Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1
Identifieur interne : 001931 ( Ncbi/Curation ); précédent : 001930; suivant : 001932Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1
Auteurs : Michel Brahic [États-Unis] ; Luc Bousset [France] ; Gregor Bieri [États-Unis] ; Ronald Melki [France] ; Aaron D. Gitler [États-Unis]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 2016.
English descriptors
- KwdEn :
- Amyloid beta-Peptides (metabolism), Animals, Armadillo Domain Proteins (genetics), Armadillo Domain Proteins (metabolism), Axonal Transport (physiology), Brain (pathology), Cholera Toxin (metabolism), Cytoskeletal Proteins (genetics), Cytoskeletal Proteins (metabolism), Embryo, Mammalian, Glutathione Peroxidase (metabolism), Humans, Huntingtin Protein (genetics), Huntingtin Protein (metabolism), Lab-On-A-Chip Devices, Mice, Mice, Inbred C57BL, Mice, Knockout, Multiprotein Complexes (metabolism), Neurons (metabolism), Peptide Fragments (metabolism), Peptide Termination Factors (metabolism), Polyglutamic Acid (genetics), Polyglutamic Acid (metabolism), Prions (metabolism), Saccharomyces cerevisiae Proteins (metabolism), alpha-Synuclein (metabolism).
- MESH :
- chemical , genetics : Armadillo Domain Proteins, Cytoskeletal Proteins, Huntingtin Protein, Polyglutamic Acid.
- chemical , metabolism : Amyloid beta-Peptides, Armadillo Domain Proteins, Cholera Toxin, Cytoskeletal Proteins, Glutathione Peroxidase, Huntingtin Protein, Multiprotein Complexes, Peptide Fragments, Peptide Termination Factors, Polyglutamic Acid, Prions, Saccharomyces cerevisiae Proteins, alpha-Synuclein.
- metabolism : Neurons.
- pathology : Brain.
- physiology : Axonal Transport.
- Animals, Embryo, Mammalian, Humans, Lab-On-A-Chip Devices, Mice, Mice, Inbred C57BL, Mice, Knockout.
Abstract
Accruing evidence suggests that prion-like behavior of fibrillar forms of α-synuclein, β-amyloid peptide and mutant huntingtin are responsible for the spread of the lesions that characterize Parkinson disease, Alzheimer disease and Huntington disease, respectively. It is unknown whether these distinct protein assemblies are transported within and between neurons by similar or distinct mechanisms. It is also unclear if neuronal death or injury is required for neuron-to-neuron transfer. To address these questions, we used mouse primary cortical neurons grown in microfluidic devices to measure the amounts of α-synuclein, Aβ42 and HTTExon1 fibrils transported by axons in both directions (anterograde and retrograde), as well as to examine the mechanism of their release from axons after anterograde transport. We observed that the three fibrils were transported in both anterograde and retrograde directions but with strikingly different efficiencies. The amount of Aβ42 fibrils transported was ten times higher than that of the other two fibrils. HTTExon1 was efficiently transported in the retrograde direction but only marginally in the anterograde direction. Finally, using neurons from two distinct mutant mouse strains whose axons are highly resistant to neurodegeneration (WldS and Sarm1−/−), we found that the three different fibrils were secreted by axons after anterograde transport, in the absence of axonal lysis, indicating that trans-neuronal spread can occur in intact healthy neurons. In summary, fibrils of α-synuclein, Aβ42 and HTTExon1 are all transported in axons but in directions and amounts that are specific of each fibril. After anterograde transport, the three fibrils were secreted in the medium in the absence of axon lysis. Continuous secretion could play an important role in the spread of pathology between neurons but may be amenable to pharmacological intervention.
The online version of this article (doi:10.1007/s00401-016-1538-0) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s00401-016-1538-0
PubMed: 26820848
PubMed Central: 4789229
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000224
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000222
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000118
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000161
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000161
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000161
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001931
Links to Exploration step
PMC:4789229Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1</title><author><name sortKey="Brahic, Michel" sort="Brahic, Michel" uniqKey="Brahic M" first="Michel" last="Brahic">Michel Brahic</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Genetics, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Bousset, Luc" sort="Bousset, Luc" uniqKey="Bousset L" first="Luc" last="Bousset">Luc Bousset</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Paris-Saclay Institute of Neuroscience, CNRS, Gif-sur-Yvette, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris-Saclay Institute of Neuroscience, CNRS, Gif-sur-Yvette</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Gif-sur-Yvette</settlement></placeName></affiliation></author><author><name sortKey="Bieri, Gregor" sort="Bieri, Gregor" uniqKey="Bieri G" first="Gregor" last="Bieri">Gregor Bieri</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Genetics, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff3">Neurosciences Graduate Program, Stanford University School of Medicine, Stanford, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Neurosciences Graduate Program, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Melki, Ronald" sort="Melki, Ronald" uniqKey="Melki R" first="Ronald" last="Melki">Ronald Melki</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Paris-Saclay Institute of Neuroscience, CNRS, Gif-sur-Yvette, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris-Saclay Institute of Neuroscience, CNRS, Gif-sur-Yvette</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Gif-sur-Yvette</settlement></placeName></affiliation></author><author><name sortKey="Gitler, Aaron D" sort="Gitler, Aaron D" uniqKey="Gitler A" first="Aaron D." last="Gitler">Aaron D. Gitler</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Genetics, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26820848</idno><idno type="pmc">4789229</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789229</idno><idno type="RBID">PMC:4789229</idno><idno type="doi">10.1007/s00401-016-1538-0</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000224</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000224</idno><idno type="wicri:Area/Pmc/Curation">000222</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000222</idno><idno type="wicri:Area/Pmc/Checkpoint">000118</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000118</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000161</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000161</idno><idno type="wicri:Area/PubMed/Curation">000161</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000161</idno><idno type="wicri:Area/PubMed/Checkpoint">000161</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000161</idno><idno type="wicri:Area/Ncbi/Merge">001931</idno><idno type="wicri:Area/Ncbi/Curation">001931</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1</title><author><name sortKey="Brahic, Michel" sort="Brahic, Michel" uniqKey="Brahic M" first="Michel" last="Brahic">Michel Brahic</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Genetics, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Bousset, Luc" sort="Bousset, Luc" uniqKey="Bousset L" first="Luc" last="Bousset">Luc Bousset</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Paris-Saclay Institute of Neuroscience, CNRS, Gif-sur-Yvette, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris-Saclay Institute of Neuroscience, CNRS, Gif-sur-Yvette</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Gif-sur-Yvette</settlement></placeName></affiliation></author><author><name sortKey="Bieri, Gregor" sort="Bieri, Gregor" uniqKey="Bieri G" first="Gregor" last="Bieri">Gregor Bieri</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Genetics, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff3">Neurosciences Graduate Program, Stanford University School of Medicine, Stanford, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Neurosciences Graduate Program, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Melki, Ronald" sort="Melki, Ronald" uniqKey="Melki R" first="Ronald" last="Melki">Ronald Melki</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Paris-Saclay Institute of Neuroscience, CNRS, Gif-sur-Yvette, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris-Saclay Institute of Neuroscience, CNRS, Gif-sur-Yvette</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Gif-sur-Yvette</settlement></placeName></affiliation></author><author><name sortKey="Gitler, Aaron D" sort="Gitler, Aaron D" uniqKey="Gitler A" first="Aaron D." last="Gitler">Aaron D. Gitler</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Genetics, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author></analytic><series><title level="j">Acta Neuropathologica</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amyloid beta-Peptides (metabolism)</term><term>Animals</term><term>Armadillo Domain Proteins (genetics)</term><term>Armadillo Domain Proteins (metabolism)</term><term>Axonal Transport (physiology)</term><term>Brain (pathology)</term><term>Cholera Toxin (metabolism)</term><term>Cytoskeletal Proteins (genetics)</term><term>Cytoskeletal Proteins (metabolism)</term><term>Embryo, Mammalian</term><term>Glutathione Peroxidase (metabolism)</term><term>Humans</term><term>Huntingtin Protein (genetics)</term><term>Huntingtin Protein (metabolism)</term><term>Lab-On-A-Chip Devices</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Multiprotein Complexes (metabolism)</term><term>Neurons (metabolism)</term><term>Peptide Fragments (metabolism)</term><term>Peptide Termination Factors (metabolism)</term><term>Polyglutamic Acid (genetics)</term><term>Polyglutamic Acid (metabolism)</term><term>Prions (metabolism)</term><term>Saccharomyces cerevisiae Proteins (metabolism)</term><term>alpha-Synuclein (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Armadillo Domain Proteins</term><term>Cytoskeletal Proteins</term><term>Huntingtin Protein</term><term>Polyglutamic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amyloid beta-Peptides</term><term>Armadillo Domain Proteins</term><term>Cholera Toxin</term><term>Cytoskeletal Proteins</term><term>Glutathione Peroxidase</term><term>Huntingtin Protein</term><term>Multiprotein Complexes</term><term>Peptide Fragments</term><term>Peptide Termination Factors</term><term>Polyglutamic Acid</term><term>Prions</term><term>Saccharomyces cerevisiae Proteins</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Axonal Transport</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Embryo, Mammalian</term><term>Humans</term><term>Lab-On-A-Chip Devices</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Accruing evidence suggests that prion-like behavior of fibrillar forms of α-synuclein, β-amyloid peptide and mutant huntingtin are responsible for the spread of the lesions that characterize Parkinson disease, Alzheimer disease and Huntington disease, respectively. It is unknown whether these distinct protein assemblies are transported within and between neurons by similar or distinct mechanisms. It is also unclear if neuronal death or injury is required for neuron-to-neuron transfer. To address these questions, we used mouse primary cortical neurons grown in microfluidic devices to measure the amounts of α-synuclein, Aβ42 and HTTExon1 fibrils transported by axons in both directions (anterograde and retrograde), as well as to examine the mechanism of their release from axons after anterograde transport. We observed that the three fibrils were transported in both anterograde and retrograde directions but with strikingly different efficiencies. The amount of Aβ42 fibrils transported was ten times higher than that of the other two fibrils. HTTExon1 was efficiently transported in the retrograde direction but only marginally in the anterograde direction. Finally, using neurons from two distinct mutant mouse strains whose axons are highly resistant to neurodegeneration (Wld<sup>S</sup> and Sarm1<sup>−/−</sup>), we found that the three different fibrils were secreted by axons after anterograde transport, in the absence of axonal lysis, indicating that trans-neuronal spread can occur in intact healthy neurons. In summary, fibrils of α-synuclein, Aβ42 and HTTExon1 are all transported in axons but in directions and amounts that are specific of each fibril. After anterograde transport, the three fibrils were secreted in the medium in the absence of axon lysis. Continuous secretion could play an important role in the spread of pathology between neurons but may be amenable to pharmacological intervention.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1007/s00401-016-1538-0) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aguzzi, A" uniqKey="Aguzzi A">A Aguzzi</name></author><author><name sortKey="Gitler, Ad" uniqKey="Gitler A">AD Gitler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alvarez Erviti, L" uniqKey="Alvarez Erviti L">L Alvarez-Erviti</name></author><author><name sortKey="Seow, Y" uniqKey="Seow Y">Y Seow</name></author><author><name sortKey="Schapira, Ah" uniqKey="Schapira A">AH Schapira</name></author><author><name sortKey="Gardiner, C" uniqKey="Gardiner C">C Gardiner</name></author><author><name sortKey="Sargent, Il" uniqKey="Sargent I">IL Sargent</name></author><author><name sortKey="Wood, Mj" uniqKey="Wood M">MJ Wood</name></author><author><name sortKey="Cooper, Jm" uniqKey="Cooper J">JM Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Angelucci, A" uniqKey="Angelucci A">A Angelucci</name></author><author><name sortKey="Clasca, F" uniqKey="Clasca F">F Clasca</name></author><author><name sortKey="Sur, M" uniqKey="Sur M">M Sur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bousset, L" uniqKey="Bousset L">L Bousset</name></author><author><name sortKey="Pieri, L" uniqKey="Pieri L">L Pieri</name></author><author><name sortKey="Ruiz Arlandis, G" uniqKey="Ruiz Arlandis G">G Ruiz-Arlandis</name></author><author><name sortKey="Gath, J" uniqKey="Gath J">J Gath</name></author><author><name sortKey="Jensen, Ph" uniqKey="Jensen P">PH Jensen</name></author><author><name sortKey="Habenstein, B" uniqKey="Habenstein B">B Habenstein</name></author><author><name sortKey="Madiona, K" uniqKey="Madiona K">K Madiona</name></author><author><name sortKey="Olieric, V" uniqKey="Olieric V">V Olieric</name></author><author><name sortKey="Bockmann, A" uniqKey="Bockmann A">A Bockmann</name></author><author><name sortKey="Meier, Bh" uniqKey="Meier B">BH Meier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braak, H" uniqKey="Braak H">H Braak</name></author><author><name sortKey="Del Tredici, K" uniqKey="Del Tredici K">K Del Tredici</name></author><author><name sortKey="Bratzke, H" uniqKey="Bratzke H">H Bratzke</name></author><author><name sortKey="Hamm Clement, J" uniqKey="Hamm Clement J">J Hamm-Clement</name></author><author><name sortKey="Sandmann Keil, D" uniqKey="Sandmann Keil D">D Sandmann-Keil</name></author><author><name sortKey="Rub, U" uniqKey="Rub U">U Rub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braak, H" uniqKey="Braak H">H Braak</name></author><author><name sortKey="Rub, U" uniqKey="Rub U">U Rub</name></author><author><name sortKey="Gai, Wp" uniqKey="Gai W">WP Gai</name></author><author><name sortKey="Del Tredici, K" uniqKey="Del Tredici K">K Del Tredici</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chutna, O" uniqKey="Chutna O">O Chutna</name></author><author><name sortKey="Goncalves, S" uniqKey="Goncalves S">S Goncalves</name></author><author><name sortKey="Villar Pique, A" uniqKey="Villar Pique A">A Villar-Pique</name></author><author><name sortKey="Guerreiro, P" uniqKey="Guerreiro P">P Guerreiro</name></author><author><name sortKey="Marijanovic, Z" uniqKey="Marijanovic Z">Z Marijanovic</name></author><author><name sortKey="Mendes, T" uniqKey="Mendes T">T Mendes</name></author><author><name sortKey="Ramalho, J" uniqKey="Ramalho J">J Ramalho</name></author><author><name sortKey="Emmanouilidou, E" uniqKey="Emmanouilidou E">E Emmanouilidou</name></author><author><name sortKey="Ventura, S" uniqKey="Ventura S">S Ventura</name></author><author><name sortKey="Klucken, J" uniqKey="Klucken J">J Klucken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cicchetti, F" uniqKey="Cicchetti F">F Cicchetti</name></author><author><name sortKey="Lacroix, S" uniqKey="Lacroix S">S Lacroix</name></author><author><name sortKey="Cisbani, G" uniqKey="Cisbani G">G Cisbani</name></author><author><name sortKey="Vallieres, N" uniqKey="Vallieres N">N Vallieres</name></author><author><name sortKey="Saint Pierre, M" uniqKey="Saint Pierre M">M Saint-Pierre</name></author><author><name sortKey="St Amour, I" uniqKey="St Amour I">I St-Amour</name></author><author><name sortKey="Tolouei, R" uniqKey="Tolouei R">R Tolouei</name></author><author><name sortKey="Skepper, Jn" uniqKey="Skepper J">JN Skepper</name></author><author><name sortKey="Hauser, Ra" uniqKey="Hauser R">RA Hauser</name></author><author><name sortKey="Mantovani, D" uniqKey="Mantovani D">D Mantovani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clavaguera, F" uniqKey="Clavaguera F">F Clavaguera</name></author><author><name sortKey="Bolmont, T" uniqKey="Bolmont T">T Bolmont</name></author><author><name sortKey="Crowther, Ra" uniqKey="Crowther R">RA Crowther</name></author><author><name sortKey="Abramowski, D" uniqKey="Abramowski D">D Abramowski</name></author><author><name sortKey="Frank, S" uniqKey="Frank S">S Frank</name></author><author><name sortKey="Probst, A" uniqKey="Probst A">A Probst</name></author><author><name sortKey="Fraser, G" uniqKey="Fraser G">G Fraser</name></author><author><name sortKey="Stalder, Ak" uniqKey="Stalder A">AK Stalder</name></author><author><name sortKey="Beibel, M" uniqKey="Beibel M">M Beibel</name></author><author><name sortKey="Staufenbiel, M" uniqKey="Staufenbiel M">M Staufenbiel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cushman, M" uniqKey="Cushman M">M Cushman</name></author><author><name sortKey="Johnson, Bs" uniqKey="Johnson B">BS Johnson</name></author><author><name sortKey="King, Od" uniqKey="King O">OD King</name></author><author><name sortKey="Gitler, Ad" uniqKey="Gitler A">AD Gitler</name></author><author><name sortKey="Shorter, J" uniqKey="Shorter J">J Shorter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dalod, M" uniqKey="Dalod M">M Dalod</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Danzer, Km" uniqKey="Danzer K">KM Danzer</name></author><author><name sortKey="Krebs, Sk" uniqKey="Krebs S">SK Krebs</name></author><author><name sortKey="Wolff, M" uniqKey="Wolff M">M Wolff</name></author><author><name sortKey="Birk, G" uniqKey="Birk G">G Birk</name></author><author><name sortKey="Hengerer, B" uniqKey="Hengerer B">B Hengerer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Calignon, A" uniqKey="De Calignon A">A de Calignon</name></author><author><name sortKey="Polydoro, M" uniqKey="Polydoro M">M Polydoro</name></author><author><name sortKey="Suarez Calvet, M" uniqKey="Suarez Calvet M">M Suarez-Calvet</name></author><author><name sortKey="William, C" uniqKey="William C">C William</name></author><author><name sortKey="Adamowicz, Dh" uniqKey="Adamowicz D">DH Adamowicz</name></author><author><name sortKey="Kopeikina, Kj" uniqKey="Kopeikina K">KJ Kopeikina</name></author><author><name sortKey="Pitstick, R" uniqKey="Pitstick R">R Pitstick</name></author><author><name sortKey="Sahara, N" uniqKey="Sahara N">N Sahara</name></author><author><name sortKey="Ashe, Kh" uniqKey="Ashe K">KH Ashe</name></author><author><name sortKey="Carlson, Ga" uniqKey="Carlson G">GA Carlson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Decker, H" uniqKey="Decker H">H Decker</name></author><author><name sortKey="Lo, Ky" uniqKey="Lo K">KY Lo</name></author><author><name sortKey="Unger, Sm" uniqKey="Unger S">SM Unger</name></author><author><name sortKey="Ferreira, St" uniqKey="Ferreira S">ST Ferreira</name></author><author><name sortKey="Silverman, Ma" uniqKey="Silverman M">MA Silverman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eisele, Ys" uniqKey="Eisele Y">YS Eisele</name></author><author><name sortKey="Obermuller, U" uniqKey="Obermuller U">U Obermuller</name></author><author><name sortKey="Heilbronner, G" uniqKey="Heilbronner G">G Heilbronner</name></author><author><name sortKey="Baumann, F" uniqKey="Baumann F">F Baumann</name></author><author><name sortKey="Kaeser, Sa" uniqKey="Kaeser S">SA Kaeser</name></author><author><name sortKey="Wolburg, H" uniqKey="Wolburg H">H Wolburg</name></author><author><name sortKey="Walker, Lc" uniqKey="Walker L">LC Walker</name></author><author><name sortKey="Staufenbiel, M" uniqKey="Staufenbiel M">M Staufenbiel</name></author><author><name sortKey="Heikenwalder, M" uniqKey="Heikenwalder M">M Heikenwalder</name></author><author><name sortKey="Jucker, M" uniqKey="Jucker M">M Jucker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Emmanouilidou, E" uniqKey="Emmanouilidou E">E Emmanouilidou</name></author><author><name sortKey="Melachroinou, K" uniqKey="Melachroinou K">K Melachroinou</name></author><author><name sortKey="Roumeliotis, T" uniqKey="Roumeliotis T">T Roumeliotis</name></author><author><name sortKey="Garbis, Sd" uniqKey="Garbis S">SD Garbis</name></author><author><name sortKey="Ntzouni, M" uniqKey="Ntzouni M">M Ntzouni</name></author><author><name sortKey="Margaritis, Lh" uniqKey="Margaritis L">LH Margaritis</name></author><author><name sortKey="Stefanis, L" uniqKey="Stefanis L">L Stefanis</name></author><author><name sortKey="Vekrellis, K" uniqKey="Vekrellis K">K Vekrellis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ericson, H" uniqKey="Ericson H">H Ericson</name></author><author><name sortKey="Blomqvist, A" uniqKey="Blomqvist A">A Blomqvist</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freundt, Ec" uniqKey="Freundt E">EC Freundt</name></author><author><name sortKey="Maynard, N" uniqKey="Maynard N">N Maynard</name></author><author><name sortKey="Clancy, Ek" uniqKey="Clancy E">EK Clancy</name></author><author><name sortKey="Roy, S" uniqKey="Roy S">S Roy</name></author><author><name sortKey="Bousset, L" uniqKey="Bousset L">L Bousset</name></author><author><name sortKey="Sourigues, Y" uniqKey="Sourigues Y">Y Sourigues</name></author><author><name sortKey="Covert, M" uniqKey="Covert M">M Covert</name></author><author><name sortKey="Melki, R" uniqKey="Melki R">R Melki</name></author><author><name sortKey="Kirkegaard, K" uniqKey="Kirkegaard K">K Kirkegaard</name></author><author><name sortKey="Brahic, M" uniqKey="Brahic M">M Brahic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghee, M" uniqKey="Ghee M">M Ghee</name></author><author><name sortKey="Melki, R" uniqKey="Melki R">R Melki</name></author><author><name sortKey="Michot, N" uniqKey="Michot N">N Michot</name></author><author><name sortKey="Mallet, J" uniqKey="Mallet J">J Mallet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gouras, Gk" uniqKey="Gouras G">GK Gouras</name></author><author><name sortKey="Almeida, Cg" uniqKey="Almeida C">CG Almeida</name></author><author><name sortKey="Takahashi, Rh" uniqKey="Takahashi R">RH Takahashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hansen, C" uniqKey="Hansen C">C Hansen</name></author><author><name sortKey="Angot, E" uniqKey="Angot E">E Angot</name></author><author><name sortKey="Bergstrom, Al" uniqKey="Bergstrom A">AL Bergstrom</name></author><author><name sortKey="Steiner, Ja" uniqKey="Steiner J">JA Steiner</name></author><author><name sortKey="Pieri, L" uniqKey="Pieri L">L Pieri</name></author><author><name sortKey="Paul, G" uniqKey="Paul G">G Paul</name></author><author><name sortKey="Outeiro, Tf" uniqKey="Outeiro T">TF Outeiro</name></author><author><name sortKey="Melki, R" uniqKey="Melki R">R Melki</name></author><author><name sortKey="Kallunki, P" uniqKey="Kallunki P">P Kallunki</name></author><author><name sortKey="Fog, K" uniqKey="Fog K">K Fog</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hiruma, H" uniqKey="Hiruma H">H Hiruma</name></author><author><name sortKey="Katakura, T" uniqKey="Katakura T">T Katakura</name></author><author><name sortKey="Takahashi, S" uniqKey="Takahashi S">S Takahashi</name></author><author><name sortKey="Ichikawa, T" uniqKey="Ichikawa T">T Ichikawa</name></author><author><name sortKey="Kawakami, T" uniqKey="Kawakami T">T Kawakami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kfoury, N" uniqKey="Kfoury N">N Kfoury</name></author><author><name sortKey="Holmes, Bb" uniqKey="Holmes B">BB Holmes</name></author><author><name sortKey="Jiang, H" uniqKey="Jiang H">H Jiang</name></author><author><name sortKey="Holtzman, Dm" uniqKey="Holtzman D">DM Holtzman</name></author><author><name sortKey="Diamond, Mi" uniqKey="Diamond M">MI Diamond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kordower, Jh" uniqKey="Kordower J">JH Kordower</name></author><author><name sortKey="Brundin, P" uniqKey="Brundin P">P Brundin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krzewska, J" uniqKey="Krzewska J">J Krzewska</name></author><author><name sortKey="Melki, R" uniqKey="Melki R">R Melki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Jy" uniqKey="Li J">JY Li</name></author><author><name sortKey="Englund, E" uniqKey="Englund E">E Englund</name></author><author><name sortKey="Holton, Jl" uniqKey="Holton J">JL Holton</name></author><author><name sortKey="Soulet, D" uniqKey="Soulet D">D Soulet</name></author><author><name sortKey="Hagell, P" uniqKey="Hagell P">P Hagell</name></author><author><name sortKey="Lees, Aj" uniqKey="Lees A">AJ Lees</name></author><author><name sortKey="Lashley, T" uniqKey="Lashley T">T Lashley</name></author><author><name sortKey="Quinn, Np" uniqKey="Quinn N">NP Quinn</name></author><author><name sortKey="Rehncrona, S" uniqKey="Rehncrona S">S Rehncrona</name></author><author><name sortKey="Bjorklund, A" uniqKey="Bjorklund A">A Bjorklund</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, Jx" uniqKey="Lu J">JX Lu</name></author><author><name sortKey="Qiang, W" uniqKey="Qiang W">W Qiang</name></author><author><name sortKey="Yau, Wm" uniqKey="Yau W">WM Yau</name></author><author><name sortKey="Schwieters, Cd" uniqKey="Schwieters C">CD Schwieters</name></author><author><name sortKey="Meredith, Sc" uniqKey="Meredith S">SC Meredith</name></author><author><name sortKey="Tycko, R" uniqKey="Tycko R">R Tycko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luk, Kc" uniqKey="Luk K">KC Luk</name></author><author><name sortKey="Kehm, V" uniqKey="Kehm V">V Kehm</name></author><author><name sortKey="Carroll, J" uniqKey="Carroll J">J Carroll</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name></author><author><name sortKey="O Rien, P" uniqKey="O Rien P">P O’Brien</name></author><author><name sortKey="Trojanowski, Jq" uniqKey="Trojanowski J">JQ Trojanowski</name></author><author><name sortKey="Lee, Vm" uniqKey="Lee V">VM Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luk, Kc" uniqKey="Luk K">KC Luk</name></author><author><name sortKey="Kehm, Vm" uniqKey="Kehm V">VM Kehm</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name></author><author><name sortKey="O Rien, P" uniqKey="O Rien P">P O’Brien</name></author><author><name sortKey="Trojanowski, Jq" uniqKey="Trojanowski J">JQ Trojanowski</name></author><author><name sortKey="Lee, Vm" uniqKey="Lee V">VM Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luk, Kc" uniqKey="Luk K">KC Luk</name></author><author><name sortKey="Song, C" uniqKey="Song C">C Song</name></author><author><name sortKey="O Rien, P" uniqKey="O Rien P">P O’Brien</name></author><author><name sortKey="Stieber, A" uniqKey="Stieber A">A Stieber</name></author><author><name sortKey="Branch, Jr" uniqKey="Branch J">JR Branch</name></author><author><name sortKey="Brunden, Kr" uniqKey="Brunden K">KR Brunden</name></author><author><name sortKey="Trojanowski, Jq" uniqKey="Trojanowski J">JQ Trojanowski</name></author><author><name sortKey="Lee, Vm" uniqKey="Lee V">VM Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lyon, Mf" uniqKey="Lyon M">MF Lyon</name></author><author><name sortKey="Ogunkolade, Bw" uniqKey="Ogunkolade B">BW Ogunkolade</name></author><author><name sortKey="Brown, Mc" uniqKey="Brown M">MC Brown</name></author><author><name sortKey="Atherton, Dj" uniqKey="Atherton D">DJ Atherton</name></author><author><name sortKey="Perry, Vh" uniqKey="Perry V">VH Perry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monsellier, E" uniqKey="Monsellier E">E Monsellier</name></author><author><name sortKey="Redeker, V" uniqKey="Redeker V">V Redeker</name></author><author><name sortKey="Ruiz Arlandis, G" uniqKey="Ruiz Arlandis G">G Ruiz-Arlandis</name></author><author><name sortKey="Bousset, L" uniqKey="Bousset L">L Bousset</name></author><author><name sortKey="Melki, R" uniqKey="Melki R">R Melki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nonaka, T" uniqKey="Nonaka T">T Nonaka</name></author><author><name sortKey="Watanabe, St" uniqKey="Watanabe S">ST Watanabe</name></author><author><name sortKey="Iwatsubo, T" uniqKey="Iwatsubo T">T Iwatsubo</name></author><author><name sortKey="Hasegawa, M" uniqKey="Hasegawa M">M Hasegawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osterloh, Jm" uniqKey="Osterloh J">JM Osterloh</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author><author><name sortKey="Rooney, Tm" uniqKey="Rooney T">TM Rooney</name></author><author><name sortKey="Fox, An" uniqKey="Fox A">AN Fox</name></author><author><name sortKey="Adalbert, R" uniqKey="Adalbert R">R Adalbert</name></author><author><name sortKey="Powell, Eh" uniqKey="Powell E">EH Powell</name></author><author><name sortKey="Sheehan, Ae" uniqKey="Sheehan A">AE Sheehan</name></author><author><name sortKey="Avery, Ma" uniqKey="Avery M">MA Avery</name></author><author><name sortKey="Hackett, R" uniqKey="Hackett R">R Hackett</name></author><author><name sortKey="Logan, Ma" uniqKey="Logan M">MA Logan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pecho Vrieseling, E" uniqKey="Pecho Vrieseling E">E Pecho-Vrieseling</name></author><author><name sortKey="Rieker, C" uniqKey="Rieker C">C Rieker</name></author><author><name sortKey="Fuchs, S" uniqKey="Fuchs S">S Fuchs</name></author><author><name sortKey="Bleckmann, D" uniqKey="Bleckmann D">D Bleckmann</name></author><author><name sortKey="Esposito, Ms" uniqKey="Esposito M">MS Esposito</name></author><author><name sortKey="Botta, P" uniqKey="Botta P">P Botta</name></author><author><name sortKey="Goldstein, C" uniqKey="Goldstein C">C Goldstein</name></author><author><name sortKey="Bernhard, M" uniqKey="Bernhard M">M Bernhard</name></author><author><name sortKey="Galimberti, I" uniqKey="Galimberti I">I Galimberti</name></author><author><name sortKey="Muller, M" uniqKey="Muller M">M Muller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peelaerts, W" uniqKey="Peelaerts W">W Peelaerts</name></author><author><name sortKey="Bousset, L" uniqKey="Bousset L">L Bousset</name></author><author><name sortKey="Van Der Perren, A" uniqKey="Van Der Perren A">A Van der Perren</name></author><author><name sortKey="Moskalyuk, A" uniqKey="Moskalyuk A">A Moskalyuk</name></author><author><name sortKey="Pulizzi, R" uniqKey="Pulizzi R">R Pulizzi</name></author><author><name sortKey="Giugliano, M" uniqKey="Giugliano M">M Giugliano</name></author><author><name sortKey="Van Den Haute, C" uniqKey="Van Den Haute C">C Van den Haute</name></author><author><name sortKey="Melki, R" uniqKey="Melki R">R Melki</name></author><author><name sortKey="Baekelandt, V" uniqKey="Baekelandt V">V Baekelandt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pieri, L" uniqKey="Pieri L">L Pieri</name></author><author><name sortKey="Madiona, K" uniqKey="Madiona K">K Madiona</name></author><author><name sortKey="Bousset, L" uniqKey="Bousset L">L Bousset</name></author><author><name sortKey="Melki, R" uniqKey="Melki R">R Melki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pigino, G" uniqKey="Pigino G">G Pigino</name></author><author><name sortKey="Morfini, G" uniqKey="Morfini G">G Morfini</name></author><author><name sortKey="Atagi, Y" uniqKey="Atagi Y">Y Atagi</name></author><author><name sortKey="Deshpande, A" uniqKey="Deshpande A">A Deshpande</name></author><author><name sortKey="Yu, C" uniqKey="Yu C">C Yu</name></author><author><name sortKey="Jungbauer, L" uniqKey="Jungbauer L">L Jungbauer</name></author><author><name sortKey="Ladu, M" uniqKey="Ladu M">M LaDu</name></author><author><name sortKey="Busciglio, J" uniqKey="Busciglio J">J Busciglio</name></author><author><name sortKey="Brady, S" uniqKey="Brady S">S Brady</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prusiner, Sb" uniqKey="Prusiner S">SB Prusiner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, Ph" uniqKey="Ren P">PH Ren</name></author><author><name sortKey="Lauckner, Je" uniqKey="Lauckner J">JE Lauckner</name></author><author><name sortKey="Kachirskaia, I" uniqKey="Kachirskaia I">I Kachirskaia</name></author><author><name sortKey="Heuser, Je" uniqKey="Heuser J">JE Heuser</name></author><author><name sortKey="Melki, R" uniqKey="Melki R">R Melki</name></author><author><name sortKey="Kopito, Rr" uniqKey="Kopito R">RR Kopito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roy, S" uniqKey="Roy S">S Roy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roy, S" uniqKey="Roy S">S Roy</name></author><author><name sortKey="Winton, Mj" uniqKey="Winton M">MJ Winton</name></author><author><name sortKey="Black, Mm" uniqKey="Black M">MM Black</name></author><author><name sortKey="Trojanowski, Jq" uniqKey="Trojanowski J">JQ Trojanowski</name></author><author><name sortKey="Lee, Vm" uniqKey="Lee V">VM Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruiz Arlandis, G" uniqKey="Ruiz Arlandis G">G Ruiz-Arlandis</name></author><author><name sortKey="Pieri, L" uniqKey="Pieri L">L Pieri</name></author><author><name sortKey="Bousset, L" uniqKey="Bousset L">L Bousset</name></author><author><name sortKey="Melki, R" uniqKey="Melki R">R Melki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scott, Da" uniqKey="Scott D">DA Scott</name></author><author><name sortKey="Das, U" uniqKey="Das U">U Das</name></author><author><name sortKey="Tang, Y" uniqKey="Tang Y">Y Tang</name></author><author><name sortKey="Roy, S" uniqKey="Roy S">S Roy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takahashi, Rh" uniqKey="Takahashi R">RH Takahashi</name></author><author><name sortKey="Milner, Ta" uniqKey="Milner T">TA Milner</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Nam, Ee" uniqKey="Nam E">EE Nam</name></author><author><name sortKey="Edgar, Ma" uniqKey="Edgar M">MA Edgar</name></author><author><name sortKey="Yamaguchi, H" uniqKey="Yamaguchi H">H Yamaguchi</name></author><author><name sortKey="Beal, Mf" uniqKey="Beal M">MF Beal</name></author><author><name sortKey="Xu, H" uniqKey="Xu H">H Xu</name></author><author><name sortKey="Greengard, P" uniqKey="Greengard P">P Greengard</name></author><author><name sortKey="Gouras, Gk" uniqKey="Gouras G">GK Gouras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, Y" uniqKey="Tang Y">Y Tang</name></author><author><name sortKey="Scott, Da" uniqKey="Scott D">DA Scott</name></author><author><name sortKey="Das, U" uniqKey="Das U">U Das</name></author><author><name sortKey="Edland, Sd" uniqKey="Edland S">SD Edland</name></author><author><name sortKey="Radomski, K" uniqKey="Radomski K">K Radomski</name></author><author><name sortKey="Koo, Eh" uniqKey="Koo E">EH Koo</name></author><author><name sortKey="Roy, S" uniqKey="Roy S">S Roy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Am" uniqKey="Taylor A">AM Taylor</name></author><author><name sortKey="Blurton Jones, M" uniqKey="Blurton Jones M">M Blurton-Jones</name></author><author><name sortKey="Rhee, Sw" uniqKey="Rhee S">SW Rhee</name></author><author><name sortKey="Cribbs, Dh" uniqKey="Cribbs D">DH Cribbs</name></author><author><name sortKey="Cotman, Cw" uniqKey="Cotman C">CW Cotman</name></author><author><name sortKey="Jeon, Nl" uniqKey="Jeon N">NL Jeon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thal, Dr" uniqKey="Thal D">DR Thal</name></author><author><name sortKey="Rub, U" uniqKey="Rub U">U Rub</name></author><author><name sortKey="Orantes, M" uniqKey="Orantes M">M Orantes</name></author><author><name sortKey="Braak, H" uniqKey="Braak H">H Braak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thual, C" uniqKey="Thual C">C Thual</name></author><author><name sortKey="Komar, Aa" uniqKey="Komar A">AA Komar</name></author><author><name sortKey="Bousset, L" uniqKey="Bousset L">L Bousset</name></author><author><name sortKey="Fernandez Bellot, E" uniqKey="Fernandez Bellot E">E Fernandez-Bellot</name></author><author><name sortKey="Cullin, C" uniqKey="Cullin C">C Cullin</name></author><author><name sortKey="Melki, R" uniqKey="Melki R">R Melki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsunemi, T" uniqKey="Tsunemi T">T Tsunemi</name></author><author><name sortKey="Hamada, K" uniqKey="Hamada K">K Hamada</name></author><author><name sortKey="Krainc, D" uniqKey="Krainc D">D Krainc</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ulusoy, A" uniqKey="Ulusoy A">A Ulusoy</name></author><author><name sortKey="Musgrove, Re" uniqKey="Musgrove R">RE Musgrove</name></author><author><name sortKey="Rusconi, R" uniqKey="Rusconi R">R Rusconi</name></author><author><name sortKey="Klinkenberg, M" uniqKey="Klinkenberg M">M Klinkenberg</name></author><author><name sortKey="Helwig, M" uniqKey="Helwig M">M Helwig</name></author><author><name sortKey="Schneider, A" uniqKey="Schneider A">A Schneider</name></author><author><name sortKey="Di Monte, Da" uniqKey="Di Monte D">DA Di Monte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volpicelli Daley, La" uniqKey="Volpicelli Daley L">LA Volpicelli-Daley</name></author><author><name sortKey="Luk, Kc" uniqKey="Luk K">KC Luk</name></author><author><name sortKey="Patel, Tp" uniqKey="Patel T">TP Patel</name></author><author><name sortKey="Tanik, Sa" uniqKey="Tanik S">SA Tanik</name></author><author><name sortKey="Riddle, Dm" uniqKey="Riddle D">DM Riddle</name></author><author><name sortKey="Stieber, A" uniqKey="Stieber A">A Stieber</name></author><author><name sortKey="Meaney, Df" uniqKey="Meaney D">DF Meaney</name></author><author><name sortKey="Trojanowski, Jq" uniqKey="Trojanowski J">JQ Trojanowski</name></author><author><name sortKey="Lee, Vm" uniqKey="Lee V">VM Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walsh, Dm" uniqKey="Walsh D">DM Walsh</name></author><author><name sortKey="Thulin, E" uniqKey="Thulin E">E Thulin</name></author><author><name sortKey="Minogue, Am" uniqKey="Minogue A">AM Minogue</name></author><author><name sortKey="Gustavsson, N" uniqKey="Gustavsson N">N Gustavsson</name></author><author><name sortKey="Pang, E" uniqKey="Pang E">E Pang</name></author><author><name sortKey="Teplow, Db" uniqKey="Teplow D">DB Teplow</name></author><author><name sortKey="Linse, S" uniqKey="Linse S">S Linse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Jt" uniqKey="Wang J">JT Wang</name></author><author><name sortKey="Medress, Za" uniqKey="Medress Z">ZA Medress</name></author><author><name sortKey="Barres, Ba" uniqKey="Barres B">BA Barres</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Jw" uniqKey="Wu J">JW Wu</name></author><author><name sortKey="Herman, M" uniqKey="Herman M">M Herman</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author><author><name sortKey="Simoes, S" uniqKey="Simoes S">S Simoes</name></author><author><name sortKey="Acker, Cm" uniqKey="Acker C">CM Acker</name></author><author><name sortKey="Figueroa, H" uniqKey="Figueroa H">H Figueroa</name></author><author><name sortKey="Steinberg, Ji" uniqKey="Steinberg J">JI Steinberg</name></author><author><name sortKey="Margittai, M" uniqKey="Margittai M">M Margittai</name></author><author><name sortKey="Kayed, R" uniqKey="Kayed R">R Kayed</name></author><author><name sortKey="Zurzolo, C" uniqKey="Zurzolo C">C Zurzolo</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001931 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 001931 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= PMC:4789229
|texte= Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:26820848" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |