Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation
Identifieur interne : 000534 ( Pmc/Corpus ); précédent : 000533; suivant : 000535Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation
Auteurs : Tiphaine Rouaud ; Sylvie Lardeux ; Nicolas Panayotis ; Dany Paleressompoulle ; Martine Cador ; Christelle BaunezSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2009.
Abstract
Deep brain stimulation (DBS) is a reversible technique that is currently used for the treatment of Parkinson disease and may be suitable for the treatment of psychiatric disorders. Whether DBS inactivates the target structure is still a matter of debate. Here, from findings obtained in rats, we propose DBS of the subthalamic nucleus (STN) as a possible treatment for cocaine addiction to be further tested in human studies. We show that STN DBS reversibly reduces the motivation to work for an i.v. injection of cocaine, and it increases motivation to work for sucrose pellets. These opposite effects may result from STN DBS effect on the positive affective properties of these rewards. Indeed, we further show that STN DBS reduces the preference for a place previously associated with the rewarding properties of cocaine, and it increases the preference for a place associated with food. Because these findings are consistent with those observed after STN lesions [Baunez C, Dias C, Cador M, Amalric M (2005)
Url:
DOI: 10.1073/pnas.0908189107
PubMed: 20080543
PubMed Central: 2824319
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PMC:2824319Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Deep brain stimulation (DBS) is a reversible technique that is currently used for the treatment of Parkinson disease and may be suitable for the treatment of psychiatric disorders. Whether DBS inactivates the target structure is still a matter of debate. Here, from findings obtained in rats, we propose DBS of the subthalamic nucleus (STN) as a possible treatment for cocaine addiction to be further tested in human studies. We show that STN DBS reversibly reduces the motivation to work for an i.v. injection of cocaine, and it increases motivation to work for sucrose pellets. These opposite effects may result from STN DBS effect on the positive affective properties of these rewards. Indeed, we further show that STN DBS reduces the preference for a place previously associated with the rewarding properties of cocaine, and it increases the preference for a place associated with food. Because these findings are consistent with those observed after STN lesions [Baunez C, Dias C, Cador M, Amalric M (2005) <italic>Nat Neurosci</italic>
8:484–489], they suggest that STN DBS mimics an inactivation of the STN on motivational processes. Furthermore, given that one of the major challenges for cocaine addiction is to find a treatment that reduces the craving for the drug without diminishing the motivation for naturally rewarding activities, our findings validate STN as a good target and DBS as the appropriate technique for a promising therapeutic strategy in the treatment of cocaine addiction.</p>
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<title-group><article-title>Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation</article-title>
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<contrib contrib-type="author"><name><surname>Paleressompoulle</surname>
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Team Neurospychopharmacologie de L’Addiction, Centre National de la Recherche Scientifique UMR 5227,<institution>Université Bordeaux</institution>
1 and 2, BP31, 33077 Bordeaux Cedex, France</aff>
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<author-notes><corresp id="cor1"><sup>2</sup>
To whom correspondence should be addressed at: Laboratoire de Neurobiologie de la Cognition, CNRS UMR6155, Aix-Marseille Université, Pôle 3C, Case C, 3 Place Victor Hugo, 13331 Marseille, France. E-mail: <email xlink:href="christelle.baunez@univ-provence.fr">christelle.baunez@univ-provence.fr</email>
.</corresp>
<fn fn-type="edited-by"><p>Edited by Floyd E. Bloom, Scripps Research Institute, La Jolla, CA, and approved November 23, 2009 (received for review July 21, 2009)</p>
</fn>
<fn fn-type="con"><p>Author contributions: C.B. designed research; T.R., S.L., N.P., and C.B. performed research; D.P. contributed new reagents/analytic tools; T.R., S.L., N.P., and C.B. analyzed data; and S.L., M.C., and C.B. wrote the paper.</p>
</fn>
<fn fn-type="equal" id="fn1"><p><sup>1</sup>
T.R. and S.L. contributed equally to this work.</p>
</fn>
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<pub-date pub-type="epub"><day>28</day>
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<abstract><p>Deep brain stimulation (DBS) is a reversible technique that is currently used for the treatment of Parkinson disease and may be suitable for the treatment of psychiatric disorders. Whether DBS inactivates the target structure is still a matter of debate. Here, from findings obtained in rats, we propose DBS of the subthalamic nucleus (STN) as a possible treatment for cocaine addiction to be further tested in human studies. We show that STN DBS reversibly reduces the motivation to work for an i.v. injection of cocaine, and it increases motivation to work for sucrose pellets. These opposite effects may result from STN DBS effect on the positive affective properties of these rewards. Indeed, we further show that STN DBS reduces the preference for a place previously associated with the rewarding properties of cocaine, and it increases the preference for a place associated with food. Because these findings are consistent with those observed after STN lesions [Baunez C, Dias C, Cador M, Amalric M (2005) <italic>Nat Neurosci</italic>
8:484–489], they suggest that STN DBS mimics an inactivation of the STN on motivational processes. Furthermore, given that one of the major challenges for cocaine addiction is to find a treatment that reduces the craving for the drug without diminishing the motivation for naturally rewarding activities, our findings validate STN as a good target and DBS as the appropriate technique for a promising therapeutic strategy in the treatment of cocaine addiction.</p>
</abstract>
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