Electrophysiological action of bepridil on atrioventricular accessory pathways.
Identifieur interne : 001C45 ( Ncbi/Merge ); précédent : 001C44; suivant : 001C46Electrophysiological action of bepridil on atrioventricular accessory pathways.
Auteurs : P. Touboul [France] ; G. Atallah ; G. Kirkorian ; P. Lavaud ; J R Kieny ; M P Mathieu ; A. DellingerSource :
- British heart journal [ 0007-0769 ] ; 1987.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Anti-Arrhythmia Agents, Pyrrolidines.
- drug effects : Heart Conduction System.
- drug therapy : Pre-Excitation Syndromes, Wolff-Parkinson-White Syndrome.
- Adolescent, Adult, Bepridil, Female, Humans, Male, Middle Aged.
Abstract
The electrophysiologic properties of bepridil, a calcium channel blocker with additional effects on fast response tissues, were investigated in 10 patients with atrioventricular accessory pathways. Seven patients had Wolff-Parkinson-White syndrome, and three had concealed atrioventricular pre-excitation. A dose of 4 mg/kg was administered intravenously over five minutes. Bepridil increased the AH interval and the functional refractory period of the atrioventricular node. The effective refractory periods of the right atrium and right ventricle were also increased. Bepridil prolonged refractoriness in the accessory pathway both in the anterograde and retrograde direction. After bepridil administration it was impossible to induce reciprocating tachycardia electrically in two patients because of conduction block in the normal pathway. On the other hand, the zone of tachycardia was often increased after bepridil. Nevertheless, the heart rate during tachycardia was slowed by depression of conduction in both the normal and accessory pathways. The findings of this study provide a basis for the antiarrhythmic action of bepridil in patients with atrioventricular accessory pathways.
PubMed: 3499924
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Touboul</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Cardiovasculaire et Pneumologique Louis Pradel, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Cardiovasculaire et Pneumologique Louis Pradel, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Atallah, G" sort="Atallah, G" uniqKey="Atallah G" first="G" last="Atallah">G. Atallah</name></author><author><name sortKey="Kirkorian, G" sort="Kirkorian, G" uniqKey="Kirkorian G" first="G" last="Kirkorian">G. Kirkorian</name></author><author><name sortKey="Lavaud, P" sort="Lavaud, P" uniqKey="Lavaud P" first="P" last="Lavaud">P. Lavaud</name></author><author><name sortKey="Kieny, J R" sort="Kieny, J R" uniqKey="Kieny J" first="J R" last="Kieny">J R Kieny</name></author><author><name sortKey="Mathieu, M P" sort="Mathieu, M P" uniqKey="Mathieu M" first="M P" last="Mathieu">M P Mathieu</name></author><author><name sortKey="Dellinger, A" sort="Dellinger, A" uniqKey="Dellinger A" first="A" last="Dellinger">A. Dellinger</name></author></analytic><series><title level="j">British heart journal</title><idno type="ISSN">0007-0769</idno><imprint><date when="1987" type="published">1987</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Anti-Arrhythmia Agents (therapeutic use)</term><term>Bepridil</term><term>Female</term><term>Heart Conduction System (drug effects)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pre-Excitation Syndromes (drug therapy)</term><term>Pyrrolidines (therapeutic use)</term><term>Wolff-Parkinson-White Syndrome (drug therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Arrhythmia Agents</term><term>Pyrrolidines</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Heart Conduction System</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Pre-Excitation Syndromes</term><term>Wolff-Parkinson-White Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Bepridil</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The electrophysiologic properties of bepridil, a calcium channel blocker with additional effects on fast response tissues, were investigated in 10 patients with atrioventricular accessory pathways. Seven patients had Wolff-Parkinson-White syndrome, and three had concealed atrioventricular pre-excitation. A dose of 4 mg/kg was administered intravenously over five minutes. Bepridil increased the AH interval and the functional refractory period of the atrioventricular node. The effective refractory periods of the right atrium and right ventricle were also increased. Bepridil prolonged refractoriness in the accessory pathway both in the anterograde and retrograde direction. After bepridil administration it was impossible to induce reciprocating tachycardia electrically in two patients because of conduction block in the normal pathway. On the other hand, the zone of tachycardia was often increased after bepridil. Nevertheless, the heart rate during tachycardia was slowed by depression of conduction in both the normal and accessory pathways. The findings of this study provide a basis for the antiarrhythmic action of bepridil in patients with atrioventricular accessory pathways.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">3499924</PMID><DateCreated><Year>1988</Year><Month>01</Month><Day>21</Day></DateCreated><DateCompleted><Year>1988</Year><Month>01</Month><Day>21</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0007-0769</ISSN><JournalIssue CitedMedium="Print"><Volume>58</Volume><Issue>4</Issue><PubDate><Year>1987</Year><Month>Oct</Month></PubDate></JournalIssue><Title>British heart journal</Title><ISOAbbreviation>Br Heart J</ISOAbbreviation></Journal><ArticleTitle>Electrophysiological action of bepridil on atrioventricular accessory pathways.</ArticleTitle><Pagination><MedlinePgn>333-8</MedlinePgn></Pagination><Abstract><AbstractText>The electrophysiologic properties of bepridil, a calcium channel blocker with additional effects on fast response tissues, were investigated in 10 patients with atrioventricular accessory pathways. Seven patients had Wolff-Parkinson-White syndrome, and three had concealed atrioventricular pre-excitation. A dose of 4 mg/kg was administered intravenously over five minutes. Bepridil increased the AH interval and the functional refractory period of the atrioventricular node. The effective refractory periods of the right atrium and right ventricle were also increased. Bepridil prolonged refractoriness in the accessory pathway both in the anterograde and retrograde direction. After bepridil administration it was impossible to induce reciprocating tachycardia electrically in two patients because of conduction block in the normal pathway. On the other hand, the zone of tachycardia was often increased after bepridil. Nevertheless, the heart rate during tachycardia was slowed by depression of conduction in both the normal and accessory pathways. The findings of this study provide a basis for the antiarrhythmic action of bepridil in patients with atrioventricular accessory pathways.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Touboul</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Hôpital Cardiovasculaire et Pneumologique Louis Pradel, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Atallah</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Kirkorian</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Lavaud</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Kieny</LastName><ForeName>J R</ForeName><Initials>JR</Initials></Author><Author ValidYN="Y"><LastName>Mathieu</LastName><ForeName>M P</ForeName><Initials>MP</Initials></Author><Author ValidYN="Y"><LastName>Dellinger</LastName><ForeName>A</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Br Heart J</MedlineTA><NlmUniqueID>0370634</NlmUniqueID><ISSNLinking>0007-0769</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000889">Anti-Arrhythmia Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011759">Pyrrolidines</NameOfSubstance></Chemical><Chemical><RegistryNumber>755BO701MA</RegistryNumber><NameOfSubstance UI="D015764">Bepridil</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Circulation. 1967 Nov;36(5):644-62</RefSource><PMID Version="1">6050923</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Cardiol. 1987 Jan 1;59(1):89-92</RefSource><PMID Version="1">3492906</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Circ Res. 1970 Sep;27(3):345-59</RefSource><PMID Version="1">5452734</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Circulation. 1975 Oct;52(4):552-62</RefSource><PMID Version="1">1157268</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Cardiol. 1977 Oct;40(4):514-20</RefSource><PMID Version="1">910715</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Prog Cardiovasc Dis. 1978 Jan-Feb;20(4):285-327</RefSource><PMID Version="1">146210</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Pharmacol Exp Ther. 1979 Sep;210(3):378-85</RefSource><PMID Version="1">480188</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Therapie. 1980 Sep-Oct;35(5):607-12</RefSource><PMID Version="1">6970998</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cardiovasc Pharmacol. 1981 Jul-Aug;3(4):655-67</RefSource><PMID Version="1">6167797</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Circulation. 1982 Feb;65(2):348-54</RefSource><PMID Version="1">7053894</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Cardiol Angeiol (Paris). 1982 Jul-Sep;31(5):409-15</RefSource><PMID Version="1">6984315</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Mal Coeur Vaiss. 1983 Mar;76(3):341-8</RefSource><PMID Version="1">6409035</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Cardiol. 1984 Sep 1;54(6):579-81</RefSource><PMID Version="1">6332516</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Cardiol. 1985 Jun 1;55(13 Pt 1):1513-9</RefSource><PMID Version="1">3873867</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Cardiol. 1985 Jun 1;55(13 Pt 1):1589-95</RefSource><PMID Version="1">3873868</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Mal Coeur Vaiss. 1985 Apr;78(4):612-9</RefSource><PMID Version="1">3923987</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Circulation. 1969 Jan;39(1):13-8</RefSource><PMID Version="1">5782803</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000889" MajorTopicYN="N">Anti-Arrhythmia Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015764" MajorTopicYN="N">Bepridil</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006329" MajorTopicYN="N">Heart Conduction System</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011226" MajorTopicYN="N">Pre-Excitation Syndromes</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011759" MajorTopicYN="N">Pyrrolidines</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014927" MajorTopicYN="N">Wolff-Parkinson-White Syndrome</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC1277263</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1987</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1987</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1987</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">3499924</ArticleId><ArticleId IdType="pmc">PMC1277263</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li></settlement></list><tree><noCountry><name sortKey="Atallah, G" sort="Atallah, G" uniqKey="Atallah G" first="G" last="Atallah">G. Atallah</name><name sortKey="Dellinger, A" sort="Dellinger, A" uniqKey="Dellinger A" first="A" last="Dellinger">A. Dellinger</name><name sortKey="Kieny, J R" sort="Kieny, J R" uniqKey="Kieny J" first="J R" last="Kieny">J R Kieny</name><name sortKey="Kirkorian, G" sort="Kirkorian, G" uniqKey="Kirkorian G" first="G" last="Kirkorian">G. Kirkorian</name><name sortKey="Lavaud, P" sort="Lavaud, P" uniqKey="Lavaud P" first="P" last="Lavaud">P. Lavaud</name><name sortKey="Mathieu, M P" sort="Mathieu, M P" uniqKey="Mathieu M" first="M P" last="Mathieu">M P Mathieu</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Touboul, P" sort="Touboul, P" uniqKey="Touboul P" first="P" last="Touboul">P. Touboul</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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