Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation.
Identifieur interne : 000482 ( Ncbi/Checkpoint ); précédent : 000481; suivant : 000483Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation.
Auteurs : Xavier Drouot [France] ; Satoru Oshino ; Bechir Jarraya ; Laurent Besret ; Haruhiko Kishima ; Philippe Remy ; Julien Dauguet ; Jean Pascal Lefaucheur ; Frédéric Dollé ; Françoise Condé ; Michel Bottlaender ; Marc Peschanski ; Yves Kéravel ; Philippe Hantraye ; Stéphane PalfiSource :
- Neuron [ 0896-6273 ] ; 2004.
English descriptors
- KwdEn :
- Animals, Chronic Disease, Disease Models, Animal, Electric Stimulation, Electrophysiology, Fluorodeoxyglucose F18, MPTP Poisoning (complications), MPTP Poisoning (diagnostic imaging), MPTP Poisoning (physiopathology), Motor Cortex (diagnostic imaging), Motor Cortex (physiopathology), Movement Disorders (etiology), Movement Disorders (physiopathology), Papio, Parkinson Disease (physiopathology), Positron-Emission Tomography, Radiopharmaceuticals, Recovery of Function.
- MESH :
- chemical : Fluorodeoxyglucose F18, Radiopharmaceuticals.
- complications : MPTP Poisoning.
- diagnostic imaging : MPTP Poisoning, Motor Cortex.
- etiology : Movement Disorders.
- physiopathology : MPTP Poisoning, Motor Cortex, Movement Disorders, Parkinson Disease.
- Animals, Chronic Disease, Disease Models, Animal, Electric Stimulation, Electrophysiology, Papio, Positron-Emission Tomography, Recovery of Function.
Abstract
A concept in Parkinson's disease postulates that motor cortex may pattern abnormal rhythmic activities in the basal ganglia, underlying the genesis of observed motor symptoms. We conducted a preclinical study of electrical interference in the primary motor cortex using a chronic MPTP primate model in which dopamine depletion was progressive and regularly documented using 18F-DOPA positron tomography. High-frequency motor cortex stimulation significantly reduced akinesia and bradykinesia. This behavioral benefit was associated with an increased metabolic activity in the supplementary motor area as assessed with 18-F-deoxyglucose PET, a normalization of mean firing rate in the internal globus pallidus (GPi) and the subthalamic nucleus (STN), and a reduction of synchronized oscillatory neuronal activities in these two structures. Motor cortex stimulation is a simple and safe procedure to modulate subthalamo-pallido-cortical loop and alleviate parkinsonian symptoms without requiring deep brain stereotactic surgery.
DOI: 10.1016/j.neuron.2004.11.023
PubMed: 15572109
Affiliations:
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Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chronic Disease</term><term>Disease Models, Animal</term><term>Electric Stimulation</term><term>Electrophysiology</term><term>Papio</term><term>Positron-Emission Tomography</term><term>Recovery of Function</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A concept in Parkinson's disease postulates that motor cortex may pattern abnormal rhythmic activities in the basal ganglia, underlying the genesis of observed motor symptoms. We conducted a preclinical study of electrical interference in the primary motor cortex using a chronic MPTP primate model in which dopamine depletion was progressive and regularly documented using 18F-DOPA positron tomography. High-frequency motor cortex stimulation significantly reduced akinesia and bradykinesia. This behavioral benefit was associated with an increased metabolic activity in the supplementary motor area as assessed with 18-F-deoxyglucose PET, a normalization of mean firing rate in the internal globus pallidus (GPi) and the subthalamic nucleus (STN), and a reduction of synchronized oscillatory neuronal activities in these two structures. Motor cortex stimulation is a simple and safe procedure to modulate subthalamo-pallido-cortical loop and alleviate parkinsonian symptoms without requiring deep brain stereotactic surgery.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Orsay</li></settlement></list><tree><noCountry><name sortKey="Besret, Laurent" sort="Besret, Laurent" uniqKey="Besret L" first="Laurent" last="Besret">Laurent Besret</name><name sortKey="Bottlaender, Michel" sort="Bottlaender, Michel" uniqKey="Bottlaender M" first="Michel" last="Bottlaender">Michel Bottlaender</name><name sortKey="Conde, Francoise" sort="Conde, Francoise" uniqKey="Conde F" first="Françoise" last="Condé">Françoise Condé</name><name sortKey="Dauguet, Julien" sort="Dauguet, Julien" uniqKey="Dauguet J" first="Julien" last="Dauguet">Julien Dauguet</name><name sortKey="Dolle, Frederic" sort="Dolle, Frederic" uniqKey="Dolle F" first="Frédéric" last="Dollé">Frédéric Dollé</name><name sortKey="Hantraye, Philippe" sort="Hantraye, Philippe" uniqKey="Hantraye P" first="Philippe" last="Hantraye">Philippe Hantraye</name><name sortKey="Jarraya, Bechir" sort="Jarraya, Bechir" uniqKey="Jarraya B" first="Bechir" last="Jarraya">Bechir Jarraya</name><name sortKey="Keravel, Yves" sort="Keravel, Yves" uniqKey="Keravel Y" first="Yves" last="Kéravel">Yves Kéravel</name><name sortKey="Kishima, Haruhiko" sort="Kishima, Haruhiko" uniqKey="Kishima H" first="Haruhiko" last="Kishima">Haruhiko Kishima</name><name sortKey="Lefaucheur, Jean Pascal" sort="Lefaucheur, Jean Pascal" uniqKey="Lefaucheur J" first="Jean Pascal" last="Lefaucheur">Jean Pascal Lefaucheur</name><name sortKey="Oshino, Satoru" sort="Oshino, Satoru" uniqKey="Oshino S" first="Satoru" last="Oshino">Satoru Oshino</name><name sortKey="Palfi, Stephane" sort="Palfi, Stephane" uniqKey="Palfi S" first="Stéphane" last="Palfi">Stéphane Palfi</name><name sortKey="Peschanski, Marc" sort="Peschanski, Marc" uniqKey="Peschanski M" first="Marc" last="Peschanski">Marc Peschanski</name><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Drouot, Xavier" sort="Drouot, Xavier" uniqKey="Drouot X" first="Xavier" last="Drouot">Xavier Drouot</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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