Levodopa Effects on Hand and Speech Movements in Patients with Parkinson’s Disease: A fMRI Study
Identifieur interne : 000F95 ( Ncbi/Curation ); précédent : 000F94; suivant : 000F96Levodopa Effects on Hand and Speech Movements in Patients with Parkinson’s Disease: A fMRI Study
Auteurs : Audrey Maillet [France] ; Alexandre Krainik [France] ; Bettina Debû [France] ; Irène Troprès [France] ; Christelle Lagrange [France] ; Stéphane Thobois [France] ; Pierre Pollak [France, Suisse] ; Serge Pinto [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Levodopa.
- drug effects : Movement, Speech.
- methods : Magnetic Resonance Imaging.
- physiopathology : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
Levodopa (L-dopa) effects on the cardinal and axial symptoms of Parkinson’s disease (PD) differ greatly, leading to therapeutic challenges for managing the disabilities in this patient’s population. In this context, we studied the cerebral networks associated with the production of a unilateral hand movement, speech production, and a task combining both tasks in 12 individuals with PD, both
Url:
DOI: 10.1371/journal.pone.0046541
PubMed: 23056337
PubMed Central: 3467207
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PMC:3467207Le document en format XML
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Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Grenoble Institut des Neurosciences, INSERM-UJF-CEA-CHU U836, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Grenoble Institut des Neurosciences, INSERM-UJF-CEA-CHU U836, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Krainik, Alexandre" sort="Krainik, Alexandre" uniqKey="Krainik A" first="Alexandre" last="Krainik">Alexandre Krainik</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Université Joseph Fourier - Grenoble I, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier - Grenoble I, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Grenoble Institut des Neurosciences, INSERM-UJF-CEA-CHU U836, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Grenoble Institut des Neurosciences, INSERM-UJF-CEA-CHU U836, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Centre Hospitalier Universitaire (CHU), Neuroradiologie & IRM, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire (CHU), Neuroradiologie & IRM, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Debu, Bettina" sort="Debu, Bettina" uniqKey="Debu B" first="Bettina" last="Debû">Bettina Debû</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Université Joseph Fourier - Grenoble I, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier - Grenoble I, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Grenoble Institut des Neurosciences, INSERM-UJF-CEA-CHU U836, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Grenoble Institut des Neurosciences, INSERM-UJF-CEA-CHU U836, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Tropres, Irene" sort="Tropres, Irene" uniqKey="Tropres I" first="Irène" last="Troprès">Irène Troprès</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Université Joseph Fourier - Grenoble I, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier - Grenoble I, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Grenoble Institut des Neurosciences, INSERM-UJF-CEA-CHU U836, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Grenoble Institut des Neurosciences, INSERM-UJF-CEA-CHU U836, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Lagrange, Christelle" sort="Lagrange, Christelle" uniqKey="Lagrange C" first="Christelle" last="Lagrange">Christelle Lagrange</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Université Joseph Fourier - Grenoble I, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier - Grenoble I, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Centre Hospitalier Universitaire (CHU), Neurologie, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire (CHU), Neurologie, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stéphane" last="Thobois">Stéphane Thobois</name><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Hospices Civils de Lyon, Hôpital Neurologique, Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hospices Civils de Lyon, Hôpital Neurologique, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Centre de Neuroscience Cognitive, UMR 5229 CNRS/Université Lyon I, Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Neuroscience Cognitive, UMR 5229 CNRS/Université Lyon I, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Centre Hospitalier Universitaire (CHU), Neurologie, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire (CHU), Neurologie, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Hôpitaux Universitaires, Genève, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Hôpitaux Universitaires, Genève</wicri:regionArea><wicri:noRegion>Genève</wicri:noRegion></affiliation></author><author><name sortKey="Pinto, Serge" sort="Pinto, Serge" uniqKey="Pinto S" first="Serge" last="Pinto">Serge Pinto</name><affiliation wicri:level="3"><nlm:aff id="aff8"><addr-line>Laboratoire Parole et Langage, UMR 7309 CNRS/Aix-Marseille Université, Aix-en-Provence, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Parole et Langage, UMR 7309 CNRS/Aix-Marseille Université, Aix-en-Provence</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Aix-en-Provence</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Levodopa (pharmacology)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Movement (drug effects)</term><term>Parkinson Disease (physiopathology)</term><term>Speech (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Movement</term><term>Speech</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Levodopa (L-dopa) effects on the cardinal and axial symptoms of Parkinson’s disease (PD) differ greatly, leading to therapeutic challenges for managing the disabilities in this patient’s population. In this context, we studied the cerebral networks associated with the production of a unilateral hand movement, speech production, and a task combining both tasks in 12 individuals with PD, both <italic>off</italic> and <italic>on</italic> levodopa (L-dopa). Unilateral hand movements in the <italic>off</italic> medication state elicited brain activations in motor regions (primary motor cortex, supplementary motor area, premotor cortex, cerebellum), as well as additional areas (anterior cingulate, putamen, associative parietal areas); following L-dopa administration, the brain activation profile was globally reduced, highlighting activations in the parietal and posterior cingulate cortices. For the speech production task, brain activation patterns were similar with and without medication, including the orofacial primary motor cortex (M1), the primary somatosensory cortex and the cerebellar hemispheres bilaterally, as well as the left- premotor, anterior cingulate and supramarginal cortices. For the combined task <italic>off</italic> L-dopa, the cerebral activation profile was restricted to the right cerebellum (hand movement), reflecting the difficulty in performing two movements simultaneously in PD. Under L-dopa, the brain activation profile of the combined task involved a larger pattern, including additional fronto-parietal activations, without reaching the sum of the areas activated during the simple hand and speech tasks separately. Our results question both the role of the basal ganglia system in speech production and the modulation of task-dependent cerebral networks by dopaminergic treatment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Brooks, Dj" uniqKey="Brooks D">DJ Brooks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leenders, Kl" uniqKey="Leenders K">KL Leenders</name></author><author><name sortKey="Wolfson, L" uniqKey="Wolfson L">L Wolfson</name></author><author><name sortKey="Gibbs, Jm" uniqKey="Gibbs J">JM Gibbs</name></author><author><name sortKey="Wise, Rj" uniqKey="Wise R">RJ Wise</name></author><author><name sortKey="Causon, R" uniqKey="Causon R">R Causon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Montastruc, Jl" uniqKey="Montastruc J">JL Montastruc</name></author><author><name sortKey="Celsis, P" uniqKey="Celsis P">P Celsis</name></author><author><name 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Dagher</name></author><author><name sortKey="Owen, Am" uniqKey="Owen A">AM Owen</name></author><author><name sortKey="Boecker, H" uniqKey="Boecker H">H Boecker</name></author><author><name sortKey="Brooks, Dj" uniqKey="Brooks D">DJ Brooks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rowe, J" uniqKey="Rowe J">J Rowe</name></author><author><name sortKey="Stephan, Ke" uniqKey="Stephan K">KE Stephan</name></author><author><name sortKey="Friston, K" uniqKey="Friston K">K Friston</name></author><author><name sortKey="Frackowiak, R" uniqKey="Frackowiak R">R Frackowiak</name></author><author><name sortKey="Lees, A" uniqKey="Lees A">A Lees</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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