ParkinsonFranceV1, Ncbi, Curation, bibRecord, 000B04

Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation

Identifieur interne : 000B04 ( Ncbi/Curation ); précédent : 000B03; suivant : 000B05

Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation

Auteurs : Tiphaine Rouaud [France] ; Sylvie Lardeux [France] ; Nicolas Panayotis [France] ; Dany Paleressompoulle [France] ; Martine Cador [France] ; Christelle Baunez [France]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2009.

RBID : PMC:2824319

English descriptors

KwdEn :
- Analysis of Variance, Animals, Cocaine (administration & dosage), Deep Brain Stimulation, Male, Motivation, Rats, Rats, Long-Evans, Subthalamic Nucleus (physiology).
MESH :
- chemical , administration & dosage : Cocaine.
- physiology : Subthalamic Nucleus.
- Analysis of Variance, Animals, Deep Brain Stimulation, Male, Motivation, Rats, Rats, Long-Evans.

Abstract

Deep brain stimulation (DBS) is a reversible technique that is currently used for the treatment of Parkinson disease and may be suitable for the treatment of psychiatric disorders. Whether DBS inactivates the target structure is still a matter of debate. Here, from findings obtained in rats, we propose DBS of the subthalamic nucleus (STN) as a possible treatment for cocaine addiction to be further tested in human studies. We show that STN DBS reversibly reduces the motivation to work for an i.v. injection of cocaine, and it increases motivation to work for sucrose pellets. These opposite effects may result from STN DBS effect on the positive affective properties of these rewards. Indeed, we further show that STN DBS reduces the preference for a place previously associated with the rewarding properties of cocaine, and it increases the preference for a place associated with food. Because these findings are consistent with those observed after STN lesions [Baunez C, Dias C, Cador M, Amalric M (2005) Nat Neurosci 8:484–489], they suggest that STN DBS mimics an inactivation of the STN on motivational processes. Furthermore, given that one of the major challenges for cocaine addiction is to find a treatment that reduces the craving for the drug without diminishing the motivation for naturally rewarding activities, our findings validate STN as a good target and DBS as the appropriate technique for a promising therapeutic strategy in the treatment of cocaine addiction.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824319

DOI: 10.1073/pnas.0908189107
PubMed: 20080543
PubMed Central: 2824319

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000534
to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000531
to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000801
to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000B18
to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000A78
to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000A78
to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000B04

Links to Exploration step

PMC:2824319

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation</title>
<author><name sortKey="Rouaud, Tiphaine" sort="Rouaud, Tiphaine" uniqKey="Rouaud T" first="Tiphaine" last="Rouaud">Tiphaine Rouaud</name>
<affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff1">Laboratoire de Neurobiologie de la Cognition, Centre National de la Recherche Scientifique UMR6155,<institution>Aix-Marseille Université</institution>
, 13331 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>, 13331 Marseille</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lardeux, Sylvie" sort="Lardeux, Sylvie" uniqKey="Lardeux S" first="Sylvie" last="Lardeux">Sylvie Lardeux</name>
<affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff1">Laboratoire de Neurobiologie de la Cognition, Centre National de la Recherche Scientifique UMR6155,<institution>Aix-Marseille Université</institution>
, 13331 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>, 13331 Marseille</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Panayotis, Nicolas" sort="Panayotis, Nicolas" uniqKey="Panayotis N" first="Nicolas" last="Panayotis">Nicolas Panayotis</name>
<affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff1">Laboratoire de Neurobiologie de la Cognition, Centre National de la Recherche Scientifique UMR6155,<institution>Aix-Marseille Université</institution>
, 13331 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>, 13331 Marseille</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Paleressompoulle, Dany" sort="Paleressompoulle, Dany" uniqKey="Paleressompoulle D" first="Dany" last="Paleressompoulle">Dany Paleressompoulle</name>
<affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff1">Laboratoire de Neurobiologie de la Cognition, Centre National de la Recherche Scientifique UMR6155,<institution>Aix-Marseille Université</institution>
, 13331 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>, 13331 Marseille</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cador, Martine" sort="Cador, Martine" uniqKey="Cador M" first="Martine" last="Cador">Martine Cador</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Team Neurospychopharmacologie de L’Addiction, Centre National de la Recherche Scientifique UMR 5227,<institution>Université Bordeaux</institution>
 1 and 2, BP31, 33077 Bordeaux Cedex, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> 1 and 2, BP31, 33077 Bordeaux Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baunez, Christelle" sort="Baunez, Christelle" uniqKey="Baunez C" first="Christelle" last="Baunez">Christelle Baunez</name>
<affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff1">Laboratoire de Neurobiologie de la Cognition, Centre National de la Recherche Scientifique UMR6155,<institution>Aix-Marseille Université</institution>
, 13331 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>, 13331 Marseille</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20080543</idno>
<idno type="pmc">2824319</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824319</idno>
<idno type="RBID">PMC:2824319</idno>
<idno type="doi">10.1073/pnas.0908189107</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">000534</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000534</idno>
<idno type="wicri:Area/Pmc/Curation">000531</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000531</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000801</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000801</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000B18</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B18</idno>
<idno type="wicri:Area/PubMed/Curation">000A78</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A78</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000A78</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A78</idno>
<idno type="wicri:Area/Ncbi/Merge">000B04</idno>
<idno type="wicri:Area/Ncbi/Curation">000B04</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation</title>
<author><name sortKey="Rouaud, Tiphaine" sort="Rouaud, Tiphaine" uniqKey="Rouaud T" first="Tiphaine" last="Rouaud">Tiphaine Rouaud</name>
<affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff1">Laboratoire de Neurobiologie de la Cognition, Centre National de la Recherche Scientifique UMR6155,<institution>Aix-Marseille Université</institution>
, 13331 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>, 13331 Marseille</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lardeux, Sylvie" sort="Lardeux, Sylvie" uniqKey="Lardeux S" first="Sylvie" last="Lardeux">Sylvie Lardeux</name>
<affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff1">Laboratoire de Neurobiologie de la Cognition, Centre National de la Recherche Scientifique UMR6155,<institution>Aix-Marseille Université</institution>
, 13331 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>, 13331 Marseille</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Panayotis, Nicolas" sort="Panayotis, Nicolas" uniqKey="Panayotis N" first="Nicolas" last="Panayotis">Nicolas Panayotis</name>
<affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff1">Laboratoire de Neurobiologie de la Cognition, Centre National de la Recherche Scientifique UMR6155,<institution>Aix-Marseille Université</institution>
, 13331 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>, 13331 Marseille</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Paleressompoulle, Dany" sort="Paleressompoulle, Dany" uniqKey="Paleressompoulle D" first="Dany" last="Paleressompoulle">Dany Paleressompoulle</name>
<affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff1">Laboratoire de Neurobiologie de la Cognition, Centre National de la Recherche Scientifique UMR6155,<institution>Aix-Marseille Université</institution>
, 13331 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>, 13331 Marseille</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cador, Martine" sort="Cador, Martine" uniqKey="Cador M" first="Martine" last="Cador">Martine Cador</name>
<affiliation wicri:level="3"><nlm:aff id="aff2">Team Neurospychopharmacologie de L’Addiction, Centre National de la Recherche Scientifique UMR 5227,<institution>Université Bordeaux</institution>
 1 and 2, BP31, 33077 Bordeaux Cedex, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> 1 and 2, BP31, 33077 Bordeaux Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baunez, Christelle" sort="Baunez, Christelle" uniqKey="Baunez C" first="Christelle" last="Baunez">Christelle Baunez</name>
<affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff1">Laboratoire de Neurobiologie de la Cognition, Centre National de la Recherche Scientifique UMR6155,<institution>Aix-Marseille Université</institution>
, 13331 Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>, 13331 Marseille</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="ISSN">0027-8424</idno>
<idno type="eISSN">1091-6490</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term>
<term>Animals</term>
<term>Cocaine (administration & dosage)</term>
<term>Deep Brain Stimulation</term>
<term>Male</term>
<term>Motivation</term>
<term>Rats</term>
<term>Rats, Long-Evans</term>
<term>Subthalamic Nucleus (physiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Cocaine</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term>
<term>Animals</term>
<term>Deep Brain Stimulation</term>
<term>Male</term>
<term>Motivation</term>
<term>Rats</term>
<term>Rats, Long-Evans</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Deep brain stimulation (DBS) is a reversible technique that is currently used for the treatment of Parkinson disease and may be suitable for the treatment of psychiatric disorders. Whether DBS inactivates the target structure is still a matter of debate. Here, from findings obtained in rats, we propose DBS of the subthalamic nucleus (STN) as a possible treatment for cocaine addiction to be further tested in human studies. We show that STN DBS reversibly reduces the motivation to work for an i.v. injection of cocaine, and it increases motivation to work for sucrose pellets. These opposite effects may result from STN DBS effect on the positive affective properties of these rewards. Indeed, we further show that STN DBS reduces the preference for a place previously associated with the rewarding properties of cocaine, and it increases the preference for a place associated with food. Because these findings are consistent with those observed after STN lesions [Baunez C, Dias C, Cador M, Amalric M (2005) <italic>Nat Neurosci</italic>
 8:484–489], they suggest that STN DBS mimics an inactivation of the STN on motivational processes. Furthermore, given that one of the major challenges for cocaine addiction is to find a treatment that reduces the craving for the drug without diminishing the motivation for naturally rewarding activities, our findings validate STN as a good target and DBS as the appropriate technique for a promising therapeutic strategy in the treatment of cocaine addiction.</p>
</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B04 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000B04 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Ncbi
   |étape=   Curation
   |type=    RBID
   |clé=     PMC:2824319
   |texte=   Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i   -Sk "pubmed:20080543" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonFranceV1

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation

Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki