Dysarthria in individuals with Parkinson's disease: a protocol for a binational, cross-sectional, case-controlled study in French and European Portuguese (FraLusoPark)
Identifieur interne : 001B59 ( Ncbi/Curation ); précédent : 001B58; suivant : 001B60Dysarthria in individuals with Parkinson's disease: a protocol for a binational, cross-sectional, case-controlled study in French and European Portuguese (FraLusoPark)
Auteurs : Serge Pinto [France] ; Rita Cardoso [Portugal] ; Jasmin Sadat [France] ; Isabel Guimarães [Portugal] ; Céline Mercier [France] ; Helena Santos [Portugal] ; Cyril Atkinson-Clement [France] ; Joana Carvalho [Portugal] ; Pauline Welby [France] ; Pedro Oliveira [Portugal] ; Mariapaola D'Imperio [France] ; S Nia Frota [Portugal] ; Alban Letanneux [France] ; Marina Vigario [Portugal] ; Marisa Cruz [Portugal] ; Isabel Pavão Martins [Portugal] ; François Viallet [France] ; Joaquim J. Ferreira [Portugal]Source :
- BMJ Open [ 2044-6055 ] ; 2016.
Abstract
Individuals with Parkinson's disease (PD) have to deal with several aspects of voice and speech decline and thus alteration of communication ability during the course of the disease. Among these communication impairments, 3 major challenges include: (1) dysarthria, consisting of orofacial motor dysfunction and dysprosody, which is linked to the neurodegenerative processes; (2) effects of the pharmacological treatment, which vary according to the disease stage; and (3) particular speech modifications that may be language-specific, that is, dependent on the language spoken by the patients. The main objective of the FraLusoPark project is to provide a thorough evaluation of changes in PD speech as a result of pharmacological treatment and disease duration in 2 different languages (French vs European Portuguese).
Individuals with PD are enrolled in the study in France (N=60) and Portugal (N=60). Their global motor disability and orofacial motor functions is assessed with specific clinical rating scales, without (OFF) and with (ON) pharmacological treatment. 2 groups of 60 healthy age-matched volunteers provide the reference for between-group comparisons. Along with the clinical examinations, several speech tasks are recorded to obtain acoustic and perceptual measures. Patient-reported outcome measures are used to assess the psychosocial impact of dysarthria on quality of life.
The study has been approved by the local responsible committees on human experimentation and is conducted in accordance with the ethical standards. A valuable large-scale database of speech recordings and metadata from patients with PD in France and Portugal will be constructed. Results will be disseminated in several articles in peer-reviewed journals and in conference presentations. Recommendations on how to assess speech and voice disorders in individuals with PD to monitor the progression and management of symptoms will be provided.
Url:
DOI: 10.1136/bmjopen-2016-012885
PubMed: 27856480
PubMed Central: 5128890
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Humanities, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cruz, Marisa" sort="Cruz, Marisa" uniqKey="Cruz M" first="Marisa" last="Cruz">Marisa Cruz</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Centre of Linguistics, School of Arts and Humanities, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martins, Isabel Pavao" sort="Martins, Isabel Pavao" uniqKey="Martins I" first="Isabel Pavão" last="Martins">Isabel Pavão Martins</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Neurology Department, Faculty of Medicine</addr-line>,<institution>Language Research Laboratory, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Viallet, Francois" sort="Viallet, Francois" uniqKey="Viallet F" first="François" last="Viallet">François Viallet</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Brain and Language Research Institute</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Neurology Department</addr-line>,<institution>Centre Hospitalier du Pays d'Aix</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ferreira, Joaquim J" sort="Ferreira, Joaquim J" uniqKey="Ferreira J" first="Joaquim J" last="Ferreira">Joaquim J. 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Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Brain and Language Research Institute</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cardoso, Rita" sort="Cardoso, Rita" uniqKey="Cardoso R" first="Rita" last="Cardoso">Rita Cardoso</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Campus Neurológico Sénior (CNS)</institution>,<addr-line>Torres Vedras</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Faculty of Medicine</addr-line>,<institution>Instituto de Medicina Molecular (IMM), University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sadat, Jasmin" sort="Sadat, Jasmin" uniqKey="Sadat J" first="Jasmin" last="Sadat">Jasmin Sadat</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Brain and Language Research Institute</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guimaraes, Isabel" sort="Guimaraes, Isabel" uniqKey="Guimaraes I" first="Isabel" last="Guimarães">Isabel Guimarães</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Faculty of Medicine</addr-line>,<institution>Instituto de Medicina Molecular (IMM), University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Speech Therapy Department</addr-line>,<institution>Escola Superior de Saude do Alcoitão</institution>,<addr-line>Alcabideche</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mercier, Celine" sort="Mercier, Celine" uniqKey="Mercier C" first="Céline" last="Mercier">Céline Mercier</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Neurology Department</addr-line>,<institution>Centre Hospitalier du Pays d'Aix</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Santos, Helena" sort="Santos, Helena" uniqKey="Santos H" first="Helena" last="Santos">Helena Santos</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Campus Neurológico Sénior (CNS)</institution>,<addr-line>Torres Vedras</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Atkinson Clement, Cyril" sort="Atkinson Clement, Cyril" uniqKey="Atkinson Clement C" first="Cyril" last="Atkinson-Clement">Cyril Atkinson-Clement</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Brain and Language Research Institute</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Carvalho, Joana" sort="Carvalho, Joana" uniqKey="Carvalho J" first="Joana" last="Carvalho">Joana Carvalho</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Campus Neurológico Sénior (CNS)</institution>,<addr-line>Torres Vedras</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Welby, Pauline" sort="Welby, Pauline" uniqKey="Welby P" first="Pauline" last="Welby">Pauline Welby</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Brain and Language Research Institute</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oliveira, Pedro" sort="Oliveira, Pedro" uniqKey="Oliveira P" first="Pedro" last="Oliveira">Pedro Oliveira</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Faculty of Medicine</addr-line>,<institution>Instituto de Medicina Molecular (IMM), University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Centre of Linguistics, School of Arts and Humanities, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="D Imperio, Mariapaola" sort="D Imperio, Mariapaola" uniqKey="D Imperio M" first="Mariapaola" last="D'Imperio">Mariapaola D'Imperio</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Brain and Language Research Institute</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Frota, S Nia" sort="Frota, S Nia" uniqKey="Frota S" first="S Nia" last="Frota">S Nia Frota</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Centre of Linguistics, School of Arts and Humanities, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Letanneux, Alban" sort="Letanneux, Alban" uniqKey="Letanneux A" first="Alban" last="Letanneux">Alban Letanneux</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vigario, Marina" sort="Vigario, Marina" uniqKey="Vigario M" first="Marina" last="Vigario">Marina Vigario</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Centre of Linguistics, School of Arts and Humanities, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cruz, Marisa" sort="Cruz, Marisa" uniqKey="Cruz M" first="Marisa" last="Cruz">Marisa Cruz</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Centre of Linguistics, School of Arts and Humanities, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martins, Isabel Pavao" sort="Martins, Isabel Pavao" uniqKey="Martins I" first="Isabel Pavão" last="Martins">Isabel Pavão Martins</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Neurology Department, Faculty of Medicine</addr-line>,<institution>Language Research Laboratory, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Viallet, Francois" sort="Viallet, Francois" uniqKey="Viallet F" first="François" last="Viallet">François Viallet</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Brain and Language Research Institute</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Neurology Department</addr-line>,<institution>Centre Hospitalier du Pays d'Aix</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ferreira, Joaquim J" sort="Ferreira, Joaquim J" uniqKey="Ferreira J" first="Joaquim J" last="Ferreira">Joaquim J. Ferreira</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Campus Neurológico Sénior (CNS)</institution>,<addr-line>Torres Vedras</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Faculty of Medicine</addr-line>,<institution>Instituto de Medicina Molecular (IMM), University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMJ Open</title><idno type="eISSN">2044-6055</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>Individuals with Parkinson's disease (PD) have to deal with several aspects of voice and speech decline and thus alteration of communication ability during the course of the disease. Among these communication impairments, 3 major challenges include: (1) dysarthria, consisting of orofacial motor dysfunction and dysprosody, which is linked to the neurodegenerative processes; (2) effects of the pharmacological treatment, which vary according to the disease stage; and (3) particular speech modifications that may be language-specific, that is, dependent on the language spoken by the patients. The main objective of the FraLusoPark project is to provide a thorough evaluation of changes in PD speech as a result of pharmacological treatment and disease duration in 2 different languages (French vs European Portuguese).</p></sec><sec><title>Methods and analysis</title><p>Individuals with PD are enrolled in the study in France (N=60) and Portugal (N=60). Their global motor disability and orofacial motor functions is assessed with specific clinical rating scales, without (OFF) and with (ON) pharmacological treatment. 2 groups of 60 healthy age-matched volunteers provide the reference for between-group comparisons. Along with the clinical examinations, several speech tasks are recorded to obtain acoustic and perceptual measures. Patient-reported outcome measures are used to assess the psychosocial impact of dysarthria on quality of life.</p></sec><sec><title>Ethics and dissemination</title><p>The study has been approved by the local responsible committees on human experimentation and is conducted in accordance with the ethical standards. A valuable large-scale database of speech recordings and metadata from patients with PD in France and Portugal will be constructed. Results will be disseminated in several articles in peer-reviewed journals and in conference presentations. Recommendations on how to assess speech and voice disorders in individuals with PD to monitor the progression and management of symptoms will be provided.</p></sec><sec><title>Trial registration number</title><p><ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/NCT02753192">NCT02753192</ext-link>, Pre-results.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Darley, Fl" uniqKey="Darley F">FL Darley</name></author><author><name sortKey="Aronson, Ae" uniqKey="Aronson A">AE Aronson</name></author><author><name sortKey="Brown, Jr" uniqKey="Brown J">JR Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Darley, Fl" uniqKey="Darley F">FL Darley</name></author><author><name sortKey="Aronson, Ae" uniqKey="Aronson A">AE Aronson</name></author><author><name sortKey="Brown, Jr" uniqKey="Brown J">JR 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