Deep brain stimulation for obsessive-compulsive disorder: subthalamic nucleus target.
Identifieur interne : 000704 ( PubMed/Corpus ); précédent : 000703; suivant : 000705Deep brain stimulation for obsessive-compulsive disorder: subthalamic nucleus target.
Auteurs : Stéphan Chabardès ; Mircea Polosan ; Paul Krack ; Julien Bastin ; Alexandre Krainik ; Olivier David ; Thierry Bougerol ; Alim Louis BenabidSource :
- World neurosurgery [ 1878-8769 ]
English descriptors
- KwdEn :
- Adult, Age of Onset, Animals, Deep Brain Stimulation (adverse effects), Deep Brain Stimulation (methods), Female, Humans, Impulsive Behavior (psychology), Impulsive Behavior (surgery), Male, Neurosurgical Procedures (adverse effects), Neurosurgical Procedures (methods), Obsessive-Compulsive Disorder (pathology), Obsessive-Compulsive Disorder (psychology), Obsessive-Compulsive Disorder (therapy), Patient Selection, Subthalamic Nucleus (pathology), Subthalamic Nucleus (surgery), Treatment Failure, Treatment Outcome.
- MESH :
- adverse effects : Deep Brain Stimulation, Neurosurgical Procedures.
- methods : Deep Brain Stimulation, Neurosurgical Procedures.
- pathology : Obsessive-Compulsive Disorder, Subthalamic Nucleus.
- psychology : Impulsive Behavior, Obsessive-Compulsive Disorder.
- surgery : Impulsive Behavior, Subthalamic Nucleus.
- therapy : Obsessive-Compulsive Disorder.
- Adult, Age of Onset, Animals, Female, Humans, Male, Patient Selection, Treatment Failure, Treatment Outcome.
Abstract
Because of its reversibility and adaptability, deep brain stimulation (DBS) has recently gained interest in psychiatric disorders, such as obsessive-compulsive disorders (OCD) and depression. In OCD, DBS is now an alternative procedure to lesions of fascicles such as the anterior capsule, which links the orbitofrontal cortex, the cingulum, and the thalamus, and has been applied to new target such as the nucleus accumbens, with promising results. However, a recent interest has been developed toward the subthalamic nucleus (STN), a key structure of the basal ganglia that connects the motor, limbic, and associative systems. It is known from patients with Parkinson disease that STN-DBS can have significant effects on mood and cognition. Those transient effects are usually seen as "side effects" in Parkinson disease, but are clues to the underappreciated role that STN plays in the limbic circuitry, a role whose precise details are as yet unknown and under active investigation. We present the rationale supporting the use of nonmotor STN as a therapeutic target to treat OCD. In particular, we discuss the recent experience and preliminary results of our group after 6 months of nonmotor STN-DBS in patients with severe OCD.
DOI: 10.1016/j.wneu.2012.03.010
PubMed: 22469523
Links to Exploration step
pubmed:22469523Le document en format XML
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Electronic address: SChabardes@chu-grenoble.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Polosan, Mircea" sort="Polosan, Mircea" uniqKey="Polosan M" first="Mircea" last="Polosan">Mircea Polosan</name></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name></author><author><name sortKey="Bastin, Julien" sort="Bastin, Julien" uniqKey="Bastin J" first="Julien" last="Bastin">Julien Bastin</name></author><author><name sortKey="Krainik, Alexandre" sort="Krainik, Alexandre" uniqKey="Krainik A" first="Alexandre" last="Krainik">Alexandre Krainik</name></author><author><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name></author><author><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim Louis" last="Benabid">Alim Louis Benabid</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2013 Sep-Oct</MedlineDate></PubDate></date><idno type="RBID">pubmed:22469523</idno><idno type="pmid">22469523</idno><idno type="doi">10.1016/j.wneu.2012.03.010</idno><idno type="wicri:Area/PubMed/Corpus">000704</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000704</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Deep brain stimulation for obsessive-compulsive disorder: subthalamic nucleus target.</title><author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name><affiliation><nlm:affiliation>Université Joseph Fourier, Grenoble, France; Clinique de Neurochirurgie, Centre Hospitalier Universitaire, Grenoble, France; INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France. Electronic address: SChabardes@chu-grenoble.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Polosan, Mircea" sort="Polosan, Mircea" uniqKey="Polosan M" first="Mircea" last="Polosan">Mircea Polosan</name></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name></author><author><name sortKey="Bastin, Julien" sort="Bastin, Julien" uniqKey="Bastin J" first="Julien" last="Bastin">Julien Bastin</name></author><author><name sortKey="Krainik, Alexandre" sort="Krainik, Alexandre" uniqKey="Krainik A" first="Alexandre" last="Krainik">Alexandre Krainik</name></author><author><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name></author><author><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim Louis" last="Benabid">Alim Louis Benabid</name></author></analytic><series><title level="j">World neurosurgery</title><idno type="eISSN">1878-8769</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Animals</term><term>Deep Brain Stimulation (adverse effects)</term><term>Deep Brain Stimulation (methods)</term><term>Female</term><term>Humans</term><term>Impulsive Behavior (psychology)</term><term>Impulsive Behavior (surgery)</term><term>Male</term><term>Neurosurgical Procedures (adverse effects)</term><term>Neurosurgical Procedures (methods)</term><term>Obsessive-Compulsive Disorder (pathology)</term><term>Obsessive-Compulsive Disorder (psychology)</term><term>Obsessive-Compulsive Disorder (therapy)</term><term>Patient Selection</term><term>Subthalamic Nucleus (pathology)</term><term>Subthalamic Nucleus (surgery)</term><term>Treatment Failure</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Deep Brain Stimulation</term><term>Neurosurgical Procedures</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term><term>Neurosurgical Procedures</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Obsessive-Compulsive Disorder</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Impulsive Behavior</term><term>Obsessive-Compulsive Disorder</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Impulsive Behavior</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Obsessive-Compulsive Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Animals</term><term>Female</term><term>Humans</term><term>Male</term><term>Patient Selection</term><term>Treatment Failure</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Because of its reversibility and adaptability, deep brain stimulation (DBS) has recently gained interest in psychiatric disorders, such as obsessive-compulsive disorders (OCD) and depression. In OCD, DBS is now an alternative procedure to lesions of fascicles such as the anterior capsule, which links the orbitofrontal cortex, the cingulum, and the thalamus, and has been applied to new target such as the nucleus accumbens, with promising results. However, a recent interest has been developed toward the subthalamic nucleus (STN), a key structure of the basal ganglia that connects the motor, limbic, and associative systems. It is known from patients with Parkinson disease that STN-DBS can have significant effects on mood and cognition. Those transient effects are usually seen as "side effects" in Parkinson disease, but are clues to the underappreciated role that STN plays in the limbic circuitry, a role whose precise details are as yet unknown and under active investigation. We present the rationale supporting the use of nonmotor STN as a therapeutic target to treat OCD. In particular, we discuss the recent experience and preliminary results of our group after 6 months of nonmotor STN-DBS in patients with severe OCD.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22469523</PMID><DateCreated><Year>2013</Year><Month>10</Month><Day>07</Day></DateCreated><DateCompleted><Year>2013</Year><Month>12</Month><Day>05</Day></DateCompleted><DateRevised><Year>2016</Year><Month>05</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-8769</ISSN><JournalIssue CitedMedium="Internet"><Volume>80</Volume><Issue>3-4</Issue><PubDate><MedlineDate>2013 Sep-Oct</MedlineDate></PubDate></JournalIssue><Title>World neurosurgery</Title><ISOAbbreviation>World Neurosurg</ISOAbbreviation></Journal><ArticleTitle>Deep brain stimulation for obsessive-compulsive disorder: subthalamic nucleus target.</ArticleTitle><Pagination><MedlinePgn>S31.e1-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.wneu.2012.03.010</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1878-8750(12)00413-5</ELocationID><Abstract><AbstractText>Because of its reversibility and adaptability, deep brain stimulation (DBS) has recently gained interest in psychiatric disorders, such as obsessive-compulsive disorders (OCD) and depression. In OCD, DBS is now an alternative procedure to lesions of fascicles such as the anterior capsule, which links the orbitofrontal cortex, the cingulum, and the thalamus, and has been applied to new target such as the nucleus accumbens, with promising results. However, a recent interest has been developed toward the subthalamic nucleus (STN), a key structure of the basal ganglia that connects the motor, limbic, and associative systems. It is known from patients with Parkinson disease that STN-DBS can have significant effects on mood and cognition. Those transient effects are usually seen as "side effects" in Parkinson disease, but are clues to the underappreciated role that STN plays in the limbic circuitry, a role whose precise details are as yet unknown and under active investigation. We present the rationale supporting the use of nonmotor STN as a therapeutic target to treat OCD. In particular, we discuss the recent experience and preliminary results of our group after 6 months of nonmotor STN-DBS in patients with severe OCD.</AbstractText><CopyrightInformation>Copyright © 2013 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chabardès</LastName><ForeName>Stéphan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Université Joseph Fourier, Grenoble, France; Clinique de Neurochirurgie, Centre Hospitalier Universitaire, Grenoble, France; INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France. Electronic address: SChabardes@chu-grenoble.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Polosan</LastName><ForeName>Mircea</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Krack</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Bastin</LastName><ForeName>Julien</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Krainik</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>David</LastName><ForeName>Olivier</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Bougerol</LastName><ForeName>Thierry</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Benabid</LastName><ForeName>Alim Louis</ForeName><Initials>AL</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>03</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>World Neurosurg</MedlineTA><NlmUniqueID>101528275</NlmUniqueID><ISSNLinking>1878-8750</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017668" MajorTopicYN="N">Age of Onset</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046690" MajorTopicYN="N">Deep Brain Stimulation</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007175" MajorTopicYN="N">Impulsive Behavior</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019635" MajorTopicYN="N">Neurosurgical Procedures</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009771" MajorTopicYN="N">Obsessive-Compulsive Disorder</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018579" MajorTopicYN="N">Patient Selection</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020531" MajorTopicYN="N">Subthalamic Nucleus</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017211" MajorTopicYN="N">Treatment Failure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AC-PC</Keyword><Keyword MajorTopicYN="N">Anterior-posterior commissural</Keyword><Keyword MajorTopicYN="N">Basal ganglia</Keyword><Keyword MajorTopicYN="N">CBT</Keyword><Keyword MajorTopicYN="N">Cognitive-behavior therapy</Keyword><Keyword MajorTopicYN="N">DBS</Keyword><Keyword MajorTopicYN="N">Deep brain stimulation</Keyword><Keyword MajorTopicYN="N">EEG</Keyword><Keyword MajorTopicYN="N">Electroencephalogram</Keyword><Keyword MajorTopicYN="N">GAF</Keyword><Keyword MajorTopicYN="N">Global assessment of functioning</Keyword><Keyword MajorTopicYN="N">HFS</Keyword><Keyword MajorTopicYN="N">High-frequency stimulation</Keyword><Keyword MajorTopicYN="N">MRI</Keyword><Keyword MajorTopicYN="N">Magnetic resonance imaging</Keyword><Keyword MajorTopicYN="N">Nonmotor subthalamic nucleus</Keyword><Keyword MajorTopicYN="N">OCD</Keyword><Keyword MajorTopicYN="N">Obsessive-compulsive disorder</Keyword><Keyword MajorTopicYN="N">PD</Keyword><Keyword MajorTopicYN="N">Parkinson disease</Keyword><Keyword MajorTopicYN="N">Psychiatric disorders</Keyword><Keyword MajorTopicYN="N">STN</Keyword><Keyword MajorTopicYN="N">STOC</Keyword><Keyword MajorTopicYN="N">Stimulation “dans le Trouble Obsessionnel Compulsif”</Keyword><Keyword MajorTopicYN="N">Subthalamic nucleus</Keyword><Keyword MajorTopicYN="N">Surgery</Keyword><Keyword MajorTopicYN="N">Y-BOCS</Keyword><Keyword MajorTopicYN="N">Yale-Brown obsession compulsion scale</Keyword><Keyword MajorTopicYN="N">noM-STN</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>11</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>02</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>03</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>4</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>4</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>12</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22469523</ArticleId><ArticleId IdType="pii">S1878-8750(12)00413-5</ArticleId><ArticleId IdType="doi">10.1016/j.wneu.2012.03.010</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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