Deep brain stimulation-associated brain tissue imprints: a new in vivo approach to biological research in human Parkinson’s disease
Identifieur interne : 001932 ( Ncbi/Curation ); précédent : 001931; suivant : 001933Deep brain stimulation-associated brain tissue imprints: a new in vivo approach to biological research in human Parkinson’s disease
Auteurs : Affif Zaccaria [Suisse] ; Ali Bouamrani [France] ; Stephan Chabardès [France] ; Michèle El Atifi [France] ; Eric Seigneuret [France] ; Johannes A. Lobrinus [Suisse] ; Michel Dubois-Dauphin [Suisse] ; François Berger [France] ; Pierre R. Burkhard [Suisse]Source :
- Molecular Neurodegeneration [ 1750-1326 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- physiology : Neurons.
- therapy : Parkinson Disease.
- Adult, Aged, Deep Brain Stimulation, Female, Globus Pallidus, Humans, Male, Middle Aged, Proteomics, Subthalamic Nucleus.
Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) has been established as a highly effective symptomatic therapy for Parkinson’s disease (PD). An intriguing biological aspect related to the DBS procedure is that a temporary contact establishes between surgical instruments and the surrounding brain tissue. In this exploratory study, we took advantage of this unique context to harvest brain material adhering to the stylet routinely used during surgery, and to examine the biological value of these samples, here referred to as “brain tissue imprints” (BTIs).
Nineteen BTIs from 12 STN- or GPi-electrode implanted patients were obtained in vivo during DBS surgery, without any modification of the surgical procedure. Immunofluorescence analyses confirmed that our approach allowed the harvesting of many neural cells including neurons harboring distinct neurotransmitter markers. Shotgun proteomic and transcriptomic analyses provided for the first time molecular information from DBS-associated brain samples, and confirmed the compatibility of this new type of sample with poly-omic approaches. The method appears to be safe and results consistent.
We here propose BTIs as original and highly valuable brain samples, and DBS-related brain imprinting as a new conceptual approach to biological research in living patients with PD.
The online version of this article (doi:10.1186/s13024-016-0077-4) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13024-016-0077-4
PubMed: 26822202
PubMed Central: 4730746
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Safra Biomedical Research Center, Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CEA-LETI, Clinatec, Edmond J. Safra Biomedical Research Center, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stephan" last="Chabardès">Stephan Chabardès</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Clinique de neurochirurgie, CHU de Grenoble, Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Clinique de neurochirurgie, CHU de Grenoble, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff7">Inserm, U836, Grenoble Institut des Neurosciences, Univ. Grenoble Alpes, Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U836, Grenoble Institut des Neurosciences, Univ. Grenoble Alpes, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="El Atifi, Michele" sort="El Atifi, Michele" uniqKey="El Atifi M" first="Michèle" last="El Atifi">Michèle El Atifi</name><affiliation wicri:level="3"><nlm:aff id="Aff2">CEA-LETI, Clinatec, Edmond J. Safra Biomedical Research Center, Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CEA-LETI, Clinatec, Edmond J. Safra Biomedical Research Center, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Seigneuret, Eric" sort="Seigneuret, Eric" uniqKey="Seigneuret E" first="Eric" last="Seigneuret">Eric Seigneuret</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Clinique de neurochirurgie, CHU de Grenoble, Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Clinique de neurochirurgie, CHU de Grenoble, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Lobrinus, Johannes A" sort="Lobrinus, Johannes A" uniqKey="Lobrinus J" first="Johannes A." last="Lobrinus">Johannes A. Lobrinus</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Pathology, Geneva University Hospitals, Geneva, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Pathology, Geneva University Hospitals, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Dubois Dauphin, Michel" sort="Dubois Dauphin, Michel" uniqKey="Dubois Dauphin M" first="Michel" last="Dubois-Dauphin">Michel Dubois-Dauphin</name><affiliation wicri:level="1"><nlm:aff id="Aff5">Department of Pathology and Immunology, University Medical Center, Faculty of Medicine, Geneva, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Pathology and Immunology, University Medical Center, Faculty of Medicine, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Berger, Francois" sort="Berger, Francois" uniqKey="Berger F" first="François" last="Berger">François Berger</name><affiliation wicri:level="3"><nlm:aff id="Aff6">Inserm UA01, Clinatec, Edmond J. Safra Biomedical Research Center, CEA, Grenoble CHU, Univ. Grenoble Alpes, Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm UA01, Clinatec, Edmond J. Safra Biomedical Research Center, CEA, Grenoble CHU, Univ. Grenoble Alpes, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Burkhard, Pierre R" sort="Burkhard, Pierre R" uniqKey="Burkhard P" first="Pierre R." last="Burkhard">Pierre R. Burkhard</name><affiliation wicri:level="1"><nlm:aff id="Aff1">NeuroProteomics Group, University Medical Center, Faculty of Medicine, Geneva, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>NeuroProteomics Group, University Medical Center, Faculty of Medicine, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8">Department of Neurology, Geneva University Hospitals, Geneva, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Geneva University Hospitals, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular Neurodegeneration</title><idno type="eISSN">1750-1326</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Deep Brain Stimulation</term><term>Female</term><term>Globus Pallidus</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurons (physiology)</term><term>Parkinson Disease (therapy)</term><term>Proteomics</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Deep Brain Stimulation</term><term>Female</term><term>Globus Pallidus</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Proteomics</term><term>Subthalamic Nucleus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) has been established as a highly effective symptomatic therapy for Parkinson’s disease (PD). An intriguing biological aspect related to the DBS procedure is that a temporary contact establishes between surgical instruments and the surrounding brain tissue. In this exploratory study, we took advantage of this unique context to harvest brain material adhering to the stylet routinely used during surgery, and to examine the biological value of these samples, here referred to as “brain tissue imprints” (BTIs).</p></sec><sec><title>Results</title><p>Nineteen BTIs from 12 STN- or GPi-electrode implanted patients were obtained in vivo during DBS surgery, without any modification of the surgical procedure. Immunofluorescence analyses confirmed that our approach allowed the harvesting of many neural cells including neurons harboring distinct neurotransmitter markers. Shotgun proteomic and transcriptomic analyses provided for the first time molecular information from DBS-associated brain samples, and confirmed the compatibility of this new type of sample with poly-omic approaches. The method appears to be safe and results consistent.</p></sec><sec><title>Conclusions</title><p>We here propose BTIs as original and highly valuable brain samples, and DBS-related brain imprinting as a new conceptual approach to biological research in living patients with PD.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s13024-016-0077-4) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lang, Ae" uniqKey="Lang A">AE Lang</name></author><author><name sortKey="Lozano, Am" uniqKey="Lozano A">AM Lozano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lang, Ae" uniqKey="Lang A">AE Lang</name></author><author><name sortKey="Lozano, Am" uniqKey="Lozano A">AM Lozano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samii, A" 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