La maladie de Parkinson en France (serveur d'exploration)

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Levodopa Effects on Hand and Speech Movements in Patients with Parkinson’s Disease: A fMRI Study

Identifieur interne : 000808 ( Pmc/Curation ); précédent : 000807; suivant : 000809

Levodopa Effects on Hand and Speech Movements in Patients with Parkinson’s Disease: A fMRI Study

Auteurs : Audrey Maillet [France] ; Alexandre Krainik [France] ; Bettina Debû [France] ; Irène Troprès [France] ; Christelle Lagrange [France] ; Stéphane Thobois [France] ; Pierre Pollak [France, Suisse] ; Serge Pinto [France]

Source :

RBID : PMC:3467207

Abstract

Levodopa (L-dopa) effects on the cardinal and axial symptoms of Parkinson’s disease (PD) differ greatly, leading to therapeutic challenges for managing the disabilities in this patient’s population. In this context, we studied the cerebral networks associated with the production of a unilateral hand movement, speech production, and a task combining both tasks in 12 individuals with PD, both off and on levodopa (L-dopa). Unilateral hand movements in the off medication state elicited brain activations in motor regions (primary motor cortex, supplementary motor area, premotor cortex, cerebellum), as well as additional areas (anterior cingulate, putamen, associative parietal areas); following L-dopa administration, the brain activation profile was globally reduced, highlighting activations in the parietal and posterior cingulate cortices. For the speech production task, brain activation patterns were similar with and without medication, including the orofacial primary motor cortex (M1), the primary somatosensory cortex and the cerebellar hemispheres bilaterally, as well as the left- premotor, anterior cingulate and supramarginal cortices. For the combined task off L-dopa, the cerebral activation profile was restricted to the right cerebellum (hand movement), reflecting the difficulty in performing two movements simultaneously in PD. Under L-dopa, the brain activation profile of the combined task involved a larger pattern, including additional fronto-parietal activations, without reaching the sum of the areas activated during the simple hand and speech tasks separately. Our results question both the role of the basal ganglia system in speech production and the modulation of task-dependent cerebral networks by dopaminergic treatment.


Url:
DOI: 10.1371/journal.pone.0046541
PubMed: 23056337
PubMed Central: 3467207

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PMC:3467207

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<p>Levodopa (L-dopa) effects on the cardinal and axial symptoms of Parkinson’s disease (PD) differ greatly, leading to therapeutic challenges for managing the disabilities in this patient’s population. In this context, we studied the cerebral networks associated with the production of a unilateral hand movement, speech production, and a task combining both tasks in 12 individuals with PD, both
<italic>off</italic>
and
<italic>on</italic>
levodopa (L-dopa). Unilateral hand movements in the
<italic>off</italic>
medication state elicited brain activations in motor regions (primary motor cortex, supplementary motor area, premotor cortex, cerebellum), as well as additional areas (anterior cingulate, putamen, associative parietal areas); following L-dopa administration, the brain activation profile was globally reduced, highlighting activations in the parietal and posterior cingulate cortices. For the speech production task, brain activation patterns were similar with and without medication, including the orofacial primary motor cortex (M1), the primary somatosensory cortex and the cerebellar hemispheres bilaterally, as well as the left- premotor, anterior cingulate and supramarginal cortices. For the combined task
<italic>off</italic>
L-dopa, the cerebral activation profile was restricted to the right cerebellum (hand movement), reflecting the difficulty in performing two movements simultaneously in PD. Under L-dopa, the brain activation profile of the combined task involved a larger pattern, including additional fronto-parietal activations, without reaching the sum of the areas activated during the simple hand and speech tasks separately. Our results question both the role of the basal ganglia system in speech production and the modulation of task-dependent cerebral networks by dopaminergic treatment.</p>
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</TEI>
<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group>
<journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher>
<publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">23056337</article-id>
<article-id pub-id-type="pmc">3467207</article-id>
<article-id pub-id-type="publisher-id">PONE-D-12-15044</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0046541</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Research Article</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v2">
<subject>Biology</subject>
<subj-group>
<subject>Neuroscience</subject>
<subj-group>
<subject>Neuroimaging</subject>
<subj-group>
<subject>Fmri</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v2">
<subject>Medicine</subject>
<subj-group>
<subject>Drugs and Devices</subject>
<subj-group>
<subject>Neuropharmacology</subject>
</subj-group>
</subj-group>
<subj-group>
<subject>Neurology</subject>
<subj-group>
<subject>Movement Disorders</subject>
<subject>Neuroimaging</subject>
<subject>Parkinson Disease</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v2">
<subject>Social and Behavioral Sciences</subject>
<subj-group>
<subject>Linguistics</subject>
<subj-group>
<subject>Neurolinguistics</subject>
<subject>Speech</subject>
</subj-group>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Levodopa Effects on Hand and Speech Movements in Patients with Parkinson’s Disease: A fMRI Study</article-title>
<alt-title alt-title-type="running-head">fMRI, L-dopa, Hand and Speech Movements</alt-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Maillet</surname>
<given-names>Audrey</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Krainik</surname>
<given-names>Alexandre</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3">
<sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Debû</surname>
<given-names>Bettina</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Troprès</surname>
<given-names>Irène</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lagrange</surname>
<given-names>Christelle</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Thobois</surname>
<given-names>Stéphane</given-names>
</name>
<xref ref-type="aff" rid="aff5">
<sup>5</sup>
</xref>
<xref ref-type="aff" rid="aff6">
<sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pollak</surname>
<given-names>Pierre</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff7">
<sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pinto</surname>
<given-names>Serge</given-names>
</name>
<xref ref-type="aff" rid="aff8">
<sup>8</sup>
</xref>
<xref ref-type="corresp" rid="cor1">
<sup>*</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1">
<label>1</label>
<addr-line>Université Joseph Fourier - Grenoble I, Grenoble, France</addr-line>
</aff>
<aff id="aff2">
<label>2</label>
<addr-line>Grenoble Institut des Neurosciences, INSERM-UJF-CEA-CHU U836, Grenoble, France</addr-line>
</aff>
<aff id="aff3">
<label>3</label>
<addr-line>Centre Hospitalier Universitaire (CHU), Neuroradiologie & IRM, Grenoble, France</addr-line>
</aff>
<aff id="aff4">
<label>4</label>
<addr-line>Centre Hospitalier Universitaire (CHU), Neurologie, Grenoble, France</addr-line>
</aff>
<aff id="aff5">
<label>5</label>
<addr-line>Hospices Civils de Lyon, Hôpital Neurologique, Lyon, France</addr-line>
</aff>
<aff id="aff6">
<label>6</label>
<addr-line>Centre de Neuroscience Cognitive, UMR 5229 CNRS/Université Lyon I, Lyon, France</addr-line>
</aff>
<aff id="aff7">
<label>7</label>
<addr-line>Hôpitaux Universitaires, Genève, Switzerland</addr-line>
</aff>
<aff id="aff8">
<label>8</label>
<addr-line>Laboratoire Parole et Langage, UMR 7309 CNRS/Aix-Marseille Université, Aix-en-Provence, France</addr-line>
</aff>
<contrib-group>
<contrib contrib-type="editor">
<name>
<surname>Meck</surname>
<given-names>Warren H.</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1">
<addr-line>Duke University, United States of America</addr-line>
</aff>
<author-notes>
<corresp id="cor1">* E-mail:
<email>serge.pinto@lpl-aix.fr</email>
</corresp>
<fn fn-type="conflict">
<p>
<bold>Competing Interests: </bold>
The authors have declared that no competing interests exist.</p>
</fn>
<fn fn-type="con">
<p>Conceived and designed the experiments: PP CL SP. Performed the experiments: AM AK IT SP. Analyzed the data: AM SP AK BD. Contributed reagents/materials/analysis tools: AK CL BD. Wrote the paper: AM AK BD ST PP SP.</p>
</fn>
</author-notes>
<pub-date pub-type="collection">
<year>2012</year>
</pub-date>
<pub-date pub-type="epub">
<day>9</day>
<month>10</month>
<year>2012</year>
</pub-date>
<volume>7</volume>
<issue>10</issue>
<elocation-id>e46541</elocation-id>
<history>
<date date-type="received">
<day>23</day>
<month>5</month>
<year>2012</year>
</date>
<date date-type="accepted">
<day>31</day>
<month>8</month>
<year>2012</year>
</date>
</history>
<permissions>
<copyright-year>2012</copyright-year>
<copyright-holder>Maillet et al</copyright-holder>
<license>
<license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
</license>
</permissions>
<abstract>
<p>Levodopa (L-dopa) effects on the cardinal and axial symptoms of Parkinson’s disease (PD) differ greatly, leading to therapeutic challenges for managing the disabilities in this patient’s population. In this context, we studied the cerebral networks associated with the production of a unilateral hand movement, speech production, and a task combining both tasks in 12 individuals with PD, both
<italic>off</italic>
and
<italic>on</italic>
levodopa (L-dopa). Unilateral hand movements in the
<italic>off</italic>
medication state elicited brain activations in motor regions (primary motor cortex, supplementary motor area, premotor cortex, cerebellum), as well as additional areas (anterior cingulate, putamen, associative parietal areas); following L-dopa administration, the brain activation profile was globally reduced, highlighting activations in the parietal and posterior cingulate cortices. For the speech production task, brain activation patterns were similar with and without medication, including the orofacial primary motor cortex (M1), the primary somatosensory cortex and the cerebellar hemispheres bilaterally, as well as the left- premotor, anterior cingulate and supramarginal cortices. For the combined task
<italic>off</italic>
L-dopa, the cerebral activation profile was restricted to the right cerebellum (hand movement), reflecting the difficulty in performing two movements simultaneously in PD. Under L-dopa, the brain activation profile of the combined task involved a larger pattern, including additional fronto-parietal activations, without reaching the sum of the areas activated during the simple hand and speech tasks separately. Our results question both the role of the basal ganglia system in speech production and the modulation of task-dependent cerebral networks by dopaminergic treatment.</p>
</abstract>
<funding-group>
<funding-statement>The authors wish to thank the French Health Ministry for the very helpful source of funding (PHRC 2005). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement>
</funding-group>
<counts>
<page-count count="12"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>

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