Effect of levodopa on both verbal and motor representations of action in Parkinson's disease: a fMRI study.
Identifieur interne : 000F44 ( Ncbi/Merge ); précédent : 000F43; suivant : 000F45Effect of levodopa on both verbal and motor representations of action in Parkinson's disease: a fMRI study.
Auteurs : P. Péran [France] ; F. Nemmi ; D. Méligne ; D. Cardebat ; A. Peppe ; O. Rascol ; C. Caltagirone ; J F Demonet ; U. SabatiniSource :
- Brain and language [ 1090-2155 ] ; 2013.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Brain (drug effects), Brain (physiopathology), Humans, Imagination, Levodopa (therapeutic use), Magnetic Resonance Imaging, Middle Aged, Motor Activity (drug effects), Motor Activity (physiology), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Psychomotor Performance (drug effects), Psychomotor Performance (physiology), Speech (drug effects), Speech (physiology).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- drug effects : Brain, Motor Activity, Psychomotor Performance, Speech.
- drug therapy : Parkinson Disease.
- physiology : Motor Activity, Psychomotor Performance, Speech.
- physiopathology : Brain, Parkinson Disease.
- Humans, Imagination, Magnetic Resonance Imaging, Middle Aged.
Abstract
Previous studies have demonstrated that non-demented Parkinson's disease (PD) patients have a specific impairment of verb production compared with noun generation. One interpretation of this deficit suggested the influence of striato-frontal dysfunction on action-related verb processing. The aim of our study was to investigate cerebral changes after motor improvement due to dopaminergic medication on the neural circuitry supporting action representation in the brain as mediated by verb generation and motor imagery in PD patients. Functional magnetic resonance imaging on 8 PD patients in "ON" dopaminergic treatment state (DTS) and in "OFF" DTS was used to explore the brain activity during three different tasks: Object Naming (ObjN), Generation of Action Verbs (GenA) in which patients were asked to overtly say an action associated with a picture and mental simulation of action (MSoA) was investigated by asking subjects to mentally simulate an action related to a depicted object. The distribution of brain activities associated with these tasks whatever DTS was very similar to results of previous studies. The results showed that brain activity related to semantics of action is modified by dopaminergic treatment in PD patients. This cerebral reorganisation concerns mainly motor and premotor cortex suggesting an involvement of the putaminal motor loop according to the "motor" theory of verb processing.
DOI: 10.1016/j.bandl.2012.06.001
PubMed: 22841350
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Péran</name><affiliation wicri:level="3"><nlm:affiliation>Inserm, Imagerie Cérébrale et Handicaps Neurologiques, UMR 825, 31059 Toulouse, France. patrice.peran@inserm.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Imagerie Cérébrale et Handicaps Neurologiques, UMR 825, 31059 Toulouse</wicri:regionArea><placeName><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Nemmi, F" sort="Nemmi, F" uniqKey="Nemmi F" first="F" last="Nemmi">F. Nemmi</name></author><author><name sortKey="Meligne, D" sort="Meligne, D" uniqKey="Meligne D" first="D" last="Méligne">D. Méligne</name></author><author><name sortKey="Cardebat, D" sort="Cardebat, D" uniqKey="Cardebat D" first="D" last="Cardebat">D. Cardebat</name></author><author><name sortKey="Peppe, A" sort="Peppe, A" uniqKey="Peppe A" first="A" last="Peppe">A. Peppe</name></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></author><author><name sortKey="Caltagirone, C" sort="Caltagirone, C" uniqKey="Caltagirone C" first="C" last="Caltagirone">C. Caltagirone</name></author><author><name sortKey="Demonet, J F" sort="Demonet, J F" uniqKey="Demonet J" first="J F" last="Demonet">J F Demonet</name></author><author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U" last="Sabatini">U. 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One interpretation of this deficit suggested the influence of striato-frontal dysfunction on action-related verb processing. The aim of our study was to investigate cerebral changes after motor improvement due to dopaminergic medication on the neural circuitry supporting action representation in the brain as mediated by verb generation and motor imagery in PD patients. Functional magnetic resonance imaging on 8 PD patients in "ON" dopaminergic treatment state (DTS) and in "OFF" DTS was used to explore the brain activity during three different tasks: Object Naming (ObjN), Generation of Action Verbs (GenA) in which patients were asked to overtly say an action associated with a picture and mental simulation of action (MSoA) was investigated by asking subjects to mentally simulate an action related to a depicted object. The distribution of brain activities associated with these tasks whatever DTS was very similar to results of previous studies. The results showed that brain activity related to semantics of action is modified by dopaminergic treatment in PD patients. This cerebral reorganisation concerns mainly motor and premotor cortex suggesting an involvement of the putaminal motor loop according to the "motor" theory of verb processing.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22841350</PMID><DateCreated><Year>2013</Year><Month>05</Month><Day>20</Day></DateCreated><DateCompleted><Year>2013</Year><Month>10</Month><Day>23</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2155</ISSN><JournalIssue CitedMedium="Internet"><Volume>125</Volume><Issue>3</Issue><PubDate><Year>2013</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Brain and language</Title><ISOAbbreviation>Brain Lang</ISOAbbreviation></Journal><ArticleTitle>Effect of levodopa on both verbal and motor representations of action in Parkinson's disease: a fMRI study.</ArticleTitle><Pagination><MedlinePgn>324-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bandl.2012.06.001</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0093-934X(12)00106-X</ELocationID><Abstract><AbstractText>Previous studies have demonstrated that non-demented Parkinson's disease (PD) patients have a specific impairment of verb production compared with noun generation. One interpretation of this deficit suggested the influence of striato-frontal dysfunction on action-related verb processing. The aim of our study was to investigate cerebral changes after motor improvement due to dopaminergic medication on the neural circuitry supporting action representation in the brain as mediated by verb generation and motor imagery in PD patients. Functional magnetic resonance imaging on 8 PD patients in "ON" dopaminergic treatment state (DTS) and in "OFF" DTS was used to explore the brain activity during three different tasks: Object Naming (ObjN), Generation of Action Verbs (GenA) in which patients were asked to overtly say an action associated with a picture and mental simulation of action (MSoA) was investigated by asking subjects to mentally simulate an action related to a depicted object. The distribution of brain activities associated with these tasks whatever DTS was very similar to results of previous studies. The results showed that brain activity related to semantics of action is modified by dopaminergic treatment in PD patients. This cerebral reorganisation concerns mainly motor and premotor cortex suggesting an involvement of the putaminal motor loop according to the "motor" theory of verb processing.</AbstractText><CopyrightInformation>Copyright © 2012 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Péran</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Inserm, Imagerie Cérébrale et Handicaps Neurologiques, UMR 825, 31059 Toulouse, France. patrice.peran@inserm.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nemmi</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Méligne</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Cardebat</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Peppe</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Rascol</LastName><ForeName>O</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Caltagirone</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Demonet</LastName><ForeName>J F</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Sabatini</LastName><ForeName>U</ForeName><Initials>U</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>07</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Brain Lang</MedlineTA><NlmUniqueID>7506220</NlmUniqueID><ISSNLinking>0093-934X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007092" MajorTopicYN="N">Imagination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009043" MajorTopicYN="N">Motor Activity</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011597" MajorTopicYN="N">Psychomotor Performance</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013060" MajorTopicYN="N">Speech</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>12</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>04</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>06</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>7</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>7</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>10</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22841350</ArticleId><ArticleId IdType="pii">S0093-934X(12)00106-X</ArticleId><ArticleId IdType="doi">10.1016/j.bandl.2012.06.001</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li></region><settlement><li>Toulouse</li></settlement></list><tree><noCountry><name sortKey="Caltagirone, C" sort="Caltagirone, C" uniqKey="Caltagirone C" first="C" last="Caltagirone">C. Caltagirone</name><name sortKey="Cardebat, D" sort="Cardebat, D" uniqKey="Cardebat D" first="D" last="Cardebat">D. Cardebat</name><name sortKey="Demonet, J F" sort="Demonet, J F" uniqKey="Demonet J" first="J F" last="Demonet">J F Demonet</name><name sortKey="Meligne, D" sort="Meligne, D" uniqKey="Meligne D" first="D" last="Méligne">D. Méligne</name><name sortKey="Nemmi, F" sort="Nemmi, F" uniqKey="Nemmi F" first="F" last="Nemmi">F. Nemmi</name><name sortKey="Peppe, A" sort="Peppe, A" uniqKey="Peppe A" first="A" last="Peppe">A. Peppe</name><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U" last="Sabatini">U. Sabatini</name></noCountry><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Peran, P" sort="Peran, P" uniqKey="Peran P" first="P" last="Péran">P. 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