: 9065543
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pubmed:9065543Le document en format XML
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<front><div type="abstract" xml:lang="en">The severity of parkinsonian motor disability and dyskinesias was evaluated in seven levodopa-responsive patients with Parkinson's disease after an acute challenge with the mixed dopamine agonist apomorphine, before and after low-dose clozapine (50 mg) for 18 +/- 2 days. There was a significant 59% improvement (p < 0.05) of apomorphine-induced dyskinesias without aggravation of parkinsonian motor disability following clozapine treatment. The results suggest that low-dose clozapine, already shown to improve psychotic symptoms, may help to reduce severe levodopa-induced dyskinesias in parkinsonian patients.</div>
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