Deep brain stimulation for obsessive-compulsive disorder: subthalamic nucleus target.
Identifieur interne : 000E83 ( Ncbi/Curation ); précédent : 000E82; suivant : 000E84Deep brain stimulation for obsessive-compulsive disorder: subthalamic nucleus target.
Auteurs : Stéphan Chabardès [France] ; Mircea Polosan ; Paul Krack ; Julien Bastin ; Alexandre Krainik ; Olivier David ; Thierry Bougerol ; Alim Louis BenabidSource :
- World neurosurgery [ 1878-8769 ]
English descriptors
- KwdEn :
- Adult, Age of Onset, Animals, Deep Brain Stimulation (adverse effects), Deep Brain Stimulation (methods), Female, Humans, Impulsive Behavior (psychology), Impulsive Behavior (surgery), Male, Neurosurgical Procedures (adverse effects), Neurosurgical Procedures (methods), Obsessive-Compulsive Disorder (pathology), Obsessive-Compulsive Disorder (psychology), Obsessive-Compulsive Disorder (therapy), Patient Selection, Subthalamic Nucleus (pathology), Subthalamic Nucleus (surgery), Treatment Failure, Treatment Outcome.
- MESH :
- adverse effects : Deep Brain Stimulation, Neurosurgical Procedures.
- methods : Deep Brain Stimulation, Neurosurgical Procedures.
- pathology : Obsessive-Compulsive Disorder, Subthalamic Nucleus.
- psychology : Impulsive Behavior, Obsessive-Compulsive Disorder.
- surgery : Impulsive Behavior, Subthalamic Nucleus.
- therapy : Obsessive-Compulsive Disorder.
- Adult, Age of Onset, Animals, Female, Humans, Male, Patient Selection, Treatment Failure, Treatment Outcome.
Abstract
Because of its reversibility and adaptability, deep brain stimulation (DBS) has recently gained interest in psychiatric disorders, such as obsessive-compulsive disorders (OCD) and depression. In OCD, DBS is now an alternative procedure to lesions of fascicles such as the anterior capsule, which links the orbitofrontal cortex, the cingulum, and the thalamus, and has been applied to new target such as the nucleus accumbens, with promising results. However, a recent interest has been developed toward the subthalamic nucleus (STN), a key structure of the basal ganglia that connects the motor, limbic, and associative systems. It is known from patients with Parkinson disease that STN-DBS can have significant effects on mood and cognition. Those transient effects are usually seen as "side effects" in Parkinson disease, but are clues to the underappreciated role that STN plays in the limbic circuitry, a role whose precise details are as yet unknown and under active investigation. We present the rationale supporting the use of nonmotor STN as a therapeutic target to treat OCD. In particular, we discuss the recent experience and preliminary results of our group after 6 months of nonmotor STN-DBS in patients with severe OCD.
DOI: 10.1016/j.wneu.2012.03.010
PubMed: 22469523
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000704
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000673
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000673
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000E83
Links to Exploration step
pubmed:22469523Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Deep brain stimulation for obsessive-compulsive disorder: subthalamic nucleus target.</title><author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name><affiliation wicri:level="4"><nlm:affiliation>Université Joseph Fourier, Grenoble, France; Clinique de Neurochirurgie, Centre Hospitalier Universitaire, Grenoble, France; INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France. Electronic address: SChabardes@chu-grenoble.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier, Grenoble, France; Clinique de Neurochirurgie, Centre Hospitalier Universitaire, Grenoble, France; INSERM U836, Grenoble Institut des Neurosciences, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Polosan, Mircea" sort="Polosan, Mircea" uniqKey="Polosan M" first="Mircea" last="Polosan">Mircea Polosan</name></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name></author><author><name sortKey="Bastin, Julien" sort="Bastin, Julien" uniqKey="Bastin J" first="Julien" last="Bastin">Julien Bastin</name></author><author><name sortKey="Krainik, Alexandre" sort="Krainik, Alexandre" uniqKey="Krainik A" first="Alexandre" last="Krainik">Alexandre Krainik</name></author><author><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name></author><author><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim Louis" last="Benabid">Alim Louis Benabid</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2013 Sep-Oct</MedlineDate></PubDate></date><idno type="RBID">pubmed:22469523</idno><idno type="pmid">22469523</idno><idno type="doi">10.1016/j.wneu.2012.03.010</idno><idno type="wicri:Area/PubMed/Corpus">000704</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000704</idno><idno type="wicri:Area/PubMed/Curation">000673</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000673</idno><idno type="wicri:Area/PubMed/Checkpoint">000673</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000673</idno><idno type="wicri:Area/Ncbi/Merge">000E83</idno><idno type="wicri:Area/Ncbi/Curation">000E83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Deep brain stimulation for obsessive-compulsive disorder: subthalamic nucleus target.</title><author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name><affiliation wicri:level="4"><nlm:affiliation>Université Joseph Fourier, Grenoble, France; Clinique de Neurochirurgie, Centre Hospitalier Universitaire, Grenoble, France; INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France. Electronic address: SChabardes@chu-grenoble.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Joseph Fourier, Grenoble, France; Clinique de Neurochirurgie, Centre Hospitalier Universitaire, Grenoble, France; INSERM U836, Grenoble Institut des Neurosciences, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Polosan, Mircea" sort="Polosan, Mircea" uniqKey="Polosan M" first="Mircea" last="Polosan">Mircea Polosan</name></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name></author><author><name sortKey="Bastin, Julien" sort="Bastin, Julien" uniqKey="Bastin J" first="Julien" last="Bastin">Julien Bastin</name></author><author><name sortKey="Krainik, Alexandre" sort="Krainik, Alexandre" uniqKey="Krainik A" first="Alexandre" last="Krainik">Alexandre Krainik</name></author><author><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name></author><author><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim Louis" last="Benabid">Alim Louis Benabid</name></author></analytic><series><title level="j">World neurosurgery</title><idno type="eISSN">1878-8769</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Animals</term><term>Deep Brain Stimulation (adverse effects)</term><term>Deep Brain Stimulation (methods)</term><term>Female</term><term>Humans</term><term>Impulsive Behavior (psychology)</term><term>Impulsive Behavior (surgery)</term><term>Male</term><term>Neurosurgical Procedures (adverse effects)</term><term>Neurosurgical Procedures (methods)</term><term>Obsessive-Compulsive Disorder (pathology)</term><term>Obsessive-Compulsive Disorder (psychology)</term><term>Obsessive-Compulsive Disorder (therapy)</term><term>Patient Selection</term><term>Subthalamic Nucleus (pathology)</term><term>Subthalamic Nucleus (surgery)</term><term>Treatment Failure</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Deep Brain Stimulation</term><term>Neurosurgical Procedures</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term><term>Neurosurgical Procedures</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Obsessive-Compulsive Disorder</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Impulsive Behavior</term><term>Obsessive-Compulsive Disorder</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Impulsive Behavior</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Obsessive-Compulsive Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Animals</term><term>Female</term><term>Humans</term><term>Male</term><term>Patient Selection</term><term>Treatment Failure</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Because of its reversibility and adaptability, deep brain stimulation (DBS) has recently gained interest in psychiatric disorders, such as obsessive-compulsive disorders (OCD) and depression. In OCD, DBS is now an alternative procedure to lesions of fascicles such as the anterior capsule, which links the orbitofrontal cortex, the cingulum, and the thalamus, and has been applied to new target such as the nucleus accumbens, with promising results. However, a recent interest has been developed toward the subthalamic nucleus (STN), a key structure of the basal ganglia that connects the motor, limbic, and associative systems. It is known from patients with Parkinson disease that STN-DBS can have significant effects on mood and cognition. Those transient effects are usually seen as "side effects" in Parkinson disease, but are clues to the underappreciated role that STN plays in the limbic circuitry, a role whose precise details are as yet unknown and under active investigation. We present the rationale supporting the use of nonmotor STN as a therapeutic target to treat OCD. In particular, we discuss the recent experience and preliminary results of our group after 6 months of nonmotor STN-DBS in patients with severe OCD.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E83 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000E83 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:22469523
|texte= Deep brain stimulation for obsessive-compulsive disorder: subthalamic nucleus target.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:22469523" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |