Electrophysiological action of bepridil on atrioventricular accessory pathways.
Identifieur interne : 001C45 ( Ncbi/Checkpoint ); précédent : 001C44; suivant : 001C46Electrophysiological action of bepridil on atrioventricular accessory pathways.
Auteurs : P. Touboul [France] ; G. Atallah ; G. Kirkorian ; P. Lavaud ; J R Kieny ; M P Mathieu ; A. DellingerSource :
- British heart journal [ 0007-0769 ] ; 1987.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Anti-Arrhythmia Agents, Pyrrolidines.
- drug effects : Heart Conduction System.
- drug therapy : Pre-Excitation Syndromes, Wolff-Parkinson-White Syndrome.
- Adolescent, Adult, Bepridil, Female, Humans, Male, Middle Aged.
Abstract
The electrophysiologic properties of bepridil, a calcium channel blocker with additional effects on fast response tissues, were investigated in 10 patients with atrioventricular accessory pathways. Seven patients had Wolff-Parkinson-White syndrome, and three had concealed atrioventricular pre-excitation. A dose of 4 mg/kg was administered intravenously over five minutes. Bepridil increased the AH interval and the functional refractory period of the atrioventricular node. The effective refractory periods of the right atrium and right ventricle were also increased. Bepridil prolonged refractoriness in the accessory pathway both in the anterograde and retrograde direction. After bepridil administration it was impossible to induce reciprocating tachycardia electrically in two patients because of conduction block in the normal pathway. On the other hand, the zone of tachycardia was often increased after bepridil. Nevertheless, the heart rate during tachycardia was slowed by depression of conduction in both the normal and accessory pathways. The findings of this study provide a basis for the antiarrhythmic action of bepridil in patients with atrioventricular accessory pathways.
PubMed: 3499924
Affiliations:
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Kirkorian</name></author><author><name sortKey="Lavaud, P" sort="Lavaud, P" uniqKey="Lavaud P" first="P" last="Lavaud">P. Lavaud</name></author><author><name sortKey="Kieny, J R" sort="Kieny, J R" uniqKey="Kieny J" first="J R" last="Kieny">J R Kieny</name></author><author><name sortKey="Mathieu, M P" sort="Mathieu, M P" uniqKey="Mathieu M" first="M P" last="Mathieu">M P Mathieu</name></author><author><name sortKey="Dellinger, A" sort="Dellinger, A" uniqKey="Dellinger A" first="A" last="Dellinger">A. 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Touboul</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Cardiovasculaire et Pneumologique Louis Pradel, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Cardiovasculaire et Pneumologique Louis Pradel, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Atallah, G" sort="Atallah, G" uniqKey="Atallah G" first="G" last="Atallah">G. Atallah</name></author><author><name sortKey="Kirkorian, G" sort="Kirkorian, G" uniqKey="Kirkorian G" first="G" last="Kirkorian">G. Kirkorian</name></author><author><name sortKey="Lavaud, P" sort="Lavaud, P" uniqKey="Lavaud P" first="P" last="Lavaud">P. Lavaud</name></author><author><name sortKey="Kieny, J R" sort="Kieny, J R" uniqKey="Kieny J" first="J R" last="Kieny">J R Kieny</name></author><author><name sortKey="Mathieu, M P" sort="Mathieu, M P" uniqKey="Mathieu M" first="M P" last="Mathieu">M P Mathieu</name></author><author><name sortKey="Dellinger, A" sort="Dellinger, A" uniqKey="Dellinger A" first="A" last="Dellinger">A. Dellinger</name></author></analytic><series><title level="j">British heart journal</title><idno type="ISSN">0007-0769</idno><imprint><date when="1987" type="published">1987</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Anti-Arrhythmia Agents (therapeutic use)</term><term>Bepridil</term><term>Female</term><term>Heart Conduction System (drug effects)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pre-Excitation Syndromes (drug therapy)</term><term>Pyrrolidines (therapeutic use)</term><term>Wolff-Parkinson-White Syndrome (drug therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Arrhythmia Agents</term><term>Pyrrolidines</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Heart Conduction System</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Pre-Excitation Syndromes</term><term>Wolff-Parkinson-White Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Bepridil</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The electrophysiologic properties of bepridil, a calcium channel blocker with additional effects on fast response tissues, were investigated in 10 patients with atrioventricular accessory pathways. Seven patients had Wolff-Parkinson-White syndrome, and three had concealed atrioventricular pre-excitation. A dose of 4 mg/kg was administered intravenously over five minutes. Bepridil increased the AH interval and the functional refractory period of the atrioventricular node. The effective refractory periods of the right atrium and right ventricle were also increased. Bepridil prolonged refractoriness in the accessory pathway both in the anterograde and retrograde direction. After bepridil administration it was impossible to induce reciprocating tachycardia electrically in two patients because of conduction block in the normal pathway. On the other hand, the zone of tachycardia was often increased after bepridil. Nevertheless, the heart rate during tachycardia was slowed by depression of conduction in both the normal and accessory pathways. The findings of this study provide a basis for the antiarrhythmic action of bepridil in patients with atrioventricular accessory pathways.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li></settlement></list><tree><noCountry><name sortKey="Atallah, G" sort="Atallah, G" uniqKey="Atallah G" first="G" last="Atallah">G. Atallah</name><name sortKey="Dellinger, A" sort="Dellinger, A" uniqKey="Dellinger A" first="A" last="Dellinger">A. Dellinger</name><name sortKey="Kieny, J R" sort="Kieny, J R" uniqKey="Kieny J" first="J R" last="Kieny">J R Kieny</name><name sortKey="Kirkorian, G" sort="Kirkorian, G" uniqKey="Kirkorian G" first="G" last="Kirkorian">G. Kirkorian</name><name sortKey="Lavaud, P" sort="Lavaud, P" uniqKey="Lavaud P" first="P" last="Lavaud">P. Lavaud</name><name sortKey="Mathieu, M P" sort="Mathieu, M P" uniqKey="Mathieu M" first="M P" last="Mathieu">M P Mathieu</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Touboul, P" sort="Touboul, P" uniqKey="Touboul P" first="P" last="Touboul">P. Touboul</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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