Dysarthria in individuals with Parkinson's disease: a protocol for a binational, cross-sectional, case-controlled study in French and European Portuguese (FraLusoPark)
Identifieur interne : 000089 ( Pmc/Checkpoint ); précédent : 000088; suivant : 000090Dysarthria in individuals with Parkinson's disease: a protocol for a binational, cross-sectional, case-controlled study in French and European Portuguese (FraLusoPark)
Auteurs : Serge Pinto [France] ; Rita Cardoso [Portugal] ; Jasmin Sadat [France] ; Isabel Guimarães [Portugal] ; Céline Mercier [France] ; Helena Santos [Portugal] ; Cyril Atkinson-Clement [France] ; Joana Carvalho [Portugal] ; Pauline Welby [France] ; Pedro Oliveira [Portugal] ; Mariapaola D'Imperio [France] ; S Nia Frota [Portugal] ; Alban Letanneux [France] ; Marina Vigario [Portugal] ; Marisa Cruz [Portugal] ; Isabel Pavão Martins [Portugal] ; François Viallet [France] ; Joaquim J. Ferreira [Portugal]Source :
- BMJ Open [ 2044-6055 ] ; 2016.
Abstract
Individuals with Parkinson's disease (PD) have to deal with several aspects of voice and speech decline and thus alteration of communication ability during the course of the disease. Among these communication impairments, 3 major challenges include: (1) dysarthria, consisting of orofacial motor dysfunction and dysprosody, which is linked to the neurodegenerative processes; (2) effects of the pharmacological treatment, which vary according to the disease stage; and (3) particular speech modifications that may be language-specific, that is, dependent on the language spoken by the patients. The main objective of the FraLusoPark project is to provide a thorough evaluation of changes in PD speech as a result of pharmacological treatment and disease duration in 2 different languages (French vs European Portuguese).
Individuals with PD are enrolled in the study in France (N=60) and Portugal (N=60). Their global motor disability and orofacial motor functions is assessed with specific clinical rating scales, without (OFF) and with (ON) pharmacological treatment. 2 groups of 60 healthy age-matched volunteers provide the reference for between-group comparisons. Along with the clinical examinations, several speech tasks are recorded to obtain acoustic and perceptual measures. Patient-reported outcome measures are used to assess the psychosocial impact of dysarthria on quality of life.
The study has been approved by the local responsible committees on human experimentation and is conducted in accordance with the ethical standards. A valuable large-scale database of speech recordings and metadata from patients with PD in France and Portugal will be constructed. Results will be disseminated in several articles in peer-reviewed journals and in conference presentations. Recommendations on how to assess speech and voice disorders in individuals with PD to monitor the progression and management of symptoms will be provided.
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DOI: 10.1136/bmjopen-2016-012885
PubMed: 27856480
PubMed Central: 5128890
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University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Letanneux, Alban" sort="Letanneux, Alban" uniqKey="Letanneux A" first="Alban" last="Letanneux">Alban Letanneux</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vigario, Marina" sort="Vigario, Marina" uniqKey="Vigario M" first="Marina" last="Vigario">Marina Vigario</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Centre of Linguistics, School of Arts and Humanities, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cruz, Marisa" sort="Cruz, Marisa" uniqKey="Cruz M" first="Marisa" last="Cruz">Marisa Cruz</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Centre of Linguistics, School of Arts and Humanities, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martins, Isabel Pavao" sort="Martins, Isabel Pavao" uniqKey="Martins I" first="Isabel Pavão" last="Martins">Isabel Pavão Martins</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Neurology Department, Faculty of Medicine</addr-line>,<institution>Language Research Laboratory, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Viallet, Francois" sort="Viallet, Francois" uniqKey="Viallet F" first="François" last="Viallet">François Viallet</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Brain and Language Research Institute</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Neurology Department</addr-line>,<institution>Centre Hospitalier du Pays d'Aix</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ferreira, Joaquim J" sort="Ferreira, Joaquim J" uniqKey="Ferreira J" first="Joaquim J" last="Ferreira">Joaquim J. Ferreira</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Campus Neurológico Sénior (CNS)</institution>,<addr-line>Torres Vedras</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Faculty of Medicine</addr-line>,<institution>Instituto de Medicina Molecular (IMM), University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27856480</idno><idno type="pmc">5128890</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128890</idno><idno type="RBID">PMC:5128890</idno><idno type="doi">10.1136/bmjopen-2016-012885</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000354</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000354</idno><idno type="wicri:Area/Pmc/Curation">000351</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000351</idno><idno type="wicri:Area/Pmc/Checkpoint">000089</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000089</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dysarthria in individuals with Parkinson's disease: a protocol for a binational, cross-sectional, case-controlled study in French and European Portuguese (FraLusoPark)</title><author><name sortKey="Pinto, Serge" sort="Pinto, Serge" uniqKey="Pinto S" first="Serge" last="Pinto">Serge Pinto</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Brain and Language Research Institute</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cardoso, Rita" sort="Cardoso, Rita" uniqKey="Cardoso R" first="Rita" last="Cardoso">Rita Cardoso</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Campus Neurológico Sénior (CNS)</institution>,<addr-line>Torres Vedras</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Faculty of Medicine</addr-line>,<institution>Instituto de Medicina Molecular (IMM), University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sadat, Jasmin" sort="Sadat, Jasmin" uniqKey="Sadat J" first="Jasmin" last="Sadat">Jasmin Sadat</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Brain and Language Research Institute</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guimaraes, Isabel" sort="Guimaraes, Isabel" uniqKey="Guimaraes I" first="Isabel" last="Guimarães">Isabel Guimarães</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Faculty of Medicine</addr-line>,<institution>Instituto de Medicina Molecular (IMM), University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Speech Therapy Department</addr-line>,<institution>Escola Superior de Saude do Alcoitão</institution>,<addr-line>Alcabideche</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mercier, Celine" sort="Mercier, Celine" uniqKey="Mercier C" first="Céline" last="Mercier">Céline Mercier</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Neurology Department</addr-line>,<institution>Centre Hospitalier du Pays d'Aix</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Santos, Helena" sort="Santos, Helena" uniqKey="Santos H" first="Helena" last="Santos">Helena Santos</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Campus Neurológico Sénior (CNS)</institution>,<addr-line>Torres Vedras</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Atkinson Clement, Cyril" sort="Atkinson Clement, Cyril" uniqKey="Atkinson Clement C" first="Cyril" last="Atkinson-Clement">Cyril Atkinson-Clement</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Brain and Language Research Institute</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Carvalho, Joana" sort="Carvalho, Joana" uniqKey="Carvalho J" first="Joana" last="Carvalho">Joana Carvalho</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Campus Neurológico Sénior (CNS)</institution>,<addr-line>Torres Vedras</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Welby, Pauline" sort="Welby, Pauline" uniqKey="Welby P" first="Pauline" last="Welby">Pauline Welby</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Brain and Language Research Institute</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oliveira, Pedro" sort="Oliveira, Pedro" uniqKey="Oliveira P" first="Pedro" last="Oliveira">Pedro Oliveira</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Faculty of Medicine</addr-line>,<institution>Instituto de Medicina Molecular (IMM), University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Centre of Linguistics, School of Arts and Humanities, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="D Imperio, Mariapaola" sort="D Imperio, Mariapaola" uniqKey="D Imperio M" first="Mariapaola" last="D'Imperio">Mariapaola D'Imperio</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Brain and Language Research Institute</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Frota, S Nia" sort="Frota, S Nia" uniqKey="Frota S" first="S Nia" last="Frota">S Nia Frota</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Centre of Linguistics, School of Arts and Humanities, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Letanneux, Alban" sort="Letanneux, Alban" uniqKey="Letanneux A" first="Alban" last="Letanneux">Alban Letanneux</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vigario, Marina" sort="Vigario, Marina" uniqKey="Vigario M" first="Marina" last="Vigario">Marina Vigario</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Centre of Linguistics, School of Arts and Humanities, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cruz, Marisa" sort="Cruz, Marisa" uniqKey="Cruz M" first="Marisa" last="Cruz">Marisa Cruz</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Centre of Linguistics, School of Arts and Humanities, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martins, Isabel Pavao" sort="Martins, Isabel Pavao" uniqKey="Martins I" first="Isabel Pavão" last="Martins">Isabel Pavão Martins</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Neurology Department, Faculty of Medicine</addr-line>,<institution>Language Research Laboratory, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Viallet, Francois" sort="Viallet, Francois" uniqKey="Viallet F" first="François" last="Viallet">François Viallet</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Brain and Language Research Institute</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Neurology Department</addr-line>,<institution>Centre Hospitalier du Pays d'Aix</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ferreira, Joaquim J" sort="Ferreira, Joaquim J" uniqKey="Ferreira J" first="Joaquim J" last="Ferreira">Joaquim J. Ferreira</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Campus Neurológico Sénior (CNS)</institution>,<addr-line>Torres Vedras</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Faculty of Medicine</addr-line>,<institution>Instituto de Medicina Molecular (IMM), University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMJ Open</title><idno type="eISSN">2044-6055</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>Individuals with Parkinson's disease (PD) have to deal with several aspects of voice and speech decline and thus alteration of communication ability during the course of the disease. Among these communication impairments, 3 major challenges include: (1) dysarthria, consisting of orofacial motor dysfunction and dysprosody, which is linked to the neurodegenerative processes; (2) effects of the pharmacological treatment, which vary according to the disease stage; and (3) particular speech modifications that may be language-specific, that is, dependent on the language spoken by the patients. The main objective of the FraLusoPark project is to provide a thorough evaluation of changes in PD speech as a result of pharmacological treatment and disease duration in 2 different languages (French vs European Portuguese).</p></sec><sec><title>Methods and analysis</title><p>Individuals with PD are enrolled in the study in France (N=60) and Portugal (N=60). Their global motor disability and orofacial motor functions is assessed with specific clinical rating scales, without (OFF) and with (ON) pharmacological treatment. 2 groups of 60 healthy age-matched volunteers provide the reference for between-group comparisons. Along with the clinical examinations, several speech tasks are recorded to obtain acoustic and perceptual measures. Patient-reported outcome measures are used to assess the psychosocial impact of dysarthria on quality of life.</p></sec><sec><title>Ethics and dissemination</title><p>The study has been approved by the local responsible committees on human experimentation and is conducted in accordance with the ethical standards. A valuable large-scale database of speech recordings and metadata from patients with PD in France and Portugal will be constructed. Results will be disseminated in several articles in peer-reviewed journals and in conference presentations. Recommendations on how to assess speech and voice disorders in individuals with PD to monitor the progression and management of symptoms will be provided.</p></sec><sec><title>Trial registration number</title><p><ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/NCT02753192">NCT02753192</ext-link>, Pre-results.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Darley, Fl" uniqKey="Darley F">FL Darley</name></author><author><name sortKey="Aronson, Ae" uniqKey="Aronson A">AE Aronson</name></author><author><name sortKey="Brown, Jr" uniqKey="Brown J">JR Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Darley, Fl" uniqKey="Darley F">FL Darley</name></author><author><name sortKey="Aronson, Ae" uniqKey="Aronson A">AE Aronson</name></author><author><name sortKey="Brown, Jr" uniqKey="Brown J">JR Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duffy, Jr" uniqKey="Duffy J">JR Duffy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hartelius, L" uniqKey="Hartelius L">L Hartelius</name></author><author><name sortKey="Svensson, P" uniqKey="Svensson P">P Svensson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, N" uniqKey="Miller N">N Miller</name></author><author><name sortKey="Deane, Kho" uniqKey="Deane K">KHO Deane</name></author><author><name sortKey="Jones, D" uniqKey="Jones D">D Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, N" uniqKey="Miller N">N Miller</name></author><author><name sortKey="Noble, E" uniqKey="Noble E">E Noble</name></author><author><name sortKey="Jones, D" uniqKey="Jones D">D Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramig, Lo" uniqKey="Ramig L">LO Ramig</name></author><author><name sortKey="Bonitati, Cm" uniqKey="Bonitati C">CM Bonitati</name></author><author><name sortKey="Lemke, Jh" uniqKey="Lemke J">JH Lemke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karlsen, Kh" uniqKey="Karlsen K">KH Karlsen</name></author><author><name sortKey="Tandberg, E" uniqKey="Tandberg E">E Tandberg</name></author><author><name sortKey="Arsland, D" uniqKey="Arsland D">D Arsland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fox, C" uniqKey="Fox C">C Fox</name></author><author><name sortKey="Ramig, L" uniqKey="Ramig L">L Ramig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, N" uniqKey="Miller N">N Miller</name></author><author><name sortKey="Noble, E" uniqKey="Noble E">E Noble</name></author><author><name sortKey="Jones, D" uniqKey="Jones D">D Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barnish, Ms" uniqKey="Barnish M">MS Barnish</name></author><author><name sortKey="Whibley, D" uniqKey="Whibley D">D Whibley</name></author><author><name sortKey="Horton, Smc" uniqKey="Horton S">SMC Horton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schneider, Js" uniqKey="Schneider J">JS Schneider</name></author><author><name sortKey="Sendek, S" uniqKey="Sendek S">S Sendek</name></author><author><name sortKey="Yang, C" uniqKey="Yang C">C Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klawans, Hl" uniqKey="Klawans H">HL Klawans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agid, Y" uniqKey="Agid Y">Y Agid</name></author><author><name sortKey="Graybiel, Am" uniqKey="Graybiel A">AM Graybiel</name></author><author><name sortKey="Ruberg, M" uniqKey="Ruberg M">M Ruberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braak, H" uniqKey="Braak H">H Braak</name></author><author><name sortKey="Braak, E" uniqKey="Braak E">E Braak</name></author><author><name sortKey="Yilmazer, D" uniqKey="Yilmazer D">D Yilmazer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halliday, G" uniqKey="Halliday G">G Halliday</name></author><author><name sortKey="Lees, A" uniqKey="Lees A">A Lees</name></author><author><name sortKey="Stern, M" uniqKey="Stern M">M Stern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, Ak" uniqKey="Ho A">AK Ho</name></author><author><name sortKey="Bradshaw, Jl" uniqKey="Bradshaw J">JL Bradshaw</name></author><author><name sortKey="Iansek, R" uniqKey="Iansek R">R Iansek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pinto, S" uniqKey="Pinto S">S Pinto</name></author><author><name sortKey="Ozsancak, C" uniqKey="Ozsancak C">C Ozsancak</name></author><author><name sortKey="Tripoliti, E" uniqKey="Tripoliti E">E Tripoliti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Atkinson Clement, C" uniqKey="Atkinson Clement C">C Atkinson-Clement</name></author><author><name sortKey="Sadat, J" uniqKey="Sadat J">J Sadat</name></author><author><name sortKey="Pinto, S" uniqKey="Pinto S">S Pinto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patel, R" uniqKey="Patel R">R Patel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Viallet, F" uniqKey="Viallet F">F Viallet</name></author><author><name sortKey="Meynadier, Y" uniqKey="Meynadier Y">Y Meynadier</name></author><author><name sortKey="Lagrue, B" uniqKey="Lagrue B">B Lagrue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheang, Hs" uniqKey="Cheang H">HS Cheang</name></author><author><name sortKey="Pell, Md" uniqKey="Pell M">MD Pell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hammen, Vl" uniqKey="Hammen V">VL Hammen</name></author><author><name sortKey="Yorkston, Km" uniqKey="Yorkston K">KM Yorkston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duez, D" uniqKey="Duez D">D Duez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duez, D" uniqKey="Duez D">D Duez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rigrodsky, S" uniqKey="Rigrodsky S">S Rigrodsky</name></author><author><name sortKey="Morrison, Eb" uniqKey="Morrison E">EB Morrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mawdsley, C" uniqKey="Mawdsley C">C Mawdsley</name></author><author><name sortKey="Gamsu, Cv" uniqKey="Gamsu C">CV Gamsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leanderson, R" uniqKey="Leanderson R">R Leanderson</name></author><author><name sortKey="Meyerson, Ba" uniqKey="Meyerson B">BA Meyerson</name></author><author><name sortKey="Persson, A" uniqKey="Persson A">A Persson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakano, Kk" uniqKey="Nakano K">KK Nakano</name></author><author><name sortKey="Zubick, H" uniqKey="Zubick H">H Zubick</name></author><author><name sortKey="Tyler, Hr" uniqKey="Tyler H">HR Tyler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferreira, Jj" uniqKey="Ferreira J">JJ Ferreira</name></author><author><name sortKey="Rascol, O" uniqKey="Rascol O">O Rascol</name></author><author><name sortKey="Poewe, W" uniqKey="Poewe W">W Poewe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mestre, T" uniqKey="Mestre T">T Mestre</name></author><author><name sortKey="Ferreira, Jj" uniqKey="Ferreira J">JJ Ferreira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolfe, Vi" uniqKey="Wolfe V">VI Wolfe</name></author><author><name sortKey="Garvin, Js" uniqKey="Garvin J">JS Garvin</name></author><author><name sortKey="Bacon, M" uniqKey="Bacon M">M Bacon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quaglieri, Ce" uniqKey="Quaglieri C">CE Quaglieri</name></author><author><name sortKey="Celesia, Gg" uniqKey="Celesia G">GG Celesia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marsden, Cd" uniqKey="Marsden C">CD Marsden</name></author><author><name sortKey="Parkes, Jd" uniqKey="Parkes J">JD Parkes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Critchley, Em" uniqKey="Critchley E">EM Critchley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Letter, M" uniqKey="De Letter M">M De Letter</name></author><author><name sortKey="Santens, P" uniqKey="Santens P">P Santens</name></author><author><name sortKey="De Bodt, M" uniqKey="De Bodt M">M De Bodt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Letter, M" uniqKey="De Letter M">M De Letter</name></author><author><name sortKey="Santens, P" uniqKey="Santens P">P Santens</name></author><author><name sortKey="Estercam, I" uniqKey="Estercam I">I Estercam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skodda, S" uniqKey="Skodda S">S Skodda</name></author><author><name sortKey="Visser, W" uniqKey="Visser W">W Visser</name></author><author><name sortKey="Schlegel, U" uniqKey="Schlegel U">U Schlegel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coelho, M" uniqKey="Coelho M">M Coelho</name></author><author><name sortKey="Ferreira, Jj" uniqKey="Ferreira J">JJ Ferreira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goberman, A" uniqKey="Goberman A">A Goberman</name></author><author><name sortKey="Coelho, C" uniqKey="Coelho C">C Coelho</name></author><author><name sortKey="Robb, M" uniqKey="Robb M">M Robb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goberman, Am" uniqKey="Goberman A">AM Goberman</name></author><author><name sortKey="Blomgren, M" uniqKey="Blomgren M">M Blomgren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pinto, S" uniqKey="Pinto S">S Pinto</name></author><author><name sortKey="Gentil, M" uniqKey="Gentil M">M Gentil</name></author><author><name sortKey="Krack, P" uniqKey="Krack P">P Krack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skodda, S" uniqKey="Skodda S">S Skodda</name></author><author><name sortKey="Flasskamp, A" uniqKey="Flasskamp A">A Flasskamp</name></author><author><name sortKey="Schlegel, U" uniqKey="Schlegel U">U Schlegel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skodda, S" uniqKey="Skodda S">S Skodda</name></author><author><name sortKey="Gronheit, W" uniqKey="Gronheit W">W Grönheit</name></author><author><name sortKey="Schlegel, U" uniqKey="Schlegel U">U Schlegel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ladd, R" uniqKey="Ladd R">R Ladd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frota, S" uniqKey="Frota S">S Frota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frota, S" uniqKey="Frota S">S Frota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Welby, P" uniqKey="Welby P">P Welby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cruz Ferreira, M" uniqKey="Cruz Ferreira M">M Cruz-Ferreira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cruz Ferreira, M" uniqKey="Cruz Ferreira M">M Cruz-Ferreira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frota, S" uniqKey="Frota S">S Frota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jun, Sa" uniqKey="Jun S">SA Jun</name></author><author><name sortKey="Fougeron, C" uniqKey="Fougeron C">C Fougeron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Welby, P" uniqKey="Welby P">P Welby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spinelli, E" uniqKey="Spinelli E">E Spinelli</name></author><author><name sortKey="Grimault, N" uniqKey="Grimault N">N Grimault</name></author><author><name sortKey="Meunier, F" uniqKey="Meunier F">F Meunier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, Jk" uniqKey="Ma J">JK Ma</name></author><author><name sortKey="Whitehill, Tl" uniqKey="Whitehill T">TL Whitehill</name></author><author><name sortKey="So, Sy" uniqKey="So S">SY So</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whitehill, Tl" uniqKey="Whitehill T">TL Whitehill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibb, Wr" uniqKey="Gibb W">WR Gibb</name></author><author><name sortKey="Lees, Aj" uniqKey="Lees A">AJ Lees</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oldfield, Rc" uniqKey="Oldfield R">RC Oldfield</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Enderby, P" uniqKey="Enderby P">P Enderby</name></author><author><name sortKey="Palmer, R" uniqKey="Palmer R">R Palmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fougeron, C" uniqKey="Fougeron C">C Fougeron</name></author><author><name sortKey="Smith, Cl" uniqKey="Smith C">CL Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mayer, M" uniqKey="Mayer M">M Mayer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berman, Ra" uniqKey="Berman R">RA Berman</name></author><author><name sortKey="Slobin, Di" uniqKey="Slobin D">DI Slobin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baken, Rj" uniqKey="Baken R">RJ Baken</name></author><author><name sortKey="Orlikoff, Rf" uniqKey="Orlikoff R">RF Orlikoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fahn, S" uniqKey="Fahn S">S Fahn</name></author><author><name sortKey="Elton, Rl" uniqKey="Elton R">RL Elton</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Nasreddine, Zs" uniqKey="Nasreddine Z">ZS Nasreddine</name></author><author><name sortKey="Phillips, Na" uniqKey="Phillips N">NA Phillips</name></author><author><name sortKey="Bedirian, V" uniqKey="Bedirian V">V Bédirian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Busner, J" uniqKey="Busner J">J Busner</name></author><author><name sortKey="Targum, Sd" uniqKey="Targum S">SD Targum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walshe, M" uniqKey="Walshe M">M Walshe</name></author><author><name sortKey="Peach, Rk" uniqKey="Peach R">RK Peach</name></author><author><name sortKey="Miller, N" uniqKey="Miller N">N Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walshe, M" uniqKey="Walshe M">M Walshe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jenkinson, C" uniqKey="Jenkinson C">C Jenkinson</name></author><author><name sortKey="Peto, V" uniqKey="Peto V">V Peto</name></author><author><name sortKey="Fitzpatrick, R" uniqKey="Fitzpatrick R">R 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Silva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vieira, Em" uniqKey="Vieira E">EM Vieira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hurst, H" uniqKey="Hurst H">H Hurst</name></author><author><name sortKey="Bolton, J" uniqKey="Bolton J">J Bolton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beck, At" uniqKey="Beck A">AT Beck</name></author><author><name sortKey="Ward, Ch" uniqKey="Ward C">CH Ward</name></author><author><name sortKey="Mendelson, M" uniqKey="Mendelson M">M Mendelson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Imperio, M" uniqKey="D Imperio M">M D'Imperio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Welby, P" uniqKey="Welby P">P Welby</name></author><author><name sortKey="Loevenbruck, H" uniqKey="Loevenbruck H">H Lœvenbruck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frota, S" uniqKey="Frota S">S Frota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martinez Martin, P" uniqKey="Martinez Martin P">P Martínez-Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuopio, Am" uniqKey="Kuopio A">AM Kuopio</name></author><author><name sortKey="Marttila, Rj" uniqKey="Marttila R">RJ Marttila</name></author><author><name sortKey="Helenius, H" uniqKey="Helenius H">H Helenius</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ghio, A" uniqKey="Ghio A">A Ghio</name></author><author><name sortKey="Pouchoulin, G" uniqKey="Pouchoulin G">G Pouchoulin</name></author><author><name sortKey="Teston, B" uniqKey="Teston B">B Teston</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="protocol"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMJ Open</journal-id><journal-id journal-id-type="iso-abbrev">BMJ Open</journal-id><journal-id journal-id-type="hwp">bmjopen</journal-id><journal-id journal-id-type="publisher-id">bmjopen</journal-id><journal-title-group><journal-title>BMJ Open</journal-title></journal-title-group><issn pub-type="epub">2044-6055</issn><publisher><publisher-name>BMJ Publishing Group</publisher-name><publisher-loc>BMA House, Tavistock Square, London, WC1H 9JR</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27856480</article-id><article-id pub-id-type="pmc">5128890</article-id><article-id pub-id-type="publisher-id">bmjopen-2016-012885</article-id><article-id pub-id-type="doi">10.1136/bmjopen-2016-012885</article-id><article-categories><subj-group subj-group-type="heading"><subject>Neurology</subject><subj-group><subject>Protocol</subject></subj-group></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>1506</subject><subject>1713</subject><subject>1684</subject><subject>1690</subject><subject>1710</subject><subject>1722</subject><subject>1723</subject></subj-group></article-categories><title-group><article-title>Dysarthria in individuals with Parkinson's disease: a protocol for a binational, cross-sectional, case-controlled study in French and European Portuguese (FraLusoPark)</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-3375-4787</contrib-id><name><surname>Pinto</surname><given-names>Serge</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Cardoso</surname><given-names>Rita</given-names></name><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-3398-606X</contrib-id><name><surname>Sadat</surname><given-names>Jasmin</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-8524-8731</contrib-id><name><surname>Guimarães</surname><given-names>Isabel</given-names></name><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Mercier</surname><given-names>Céline</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Santos</surname><given-names>Helena</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Atkinson-Clement</surname><given-names>Cyril</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Carvalho</surname><given-names>Joana</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Welby</surname><given-names>Pauline</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Oliveira</surname><given-names>Pedro</given-names></name><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af7">7</xref></contrib><contrib contrib-type="author"><name><surname>D'Imperio</surname><given-names>Mariapaola</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Frota</surname><given-names>Sónia</given-names></name><xref ref-type="aff" rid="af7">7</xref></contrib><contrib contrib-type="author"><name><surname>Letanneux</surname><given-names>Alban</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Vigario</surname><given-names>Marina</given-names></name><xref ref-type="aff" rid="af7">7</xref></contrib><contrib contrib-type="author"><name><surname>Cruz</surname><given-names>Marisa</given-names></name><xref ref-type="aff" rid="af7">7</xref></contrib><contrib contrib-type="author"><name><surname>Martins</surname><given-names>Isabel Pavão</given-names></name><xref ref-type="aff" rid="af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Viallet</surname><given-names>François</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-3950-5113</contrib-id><name><surname>Ferreira</surname><given-names>Joaquim J</given-names></name><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af4">4</xref></contrib></contrib-group><aff id="af1"><label>1</label><institution>Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), Laboratoire Parole et Langage (LPL)</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></aff><aff id="af2"><label>2</label><institution>Brain and Language Research Institute</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></aff><aff id="af3"><label>3</label><institution>Campus Neurológico Sénior (CNS)</institution>,<addr-line>Torres Vedras</addr-line>,<country>Portugal</country></aff><aff id="af4"><label>4</label><addr-line>Faculty of Medicine</addr-line>,<institution>Instituto de Medicina Molecular (IMM), University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></aff><aff id="af5"><label>5</label><addr-line>Speech Therapy Department</addr-line>,<institution>Escola Superior de Saude do Alcoitão</institution>,<addr-line>Alcabideche</addr-line>,<country>Portugal</country></aff><aff id="af6"><label>6</label><addr-line>Neurology Department</addr-line>,<institution>Centre Hospitalier du Pays d'Aix</institution>,<addr-line>Aix-en-Provence</addr-line>,<country>France</country></aff><aff id="af7"><label>7</label><institution>Centre of Linguistics, School of Arts and Humanities, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></aff><aff id="af8"><label>8</label><addr-line>Neurology Department, Faculty of Medicine</addr-line>,<institution>Language Research Laboratory, University of Lisbon</institution>,<addr-line>Lisbon</addr-line>,<country>Portugal</country></aff><author-notes><corresp><label>Correspondence to</label> Dr Serge Pinto; <email>serge.pinto@lpl-aix.fr</email></corresp></author-notes><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>17</day><month>11</month><year>2016</year></pub-date><volume>6</volume><issue>11</issue><elocation-id>e012885</elocation-id><history><date date-type="received"><day>30</day><month>5</month><year>2016</year></date><date date-type="rev-recd"><day>21</day><month>9</month><year>2016</year></date><date date-type="accepted"><day>21</day><month>10</month><year>2016</year></date></history><permissions><copyright-statement>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access"><license-p>This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link></license-p></license></permissions><self-uri xlink:title="pdf" xlink:href="bmjopen-2016-012885.pdf"></self-uri><abstract><sec><title>Introduction</title><p>Individuals with Parkinson's disease (PD) have to deal with several aspects of voice and speech decline and thus alteration of communication ability during the course of the disease. Among these communication impairments, 3 major challenges include: (1) dysarthria, consisting of orofacial motor dysfunction and dysprosody, which is linked to the neurodegenerative processes; (2) effects of the pharmacological treatment, which vary according to the disease stage; and (3) particular speech modifications that may be language-specific, that is, dependent on the language spoken by the patients. The main objective of the FraLusoPark project is to provide a thorough evaluation of changes in PD speech as a result of pharmacological treatment and disease duration in 2 different languages (French vs European Portuguese).</p></sec><sec><title>Methods and analysis</title><p>Individuals with PD are enrolled in the study in France (N=60) and Portugal (N=60). Their global motor disability and orofacial motor functions is assessed with specific clinical rating scales, without (OFF) and with (ON) pharmacological treatment. 2 groups of 60 healthy age-matched volunteers provide the reference for between-group comparisons. Along with the clinical examinations, several speech tasks are recorded to obtain acoustic and perceptual measures. Patient-reported outcome measures are used to assess the psychosocial impact of dysarthria on quality of life.</p></sec><sec><title>Ethics and dissemination</title><p>The study has been approved by the local responsible committees on human experimentation and is conducted in accordance with the ethical standards. A valuable large-scale database of speech recordings and metadata from patients with PD in France and Portugal will be constructed. Results will be disseminated in several articles in peer-reviewed journals and in conference presentations. Recommendations on how to assess speech and voice disorders in individuals with PD to monitor the progression and management of symptoms will be provided.</p></sec><sec><title>Trial registration number</title><p><ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/NCT02753192">NCT02753192</ext-link>, Pre-results.</p></sec></abstract><kwd-group><kwd>Parkinson’s disease</kwd><kwd>Dysarthria</kwd><kwd>Speech</kwd><kwd>Cross-language</kwd><kwd>Disease progression</kwd><kwd>Pharmacological treatment</kwd></kwd-group><funding-group specific-use="FundRef"><award-group id="funding-1"><funding-source><institution-wrap><institution>Agence Nationale de la Recherche</institution><institution-id>http://dx.doi.org/10.13039/501100001665</institution-id></institution-wrap></funding-source><award-id>ANR-13-ISH2-0001-01</award-id></award-group><award-group id="funding-2"><funding-source><institution-wrap><institution>Fundação para a Ciência e a Tecnologia</institution><institution-id>http://dx.doi.org/10.13039/501100001871</institution-id></institution-wrap></funding-source><award-id>FCT-ANR/NEU-SCC/0005/2013</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>France</li><li>Portugal</li></country></list><tree><country name="France"><noRegion><name sortKey="Pinto, Serge" sort="Pinto, Serge" uniqKey="Pinto S" first="Serge" last="Pinto">Serge Pinto</name></noRegion><name sortKey="Atkinson Clement, Cyril" sort="Atkinson Clement, Cyril" uniqKey="Atkinson Clement C" first="Cyril" last="Atkinson-Clement">Cyril Atkinson-Clement</name><name sortKey="Atkinson Clement, Cyril" sort="Atkinson Clement, Cyril" uniqKey="Atkinson Clement C" first="Cyril" last="Atkinson-Clement">Cyril Atkinson-Clement</name><name sortKey="D Imperio, Mariapaola" sort="D Imperio, Mariapaola" uniqKey="D Imperio M" first="Mariapaola" last="D'Imperio">Mariapaola D'Imperio</name><name sortKey="D Imperio, Mariapaola" sort="D Imperio, Mariapaola" uniqKey="D Imperio M" first="Mariapaola" last="D'Imperio">Mariapaola D'Imperio</name><name sortKey="Letanneux, Alban" sort="Letanneux, Alban" uniqKey="Letanneux A" first="Alban" last="Letanneux">Alban Letanneux</name><name sortKey="Mercier, Celine" sort="Mercier, Celine" uniqKey="Mercier C" first="Céline" last="Mercier">Céline Mercier</name><name sortKey="Mercier, Celine" sort="Mercier, Celine" uniqKey="Mercier C" first="Céline" last="Mercier">Céline Mercier</name><name sortKey="Pinto, Serge" sort="Pinto, Serge" uniqKey="Pinto S" first="Serge" last="Pinto">Serge Pinto</name><name sortKey="Sadat, Jasmin" sort="Sadat, Jasmin" uniqKey="Sadat J" first="Jasmin" last="Sadat">Jasmin Sadat</name><name sortKey="Sadat, Jasmin" sort="Sadat, Jasmin" uniqKey="Sadat J" first="Jasmin" last="Sadat">Jasmin Sadat</name><name sortKey="Viallet, Francois" sort="Viallet, Francois" uniqKey="Viallet F" first="François" last="Viallet">François Viallet</name><name sortKey="Viallet, Francois" sort="Viallet, Francois" uniqKey="Viallet F" first="François" last="Viallet">François Viallet</name><name sortKey="Viallet, Francois" sort="Viallet, Francois" uniqKey="Viallet F" first="François" last="Viallet">François Viallet</name><name sortKey="Welby, Pauline" sort="Welby, Pauline" uniqKey="Welby P" first="Pauline" last="Welby">Pauline Welby</name><name sortKey="Welby, Pauline" sort="Welby, Pauline" uniqKey="Welby P" first="Pauline" last="Welby">Pauline Welby</name></country><country name="Portugal"><noRegion><name sortKey="Cardoso, Rita" sort="Cardoso, Rita" uniqKey="Cardoso R" first="Rita" last="Cardoso">Rita Cardoso</name></noRegion><name sortKey="Cardoso, Rita" sort="Cardoso, Rita" uniqKey="Cardoso R" first="Rita" last="Cardoso">Rita Cardoso</name><name sortKey="Carvalho, Joana" sort="Carvalho, Joana" uniqKey="Carvalho J" first="Joana" last="Carvalho">Joana Carvalho</name><name sortKey="Cruz, Marisa" sort="Cruz, Marisa" uniqKey="Cruz M" first="Marisa" last="Cruz">Marisa Cruz</name><name sortKey="Ferreira, Joaquim J" sort="Ferreira, Joaquim J" uniqKey="Ferreira J" first="Joaquim J" last="Ferreira">Joaquim J. Ferreira</name><name sortKey="Ferreira, Joaquim J" sort="Ferreira, Joaquim J" uniqKey="Ferreira J" first="Joaquim J" last="Ferreira">Joaquim J. Ferreira</name><name sortKey="Frota, S Nia" sort="Frota, S Nia" uniqKey="Frota S" first="S Nia" last="Frota">S Nia Frota</name><name sortKey="Guimaraes, Isabel" sort="Guimaraes, Isabel" uniqKey="Guimaraes I" first="Isabel" last="Guimarães">Isabel Guimarães</name><name sortKey="Guimaraes, Isabel" sort="Guimaraes, Isabel" uniqKey="Guimaraes I" first="Isabel" last="Guimarães">Isabel Guimarães</name><name sortKey="Martins, Isabel Pavao" sort="Martins, Isabel Pavao" uniqKey="Martins I" first="Isabel Pavão" last="Martins">Isabel Pavão Martins</name><name sortKey="Oliveira, Pedro" sort="Oliveira, Pedro" uniqKey="Oliveira P" first="Pedro" last="Oliveira">Pedro Oliveira</name><name sortKey="Oliveira, Pedro" sort="Oliveira, Pedro" uniqKey="Oliveira P" first="Pedro" last="Oliveira">Pedro Oliveira</name><name sortKey="Santos, Helena" sort="Santos, Helena" uniqKey="Santos H" first="Helena" last="Santos">Helena Santos</name><name sortKey="Vigario, Marina" sort="Vigario, Marina" uniqKey="Vigario M" first="Marina" last="Vigario">Marina Vigario</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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