Effect of levodopa on both verbal and motor representations of action in Parkinson's disease: a fMRI study.
Identifieur interne : 000F44 ( Ncbi/Curation ); précédent : 000F43; suivant : 000F45Effect of levodopa on both verbal and motor representations of action in Parkinson's disease: a fMRI study.
Auteurs : P. Péran [France] ; F. Nemmi ; D. Méligne ; D. Cardebat ; A. Peppe ; O. Rascol ; C. Caltagirone ; J F Demonet ; U. SabatiniSource :
- Brain and language [ 1090-2155 ] ; 2013.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Brain (drug effects), Brain (physiopathology), Humans, Imagination, Levodopa (therapeutic use), Magnetic Resonance Imaging, Middle Aged, Motor Activity (drug effects), Motor Activity (physiology), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Psychomotor Performance (drug effects), Psychomotor Performance (physiology), Speech (drug effects), Speech (physiology).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- drug effects : Brain, Motor Activity, Psychomotor Performance, Speech.
- drug therapy : Parkinson Disease.
- physiology : Motor Activity, Psychomotor Performance, Speech.
- physiopathology : Brain, Parkinson Disease.
- Humans, Imagination, Magnetic Resonance Imaging, Middle Aged.
Abstract
Previous studies have demonstrated that non-demented Parkinson's disease (PD) patients have a specific impairment of verb production compared with noun generation. One interpretation of this deficit suggested the influence of striato-frontal dysfunction on action-related verb processing. The aim of our study was to investigate cerebral changes after motor improvement due to dopaminergic medication on the neural circuitry supporting action representation in the brain as mediated by verb generation and motor imagery in PD patients. Functional magnetic resonance imaging on 8 PD patients in "ON" dopaminergic treatment state (DTS) and in "OFF" DTS was used to explore the brain activity during three different tasks: Object Naming (ObjN), Generation of Action Verbs (GenA) in which patients were asked to overtly say an action associated with a picture and mental simulation of action (MSoA) was investigated by asking subjects to mentally simulate an action related to a depicted object. The distribution of brain activities associated with these tasks whatever DTS was very similar to results of previous studies. The results showed that brain activity related to semantics of action is modified by dopaminergic treatment in PD patients. This cerebral reorganisation concerns mainly motor and premotor cortex suggesting an involvement of the putaminal motor loop according to the "motor" theory of verb processing.
DOI: 10.1016/j.bandl.2012.06.001
PubMed: 22841350
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000724
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000692
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000692
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000F44
Links to Exploration step
pubmed:22841350Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of levodopa on both verbal and motor representations of action in Parkinson's disease: a fMRI study.</title><author><name sortKey="Peran, P" sort="Peran, P" uniqKey="Peran P" first="P" last="Péran">P. Péran</name><affiliation wicri:level="3"><nlm:affiliation>Inserm, Imagerie Cérébrale et Handicaps Neurologiques, UMR 825, 31059 Toulouse, France. patrice.peran@inserm.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Imagerie Cérébrale et Handicaps Neurologiques, UMR 825, 31059 Toulouse</wicri:regionArea><placeName><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Nemmi, F" sort="Nemmi, F" uniqKey="Nemmi F" first="F" last="Nemmi">F. Nemmi</name></author><author><name sortKey="Meligne, D" sort="Meligne, D" uniqKey="Meligne D" first="D" last="Méligne">D. Méligne</name></author><author><name sortKey="Cardebat, D" sort="Cardebat, D" uniqKey="Cardebat D" first="D" last="Cardebat">D. Cardebat</name></author><author><name sortKey="Peppe, A" sort="Peppe, A" uniqKey="Peppe A" first="A" last="Peppe">A. Peppe</name></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></author><author><name sortKey="Caltagirone, C" sort="Caltagirone, C" uniqKey="Caltagirone C" first="C" last="Caltagirone">C. Caltagirone</name></author><author><name sortKey="Demonet, J F" sort="Demonet, J F" uniqKey="Demonet J" first="J F" last="Demonet">J F Demonet</name></author><author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U" last="Sabatini">U. Sabatini</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:22841350</idno><idno type="pmid">22841350</idno><idno type="doi">10.1016/j.bandl.2012.06.001</idno><idno type="wicri:Area/PubMed/Corpus">000724</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000724</idno><idno type="wicri:Area/PubMed/Curation">000692</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000692</idno><idno type="wicri:Area/PubMed/Checkpoint">000692</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000692</idno><idno type="wicri:Area/Ncbi/Merge">000F44</idno><idno type="wicri:Area/Ncbi/Curation">000F44</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of levodopa on both verbal and motor representations of action in Parkinson's disease: a fMRI study.</title><author><name sortKey="Peran, P" sort="Peran, P" uniqKey="Peran P" first="P" last="Péran">P. Péran</name><affiliation wicri:level="3"><nlm:affiliation>Inserm, Imagerie Cérébrale et Handicaps Neurologiques, UMR 825, 31059 Toulouse, France. patrice.peran@inserm.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Imagerie Cérébrale et Handicaps Neurologiques, UMR 825, 31059 Toulouse</wicri:regionArea><placeName><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Nemmi, F" sort="Nemmi, F" uniqKey="Nemmi F" first="F" last="Nemmi">F. Nemmi</name></author><author><name sortKey="Meligne, D" sort="Meligne, D" uniqKey="Meligne D" first="D" last="Méligne">D. Méligne</name></author><author><name sortKey="Cardebat, D" sort="Cardebat, D" uniqKey="Cardebat D" first="D" last="Cardebat">D. Cardebat</name></author><author><name sortKey="Peppe, A" sort="Peppe, A" uniqKey="Peppe A" first="A" last="Peppe">A. Peppe</name></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></author><author><name sortKey="Caltagirone, C" sort="Caltagirone, C" uniqKey="Caltagirone C" first="C" last="Caltagirone">C. Caltagirone</name></author><author><name sortKey="Demonet, J F" sort="Demonet, J F" uniqKey="Demonet J" first="J F" last="Demonet">J F Demonet</name></author><author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U" last="Sabatini">U. Sabatini</name></author></analytic><series><title level="j">Brain and language</title><idno type="eISSN">1090-2155</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (therapeutic use)</term><term>Brain (drug effects)</term><term>Brain (physiopathology)</term><term>Humans</term><term>Imagination</term><term>Levodopa (therapeutic use)</term><term>Magnetic Resonance Imaging</term><term>Middle Aged</term><term>Motor Activity (drug effects)</term><term>Motor Activity (physiology)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Psychomotor Performance (drug effects)</term><term>Psychomotor Performance (physiology)</term><term>Speech (drug effects)</term><term>Speech (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brain</term><term>Motor Activity</term><term>Psychomotor Performance</term><term>Speech</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Motor Activity</term><term>Psychomotor Performance</term><term>Speech</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Imagination</term><term>Magnetic Resonance Imaging</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous studies have demonstrated that non-demented Parkinson's disease (PD) patients have a specific impairment of verb production compared with noun generation. One interpretation of this deficit suggested the influence of striato-frontal dysfunction on action-related verb processing. The aim of our study was to investigate cerebral changes after motor improvement due to dopaminergic medication on the neural circuitry supporting action representation in the brain as mediated by verb generation and motor imagery in PD patients. Functional magnetic resonance imaging on 8 PD patients in "ON" dopaminergic treatment state (DTS) and in "OFF" DTS was used to explore the brain activity during three different tasks: Object Naming (ObjN), Generation of Action Verbs (GenA) in which patients were asked to overtly say an action associated with a picture and mental simulation of action (MSoA) was investigated by asking subjects to mentally simulate an action related to a depicted object. The distribution of brain activities associated with these tasks whatever DTS was very similar to results of previous studies. The results showed that brain activity related to semantics of action is modified by dopaminergic treatment in PD patients. This cerebral reorganisation concerns mainly motor and premotor cortex suggesting an involvement of the putaminal motor loop according to the "motor" theory of verb processing.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F44 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000F44 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:22841350
|texte= Effect of levodopa on both verbal and motor representations of action in Parkinson's disease: a fMRI study.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:22841350" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |